PCR | real-time PCR | qPCR
new and forthcoming publications ...
Virology
new and forthcoming publications ...
Genome analysis | Biotechnology
new and forthcoming publications ...
Newsletter

2011 Books

Our high level microbiology and molecular biology books bring together expert international authors under the skilled editorship of leading scientists to produce state-of-the-art compendiums of current research. Aimed at the research scientist, graduate student, medical reseacher and other professionals, these books are highly recommended for all microbiology and molecular biology laboratories. Every microbiology, molecular biology and bioscience library should have a copy of each of our books.
Library recommendation form
Advanced Vaccine Research Methods for the Decade of Vaccines
Edited by: Fabio Bagnoli and Rino Rappuoli
Published: 2015
Hardback: ISBN 978-1-910190-03-6 £180, $360. Ebook: ISBN 978-1-910190-04-3 £180, $360
We have retained the same format of our 2011 book and divided the book into two main parts. The first explores in considerable depth the key innovations that we think are dramatically changing the field; both for preclinical as well as clinical vaccine research fields. Some of the topics covered include: the use of deep sequencing, cellular screens to interrogate the human T and B cell repertoires, comparative genomics to track bacterial pathogens, quantitative proteomics, structural biology, novel strategies for vaccine administration, T-cell inducing vaccines, etc. The second part focuses on diseases for which current medical treatment is not very effective and disease that could be either prevented or treated by vaccination. The examples that we have used comprise very different diseases; we include not only infectious diseases (e.g. caused by bacteria), but also cancer. We believe that these will be the vaccines of the future, the 'vaccines for 2020'. This books is essential reading for everyone working in vaccine R and D in academia, biotechnology companies, and the pharmaceutical industry and a recommended volume for all microbiology libraries. read more ...
Bunyaviridae: Molecular and Cellular Biology
Edited by: Alexander Plyusnin and Richard M. Elliott
Published: 2011
Hardback: ISBN 978-1-904455-90-5 £159, $319
The book is essential reading for everyone working on bunyaviruses and related viruses. A recommended text for all virology libraries. read more ...
Emerging Trends in Antibacterial Discovery: Answering the Call to Arms
Edited by: Alita A. Miller and Paul F. Miller
Published: 2011
Hardback: ISBN 978-1-904455-89-9 £180, $360
In this book, respected international experts summarize the most important concepts and pioneering strategies currently being used to develop novel antibacterials. The book opens with chapters on cellular processes that could be used as novel antibacterial targets. Examples include cell division, efflux pumps, metabolite-sensing riboswitches and bacterial secretion systems. These are followed by excellent chapters on the identification of new, naturally occurring antibacterial agents, including phage and biosynthetically engineered compounds. Understanding the host-microbe interaction and microbial communities and how they can be exploited to develop new antibacterial strategies is discussed in subsequent chapters. Other topics included are: antibacterial vaccines adjuvants, host defence peptides, antibodies, within-host models, and diagnostics. A major reference volume on antibacterial research and how it impacts on public health worldwide, the book is essential reading for everyone working in antibacterial research and is a recommended volume for all microbiology libraries. read more ...
Epigenetics: A Reference Manual
Edited by: Jeffrey M. Craig and Nicholas C. Wong
Published: 2011
Hardback: ISBN 978-1-904455-88-2 £180, $360
The editors of this book have assembled top-quality scientists from diverse fields of epigenetics to produce a major new volume. Comprehensive and cutting-edge, the 26 chapters in this book constitute a key reference manual for everyone involved in epigenetics, DNA methylation, cancer epigenetics and related fields. Topics include: early life environment, DNA methylation and behavior, histone acetyltransferase biology, transgenerational epigenetic inheritance, mammalian X inactivation, epigenetic memory in plants, polycomb-group regulation, centromeres and telomeres, DNA sequence contribution to nucleosome distribution, macrosatellite epigenetics, histones, cell-fate specification and reprogramming, DNA methylation in cancer, variant histone H2A and cancer development, RNA modification, paramutation in plants, DNMT3L dependent methylation during gametogenesis, non-coding RNA, bisulphite-enabled technologies, rapid analysis of DNA methylation, microarray mapping, DNA methylation profiling, ChIP-sequencing, genome-wide DNA methylation analysis, and epigenetics in maize. In addition there are useful chapters on bioinformatics in epigenomics, online resources and tools for epigeneticists, and educational resources for epigenetics. This up-to-date reference manual is an essential book for those working in the field and for scientists in other disciplines it represents a major information resource on the fascinating and fast-moving field of epigenetics. read more ...
Metagenomics: Current Innovations and Future Trends
Edited by: Diana Marco
Published: 2011
Hardback: ISBN 978-1-904455-87-5 £159, $319
This book covers the most innovative and recent advances in theoretical, methodological and applied areas of metagenomics. Topics covered include metagenomics integration with complementary technologies, bacterial genealogy, viral metagenomics, the regulation of prokaryotic communities, functional metagenomics, systems biology, next-generation sequencing, stable isotope probing, DNA sequencing of uncultured microbes, cyberinfrastructure resource, identification of novel viruses, metagenomics of fungal communities, the human microbiome, microbial bioremediation, metagenomic enzyme discovery, quorum-sensing, plant-pathogen interactions, and metagenomics of belowground microbial communities. The book is aimed at researchers and environmental managers involved in metagenomics, students starting research in this field and teachers interested in the new developments. read more ...
Nitrogen Cycling in Bacteria: Molecular Analysis
Edited by: James W. B. Moir
Published: 2011
Hardback: ISBN 978-1-904455-86-8 £159, $319
This timely book aims to provide comprehensive reviews of current nitrogen cycle research and to give a broader perspective on the state of our understanding of this key biogeochemical cycle. With contributions from expert authors from around the world, topics covered include: the archaean N-cycle; redox complexes N-cycle; organisation of respiratory chains in N-cycle processes; Mo-nitrogenase; nitrogen assimilation in bacteria; alternative routes to dinitrogen; nitrite and nitrous oxide reductases; assembly of respiratory proteins; nitric oxide metabolism; denitrification in legume-associated endosymbiotic bacteria; nitrous oxide production in the terrestrial environment; bacterial nitrogen cycling in humans. This book will serve as a valuable reference work for everyone working in this field and will also be of interest to researchers studying symbioses, environmental microbiology, plant metabolism, infection events and other prokaryote-eukaryote interactions. read more ...
The Biology of Paramyxoviruses
Edited by: Siba K. Samal
Published: 2011
Hardback: ISBN 978-1-904455-85-1 £180, $360
This book provides a timely and comprehensive review of current knowledge of all paramyxoviruses and is written by renowned scientists who have made seminal contributions in their respective paramyxovirus fields of expertise. Topics include: mumps virus, simian virus 5, parainfluenza viruses, Newcastle disease and related avian paramyxoviruses, Sendai virus, Hendra virus, Nipah virus, measles virus, canine distemper virus, rinderpest virus, peste des petits ruminants virus, human respiratory syncytial virus, metapneumoviruses, and new and emerging paramyxoviruses. Each chapter covers our current knowledge on history, genome organization, viral proteins, reverse genetics, epidemiology, pathogenesis, immunity, diagnosis, prevention and control and future challenges. This book is an invaluable reference source of timely information for virologists, microbiologists, immunologists, physicians, veterinarians and scientists working on paramyxoviruses. It is also strongly recommended for all medical and veterinary school libraries. read more ...
Helicobacter pylori
Edited by: Lyudmila Boyanova
Published: 2011
Hardback: ISBN 978-1-904455-84-4 £159, $319
This book highlights recent research and provides in a single volume an up-to-date summary of our current knowledge for microbiologists, clinicians and advanced students working with Helicobacter and for those wishing to enter the field. The authors offer an outstanding collection of reviews on many aspects of Helicobacter research including microbiology, virulence factors, immunology, vaccine research, epidemiology, diseases associated with the infection, antibiotic resistance, and treatment (including the use of non-antibiotic agents). A major reference volume on Helicobacter pylori and how it impacts on public health worldwide, the book is essential reading for those with an interest in the microbiology of H. pylori and is a recommended volume for all microbiology libraries. read more ...
Microbial Bioremediation of Non-metals: Current Research
Edited by: Anna-Irini Koukkou
Published: 2011
Hardback: ISBN 978-1-904455-83-7 £159, $319
Topics covered include: enzymatic biodegradation reactions; the impact of bioturbation on hydrocarbon dynamics in marine sediments; the structure, function and biodiversity of ring-hydroxylating dioxygenases involved in PAH biodegradation; strategies to engineer PCB-degrading bacteria; PCB-degrading plant-microbe systems strategies; the structure, regulation and diversity of microbial genes encoding biodegradative enzymes. In addition there are excellent reviews detailing the application of the state-of-the-art molecular technologies to study biodegradative processes. Technologies covered are community fingerprinting, molecular detection of degradative genes, and metagenomics for the analysis and monitoring of microorganisms in situ. These are complemented well by the fascinating reviews of the catabolic plasmids and mobile genetic elements involved in bioremediation, including discussions on the origin and evolution of these catabolic pathways to different genera. In addition the best procedures for the evaluation and design of relevant in situ remediation strategies are examined and classical ex-situ technologies such Landfarming, Composting, Biopiling and Slurry-phase bioremediation are described. This book is a vital reference resource for research scientists, graduate students, and other specialists interested on microbial bioremediation of organic pollutants and is recommended reading for environmental microbiologists, chemists and engineers. read more ...
Lactic Acid Bacteria and Bifidobacteria: Current Progress in Advanced Research
Edited by: Kenji Sonomoto and Atsushi Yokota
Published: 2011
Hardback: ISBN 978-1-904455-82-0 £159, $319
In this comprehensive book, expert international authors review the most recent cutting-edge research in these areas. Topics include: Lactobacillus genomics; Bifidobacterium gene manipulation technologies; metabolism of human milk oligosaccharides in bifidobacteria; proton-motive metabolic cycles; oxidative stress and oxygen metabolism; Bifidobacterium response to O2; bile acid stress in LAB and bifidobacteria; protein structure quality control; bacteriocin classification and diversity; lactococcal bacteriocins; lactobacilli bacteriocins; other bacteriocins; production of optically pure lactic acid; antihypertensive metabolites from LAB; the anti-H. pylori effect of Lactobacillus gasseri; probiotics for allergic rhinitis; probiotics health claims in Japan and Europe. Essential reading for every researcher working with LAB, bifidobacteria and probiotics, from the PhD student to the experienced scientist. read more ...
Viruses and Interferon: Current Research
Edited by: Karen Mossman
Published: 2011
Hardback: ISBN 978-1-904455-81-3 £159, $319
In this book, a panel of international experts reviews the current hot-topics, producing a timely overview of this exciting field. The book opens with a chapter that comprehensively reviews the antiviral effects of extracellular double-stranded RNA, the "viral toxin". This is followed by chapters that review the properties of type I and type III interferons, and the role of interferon-stimulated genes. The next five chapters are devoted to understanding the diverse strategies used by clinically relevant human viruses to subvert host interferon responses. The closing chapter provides an interesting overview of the clinical application of interferon as antiviral and anticancer agents. Essential reading for every scientist involved in interferon or antiviral research and a recommended text for all virology laboratories. read more ...
Essentials of Veterinary Parasitology
Edited by: Hany M. Elsheikha and Naveed Ahmed Khan
Published: 2011
Hardback: ISBN 978-1-904455-80-6 £99, $169. Paperback: ISBN 978-1-904455-79-0 £59, $99
Essentials of Veterinary Parasitology provides an up-to-date resource for students and practicing veterinarians on how to recognize, diagnose and treat parasitic diseases in livestock and companion animals. Featuring full-colour illustrations and a user friendly layout, it begins with a section dedicated to the fundamentals of veterinary parasitology and ends with a section on the prevention of parasitic infections entailing recent developments in our understanding of the pathogenesis and control of parasitic diseases. In-between are sections on important parasitic infections in livestock organized by the parasite agents - helminths, protozoa and arthropods - plus a section on diagnostic parasitology. This book is an essential reference for veterinary students, practicing veterinarians and researchers in the field of parasitology. read more ...
Hepatitis C: Antiviral Drug Discovery and Development
Edited by: Seng-Lai Tan and Yupeng He
Published: 2011
Hardback: ISBN 978-1-904455-78-3 £180, $360
The editors of this book have recruited experts from around the world to produce a timely and well-compiled review of current HCV research with an emphasis on antiviral drug development. The chapters provide in-depth reviews of the most critical areas of research. Topics covered include: the HCV life cycle, HCV assays, HCV resources, HCV databases, HCV infection systems, models of hepatitis C infections, overview of the drug pipeline, clinical trial design, clinical virology and drug development, NS3 protease inhibitors, NS3-NS4A complex inhibitors, NS3 helicase inhibitors, NS4B targets and inhibitors, NS5A inhibitors, nucleoside inhibitors, NS5B polymerase inhibitors, glycoprotein-dependent entry, host cell targets and inhibitors, and innate immunity for HCV antiviral therapy. An essential book for scientists involved with HCV and anyone interested in antiviral drug development. A recommended text for all virology libraries. read more ...
Streptomyces: Molecular Biology and Biotechnology
Edited by: Paul Dyson
Published: 2011
Hardback: ISBN 978-1-904455-77-6 £159, $319
With contributions from some of the leading scientists in the field, this volume documents recent research and development in streptomycetes genomics, physiology and metabolism. With a focus on biotechnology and genomics, the book provides an excellent source of up-to-date information. Topics include: genome architecture, conjugative genetic elements, differentiation, protein secretion, central carbon metabolic pathways, regulation of nitrogen assimilation, phosphate control of metabolism, gamma-butyrolactones and their role in antibiotic regulation, clavulanic acid and clavams, genome-guided exploration, gene clusters for bioactive natural products, genomics of cytochromes p450. Essential reading for research scientists, biotechnologists, graduate students and other professionals involved in streptomycetes research, antibiotic and antimicrobial development, drug discovery, soil microbiology and related fields. A recommended text for all microbiology laboratories. read more ...
Alphaherpesviruses: Molecular Virology
Edited by: Sandra K. Weller
Published: 2011
Hardback: ISBN 978-1-904455-76-9 £180, $360
Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections. read more ...
Recent Advances in Plant Virology
Edited by: Carole Caranta, Miguel A. Aranda, Mark Tepfer and J.J. Lopez-Moya
Published: 2011
Hardback: ISBN 978-1-904455-75-2 £180, $360
Viruses that infect plants are responsible for reduction in both yield and quality of crops around the world, and are thus of great economic importance. This has provided the impetus for the extensive research into the molecular and cellular biology of these pathogens and into their interaction with their plant hosts and their vectors. However interest in plant viruses extends beyond their ability to damage crops. Many plant viruses, for example tobacco mosaic virus, have been used as model systems to provide basic understanding of how viruses express genes and replicate. Others permitted the elucidation of the processes underlying RNA silencing, now recognised as a core epigenetic mechanism underpinning numerous areas of biology. This book attests to the huge diversity of research in plant molecular virology. Written by world authorities in the field, the book opens with two chapters on the translation and replication of viral RNA. Following chapters cover topics such as viral movement within and between plants, plant responses to viral infection, antiviral control measures, virus evolution, and newly emerging plant viruses. To close there are two chapters on biotechnological applications of plant viruses. Throughout the book the focus is on the most recent, cutting-edge research, making this book essential reading for everyone, from researchers and scholars to students, working with plant viruses. read more ...
Vaccine Design: Innovative Approaches and Novel Strategies
Edited by: Rino Rappuoli and Fabio Bagnoli
Published: 2011
Hardback: ISBN 978-1-904455-74-5 £180, $360
In this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies. The book has been divided into two parts. The first part reviews the technologies and approaches used to identify, generate and test new vaccines. Topics include: new strategies to identify protective antigens, generation of improved adjuvants, use of alternative immunization routes, improving vaccine safety, and finding and establishing the correlates of protection. The second part of the book focuses on the development of new vaccines to replace or complement currently available products or for diseases against which prophylactic strategies are missing. Examples include vaccines against nosocomial infections, streptococci, emerging viral diseases, P. aeruginosa, and bovine mastitis. Essential reading for everyone with an interest in vaccine R & D. read more ...
Salmonella: From Genome to Function
Edited by: Steffen Porwollik
Published: 2011
Hardback: ISBN 978-1-904455-73-8 £159, $319
In this book, internationally acclaimed experts review cutting-edge topics in Salmonella genomics and molecular biology, providing a timely snapshot of the current state of research. Topics include latest approaches to sub-species level classification and phage typing of Salmonella, comparative genomics, the search for genetic determinants for survival of the bacterium in different environments and the evolution of niche specialization by Salmonella. The book also explores the latest genomic information and molecular characterizations of sRNAs and complements of fimbriae, flagella and secreted virulence factors. Moreover, S. Typhi pathogenesis, interactions of the host with intracellular Salmonella and the host's anti-Salmonella immune response are reviewed. The current knowledge on Salmonella biofilm formation and a progress report on using Salmonella as an anti-tumour tool conclude this compendium. Essential reading for all researchers working with Salmonella and related organisms, and recommended reading for other scientists working on bacterial genomics, molecular biology and bacterial molecular and cellular pathogenesis. read more ...
PCR Troubleshooting and Optimization: The Essential Guide
Edited by: Suzanne Kennedy and Nick Oswald
Published: 2011
Hardback: ISBN 978-1-904455-72-1 £159, $319
This book discusses the strategies for preparing effective controls and standards for PCR, when they should be employed and how to interpret the information they provide. It highlights the significance of optimization for efficiency, precision and sensitivity of PCR methodology and provides essential guidance on how to troubleshoot inefficient reactions. Experts in PCR describe design and optimization techniques, discuss the use of appropriate controls, explain the significance of standard curves and explore the principles and strategies required for effective troubleshooting. Authors highlight the importance of sample preparation and quality, primer design, controlling inhibitors, avoiding amplicon and environmental contamination, optimizing reagent quality and concentration, and modifying the thermal cycling protocol for optimal sensitivity and specificity. In addition, specific chapters discuss the history of PCR, the choice of instrumentation, the applications of PCR in metagenomics, high resolution melting analysis, the MIQE guidelines, and PCR at the microliter scale. The strategies, tips and advice contained in this concise volume enable the scientist to optimize and effectively troubleshoot a wide range of techniques including PCR, reverse transcriptase PCR, real-time PCR and quantitative PCR. An essential book for anyone using PCR technology. read more ...
Environmental Microbiology: Current Technology and Water Applications
Edited by: Keya Sen and Nicholas J. Ashbolt
Published: 2011
Hardback: ISBN 978-1-904455-70-7 £159, $319
Authors have included comparative tables and figures that address detection sensitivity, specificity, ease of use and other criteria. The value of the book emanates from its explanation of the principles of techniques and the comparison of related techniques. In addition the reader is introduced to key references and important web sites where further details of the technology can be found. An essential book for water microbiologists, environmental microbiologists and regulators and recommended reading for all microbiologists and environmental scientists. read more ...