Probiotics and Prebiotics
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2014 Books

Our high level microbiology and molecular biology books bring together expert international authors under the skilled editorship of leading scientists to produce state-of-the-art compendiums of current research. Aimed at the research scientist, graduate student, medical reseacher and other professionals, these books are highly recommended for all microbiology and molecular biology laboratories. Every microbiology, molecular biology and bioscience library should have a copy of each of our books.
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Microarrays: Current Technology, Innovations and Applications
Edited by: Zhili He
Published: 2014
Hardback: ISBN 978-1-908230-49-2 £159, $319. Ebook: ISBN 978-1-908230-59-1 £159, $319
Written by expert authors this book is focused on current microarray technologies and their applications in environmental microbiology. In the first chapter microarray technologies and applications are briefly introduced and in following chapters microarray probe design, development and evaluation, and data analysis are described in detail. In later chapters, more attention is paid to phylogenetic arrays (e.g., PhyloChip) and functional gene arrays (e.g., GeoChip). These generic tools for analyzing microbial communities from disparate environments, ecosystems, and habitats including soil, water, sediment, animals and humans, are described in detail with examples of specific applications. Also included are microarrays for analyzing microbial communities from specific environments, such as soil, bioleaching ecosystems, and human microbiomes, and microarrays for detecting specific microorganisms (e.g., pathogens) in the environment. The authors also discuss the advantages and limitations of microarray technologies compared to high throughput sequencing technologies. This book is a valuable and useful source of information about microarrays for microbial community analysis and is recommended for anyone working on microbial communities, biofilms or environmental microbiology. read more ...
Metagenomics of the Microbial Nitrogen Cycle: Theory, Methods and Applications
Edited by: Diana Marco
Published: 2014
Hardback: ISBN 978-1-908230-48-5 £159, $319. Ebook: ISBN 978-1-908230-60-7 £159, $319
Written by renowned researchers specialised in the most relevant and emerging topics in the field, this book provides comprehensive information on the new theoretical, methodological and applied aspects of metagenomics and other 'omics' approaches used to study the microbial N cycle. Recommended for microbiologists, environmental scientists and anyone interested in microbial communities, metagenomics, metatranscriptomics and metaproteomics of the microbial N cycle. This volume provides a thorough account of the contributions of metagenomics to microbial N cycle background theory, reviews state-of-the-art investigative methods and explores new applications in water treatment, agricultural practices and climate change, among others. read more ...
Pathogenic Neisseria: Genomics, Molecular Biology and Disease Intervention
Edited by: John K. Davies and Charlene M. Kahler
Published: 2014
Hardback: ISBN 978-1-908230-47-8 £159, $319. Ebook: ISBN 978-1-908230-61-4 £159, $319
The human pathogens, Neisseria meningitidis and Neisseria gonorrhoeae are exquisitely adapted to life within the human mucosa, their only natural niche. N. meningitidis is the causative agent of rapidly transmissible meningitis and septic shock. Vaccines developed to control this pathogen can be rendered ineffective by the pathogen's ability to undergo antigenic variation. In contrast, there are no current vaccination prospects for N. gonorrhoeae, the causative agent of sexually transmitted gonorrhoea. Historically infections caused by N. gonorrhoeae were treated with antibiotics. However the recent advent of new strains with resistance to all known antibiotics is causing such treatment regimes to fail, necessitating the need for new and more effective control strategies. In this book leading Neisseria authorities review the most important research on pathogenic Neisseria to provide a timely overview of the field. Topics covered include: the link between pathogenesis and important metabolic pathways; vaccine development; antibiotic resistance; transcriptomics of regulatory networks; regulatory small RNAs; interactions with neutrophils; and advances in humanized mouse models. An essential guide for research scientists, advanced students, clinicians and other professionals working with Neisseria, this book is a recommended text for all microbiology libraries. read more ...
Proteomics: Targeted Technology, Innovations and Applications
Edited by: Manuel Fuentes and Joshua LaBaer
Published: 2014
Hardback: ISBN 978-1-908230-46-1 £159, $319. Ebook: ISBN 978-1-908230-62-1 £159, $319
In this book a panel of high-profile authors provides an overview of targeted proteomics in biomedical science. The book is focused on current, state-of-the-art technology and applications and is a valuable source of information for everyone working in this field. The first part of the book provides detailed examples of the application of targeted proteomics in biomarker discovery and pathogenesis. The second part is focused on the various tools used in targeted proteomics including bioinformatics approaches while the final section is dedicated to biobanks, a vital aspect of targeted proteomics. This volume is highly recommended for anyone interested in proteomics, disease pathogenesis, clinical protein science and biomarker discovery. read more ...
Biofuels: From Microbes to Molecules
Edited by: Xuefeng Lu
Published: 2014
Hardback: ISBN 978-1-908230-45-4 £159, $319. Ebook: ISBN 978-1-908230-63-8 £159, $319
In this book a panel of international experts reviews the most important hot-topics in this area to provide a timely overview. The production of different biofuel molecules including hydrogen, methane, ethanol, butanol, higher chain alcohols, isoprenoids and fatty acid derivatives, from genetically engineered microbes, is comprehensively covered. Special focus is given to the use of metabolic engineering of microbes, including bacteria, yeast and microalgae, to enhance biofuel production. In addition authors discuss current research progress, technical challenges and future development trends for biofuel production. Essential reading for research scientists, graduate students, and other specialists interested in microbial biofuels, the book is also recommended reading for environmental microbiologists, chemists and engineers. read more ...
Human Pathogenic Fungi: Molecular Biology and Pathogenic Mechanisms
Edited by: Derek J. Sullivan and Gary P. Moran
Published: 2014
Hardback: ISBN 978-1-908230-44-7 £180, $360. Ebook: ISBN 978-1-908230-66-9 £180, $360
In this book a panel of high profile authors critically reviews the most important research to provide a timely overview. The extensive reference sections in each chapter positively encourage readers to pursue the subject in greater detail. The book is divided into two sections: The first six chapters review the transformative effect of applying state-of-the-art tools and innovative approaches to research, particularly in the area of comparative biology. The second section consists of eight chapters, each dedicated to the molecular and cellular biology of a major fungal pathogen of humans: Candida, Aspergillus, Cryptococcus, dermatophytes, Histoplasma, Blastomyces, Pneumocystis and Paracoccidoides. These chapters provide a timely snapshot of the current state of research. This volume is an essential reference for students, researchers and clinicians with an interest in fungal pathogenesis. read more ...
Applied RNAi: From Fundamental Research to Therapeutic Applications
Edited by: Patrick Arbuthnot and Marc S. Weinberg
Published: 2014
Hardback: ISBN 978-1-908230-43-0 £159, $319. Ebook: ISBN 978-1-908230-67-6 £159, $319
In this book an international panel of RNAi experts critically reviews the most interesting advances in basic applied RNAi research, highlighting the applications in RNAi-based therapies and discussing the technical hurdles that remain. Topics covering the fundamental biological aspects of applied RNAi research include: the role of miRNAs in trinucleotide repeat disorders; miRNAs and HIV pathogenesis; miRNAs for epigenetic gene silencing; the role of miRNAs in virus-related cancers; non-canonical miRNA biogenesis. In the area of RNAi-based therapy, topics include: harnessing RNAi for the treatment of viral infections; optimising the design of exogenous RNAi activators; blocking miRNA function with synthetic agents; somatic cell reprogramming; high-content miRNA-based screening tools and the use of miRNA target sites for control of transgene expression. Essential reading for everyone involved in RNAi research, drug discovery and delivery, biomedical engineering and biomaterials. read more ...
Halophiles: Genetics and Genomes
Edited by: R. Thane Papke and Aharon Oren
Published: 2014
Hardback: ISBN 978-1-908230-42-3 £159, $319. Ebook: ISBN 978-1-908230-65-2 £159, $319
This book highlights current genetics and genomics research to provide a timely overview. Chapters are written by expert authors from around the world and include topics such as: ecology and evolution of Haloquadratum walsbyi; microdiversity of Salinibacter ruber; horizontal gene transfer in halobacteria; comparative genomics of haloarchaeal viruses; genomics of the halophilic bacteria Natranaerobius thermophilus and Halobacillus halophilus; the haloarchaeal cell wall; cell cycle and polyploidy in haloarchaea; cell regulation by proteolytic systems and protein conjugation. This major new work represents a valuable source of information to all those scientists interested in halophilic microorganisms, extremophiles, microbial ecology and environmental microbiology. read more ...
Molecular Diagnostics: Current Research and Applications
Edited by: Jim Huggett and Justin O'Grady
Published: 2014
Hardback: ISBN 978-1-908230-41-6 £159, $319. Ebook: ISBN 978-1-908230-64-5 £159, $319
The editors of this book have commissioned an excellent series of chapters representing two key molecular diagnostic areas: cancer and infectious diseases. The cancer section deals with the challenges in identifying genetic, epigenetic and transcriptomic biomarkers. The infectious disease section describes the current clinical applications of molecular diagnostics for the detection of viral, bacterial and fungal pathogens as well as an example of the use of molecular diagnostics outside the clinic environment. A cautionary tale describing what can go wrong when molecular methods are applied incorrectly is also provided and makes fascinating reading. A substantial component of the book is dedicated to the process of translating a preclinical test to the bedside and describes the progress in the near patient point-of-care molecular diagnostics market. This is a fundamental consideration for successful translation of diagnostics tests from bench to bedside and is crucial for molecular diagnostics to have an impact on patient care. The final chapter offers a prediction of future trends in the molecular diagnostics of infectious diseases. This volume is essential reading for anyone involved in the development or application of molecular diagnostics and is recommended for all clinical diagnostics laboratories. read more ...
Phage Therapy: Current Research and Applications
Edited by: Jan Borysowski, Ryszard Międzybrodzki and Andrzej Górski
Published: 2014
Hardback: ISBN 978-1-908230-40-9 £180, $360. Ebook: ISBN 978-1-908230-74-4 £180, $360
This volume is an essential reference for anyone interested in phage therapy and a highly recommended book for everyone working in the areas of antibacterial resistance, antimicrobial development, bacteriophage research, biocontrol and biodetection. read more ...
Bioinformatics and Data Analysis in Microbiology
Edited by: Özlem Taştan Bishop
Published: 2014
Hardback: ISBN 978-1-908230-39-3 £159, $319. Ebook: ISBN 978-1-908230-73-7 £159, $319
This book provides invaluable, up-to-date and detailed information on various aspects of bioinformatics data analysis with applications to microbiology. It describes a number of different useful bioinformatics tools, makes links to some wet-lab techniques, explains different approaches to tackle a problem, talks about current challenges and limitations, gives examples of applications of bioinformatics methods to microbiology, and discusses future trends. The chapters include topics such as genome sequencing techniques, assembly, SNP analysis, annotation, comparative genomics, microbial community profiling, metagenomics, phylogenetic microarrays, barcoding and more. Each chapter is written by scientists who are expert in the field, and is peer-reviewed. Bioinformatics and Data Analysis in Microbiology is an essential book for researchers, lecturers and students involved in microbiology, bioinformatics and genome analysis. read more ...
The Cell Biology of Cyanobacteria
Edited by: Enrique Flores and Antonia Herrero
Published: 2014
Hardback: ISBN 978-1-908230-38-6 £159, $319. Ebook: ISBN 978-1-908230-92-8 £159, $319
In this book, leading senior scientists and young researchers review the current key topics in cyanobacterial cell biology to provide a timely overview. Topics covered include: historical background; cell division; the cell envelope; the thylakoid membrane; protein targeting, transport and translocation; chromatic acclimation; the carboxysome; glycogen as a dynamic storage of photosynthetically fixed carbon; cyanophycin; gas vesicles; motility in unicellular and filamentous cyanobacteria; cellular differentiation in filamentous cyanobacteria; and cell-cell joining proteins in heterocyst-forming cyanobacteria. This cutting-edge text will provide a valuable resource for all those working in this field and is recommended for all microbiology libraries. read more ...
Pathogenic Escherichia coli: Molecular and Cellular Microbiology
Edited by: Stefano Morabito
Published: 2014
Hardback: ISBN 978-1-908230-37-9 £159, $319. Ebook: ISBN 978-1-908230-99-7 £159, $319
This book reviews the most important recent findings of the studies on pathogenic E. coli providing a timely overview of the field. Topics covered include: epidemiology of the disease in humans and animals and the biological mechanisms that shaped the pathogenic types of E. coli; shiga toxins; subtilase cytotoxin; cell cycle modulating toxins; the heat stable and heat labile enterotoxins; haemolysins; structural, molecular and functional characteristics of A/E lesions; colonization factor antigens of ETEC; enteroaggregative adhesion; host cell invasion; and the development of vaccinal strategies to confront the burden of disease. Chapters are written from a molecular and cellular biology standpoint but also include discussions of the findings with a wider perspective including considerations on public health and the impact on animal productions. Essential reading for everyone working on these and related pathogens. read more ...
Campylobacter Ecology and Evolution
Edited by: Samuel K. Sheppard
Published: 2014
Hardback: ISBN 978-1-908230-36-2 £159, $319. Ebook: ISBN 978-1-908230-98-0 £159, $319
In this book, internationally recognised experts critically review and provide novel insights into important aspects Campylobacter research. The book is divided into four sections: Mechanisms of evolution; Adaptations to host colonisation; Molecular epidemiology; and Ecology in poultry. The topics covered range from the mechanisms of evolution through the processes of host colonisation and within host adaptation, and epidemiology to considerations of their broader biochemical and ecological properties. An important resource summarising our current knowledge of Campylobacter ecology and evolution, this book is essential reading for all researchers working with Campylobacter and related organisms. read more ...
Burkholderia: From Genomes to Function
Edited by: Tom Coenye and Eshwar Mahenthiralingam
Published: 2014
Hardback: ISBN 978-1-908230-35-5 £159, $319. Ebook: ISBN 978-1-908230-97-3 £159, $319
In this book leading international investigators review key advances in Burkholderia research to provide timely overview. The topics covered include: genomic taxonomy and biodiversity, comparative genomics, molecular epidemiology, transcriptomics, proteomics, molecular pathogenesis of virulence in B. mallei/B. pseudomallei and the Burkholderia cepacia complex, molecular basis of phytopathogenicity and antibiotic resistance, signalling and biofilms, and the genomic biology of Burkholderia phages. The theme underpinning each chapter is the use of DNA/protein sequence data and post-genomic technologies to understand Burkholderia biology. Essential reading for everyone working with these and related bacteria. read more ...
Myxobacteria: Genomics, Cellular and Molecular Biology
Edited by: Zhaomin Yang and Penelope I. Higgs
Published: 2014
Hardback: ISBN 978-1-908230-34-8 £159, $319. Ebook: ISBN 978-1-908230-96-6 £159, $319
In this book, expert myxobiologists describe important recent advances in understanding the behaviour of these bacteria at a molecular and cellular level. The book covers ecology, genomics and cell biology as well as modelling and simulation on topics including motility, development and their associated genetic regulatory networks. Authors provide the most up-to-date overview on myxobacteria and highlight open questions in the active areas of research. The book will serve as an essential reference for everyone working with myxobacteria. Chapters have been written and structured to be accessible to teachers, graduate and advanced undergraduate students new to myxobacteria, as well as experts in other fields including physical and computational sciences. read more ...
Next-generation Sequencing: Current Technologies and Applications
Edited by: Jianping Xu
Published: 2014
Hardback: ISBN 978-1-908230-33-1 £120, $240. Ebook: ISBN 978-1-908230-95-9 £120, $240
Written by experts from around the world, this book explores the most recent advances in NGS instrumentation and data analysis. The book begins with a comprehensive description of current NGS platforms, their sequencing chemistries, instrument specifications, and general workflows and procedures. A separate chapter is dedicated to low-quantity, single molecule sequencing technology. Further chapters explore the application of NGS technologies in various fields including polymorphism detection, sRNA research, rare variant detection, large variant detection, exome sequencing, plant development studies, microbial metagenomics, and studies on the human microbiome. Practical and cutting-edge, this volume represents an excellent collection of chapters to aid all scientists who wish to apply these innovative research tools. read more ...
Omics in Soil Science
Edited by: Paolo Nannipieri, Giacomo Pietramellara and Giancarlo Renella
Published: 2014
Hardback: ISBN 978-1-908230-32-4 £159, $319. Ebook: ISBN 978-1-908230-94-2 £159, $319
This volume presents the state-of-the-art of omic applications in soil science, a field that is advancing rapidly on many fronts. Distinguished authors describe the application of metagenomics, metatranscriptomics and proteomics to soil science. In particular the book covers the current and emerging omics techniques and the contribution of these approaches to a better assessment of soil functionality. The authors also explore the specific problems encountered in the application of various omics technologies to soil science and the future research requirements necessary to overcome the current limitations in this area. Topics covered include soil functional genomics, soil metagenomics, soil microbial ecology, soil metatranscriptomics, soil proteomics, soil volatilomics and soil proteogenomics. Omics techniques are also discussed in comparison with classical techniques. This book is both a practical guide and a recommended reference volume for all soil scientists. read more ...
Applications of Molecular Microbiological Methods
Edited by: Torben L. Skovhus, Sean M. Caffrey and Casey R.J. Hubert
Published: 2014
Hardback: ISBN 978-1-908230-31-7 £159, $319. Ebook: ISBN 978-1-908230-69-0 £159, $319
This book, written by international experts in the field, presents emerging molecular methods that allow the diversity of a microbial community to be surveyed and its functions to be investigated. The first part of the book provides examples of the application of molecular microbiological methods in various industrial applications. Part two deals with the identification of microorganisms in medical settings while the third part presents case studies that use molecular methods to assess the structure and function of microbial communities in natural environments. The fourth part of the book describes in greater detail the methods and technologies featured in the preceding case studies including metagenomics, stable isotope probing, fluorescence in situ hybridization, quantitative PCR, reverse transcription PCR and single cell methods. These detailed descriptions enable readers to evaluate the applicability of various tools for approaching questions and case studies of their own. This practical, authoritative and up-to-date volume is a valuable resource for anyone applying or developing molecular methods in any area of microbiology and is a recommended acquisition for all microbiology laboratories. read more ...
Mollicutes: Molecular Biology and Pathogenesis
Edited by: Glenn F. Browning and Christine Citti
Published: 2014
Hardback: ISBN 978-1-908230-30-0 £159, $319. Ebook: ISBN 978-1-908230-93-5 £159, $319
In this book acknowledged experts critically review the most recent advances in the evolution, genetics and molecular pathogenesis of these important pathogens. Topics covered include: taxonomy; genomic mosaics; molecular genetic tools for mollicutes; identification and characterisation of virulence genes in mycoplasmas; post-translational modification of proteins; multifunctional cytoadherence factors; the glycocalyx; glycosidase activity; phase and antigenic variation in mycoplasmas; spiroplasma transmission from insect to plants; cytoskeletons organization; gliding mechanism of the Mycoplasma pneumoniae subgroup; biofilm formation by mycoplasmas; host immune responses to mycoplasmas; and emerging antimicrobial resistance in mycoplasmas of humans and animals. An essential book for researchers working with mollicutes and recommended reading for everyone interested in bacterial genomics, bacterial pathogenesis and the evolution of bacterial virulence. read more ...
Genome Analysis: Current Procedures and Applications
Edited by: Maria S. Poptsova
Published: 2014
Hardback: ISBN 978-1-908230-29-4 £159, $319. Ebook: ISBN 978-1-908230-68-3 £159, $319
In this book, an impressive array of expert authors highlight and review current advances in genome analysis. This volume provides an invaluable, up-to-date and comprehensive overview of the methods currently employed for next-generation sequencing (NGS) data analysis, highlights their problems and limitations, demonstrates the applications and indicates the developing trends in various fields of genome research. The first part of the book is devoted to the methods and applications that arose from, or were significantly advanced by, NGS technologies: the identification of structural variation from DNA-seq data; whole-transcriptome analysis and discovery of small interfering RNAs (siRNAs) from RNA-seq data; motif finding in promoter regions, enhancer prediction and nucleosome sequence code discovery from ChiP-Seq data; identification of methylation patterns in cancer from MeDIP-seq data; transposon identification in NGS data; metagenomics and metatranscriptomics; NGS of viral communities; and causes and consequences of genome instabilities. The second part is devoted to the field of RNA biology with the last three chapters devoted to computational methods of RNA structure prediction including context-free grammar applications. An essential book for everyone involved in sequence data analysis, next-generation sequencing, high-throughput sequencing, RNA structure prediction, bioinformatics and genome analysis. read more ...
Bacterial Membranes: Structural and Molecular Biology
Edited by: Han Remaut and Rémi Fronzes
Published: 2014
Hardback: ISBN 978-1-908230-27-0 £180, $360. Ebook: ISBN 978-1-908230-91-1 £180, $360
Written by specialists in the field, this book provides a comprehensive overview of the structural and molecular biology of cellular processes that occur at or near bacterial membranes. The authors present and discuss recent progress on the function and involvement of membranes in bacterial physiology enabling a greater understanding of the molecular details of the cell envelope, its biogenesis and function. Topics covered include: cell wall growth, shape and division, the outer membrane of Gram-negative bacteria, outer membrane protein biosynthesis, bacterial lipoproteins, mycobacteria, lipid composition, ABC transporters, transport across the outer membrane, drug passage across membranes, bacterial membrane proteins, secretion systems, signal transduction, signalling mechanisms, bacterial membranes in adhesion and pathogenesis, and membranes as a drug target. This cutting-edge text will provide a valuable resource for all those working in this field and is recommended for all microbiology libraries. read more ...