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2013 Books

Our high level microbiology and molecular biology books bring together expert international authors under the skilled editorship of leading scientists to produce state-of-the-art compendiums of current research. Aimed at the research scientist, graduate student, medical reseacher and other professionals, these books are highly recommended for all microbiology and molecular biology laboratories. Every microbiology, molecular biology and bioscience library should have a copy of each of our books.
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Bacterial Toxins: Genetics, Cellular Biology and Practical Applications
Edited by: Thomas Proft
Published: 2013
Hardback: ISBN 978-1-908230-28-7 £159, $319. Ebook: ISBN 978-1-908230-70-6 £159, $319
This timely volume serves as an update on the most important recent advances in the genetics, cellular biology and practical applications of the most important bacterial toxins. Written by internationally respected scientists from eight different countries, topics reviewed include: the molecular basis and risk factors for verotoxin pathogenesis; molecular mechanisms of Helicobacter pylori CagA translocation and function; structure and mechanisms of action of pore-forming toxins; bacterial enterotoxins as immunomodulators and vaccine adjuvants; mobile genetic elements as carriers for bacterial virulence genes; the novel family of staphylococcal superantigen-like toxins (SSLs); new insights into the use of botulinum neurotoxins as therapeutics; microbial toxins as tools in cell biology; the role of the large clostridial cytotoxins in C. difficile disease. Essential reading for everyone with an interest in bacterial toxins and recommended book for researchers interested in microbial genomics and microbial pathogenesis. read more ...
Cold-Adapted Microorganisms
Edited by: Isao Yumoto
Published: 2013
Hardback: ISBN 978-1-908230-26-3 £159, $319. Ebook: ISBN 978-1-908230-90-4 £159, $319
In this up-to-date book, prominent authors present cutting-edge knowledge and current concepts on cold-adapted microorganisms. Divided into three main sections the book covers the major aspects of biodiversity in cold ecosystems, the physiology and molecular adaptation mechanisms, and the various biomolecules related to cold adaptation. Individual chapters cover the various habitats and the diverse strategies employed to cope with the cold. This major new work represents a valuable source of information to all those scientists interested in cold-adapted microorganisms, extremophiles, microbial ecology and environmental microbiology. read more ...
Fusarium: Genomics, Molecular and Cellular Biology
Edited by: Daren W. Brown and Robert H. Proctor
Published: 2013
Hardback: ISBN 978-1-908230-25-6 £159, $319. Ebook: ISBN 978-1-908230-75-1 £159, $319
In this book, an international group of researchers critically reviews the most important current research on the genomics and molecular and cellular biology of Fusarium. The opening chapter provides a fascinating introduction to the organism. Subsequent chapters deal with: sex and fruiting; genome structural dynamics; molecular genetics and genomic approaches to study pathogenesis in wheat; proteomic analysis of the fungus-host interaction; Repeat-induced point mutation, DNA methylation and heterochromatin in Fusarium graminearum (Gibberella zeae); nitrogen regulation network and its impact on secondary metabolism and pathogenicity; diversity of polyketide synthases; and plant responses to Fusarium metabolites. This volume is essential for everyone working with Fusarium and other filamentous fungi. A recommended book for all biology, agriculture and medical libraries. read more ...
Prions: Current Progress in Advanced Research
Edited by: Akikazu Sakudo and Takashi Onodera
Published: 2013
Hardback: ISBN 978-1-908230-24-9 £120, $240. Ebook: ISBN 978-1-908230-89-8 £120, $240
In this book, renowned prion experts review the most recent advances to provide a timely and up-to-date overview of the field. Topics covered include: prion proteins (PrP) and their family members; PrP function; molecular mechanisms of prions diseases; immunological strategies for the prevention and treatment of prion disease; microglial inflammation and prion diseases; methods for prion inactivation; clinical aspects of CJD; the BSE and scrapie prions; chronic wasting disease; future strategies for the prevention and treatment of prion diseases. The book closes with a look to the future of prion research. Essential reading for everyone with an interest in prions and prion diseases. A recommended book for all biology, veterinary and medical libraries. read more ...
RNA Editing: Current Research and Future Trends
Edited by: Stefan Maas
Published: 2013
Hardback: ISBN 978-1-908230-23-2 £159, $319. Ebook: ISBN 978-1-908230-88-1 £159, $319
This major new work presents an up-to-date overview of RNA editing. All the chapters here have been written by experts in the various research areas and describe key recent findings as well as exploring current frontiers in the mechanisms and functional roles of RNA editing. The chapters span the editing of protein coding mRNAs, small regulatory RNAs, tRNAs and non-coding sequences. Also included are studies employing bioinformatics to identify and predict RNA editing sites as well as the evolution of RNA modification. An essential text for anyone interested in RNA editing and modification, RNA structure and function, post-transcriptional regulation, and the regulation of gene expression and a recommended purchase for molecular biology libraries. read more ...
Real-Time PCR: Advanced Technologies and Applications
Edited by: Nick A. Saunders and Martin A. Lee
Published: 2013
Hardback: ISBN 978-1-908230-22-5 £159, $319. Ebook: ISBN 978-1-908230-87-4 £159, $319
This essential manual provides both the novice and experienced user with an invaluable reference to a wide-range of real-time PCR technologies and applications and provides an overview of the theory of this increasingly important technique. Renowned international authors present detailed technical insights into the underlying principles, methods and practice of real-time PCR. The initial chapters cover the important aspects of real-time PCR including choosing an instrument and probe system, set-up, nucleic acid synthesis, sample extraction controls, and validation and data analysis. Further chapters provide a comprehensive overview of important real-time PCR methodologies such as quantification, expression analysis and mutation detection. This is complemented by the final chapters, which address the application of real-time PCR to diagnosis of infectious diseases, biodefence, veterinary science, food authenticity and molecular haplotyping. This timely and authoritative volume serves both as a basic introduction to real-time PCR and as a source of current trends and applications for those already familiar with the technology. The editors also aim to stimulate readers of all levels to develop their own innovative approaches to real-time PCR. An essential book for all laboratories using PCR. read more ...
Microbial Efflux Pumps: Current Research
Edited by: Edward W. Yu, Qijing Zhang and Melissa H. Brown
Published: 2013
Hardback: ISBN 978-1-908230-21-8 £159, $319. Ebook: ISBN 978-1-908230-86-7 £159, $319
Infectious diseases caused by bacteria remain a leading cause of death worldwide. Many of the antibiotics developed to combat bacterial infections have been rendered almost impotent due to the rapid evolution and spread of antibiotic resistance. A common and major resistance mechanism, the efflux system, enables bacteria to extrude structurally diverse antimicrobials, facilitating survival in toxic environments. The pumps also have important physiological functions, play major roles in bacterial pathogenesis and are distributed widely across diverse bacterial species. In addition a single species may harbour several different types of efflux systems: of these, active efflux has proven to be one of the most successful detoxification mechanisms used by both Gram-positive and -negative pathogens. Unravelling the intricacies of the microbial efflux systems is essential for the development of new strategies to overcome antimicrobial resistance. This has inspired a plethora of multidisciplinary research projects that have focused on the biochemistry, bioinformatics, structural and molecular biology of this fascinating field. With contributions from leading researchers in the field, this book reviews the most important current research and summarizes the most spectacular discoveries. Essential reading for all scientists with an interest in drug and antibiotic resistance in a range of different microorganisms. read more ...
Cytomegaloviruses: From Molecular Pathogenesis to Intervention
Edited by: Matthias J. Reddehase
Published: 2013
Hardback: ISBN 978-1-908230-18-8 £300, $600. Ebook: ISBN 978-1-908230-83-6 £300, $600
This two-volume work, is an updated and upgraded 2nd-edition of 'Cytomegaloviruses: Molecular Biology and Immunology' (2006). The title 'Cytomegaloviruses: From Molecular Pathogenesis to Intervention' reflects its expanded commitment not only to cover cutting-edge basic science but also to include the translation of this to clinical science. In an interdisciplinary approach to understanding CMV disease and outlining options for prevention and treatment, leading international experts provide comprehensive and authoritative reviews on literally every aspect of current research with an unprecedented completeness, integrating research on human CMV and insights gained from experimental animal models. With contributions from over 100 authors, the topics covered in the 46 chapters range from the most contemporary systems biology 'omics' views on virus-host interaction to considerations of the health and economic impact of CMV disease for evaluating the hoped-for benefit from a vaccine. Volume I focuses on basic science laying the foundations of clinical research, starting with the comparative genomics of primate CMVs and ending with the emerging field of humanized mouse models. Volume II is more clinically-oriented, covering the immune response to CMV, the most pressing medical problems in the newborn and in transplantation patients, as well as diagnostics, the management of antiviral drug resistance, the state and future of a CMV vaccine, and the potential of using CMV as a vaccine vector to fight unrelated diseases. The book closes with a critical survey of disputed associations between CMV and atherosclerotic cardiovascular disease, certain tumors such as Glioblastoma Multiforme, and the phenomenon of 'immune senescence' in the elderly. The book is liberally illustrated with more than 200 figures, most of which are in full colour. There are over 60 tables and several thousand references which enhance the book even further making it an invaluable source of information. Essential reading for all virologists with an interest in cytomegaloviruses, for all clinicians in pediatric intensive-care medicine and at transplantation centers, for scientists working on antiviral drug and vaccine development, as well as for public health service and science funding system authorities. read more ...
Oral Microbial Ecology: Current Research and New Perspectives
Edited by: Nicholas S. Jakubovics and Robert J. Palmer Jr.
Published: 2013
Hardback: ISBN 978-1-908230-17-1 £159, $319. Ebook: ISBN 978-1-908230-82-9 £159, $319
Expert authors from around the world provide an update on recent developments in the burgeoning field of oral microbial ecology. The focus of the book is on the most topical areas in oral microbiology and the volume is a major new work in the field. The chapters are arranged into five sections: microbial populations in oral biofilms, the structure of oral biofilms, communication and sensing within biofilms, health to disease - the microbial community perspective, and new approaches for oral biofilm control. Specialist authors contribute chapters on various topics including population biology, detection and culture of novel oral bacteria, bacterial catabolism of salivary substrates, structural organization of oral biofilms, the extracellular polysaccharides matrix, extracellular proteins and DNA in the matrix, a holistic view of inter-species bacterial interactions, environmental sensory perception, microbial community interactions of Streptococcus mutans, biofilms in periodontal health and disease, oral biofilms as a reservoir for pathogens, oral biofilms as a device for therapeutic agents, and probiotics in oral healthcare. The book is an essential text for scientists interested in oral microbiology, bacterial communities and biofilms and is recommended reading for anyone working in the areas of oral health, and the pathogenesis of dental caries and periodontal disease. A recommended book for all microbiology laboratories. read more ...
Bionanotechnology: Biological Self-assembly and its Applications
Edited by: Bernd H. A. Rehm
Published: 2013
Hardback: ISBN 978-1-908230-16-4 £159, $319. Ebook: ISBN 978-1-908230-81-2 £159, $319
Under the expert guidance of Bernd H. A. Rehm, the authors of this book provide a survey of the most striking and successful approaches for the production of biogenic nanodevices considering not only living organisms as manufacturer but also in vitro processes that utilize the self-assembly of isolated biomolecules. The book provides a topical overview of the vast field of bionanotechnology by describing various biological nanostructures, the implied design space and the enormous potential for applications in medicine and technology. Two chapters describe the microbial production of tailor-made self-assembled nanostructures which can be processed into functional nanoparticles. Other chapters comprehensively summarize recent developments in the use of protein-based assemblies for nanodevice and nanomaterials production. Topics include: polymer synthesis, self-assembly and display technology, self-assembly and application of cellulosomal components, protein-aided mineralization of inorganic nanostructures, amyloid fibrils as bionanomaterials, self-assembly and applications of bacteriophages and virus-like particles, plant oil bodies and oleosins-structure function and biotechnological applications, visual restoration using microbial rhodopsins, magnetosomes and liposome-nanoparticle assemblies. This is a recommended book for anyone interested in the fields of nanotechnology, biotechnology, metabolic engineering, molecular biology, genetic engineering and protein design. read more ...
Real-Time PCR in Food Science: Current Technology and Applications
Edited by: David Rodríguez-Lázaro
Published: 2013
Hardback: ISBN 978-1-908230-15-7 £159, $319. Ebook: ISBN 978-1-908230-80-5 £159, $319
Written by experts in the field, this book is an indispensable manual for scientists in the food industry. The first section, Real-Time PCR Basics, provides an introduction to real-time PCR, discusses the use of PCR diagnostics in food science, describes the principles and methods of sample preparation, and covers the verification and control of PCR procedures. The eleven chapters in the second section, Food Microbiology, cover the use of real-time PCR to detect various pathogens including Salmonella, Listeria, E. coli, Campylobacter, Yersinia, Staphylococcus, Clostridium, viruses and parasites. Also included is a chapter on the standardisation of real-time PCR methods in food microbiology. The final section, Food Quality, covers the use of real-time PCR for the analysis of GMOs, food allergens and for the identification of animal or plant species. An invaluable book for anyone involved in food science or the detection of foodborne pathogens and a recommended volume for all microbiology laboratories. read more ...
Bacterial Gene Regulation and Transcriptional Networks
Edited by: M. Madan Babu
Published: 2013
Hardback: ISBN 978-1-908230-14-0 £159, $319. Ebook: ISBN 978-1-908230-79-9 £159, $319
Along with the strategic guidance of M. Madan Babu (Cambridge, UK) authors from around the world have joined forces to review and discuss the latest research observations and current theories in this highly topical and important area of microbiology. The first few chapters describe the components required for transcriptional regulation, elucidate their complexity and discuss the genome-scale theories that currently prevail by investigating a large number of completely sequenced microbial genomes. Other chapters discuss how transcriptional regulation and gene circuits can be used by bacteria to sense signals and generate phenotypic variation. The next chapters introduce experimental and computational methods for investigating transcriptional regulatory networks on a genomic scale. Later chapters explore the transcriptional complexity of specific organisms, discuss current understanding of the genome-scale regulatory networks and the importance of key transcription factors. Specific organisms covered include Escherichia coli, Bacillus subtilis, Helicobacter pylori, Mycobacterium tuberculosis, Pseudomonas aeruginosa and Cyanobacteria. This book constitutes a major work on bacterial gene regulation and is a recommended purchase for all institutions and organisations interested in microbiology. read more ...
Bioremediation of Mercury: Current Research and Industrial Applications
Edited by: Irene Wagner-Döbler
Published: 2013
Hardback: ISBN 978-1-908230-13-3 £120, $240. Ebook: ISBN 978-1-908230-78-2 £120, $240
In this timely book, established mercury experts review the latest research in this area, including the genetic engineering of bacteria and plants. The gap between laboratory research and field application is bridged using case studies: An abandoned chlor-alkali electrolysis factory in Kazhakhstan, a former PVC plant in Albania, and the Madeira River Basin in the Amazon region. The remaining chapters cover: the mercury-cell process of the chlor-alkali electrolysis industry; a pilot plant for wastewater bioremediation; and a comparison of the efficiency of microbial bioremediation to clean-up three types of industrial wastewater. The book covers the complete range from laboratory scale research to full scale industrial operation and shows a multitude of options for future mercury bioremediation technologies. Essential reading for research scientists, graduate students, and other specialists interested in mercury bioremediation, the book is also recommended reading for environmental microbiologists, chemists and engineers. read more ...
Neurospora: Genomics and Molecular Biology
Edited by: Durgadas P. Kasbekar and Kevin McCluskey
Published: 2013
Hardback: ISBN 978-1-908230-12-6 £159, $319. Ebook: ISBN 978-1-908230-77-5 £159, $319
In this book, internationally recognised Neurospora experts critically review the most important research and demonstrate the breadth of applications to industrial biology, biofuels, agriculture, and human health. The opening chapter is an introduction to the organism. Following chapters cover topics such as: carotenoid biosynthesis, polysaccharide deconstruction, genome biology, genome recombination, gene regulation, signal transduction, self-recognition, development, circadian rhythms and mutation. The book closes with a fascinating look at the history and future trends for research on Neurospora gene and genome analysis. This volume is essential for everyone working with Neurospora and other filamentous fungi. A recommended book for all biology, agriculture and medical libraries. read more ...
Malaria Parasites: Comparative Genomics, Evolution and Molecular Biology
Edited by: Jane M. Carlton, Susan L. Perkins and Kirk W. Deitsch
Published: 2013
Hardback: ISBN 978-1-908230-07-2 £159, $319. Ebook: ISBN 978-1-908230-76-8 £159, $319
Since the publication of the first two Plasmodium genome sequences in 2002, numerous other parasite genomes have been sequenced. These include the genomes of several more Plasmodium species as well as those of other apicomplexans, including species of Toxoplasma, Cryptosporidium, Babesia, and Eimeria. This wealth of genome sequence data has provided researchers with a powerful new tool, comparative genomics, which has revolutionised research in this area. In this book, expert authors from around the world comprehensively review the current advances in Plasmodium comparative genomics, highlighting the fascinating new insights into parasite evolution and molecular biology that have ensued. Topics include: Plasmodium taxonomy and phylogeny; the apicomplexan genomic landscape; the 'art' of sequencing Plasmodium genomes; diversity of Plasmodium falciparum and Plasmodium vivax genomes; Plasmodium functional genomics; Plasmodium experimental genetic crosses; P. falciparum epigenetic modification and transcriptional regulation; Plasmodium invasion of host red blood cells; protein export and trafficking by malaria parasites; Plasmodium-mosquito vector interactions; and a practical guide to many of the revolutionary new techniques and molecular tools for Plasmodium research. The book is essential reading for every researcher working with malaria parasites and related organisms, from the PhD student to the experienced scientist, and is a recommended text for all parasitologists. read more ...