Microbial Multidrug Efflux
Publisher: Horizon Scientific Press
Editors: Ian T. Paulsen and Kim Lewis of The Institute for Genomic Research, Rockville, MD 20850, USA and Tufts University, Medford, MA 02155, USA respectively
Publication date: February 2002
ISBN-10: 1-898486-33-6 (hbk)
ISBN-13: 978-1-898486-33-6 (hbk)
Pages: x + 301
Resistance of microorganisms to multiple antibiotics and other drugs is a major problem throughout the world. Multidrug efflux is a process whereby a single transporter can remove a broad range of substrates from the cell thereby causing resistance to substances such as drugs and antibiotics. This book provides the first comprehensive overview of this phenomenon in microorganisms and contains reviews of the current research in this important field. With contributions from Internationally renown authors topics covered include genomic analysis of drug efflux pumps, the large scale knock-out of drug transporters, structure/function analysis of drug pumps, the inhibition of the efflux pump as a clinical approach, and much more. An essential text for all scientists with an interest in drug and antibiotic resistance in a range of different microorganisms.
Reviews:
" ... a compendium of sixteen reviews on cutting-edge aspects of multidrug transporters, written by leaders of research groups from around the world. Most of the chapters are excellent. ... the book contains a wealth of useful information and is essential reading for anyone interested in, or working on, microbial multidrug efflux systems." from International Microbiology (2003) 6: 79-80.
Table of Contents
Chapter 1: Microbial Multidrug Efflux: Introduction
Ian T. Paulsen, and Kim Lewis
Chapter 2: Comparative Genomics of Microbial Drug Efflux Systems
Ian T. Paulsen, Joan Chen, Karen E. Nelson, and Milton H. Saier, Jr
Chapter 3: The Ostensible Paradox of Multidrug Recognition
Alex A. Neyfakh
Chapter 4: Precious Things Come in Little Packages
Shimon Schuldiner, Dorit Granot, Sonia Steiner Mordoch, Shira Ninio, Dvir Rotem, Michael Soskin and Hagit Yerushalmi
Chapter 5: Structure, Function and Regulation of the Staphylococcal Multidrug Efflux Protein QacA
Melissa H. Brown, and Ronald A. Skurray
Chapter 6: MdfA, an Interesting Model Protein for Studying Multidrug Transport
Eitan Bibi, Julia Adler, Oded Lewinson, and Rotem Edgar
Chapter 7: Enterococcus faecalis Multi-Drug Resistance Transporters: Application for Antibiotic Discovery
Deborah R. Davis, James B. McAlpine, Christopher J. Pazoles, M. Kelly Talbot, Elisabeth A. Alder, Abbie C. White, Brandie M. Jonas, Barbara E. Murray, George M. Weinstock, and Bruce L. Rogers
Chapter 8: Molecular Basis of Multidrug Transport by ATP-Binding Cassette Transporters: A Proposed Two-Cylinder Engine Model
Hendrik W. van Veen, Christopher F. Higgins, and Wil N. Konings
Chapter 9: Prokaryote Multidrug Efflux Proteins of the Major Facilitator Superfamily: Amplified Expression, Purification and Characterisation
Kate Langton,John O'Reilly, Nick Rutherford, Jeff Griffith, Martin Pos, Bert Poolman,Mick Gwynne, Geoff Badman, Richard Herbert, and Peter Henderson
Chapter 10: Multidrug Resistance and ABC Transporters in Parasitic Protozoa
Marc Ouellette, Danielle Légaré and Barbara Papadopoulou
Chapter 11: The Pleitropic Drug ABC Transporters from Saccharomyces cerevisiae
Anabelle Decottignies, Bruce Rogers, Marcin Kolaczkowski, Elvira Carvajal, Elisabetta Balzi, Gwenaelle Conseil, Kyoko Niimi, Attilio Di Pietro, Brian C. Monk and André Goffeau
Chapter 12: AcrAB and Related Multidrug Efflux Pumps of Escherichia coli
Hiroshi Nikaido and Helen I. Zgurskaya
Chapter 13: Antimicrobial Efflux Systems Possessed by Neisseria gonorrhoeae and Neisseria meningitidis Viewed as Virulence Factors
Corinne Rouquette-Loughlin, Wendy L. Veal, Eun-Hee Lee, Leticia Zarantonelli, Jacqueline T. Balthazar, and William M. Shafer
Chapter 14: Inhibition of Efflux Pumps as a Novel Approach to Combat Drug Resistance in Bacteria
Olga Lomovskaya and Will Watkins
Chapter 15: Functions of Tetracycline Efflux Proteins That Do Not Involve Tetracycline
Terry A. Krulwich, Jie Jin, Arthur A. Guffanti, and David H. Bechhofer
Chapter 16: In Search of Natural Substrates and Inhibitors of MDR Pumps
Kim Lewis
Chapter 17: Multidrug Efflux Pumps and Antimicrobial Resistance in Pseudomonas aeruginosa and Related Organisms
Keith Poole
(EAN: 9781898486336)
