Bacterial Toxins: Genetics, Cellular Biology and Practical Applications Buy now!

Edited by: Thomas Proft
Published: 2013   ISBN: 978-1-908230-28-7
Price: GB £159 or US $319
This timely volume serves as an update on the most important recent advances in the genetics, cellular biology and practical applications of the most important bacterial toxins. Written by internationally respected scientists from eight different countries, topics reviewed include: the molecular basis and risk factors for verotoxin pathogenesis; molecular mechanisms of Helicobacter pylori CagA translocation and function; structure and mechanisms of action of pore-forming toxins; bacterial enterotoxins as immunomodulators and vaccine adjuvants; mobile genetic elements as carriers for bacterial virulence genes; the novel family of staphylococcal superantigen-like toxins (SSLs); new insights into the use of botulinum neurotoxins as therapeutics; microbial toxins as tools in cell biology; the role of the large clostridial cytotoxins in C. difficile disease. Essential reading for everyone with an interest in bacterial toxins and recommended book for researchers interested in microbial genomics and microbial pathogenesis. read more ...

Bacterial Membranes: Structural and Molecular Biology Buy now!

Edited by: Han Remaut and Rémi Fronzes
Published: 2014   ISBN: 978-1-908230-27-0
Price: GB £180 or US $360
Written by specialists in the field, this book provides a comprehensive overview of the structural and molecular biology of cellular processes that occur at or near bacterial membranes. The authors present and discuss recent progress on the function and involvement of membranes in bacterial physiology enabling a greater understanding of the molecular details of the cell envelope, its biogenesis and function. Topics covered include: cell wall growth, shape and division, the outer membrane of Gram-negative bacteria, outer membrane protein biosynthesis, bacterial lipoproteins, mycobacteria, lipid composition, ABC transporters, transport across the outer membrane, drug passage across membranes, bacterial membrane proteins, secretion systems, signal transduction, signalling mechanisms, bacterial membranes in adhesion and pathogenesis, and membranes as a drug target. This cutting-edge text will provide a valuable resource for all those working in this field and is recommended for all microbiology libraries. read more ...

Cold-Adapted Microorganisms Buy now!

Edited by: Isao Yumoto
Published: 2013   ISBN: 978-1-908230-26-3
Price: GB £159 or US $319
In this up-to-date book, prominent authors present cutting-edge knowledge and current concepts on cold-adapted microorganisms. Divided into three main sections the book covers the major aspects of biodiversity in cold ecosystems, the physiology and molecular adaptation mechanisms, and the various biomolecules related to cold adaptation. Individual chapters cover the various habitats and the diverse strategies employed to cope with the cold. This major new work represents a valuable source of information to all those scientists interested in cold-adapted microorganisms, extremophiles, microbial ecology and environmental microbiology. read more ...

Microbial Efflux Pumps: Current Research Buy now!

Edited by: Edward W. Yu, Qijing Zhang and Melissa H. Brown
Published: 2013   ISBN: 978-1-908230-21-8
Price: GB £159 or US $319
Infectious diseases caused by bacteria remain a leading cause of death worldwide. Many of the antibiotics developed to combat bacterial infections have been rendered almost impotent due to the rapid evolution and spread of antibiotic resistance. A common and major resistance mechanism, the efflux system, enables bacteria to extrude structurally diverse antimicrobials, facilitating survival in toxic environments. The pumps also have important physiological functions, play major roles in bacterial pathogenesis and are distributed widely across diverse bacterial species. In addition a single species may harbour several different types of efflux systems: of these, active efflux has proven to be one of the most successful detoxification mechanisms used by both Gram-positive and -negative pathogens. Unravelling the intricacies of the microbial efflux systems is essential for the development of new strategies to overcome antimicrobial resistance. This has inspired a plethora of multidisciplinary research projects that have focused on the biochemistry, bioinformatics, structural and molecular biology of this fascinating field. With contributions from leading researchers in the field, this book reviews the most important current research and summarizes the most spectacular discoveries. Essential reading for all scientists with an interest in drug and antibiotic resistance in a range of different microorganisms. read more ...

Oral Microbial Ecology: Current Research and New Perspectives Buy now!

Edited by: Nicholas S. Jakubovics and Robert J. Palmer Jr.
Published: 2013   ISBN: 978-1-908230-17-1
Price: GB £159 or US $319
Expert authors from around the world provide an update on recent developments in the burgeoning field of oral microbial ecology. The focus of the book is on the most topical areas in oral microbiology and the volume is a major new work in the field. The chapters are arranged into five sections: microbial populations in oral biofilms, the structure of oral biofilms, communication and sensing within biofilms, health to disease - the microbial community perspective, and new approaches for oral biofilm control. Specialist authors contribute chapters on various topics including population biology, detection and culture of novel oral bacteria, bacterial catabolism of salivary substrates, structural organization of oral biofilms, the extracellular polysaccharides matrix, extracellular proteins and DNA in the matrix, a holistic view of inter-species bacterial interactions, environmental sensory perception, microbial community interactions of Streptococcus mutans, biofilms in periodontal health and disease, oral biofilms as a reservoir for pathogens, oral biofilms as a device for therapeutic agents, and probiotics in oral healthcare. The book is an essential text for scientists interested in oral microbiology, bacterial communities and biofilms and is recommended reading for anyone working in the areas of oral health, and the pathogenesis of dental caries and periodontal disease. A recommended book for all microbiology laboratories. read more ...

Real-Time PCR in Food Science: Current Technology and Applications Buy now!

Edited by: David Rodríguez-Lázaro
Published: 2013   ISBN: 978-1-908230-15-7
Price: GB £159 or US $319
Written by experts in the field, this book is an indispensable manual for scientists in the food industry. The first section, Real-Time PCR Basics, provides an introduction to real-time PCR, discusses the use of PCR diagnostics in food science, describes the principles and methods of sample preparation, and covers the verification and control of PCR procedures. The eleven chapters in the second section, Food Microbiology, cover the use of real-time PCR to detect various pathogens including Salmonella, Listeria, E. coli, Campylobacter, Yersinia, Staphylococcus, Clostridium, viruses and parasites. Also included is a chapter on the standardisation of real-time PCR methods in food microbiology. The final section, Food Quality, covers the use of real-time PCR for the analysis of GMOs, food allergens and for the identification of animal or plant species. An invaluable book for anyone involved in food science or the detection of foodborne pathogens and a recommended volume for all microbiology laboratories. read more ...

Bacterial Gene Regulation and Transcriptional Networks Buy now!

Edited by: M. Madan Babu
Published: 2013   ISBN: 978-1-908230-14-0
Price: GB £159 or US $319
Along with the strategic guidance of M. Madan Babu (Cambridge, UK) authors from around the world have joined forces to review and discuss the latest research observations and current theories in this highly topical and important area of microbiology. The first few chapters describe the components required for transcriptional regulation, elucidate their complexity and discuss the genome-scale theories that currently prevail by investigating a large number of completely sequenced microbial genomes. Other chapters discuss how transcriptional regulation and gene circuits can be used by bacteria to sense signals and generate phenotypic variation. The next chapters introduce experimental and computational methods for investigating transcriptional regulatory networks on a genomic scale. Later chapters explore the transcriptional complexity of specific organisms, discuss current understanding of the genome-scale regulatory networks and the importance of key transcription factors. Specific organisms covered include Escherichia coli, Bacillus subtilis, Helicobacter pylori, Mycobacterium tuberculosis, Pseudomonas aeruginosa and Cyanobacteria. This book constitutes a major work on bacterial gene regulation and is a recommended purchase for all institutions and organisations interested in microbiology. read more ...

Bioremediation of Mercury: Current Research and Industrial Applications Buy now!

Edited by: Irene Wagner-Döbler
Published: 2013   ISBN: 978-1-908230-13-3
Price: GB £120 or US $240
In this timely book, established mercury experts review the latest research in this area, including the genetic engineering of bacteria and plants. The gap between laboratory research and field application is bridged using case studies: An abandoned chlor-alkali electrolysis factory in Kazhakhstan, a former PVC plant in Albania, and the Madeira River Basin in the Amazon region. The remaining chapters cover: the mercury-cell process of the chlor-alkali electrolysis industry; a pilot plant for wastewater bioremediation; and a comparison of the efficiency of microbial bioremediation to clean-up three types of industrial wastewater. The book covers the complete range from laboratory scale research to full scale industrial operation and shows a multitude of options for future mercury bioremediation technologies. Essential reading for research scientists, graduate students, and other specialists interested in mercury bioremediation, the book is also recommended reading for environmental microbiologists, chemists and engineers. read more ...

Horizontal Gene Transfer in Microorganisms Buy now!

Edited by: M. Pilar Francino
Published: 2012   ISBN: 978-1-908230-10-2
Price: GB £159 or US $319
Under the expert guidance of the editor, M. Pilar Francino, expert authors from around the world have contributed novel work and comprehensive, up-to-date reviews on the most topical aspects of horizontal gene transfer in microorganisms. Topics include: gene survival in emergent genomes, evolution of prokaryotic pangenomes, horizontal transfer of host-adaptability systems, barriers to horizontal gene transfer, evolution of horizontally transferred genes, lateral gene transfer in natural ecosystems, maintenance of plasmids among bacteria, mobile genetic elements in metagenomes, and the evolution of antibiotic resistance genes. Aimed primarily at research scientists, graduate students and other experts, this book is a major resource for anyone interested in horizontal gene transfer, microbial evolution or antibiotic resistance in bacteria. A recommended book for all microbiology laboratories. read more ...

Microbial Ecological Theory: Current Perspectives Buy now!

Edited by: Lesley A. Ogilvie and Penny R. Hirsch
Published: 2012   ISBN: 978-1-908230-09-6
Price: GB £120 or US $240
Written for graduate students and academic researchers, the book aims to encourage cross-disciplinary thinking and provide direction and perspective on the still fledgling field of microbial ecological theory. This volume is highly recommended for all microbiology libraries. read more ...

Two-Component Systems in Bacteria Buy now!

Edited by: Roy Gross and Dagmar Beier
Published: 2012   ISBN: 978-1-908230-08-9
Price: GB £180 or US $360
In this book, expert authors from around the world present the current knowledge on two-component systems in bacteria and critically evaluate the vast amount of exciting new information that has been brought to light in recent years. The eighteen chapters cover various topics including the structure-function analysis of two-component systems, the sensing mechanisms, essential or atypical two-component systems and signaling networks, two-component systems in stress responses, two-component systems in developmental processes, and two-component systems in virulence and symbiosis. The aim of this book is to provide a comprehensive overview of the area for graduate students, academic scientists and researchers in the pharmaceutical industry. This major reference work is essential reading for everyone working on bacterial regulation or antimicrobial drug design and a recommended volume for all microbiology libraries. read more ...

Foodborne and Waterborne Bacterial Pathogens: Epidemiology, Evolution and Molecular Biology Buy now!

Edited by: Shah M. Faruque
Published: 2012   ISBN: 978-1-908230-06-5
Price: GB £159 or US $319
Food- and waterborne pathogens continue to be a major cause of mortality in developing countries and cause significant morbidity in developed nations. Important pathogens include species or strains of Salmonella, Vibrio, Shigella, Escherichia coli, Yersinia, Staphylococcus and Campylobacter. Understanding the molecular basis of pathogenesis, its evolution and spread is critical to the development of new strategies for disease prevention and control. The application of genomic and other omics technologies in recent years has led to a deluge of information in this area, making it difficult for the busy researcher to keep abreast of developments. This timely book aims to capture the essence of the latest developments to provide a timely overview of the field. Written by leading bacteriologists, chapters cover all the important bacteria and review topics such as pathogenic properties, population genetics, virulence genes, evolution, drug resistance, epidemiology, detection, identification and control strategies. Other topics include the molecular basis for enhanced transmissibility of waterborne pathogens, their mode of survival in the environment, and the evolution of new species with increased fitness both as pathogens and environmental organisms. Essential reading for microbiologists working with these and related pathogens. read more ...

Yersinia: Systems Biology and Control Buy now!

Edited by: Elisabeth Carniel and B. Joseph Hinnebusch
Published: 2012   ISBN: 978-1-908230-05-8
Price: GB £159 or US $319
Three members of the genus Yersinia are important human pathogens, causing diseases ranging from the deadly Plague (Yersinia pestis) to a relatively mild gastroenteritis (Y. enterocolitica and Y. pseudotuberculosis). Plague, a re-emerging disease, is endemic in many parts of the world. The extraordinary pathogenicity of Y. pestis makes it a potential bioterrorist weapon. On the other hand, the two enteropathogenic Yersinia species represent the third most common bacterial cause of gastroenteritis in Europe and probably elsewhere, although their prevalence is largely underestimated. This and the emergence of antibiotic resistant Y. pestis in recent years highlight the urgency to understand the mechanisms of pathogenicity and the need to devise new strategies for the prevention and control of human pathogenic Yersinia. In this book, leading Yersinia researchers review the hot topics in the systems biology and control of these important bacteria. Topics include: transcriptome analysis of the bacterial response to the host and of the host response to a Yersinia infection; proteome analysis of the bacterial and host responses; treatment and antibiotic resistance; vaccines; surveillance and control. Essential reading for everyone working on Yersinia and related organisms and recommended reading for researchers interested in biodefence, microbial genomics and the evolution of microbial virulence. read more ...

Stress Response in Microbiology Buy now!

Edited by: Jose M. Requena
Published: 2012   ISBN: 978-1-908230-04-1
Price: GB £180 or US $360
In this book, expert authors from around the world summarise the current knowledge on microbial stress response and comprehensively review the recent findings that have greatly advanced the understanding of stress response systems. Each chapter is devoted to a particular organism or group of organisms including Gram-negative bacteria, Streptococcus,Neisseria, Listeria monocytogenes, Bacillus cereus, Salmonella, Yersinia, Vibrio, Mycobacterium, mycoplasmas, yeast, Plasmodium falciparum, Toxoplasma gondii, Leishmania, Trypanosoma cruzi, Trypanosoma brucei and Entamoeba histolytica. In addition to providing an up-to-date review of current trends the authors also describe the challenges for future research and provide comprehensive reference sections. The volume represents a major collection of information and knowledge across a wide range of microorganisms and is essential reading for anyone with an interest in stress response. A highly recommended book for anyone interested in stress response, regulatory networks, environmental microbiology or the pathogenicity of microorganisms. read more ...

Bacterial Regulatory Networks Buy now!

Edited by: Alain A.M. Filloux
Published: 2012   ISBN: 978-1-908230-03-4
Price: GB £180 or US $360
Renowned authors under the expert guidance of the editor Alain A.M. Filloux, have contributed authoritative, up-to-date reviews of the current research and theories on regulatory networks in bacteria. The volume contains critical reviews written by the leading research scientists in this topical field. The authors fully explore various regulatory networks, discuss variations of common themes and provide fresh insights into bacterial regulatory mechanisms. Topics include: the sigma network in Escherichia coli, control of bacterial virulence, ECF sigma factors, quorum sensing, cyclic di-GMP, RNA-mediated regulation, the H-NS regulator, two-component regulatory systems, bacterial chemotaxis, regulation of iron homeostasis, anaerobic regulatory networks, bacterial bistable regulatory networks, and evolution of transcription factors and regulatory networks. This book is essential reading for everyone interested in gene expression and regulation in bacteria and is a recommended text for all microbiology libraries. read more ...

Systems Microbiology: Current Topics and Applications Buy now!

Edited by: Brian D. Robertson and Brendan W. Wren
Published: 2012   ISBN: 978-1-908230-02-7
Price: GB £159 or US $319
This volume contains cutting-edge reviews by world-leading experts on the systems biology of microorganisms. As well as covering theoretical approaches and mathematical modelling this book includes case studies on single microbial species of bacteria and archaea, and explores the systems analysis of microbial phenomena such as chemotaxis and phagocytosis. Topics covered include mathematical models for systems biology, systems biology of Escherichia coli metabolism, bacterial chemotaxis, systems biology of infection, host-microbe interactions, phagocytosis, system-level study of metabolism in Mycobacterium tuberculosis, and the systems biology of Sulfolobus. This book is a major resource for anyone interested in systems biology and a recommended text for all microbiology laboratories. read more ...

Bacterial Spores: Current Research and Applications Buy now!

Edited by: Ernesto Abel-Santos
Published: 2012   ISBN: 978-1-908230-00-3
Price: GB £159 or US $319
In this book expert authors from around the world contribute comprehensive, up-to-date reviews on the current state of our knowledge of bacterial endospores. Topics covered include: gene regulation of sporulation, fruiting body development in Myxococcus xanthus, sporulation in Streptomyces, structure and composition of the bacterial spore, mechanisms of spore survival, germination of spores, spore peptidoglycan degradation, water and cations flux during sporulation and germination, the spore as an infectious agent, heterogeneity in spore populations, detection of bacterial spores, and the expression of recombinant proteins using spores. An essential text for everyone involved in spore research, the expression of recombinant proteins and pathogen detection, this book is also recommended for all scientists that like to keep up with cutting-edge research in microbiology and biotechnology. read more ...

Extremophiles: Microbiology and Biotechnology Buy now!

Edited by: Roberto Paul Anitori
Published: 2012   ISBN: 978-1-904455-98-1
Price: GB £159 or US $319
This book highlights the current and topical areas of research in this rapidly growing field. Expert authors from around the world provide the latest insights into the mechanisms these fascinating organisms use to survive. The topics covered include the ability of acidophiles to maintain a neutral intracellular pH, the way that psychrophiles "loosen up" their proteins at low temperatures, and other equally ingenious adaptations and metabolic strategies that extremophiles use to survive and flourish under extreme conditions. The book also covers the established biotechnological uses of extremophiles and the most recent and novel applications including the exploitation of these organisms for enzyme production, their potential use in the generation of sustainable energy and in the oil industry. Aimed at research scientists, students, microbiologists and biotechnologists this book is essential reading for scientists working with extremophiles and a recommended reference text for anyone interested in the microbiology of these organisms, as well as bioprospecting, biomining, biofuels and extremozymes. read more ...

Bacillus: Cellular and Molecular Biology (Second edition) Buy now!

Edited by: Peter Graumann
Published: 2012   ISBN: 978-1-904455-97-4
Price: GB £180 or US $360
Extensively revised and updated, the new edition of this valuable reference work provides a comprehensive and up-to-date analysis of the current knowledge and new research in Bacillus molecular and cellular biology. Under the expert guidance of the editor Peter Graumann, renowned authors from around the world have contributed critical reviews on the most recent and topical research. Subjects covered include chromosome replication, DNA repair, chromosome segregation, cell division, transcription and translation, RNA-mediated regulation, general and regulatory proteolysis, the actin-like MreB cytoskeleton, the membrane proteome, the cell wall, endospore formation, biofilms, multicellularity and social behaviour, competence and transformation. An essential book for anyone interested in Bacillus and an important reference volume for those working in fields as diverse as medicine, biotechnology, agriculture, food and industry. A recommended book for all microbiology laboratories. read more ...

Microbial Biofilms: Current Research and Applications Buy now!

Edited by: Gavin Lear and Gillian D. Lewis
Published: 2012   ISBN: 978-1-904455-96-7
Price: GB £159 or US $319
In this book, leading scientists provide an up-to-date review of the latest scientific research on these fascinating microbial communities and predict future trends and growth areas in biofilm-related research. Under the expert guidance of the editors Gavin Lear and Gillian Lewis, authors from around the world have contributed critical reviews on the most topical aspects of current biofilm research. Subjects covered include quorum sensing and social interactions in microbial biofilms, biofilms in disease, plant-associated biofilms, biofilms in the soil, applications in bioremediation, biofilms in wastewater treatment, corrosion and fouling, aquatic biofilms, microbial fuel cells, and catalytic biofilms. The book is essential for everyone interested in biofilms and their applications. It is also highly recommended for environmental microbiologists, soil scientists, medical microbiologists, bioremediation experts and microbiologists working in biocorrosion, biofouling, biodegradation, water microbiology, quorum sensing and many other areas. read more ...

Bacterial Glycomics: Current Research, Technology and Applications Buy now!

Edited by: Christopher W. Reid, Susan M. Twine, and Anne N. Reid
Published: 2012   ISBN: 978-1-904455-95-0
Price: GB £159 or US $319
Written by a team of acknowledged experts, this book provides an up-to-date overview of our current understanding of bacterial glycomes, describes the main analytical methods in use and discusses recent and novel applications. The book is divided into three sections. The first section includes overviews of microbial glyconjugates, lipopolysaccharide, capsular polysaccharide, lipoarabinomannan biosynthesis, cell wall metabolism, and glycosylation of bacterial and archaeal proteins. The second section reviews the analytical approaches used in the characterization of the bacterial glycome. The final section describes applications of bacterial glycomics, including metabolic oligosaccharide labeling, the synthesis of bioactive glycans and the potential for glycoconjugate vaccines. Essential reading for microbiologists working in polysaccharide and carbohydrate research, the book is also recommended for carbohydrate experts, microbiologists, immunologists and researchers in many other fields of life sciences. read more ...

Brucella: Molecular Microbiology and Genomics Buy now!

Edited by: Ignacio López-Goñi and David O'Callaghan
Published: 2012   ISBN: 978-1-904455-93-6
Price: GB £159 or US $319
Written by highly acclaimed Brucella scientists, this book comprehensively reviews the most important advances in the field. Opening chapters focus on genetic diversity within Brucella, covering both classical and new species. Particular emphasis is given to how comparative genomics has led to advances in molecular diagnostics, taxonomy and phylogeny. Following chapters cover proteomic analysis, transcriptomic analysis, the VirB type IV secretion system, signalling complexes, e.g. the BvrR/BvrS two-component regulatory system and quorum sensing. These chapters highlight the intricate interplay between factors involved in virulence. Another chapter discusses the role of the Brucella cell envelope in bacterial virulence and evasion of host defences. The final two chapters review the current strategies for the development of novel antibacterial agents and improved vaccines. This volume is essential reading for everyone with an interest in Brucella and brucellosis. It is also recommended reading for the wider body of scientists, veterinarians and MDs with an interest in microbial diagnostics, microbial pathogenesis, host-parasite interactions, cellular microbiologists and immunologists and vaccine development scientists. read more ...

Bacterial Pathogenesis: Molecular and Cellular Mechanisms Buy now!

Edited by: Camille Locht and Michel Simonet
Published: 2012   ISBN: 978-1-904455-91-2
Price: GB £180 or US $360
In this book, a group of distinguished scientists from eight different countries and three continents, under the expert guidance of the editors Camille Locht and Michel Simonet, overview the molecular and cellular mechanisms of bacterial pathogenesis. The fifteen chapters are organized into five sections: approaches to the study of bacterial pathogenesis; bacterial adhesion to the cell surface and extracellular matrix of host tissues; poisoning the host by toxins; cellular invasion by bacterial pathogens; and bacterial evasion of host defences. The authors comprehensively describe the most relevant and up-to-date information on pathogenic features across the bacterial world. Aimed at the entire scientific community from students to senior scientists and physicians, the book is relevant to a broad range of people interested in the mechanisms of bacterial infectious diseases and is a recommended text for all microbiology laboratories. read more ...

Emerging Trends in Antibacterial Discovery: Answering the Call to Arms Buy now!

Edited by: Alita A. Miller and Paul F. Miller
Published: 2011   ISBN: 978-1-904455-89-9
Price: GB £180 or US $360
In this book, respected international experts summarize the most important concepts and pioneering strategies currently being used to develop novel antibacterials. The book opens with chapters on cellular processes that could be used as novel antibacterial targets. Examples include cell division, efflux pumps, metabolite-sensing riboswitches and bacterial secretion systems. These are followed by excellent chapters on the identification of new, naturally occurring antibacterial agents, including phage and biosynthetically engineered compounds. Understanding the host-microbe interaction and microbial communities and how they can be exploited to develop new antibacterial strategies is discussed in subsequent chapters. Other topics included are: antibacterial vaccines adjuvants, host defence peptides, antibodies, within-host models, and diagnostics. A major reference volume on antibacterial research and how it impacts on public health worldwide, the book is essential reading for everyone working in antibacterial research and is a recommended volume for all microbiology libraries. read more ...

Metagenomics: Current Innovations and Future Trends Buy now!

Edited by: Diana Marco
Published: 2011   ISBN: 978-1-904455-87-5
Price: GB £159 or US $319
This book covers the most innovative and recent advances in theoretical, methodological and applied areas of metagenomics. Topics covered include metagenomics integration with complementary technologies, bacterial genealogy, viral metagenomics, the regulation of prokaryotic communities, functional metagenomics, systems biology, next-generation sequencing, stable isotope probing, DNA sequencing of uncultured microbes, cyberinfrastructure resource, identification of novel viruses, metagenomics of fungal communities, the human microbiome, microbial bioremediation, metagenomic enzyme discovery, quorum-sensing, plant-pathogen interactions, and metagenomics of belowground microbial communities. The book is aimed at researchers and environmental managers involved in metagenomics, students starting research in this field and teachers interested in the new developments. read more ...

Nitrogen Cycling in Bacteria: Molecular Analysis Buy now!

Edited by: James W. B. Moir
Published: 2011   ISBN: 978-1-904455-86-8
Price: GB £159 or US $319
This timely book aims to provide comprehensive reviews of current nitrogen cycle research and to give a broader perspective on the state of our understanding of this key biogeochemical cycle. With contributions from expert authors from around the world, topics covered include: the archaean N-cycle; redox complexes N-cycle; organisation of respiratory chains in N-cycle processes; Mo-nitrogenase; nitrogen assimilation in bacteria; alternative routes to dinitrogen; nitrite and nitrous oxide reductases; assembly of respiratory proteins; nitric oxide metabolism; denitrification in legume-associated endosymbiotic bacteria; nitrous oxide production in the terrestrial environment; bacterial nitrogen cycling in humans. This book will serve as a valuable reference work for everyone working in this field and will also be of interest to researchers studying symbioses, environmental microbiology, plant metabolism, infection events and other prokaryote-eukaryote interactions. read more ...

Helicobacter pylori Buy now!

Edited by: Lyudmila Boyanova
Published: 2011   ISBN: 978-1-904455-84-4
Price: GB £159 or US $319
This book highlights recent research and provides in a single volume an up-to-date summary of our current knowledge for microbiologists, clinicians and advanced students working with Helicobacter and for those wishing to enter the field. The authors offer an outstanding collection of reviews on many aspects of Helicobacter research including microbiology, virulence factors, immunology, vaccine research, epidemiology, diseases associated with the infection, antibiotic resistance, and treatment (including the use of non-antibiotic agents). A major reference volume on Helicobacter pylori and how it impacts on public health worldwide, the book is essential reading for those with an interest in the microbiology of H. pylori and is a recommended volume for all microbiology libraries. read more ...

Microbial Bioremediation of Non-metals: Current Research Buy now!

Edited by: Anna-Irini Koukkou
Published: 2011   ISBN: 978-1-904455-83-7
Price: GB £159 or US $319
Topics covered include: enzymatic biodegradation reactions; the impact of bioturbation on hydrocarbon dynamics in marine sediments; the structure, function and biodiversity of ring-hydroxylating dioxygenases involved in PAH biodegradation; strategies to engineer PCB-degrading bacteria; PCB-degrading plant-microbe systems strategies; the structure, regulation and diversity of microbial genes encoding biodegradative enzymes. In addition there are excellent reviews detailing the application of the state-of-the-art molecular technologies to study biodegradative processes. Technologies covered are community fingerprinting, molecular detection of degradative genes, and metagenomics for the analysis and monitoring of microorganisms in situ. These are complemented well by the fascinating reviews of the catabolic plasmids and mobile genetic elements involved in bioremediation, including discussions on the origin and evolution of these catabolic pathways to different genera. In addition the best procedures for the evaluation and design of relevant in situ remediation strategies are examined and classical ex-situ technologies such Landfarming, Composting, Biopiling and Slurry-phase bioremediation are described. This book is a vital reference resource for research scientists, graduate students, and other specialists interested on microbial bioremediation of organic pollutants and is recommended reading for environmental microbiologists, chemists and engineers. read more ...

Lactic Acid Bacteria and Bifidobacteria: Current Progress in Advanced Research Buy now!

Edited by: Kenji Sonomoto and Atsushi Yokota
Published: 2011   ISBN: 978-1-904455-82-0
Price: GB £159 or US $319
In this comprehensive book, expert international authors review the most recent cutting-edge research in these areas. Topics include: Lactobacillus genomics; Bifidobacterium gene manipulation technologies; metabolism of human milk oligosaccharides in bifidobacteria; proton-motive metabolic cycles; oxidative stress and oxygen metabolism; Bifidobacterium response to O₂; bile acid stress in LAB and bifidobacteria; protein structure quality control; bacteriocin classification and diversity; lactococcal bacteriocins; lactobacilli bacteriocins; other bacteriocins; production of optically pure lactic acid; antihypertensive metabolites from LAB; the anti-H. pylori effect of Lactobacillus gasseri; probiotics for allergic rhinitis; probiotics health claims in Japan and Europe. Essential reading for every researcher working with LAB, bifidobacteria and probiotics, from the PhD student to the experienced scientist. read more ...

Streptomyces: Molecular Biology and Biotechnology Buy now!

Edited by: Paul Dyson
Published: 2011   ISBN: 978-1-904455-77-6
Price: GB £159 or US $319
With contributions from some of the leading scientists in the field, this volume documents recent research and development in streptomycetes genomics, physiology and metabolism. With a focus on biotechnology and genomics, the book provides an excellent source of up-to-date information. Topics include: genome architecture, conjugative genetic elements, differentiation, protein secretion, central carbon metabolic pathways, regulation of nitrogen assimilation, phosphate control of metabolism, gamma-butyrolactones and their role in antibiotic regulation, clavulanic acid and clavams, genome-guided exploration, gene clusters for bioactive natural products, genomics of cytochromes p450. Essential reading for research scientists, biotechnologists, graduate students and other professionals involved in streptomycetes research, antibiotic and antimicrobial development, drug discovery, soil microbiology and related fields. A recommended text for all microbiology laboratories. read more ...

Vaccine Design: Innovative Approaches and Novel Strategies Buy now!

Edited by: Rino Rappuoli and Fabio Bagnoli
Published: 2011   ISBN: 978-1-904455-74-5
Price: GB £180 or US $360
In this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies. The book has been divided into two parts. The first part reviews the technologies and approaches used to identify, generate and test new vaccines. Topics include: new strategies to identify protective antigens, generation of improved adjuvants, use of alternative immunization routes, improving vaccine safety, and finding and establishing the correlates of protection. The second part of the book focuses on the development of new vaccines to replace or complement currently available products or for diseases against which prophylactic strategies are missing. Examples include vaccines against nosocomial infections, streptococci, emerging viral diseases, P. aeruginosa, and bovine mastitis. Essential reading for everyone with an interest in vaccine R & D. read more ...

Salmonella: From Genome to Function Buy now!

Edited by: Steffen Porwollik
Published: 2011   ISBN: 978-1-904455-73-8
Price: GB £159 or US $319
In this book, internationally acclaimed experts review cutting-edge topics in Salmonella genomics and molecular biology, providing a timely snapshot of the current state of research. Topics include latest approaches to sub-species level classification and phage typing of Salmonella, comparative genomics, the search for genetic determinants for survival of the bacterium in different environments and the evolution of niche specialization by Salmonella. The book also explores the latest genomic information and molecular characterizations of sRNAs and complements of fimbriae, flagella and secreted virulence factors. Moreover, S. Typhi pathogenesis, interactions of the host with intracellular Salmonella and the host's anti-Salmonella immune response are reviewed. The current knowledge on Salmonella biofilm formation and a progress report on using Salmonella as an anti-tumour tool conclude this compendium. Essential reading for all researchers working with Salmonella and related organisms, and recommended reading for other scientists working on bacterial genomics, molecular biology and bacterial molecular and cellular pathogenesis. read more ...

Environmental Microbiology: Current Technology and Water Applications Buy now!

Edited by: Keya Sen and Nicholas J. Ashbolt
Published: 2011   ISBN: 978-1-904455-70-7
Price: GB £159 or US $319
Authors have included comparative tables and figures that address detection sensitivity, specificity, ease of use and other criteria. The value of the book emanates from its explanation of the principles of techniques and the comparison of related techniques. In addition the reader is introduced to key references and important web sites where further details of the technology can be found. An essential book for water microbiologists, environmental microbiologists and regulators and recommended reading for all microbiologists and environmental scientists. read more ...

Sensory Mechanisms in Bacteria: Molecular Aspects of Signal Recognition Buy now!

Edited by: Stephen Spiro and Ray Dixon
Published: 2010   ISBN: 978-1-904455-69-1
Price: GB £159 or US $319
In this unique book, an international team of experts reviews a selection of important model systems, providing a timely snapshot of the current state of research in the field. The book opens with an introductory chapter that reviews the diversity of signal recognition mechanisms, illustrating the breadth of the field. Subsequent chapters include descriptions of the sensing of ligands (α-ketoglutarate, adenylate energy charge, glutamine and xenobiotic compounds), chemoreceptors, iron-sulfur cluster-based sensors, metal-dependent and metal-responsive sensors, thiol-based sensors, and PDZ domains as sensors of other proteins. This book provides essential reading for everyone with an interest in sensory mechanisms, regulatory networks and responses to environmental stress in bacteria. read more ...

Bifidobacteria: Genomics and Molecular Aspects Buy now!

Edited by: Baltasar Mayo and Douwe van Sinderen
Published: 2010   ISBN: 978-1-904455-68-4
Price: GB £159 or US $319
This book brings together the expertise and enthusiasm of the leading bifidobacteria experts from around the world to provide a state-of-the art overview of the molecular biology and genomics of this exciting and important microbial genus. Topics include: ecology, genomics, comparative genomics, metabolism, acid and bile resistance, stress response, probiotic properties, antimicrobial activity, interaction with the intestinal mucosa, safety assessment of bifidobacteria, synthesis and utilization of exopolysaccharides and prebiotics, antibiotic resistance/susceptibility profiles, viability and stability in commercial preparations, mobile genetic elements, cloning vectors and genetic manipulation of bifidobacteria. Essential reading for every bifidobacteria researcher, from the PhD student to the experienced scientist, and recommended reading for everyone with an interest in probiotics. read more ...

Molecular Phylogeny of Microorganisms Buy now!

Edited by: Aharon Oren and R. Thane Papke
Published: 2010   ISBN: 978-1-904455-67-7
Price: GB £159 or US $319
In this book, leading scientists from around the world explore current concepts in molecular phylogeny and their application with respect to microorganisms. The authors describe the different approaches applied today to elucidate the molecular phylogeny of prokaryotes (and eukaryotic protists) and review current phylogenetic methods, techniques and software tools. Topics covered include: a historical overview, computational tools, multilocus sequence analysis, 16S rRNA phylogenetic trees, rooting of the universal tree of life, applications of conserved indels, lateral gene transfer, endosymbiosis and the evolution of plastids. This book is an ideal introduction to molecular phylogeny for all microbiologists and is an essential review of current concepts for experts in the field. A recommended text for all microbiology laboratories. read more ...

Nanotechnology in Water Treatment Applications Buy now!

Edited by: T. Eugene Cloete, Michele de Kwaadsteniet, Marelize Botes and J. Manuel López-Romero
Published: 2010   ISBN: 978-1-904455-66-0
Price: GB £159 or US $319
This timely volume reviews the current state-of-the-art research and development of different nanomaterials (nanostructured catalytic membranes, nanosorbents, nanocatalysts and bioactive nanoparticles) and their application in water treatment, purification and disinfection. The expert authors have contributed chapters focusing on the cutting-edge research in this emerging technology and its applications in microbiology and water treatment. Topics covered include the detection of microbial pathogens, nanofibers and nanobiocides in water purification, nanozymes for biofilm removal, water and wastewater treatment and reverse osmosis. Also included is a chapter dedicated to the health and environmental concerns for the use of nanotechnology in water treatment. This book is aimed at everyone interested in nanobiotechnology, bioremediation, biodiagnostics, molecular diagnostics and environmental microbiology and is a recommended text for all microbiology laboratories. read more ...

Iron Uptake and Homeostasis in Microorganisms Buy now!

Edited by: Pierre Cornelis and Simon C. Andrews
Published: 2010   ISBN: 978-1-904455-65-3
Price: GB £159 or US $319
In this book, an international team of authors presents a comprehensive collection of reviews on iron uptake and metabolism in various microorganisms including rhizobia, Bordetella, Shigella, E. coli, Erwinia, Vibrio, Aeromonas, Francisella, Bacteroides, Campylobacter, cyanobacteria, Bacillus, staphylococci and yeasts. An entire chapter is dedicated to siderophores and another to heme uptake. The volume provides an expert and timely summary of current knowledge, with a focus on molecular and genetic aspects, and highlights some of the most exciting recent developments. Aimed at research scientists, advanced students and other specialists, this book is highly recommended for everyone interested in iron uptake and metabolism, microbial pathogenesis and microbial ecology. read more ...

Microbial Population Genetics Buy now!

Edited by: Jianping Xu
Published: 2010   ISBN: 978-1-904455-59-2
Price: GB £159 or US $319
Written by leading researchers in the field, this invaluable book details the major current advances in microbial population genetics and genomics. Distinguished international scientists introduce fundamental concepts, describe genetic tools and comprehensively review recent data from SNP surveys, whole-genome DNA sequences and microarray hybridizations. Chapters cover broad groups of microorganisms including viruses, bacteria, archaea, fungi, protozoa and algae. A major focus of the book is the application of molecular tools in the study of genetic variation. Topics covered include microbial systematics, comparative microbial genomics, horizontal gene transfer, pathogenic bacteria, nitrogen-fixing bacteria, cyanobacteria, microalgae, fungi, malaria parasites, viral pathogens and metagenomics. An essential volume for everyone interested in population genetics and highly recommended reading for all microbiologists. read more ...

Borrelia: Molecular Biology, Host Interaction and Pathogenesis Buy now!

Edited by: D. Scott Samuels and Justin D. Radolf
Published: 2010   ISBN: 978-1-904455-58-5
Price: GB £159 or US $319
Written by renowned scientists who have made seminal contributions to the field, this book is a comprehensive guide to the pathogenic Borrelia, providing researchers, advanced students, clinicians, and other professionals with an encyclopedic overview of the molecular biology of this important genus and the pathogenesis of diseases caused. Leading authorities have contributed chapters on topics such as Borrelia genomics, DNA replication, gene regulation, transcriptomics, proteomics, metabolism and physiology, cellular structure, motility and chemotaxis, genetic manipulation, evolutionary genetics, ecology, tick interactions, Lyme disease and relapsing fever pathogenesis, animal models, host response, detection, and vaccines. The volume is essential for anyone involved in Borrelia research and is strongly recommended for microbiologists, immunologists, and physicians involved in spirochete research, Lyme borreliosis, or relapsing fever. The book is a recommended reference volume for all microbiology libraries. read more ...

Metagenomics: Theory, Methods and Applications Buy now!

Edited by: Diana Marco
Published: 2010   ISBN: 978-1-904455-54-7
Price: GB £159 or US $319
This book addresses in a coherent manner the diverse and multiple aspects of metagenomics and the multiplicity of its potential applications. Renowned authors from around the world have contributed chapters covering the new theoretical insights, the more recent applications, and the dynamically developing methods of data acquisition and analysis. Topics include: Conceptual frameworks, tools and methods, integration of complementary approaches, horizontal gene transfer, analysis of complex microbial communities, public data resources, plant-microbe interactions, bioremediation, industrial bioproducts, archaeal metagenomics, bioprospecting novel genes, the human microbiome, and philosophical themes in metagenomics. The book is essential reading for all researchers currently performing metagenomics studies and is highly recommended for all students and scientists wishing to increase their understanding of this field. read more ...

Environmental Molecular Microbiology Buy now!

Edited by: Wen-Tso Liu and Janet K. Jansson
Published: 2010   ISBN: 978-1-904455-52-3
Price: GB £159 or US $319
This book highlights the current state-of-the-art of environmental molecular microbiology. International experts have contributed chapters that describe the various technologies and their applications in environmental microbiology. The first half of the book focuses on the microbial diversity and phylogeny of microorganisms in the environment and describes the molecular toolbox currently available for the study of the composition and diversity of microbial communities and their functions. Topics include the use of the 16S rRNA gene as a phylogenetic marker, metagenomics, metaproteomics, microarrays, and molecular fingerprinting. The second half focuses on the application of these approaches in various environments including soil, marine water, plants, humans and wastewater treatment. The last chapter of the book discusses the genetics and environmental implications of microbial biofilms. An essential book for advanced students, research scientists, environmental agencies and industries involved in any aspect of environmental microbiology. read more ...

Neisseria: Molecular Mechanisms of Pathogenesis Buy now!

Edited by: Caroline Genco and Lee Wetzler
Published: 2010   ISBN: 978-1-904455-51-6
Price: GB £159 or US $319
This important reference volume provides research scientists, advanced students, clinicians, and other professionals with a comprehensive update on the current understanding of the molecular mechanisms of pathogenesis in Neisseria. The editors have assembled a team of highly regarded scientists, over 40 contributors, to describe the latest, up-to-date research, theory and clinical significance of molecular mechanisms in meningococcal disease. Leading authorities have contributed chapters on topics such as gene expression, genomics, biofilms, denitrification, adhesion strategies and mechanisms of cellular invasion. A section on the host response to neisserial infection covers inate immunity, complement, apoptosis, and acquired immunity while a section devoted to clinical correlation deals with vaccine development, epidemiology and antibiotic resistance. The volume is highly recommended for microbiologists, epidemiologists and clinicians involved with Neisseria research or meningococcal disease and is a recommended text for all microbiology libraries. read more ...

ABC Transporters in Microorganisms Buy now!

Edited by: Alicia Ponte-Sucre
Published: 2009   ISBN: 978-1-904455-49-3
Price: GB £159 or US $319
This concise volume describes the latest, up-to-date theory, methodology and applications of ABC transporters in microorganisms. The topics include the structure, physiology and evolution of ABC transporters, as well as their special characteristics in specific microorganisms including bacteria, yeast, trypanosomes and malaria parasites. In particular the book describes the most recent research and innovations relative to the role of ABC transporters in the design of strategies to circumvent drug resistance in microorganisms. Each chapter comprises an exhaustive review of the particular topic and provides insights into the future of the field both from the scientific and clinical perspective. Essential reading for anyone involved in this field and a recommended volume for all microbiology laboratories. read more ...

Pili and Flagella: Current Research and Future Trends Buy now!

Edited by: Ken Jarrell
Published: 2009   ISBN: 978-1-904455-48-6
Price: GB £159 or US $319
This book, the first for many years on this important topic, brings together some of the top scientists in the field and describes the current knowledge and latest research on prokaryotic pili and flagella. The emphasis of the chapters is on the molecular biology, genetics, structure, assembly and function of these structures. Topics include biogenesis, structure, and function of various pili in Gram-negative and Gram-positive organisms, flagellar gene expression, structure and assembly, the flagella motor, posttranslational modifications of flagella systems, lateral flagella systems, the origin and evolution of flagella, applications of flagella as a surface display and expression system, and a chapter on the flagella and pili of Archaea. A recommended text for all microbiology laboratories and an essential volume for anyone involved in microbial adhesion, pathogenesis, virulence, structural biology, host colonization and motility. read more ...

Bacterial Polysaccharides: Current Innovations and Future Trends Buy now!

Edited by: Matthias Ullrich
Published: 2009   ISBN: 978-1-904455-45-5
Price: GB £159 or US $319
In this timely book a cohort of experienced and authoritative experts review the most important innovations in research on and biotechnological applications of bacterial polysaccharides. The book takes an interdisciplinary view that examines this fascinating subject area in detail from molecular biology, genome-, transcriptome- and proteome-wide perspectives, and looks at the ecological aspects and systems biology approaches. Hence the book provides a sound basis for future research directions including high efficiency applications of bacterial polysaccharides in medicine, the food industry, and renewable energy production. Topics include: peptidoglycan, lipopolysaccharide, arabinogalactan, capsule gene expression in Escherichia coli, immune response to polysaccharides, polysaccharides from periodontopathic bacteria, role in dental plaque, biofilms, levan, amylovoran and much more. Essential reading for everyone with an interest in bacterial polysaccharides, from the PhD student to the experienced scientist, as it provides a timely review of the current and most topical areas of research. read more ...

Microbial Toxins: Current Research and Future Trends Buy now!

Edited by: Thomas Proft
Published: 2009   ISBN: 978-1-904455-44-8
Price: GB £159 or US $319
Essential reading for everyone with an interest in microbial toxins and recommended reading for other scientists with an interest in bioterrorism, microbial pathogenesis, and microbial genomics. read more ...

Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis Buy now!

Edited by: Karl Wooldridge
Published: 2009   ISBN: 978-1-904455-42-4
Price: GB £159 or US $319
This extensive publication on bacterial secreted proteins, the secretory systems of bacteria and the vital role of secreted proteins in bacterial pathogenesis will be of immense value to all microbiologists, molecular biologists, public health scientists and researchers engaged in the study of pathogenesis, drug design and vaccine development. A skillful selection of topics and a panel of acknowledged experts as authors have ensured that this volume will become an important reference source for many years to come. The book is divided into two sections. The first section describes the various protein secretion systems including mechanisms for secretion across the cytoplasmic membrane of Gram-negative and Gram-positive bacteria, specialized mechanisms for secretion across the Gram-negative outer membrane, systems for transport across both membranes of Gram-negative bacteria, protein secretion systems in Gram-positive bacteria, the secretion of surface fimbrae/pili and a chapter on the less well defined pathways. Section 2 describes the protein secretion mechanisms and secreted proteins of a number of important human, veterinary and plant pathogens and their role in the pathogenicity of these organisms. The pathogens covered have been selected on the basis that there is active research on protein secretion by these pathogens and they employ a diverse array of secreted proteins and protein secretion systems. Each chapter of the book can be read in isolation, particularly the chapters in section 2. The book constitutes a broad and in-depth description of the current knowledge of bacterial protein secretion and its role in pathogenesis. A recommended reference volume for all microbiology libraries. read more ...

Lactobacillus Molecular Biology: From Genomics to Probiotics Buy now!

Edited by: Åsa Ljungh and Torkel Wadström
Published: 2009   ISBN: 978-1-904455-41-7
Price: GB £159 or US $319
This major new work focuses on recent research on the molecular biology and genomics of Lactobacillus. Written by an international team of scientists the volume is an essential reference for all medical researchers, dairy technologists, microbiologists and biotechnologists in the academic and industrial sectors. Topics covered include phylogenetics, taxonomy, comparative genomics, functional genomics, the intestinal microflora, surface proteins, stress responses, interaction with the immune system, probiotics, anti-cancer potential, and much more. Essential reading for all scientists involved with lactic acid bacteria or probiotic research and a recommended book for all microbiology laboratories. read more ...

Mycobacterium: Genomics and Molecular Biology Buy now!

Edited by: Tanya Parish and Amanda Brown
Published: 2009   ISBN: 978-1-904455-40-0
Price: GB £159 or US $319
A valuable reference text for all microbiology laboratories and essential reading for all scientists and researchers involved with mycobacteria. read more ...

Clostridia: Molecular Biology in the Post-genomic Era Buy now!

Edited by: Holger Brüggemann and Gerhard Gottschalk
Published: 2009   ISBN: 978-1-904455-38-7
Price: GB £159 or US $319
In this book internationally recognised Clostridium experts critically review the most important aspects of clostridial research, providing the first coherent picture of the organism's molecular and cellular biology in this post-genomic era. The first major focus of the book is the genetics and molecular biology of the major clostridial toxins including: botulinum and tetanus neurotoxins, C. difficile large exotoxins, C. perfringens enterotoxin, pore-forming and binary bacterial toxins. Other topics include: molecular epidemiology of C. botulinum and C. difficile, metabolic networks in C. acetobutylicum, development of genetic knock-out systems for clostridia, surface structures, anti tumor potential of clostridia, and antibiotic resistance determinants in C. difficile. Essential reading for every clostridia researcher, from the PhD student to the experienced scientist, as it provides a timely review of current research. read more ...

Plant Pathogenic Bacteria: Genomics and Molecular Biology Buy now!

Edited by: Robert W. Jackson
Published: 2009   ISBN: 978-1-904455-37-0
Price: GB £159 or US $319
In this book, internationally acclaimed experts review the most important developments providing an invaluable, up-to-date summary of the molecular biology and genomics of plant pathogenic bacteria. The book opens with two chapters on bacterial evolution, diversity and taxonomy, topics that have been transformed by molecular biology and genomics analyses. The third chapter delves into the crucially understudied area of pathogen adaptation to the plant apoplast environment. The following seven chapters focus on specific plant pathogens: Agrobacterium, Leifsonia, Pectobacterium, Pseudomonas, Ralstonia, Xanthomonas, and Xylella. The next four chapters review specific, intensively studied areas of research in the plant pathogen field: microbe associated molecular patterns (MAMPs) and innate immunity; use of bacterial virulence factors to suppress plant defence; cyclic di-GMP signalling and the regulation of virulence; and plasmids and the spread of virulence. The final chapter covers the critical area of bioinformatics. With contributions from some of the pioneering bacterial plant pathogen genome sequencers, this book is essential reading for every plant pathogen researcher, from the PhD student to the experienced scientist, as it provides a timely review of the current and most topical areas of research. read more ...

Microbial Production of Biopolymers and Polymer Precursors: Applications and Perspectives Buy now!

Edited by: Bernd H. A. Rehm
Published: 2009   ISBN: 978-1-904455-36-3
Price: GB £159 or US $319
Written by expert, internationally renowned scientists, this comprehensive volume describes in detail the use of microorganisms for the production of the most important biopolymers and polymer precursors. The authors describe, in depth, the biosynthetic pathways, physical properties and industrial production processes and discuss in detail the genetic and metabolic engineering of microorganisms for biopolymer production. Also highlighted are the applications and potential applications of the biopolymers and microbial biotechnology. Topics include the biochemistry and genetics of biosynthesis of xanthan, alginate, cellulose, cyanophycin, poly(gamma-glutamic acid), levan, hyaluronic acid, organic acids, oligosaccharides and polysaccharides, and polyhydroxyalkanoates. A recommended book for all biotechnology and microbiology laboratories. read more ...

Plasmids: Current Research and Future Trends Buy now!

Edited by: Georg Lipps
Published: 2008   ISBN: 978-1-904455-35-6
Price: GB £159 or US $319
Written by acknowledged experts in the field, this volume provides an up to date treatment of the structure, function and application of plasmids with a particular emphasis on current and future trends. The book is aimed primarily at research scientists, graduate students and professional scientists but will also be of great interest to all molecular biologists and microbiologists involved in research or teaching. Chapters include a historical perspective on E. coli plasmids and the scientific background of the plasmids used routinely in laboratories to clone genes and to express proteins; an overview on the plasmids of archaea and eukarya; bioinformatic tools; horizontal gene transfer and the process of DNA transfer. Two entire chapters are devoted to the important medical applications of plasmids, including the correction of gene defects and vaccines to treat cancer or infectious diseases. An essential book for all molecular biology laboratories. read more ...

Pasteurellaceae: Biology, Genomics and Molecular Aspects Buy now!

Edited by: Peter Kuhnert and Henrik Christensen
Published: 2008   ISBN: 978-1-904455-34-9
Price: GB £159 or US $319
Pasteurellaceae comprise a large and diverse family of Gram-negative bacteria with members ranging from important pathogens such as Haemophilus influenzae to commensals of the animal and human mucosa. Information on the biology of these organisms has mushroomed in recent years, driven by the development of novel genetic and molecular methodologies. Since 1995, the family has been expanded from three genera to the current thirteen through the use of new genetic-based classification and identification technologies. Many members of the Pasteurellaceae family make excellent natural models for the study of bacterial pathogenesis and host-pathogen-interactions thus giving valuable insights into related human diseases. Research in this area is at a very exciting stage. In this timely book, leading international Pasteurellaceae scientists critically review the most important current research providing an up-to-date review of the molecular biology, genomics and virulence of these fascinating organisms. Topics covered include taxonomy and biodiversity, phylogeny, comparative genomics, competence, DNA uptake and transformation, proteomics and protein secretion, RTX toxins, lipopolysaccharides, biofilms, quorum sensing, antimicrobial resistance, diagnosis, and OMP and iron uptake. Each chapter is independent and can be read in isolation and as a whole the book provides an important resource summarising our current knowledge of Pasteurellaceae genomics and molecular biology. Essential reading for everyone working on Pasteurellaceae and related organisms. read more ...

Vibrio cholerae: Genomics and Molecular Biology Buy now!

Edited by: Shah M. Faruque and G. Balakrish Nair
Published: 2008   ISBN: 978-1-904455-33-2
Price: GB £159 or US $319
Written by leading V. cholerae experts, the chapters review the most important cutting-edge genetic facets of V. cholerae including its genomic organization, population genetics, molecular epidemiology, and synchronized regulation of gene expression. Other topics include the molecular basis for enhanced transmissibility of cholera during epidemics, survival of the pathogen in the environment, and above all the evolution of the species to attain increased fitness both as a pathogen and an environmental organism. Essential reading for everyone with an interest in Vibrio and recommended reading for other scientists working in microbial pathogenesis, microbial genomics and antimicrobial research. read more ...

Helicobacter pylori: Molecular Genetics and Cellular Biology Buy now!

Edited by: Yoshio Yamaoka
Published: 2008   ISBN: 978-1-904455-31-8
Price: GB £159 or US $319
A useful introduction to the subject for new researchers and an invaluable reference for the experienced researcher, this book is essential reading for all researchers working with Helicobacter and related organisms. read more ...

Corynebacteria: Genomics and Molecular Biology Buy now!

Edited by: Andreas Burkovski
Published: 2008   ISBN: 978-1-904455-30-1
Price: GB £159 or US $319
This volume brings together the expertise and enthusiasm of today's leading experts to provide a description of the current state-of-the-art molecular biology toolbox available for Corynebacterium research, including global analyses techniques such as comparative genomics, transcriptome, proteome and metabolome analysis as well as the most recent knowledge on Corynebacterium promoter structures and vector systems. Furthermore, topics such as regulatory networks controlling carbon, nitrogen, phosphorus, sulphur and iron metabolism, cell wall structure, proteolysis and environmental stress response are covered. Essential reading for all Corynebacterium scientists and everyone with an interest in global analysis techniques, global regulation and systems biology. read more ...

Staphylococcus: Molecular Genetics Buy now!

Edited by: Jodi Lindsay
Published: 2008   ISBN: 978-1-904455-29-5
Price: GB £159 or US $319
This volume, the first to focus on staphylococcal genetics, brings together the expertise and enthusiasm of an international panel of leading staphylococcal researchers to provide a state-of-the art overview of the field. Topics include the sequencing projects, including spin-off microarray and systems biology tools, epidemiology, evolution, manipulation of the genome, diagnostics, gene expression due to global regulators and environmental triggers, cell-wall synthesis, coagulase-negative species, and animal pathogens. It is designed for two major audiences. Firstly, to introduce the subject to new researchers, including those unfamiliar with genetics. Secondly, for established researchers, for whom it will serve as an invaluable reference and summary of a large field, as well as presenting the latest advances and future trends written by those who are developing them. Essential reading for anyone involved in Staphylococcus research. read more ...

Legionella: Molecular Microbiology Buy now!

Edited by: Klaus Heuner and Michele Swanson
Published: 2008   ISBN: 978-1-904455-26-4
Price: GB £159 or US $319
Legionellosis is a disease of significant medical and public interest. Legionella is commonly found in aquatic habitats where its ability to survive and to multiply within different protozoa equips the bacterium to be transmissible and pathogenic to humans. In addition Legionella has become a favored model system to analyse the mechanisms of bacterial survival, acquisition of nutrients and intracellular replication. Following the recent publication of the genome sequences of four L. pneumophila strains it is now feasible to investigate the whole genome in silico, the transcriptome via micro arrays and the proteome by two-dimensional gel electrophoresis. Research in the fields of clinical features, diagnosis, treatment and epidemiology continues to generate new data. The topics covered by this volume range from the history of the identification of Legionella and clinical disease treatment, to the microbe's gene expression and secretion systems as well as its strategies for intracellular multiplication and nutrient acquisition. The main focus of the book is the current state of many of the most critical features of Legionella. Internationally renowned authors have contributed chapters describing and discussing the latest research findings with an emphasis on molecular aspects. The editors and authors have produced an excellent book that will be an extremely useful reference source. This comprehensive publication is aimed at readers with teaching or research interests in microbiology, genetics, genomics, infectious diseases or clinical research. A recommended book for all microbiology and clinical research laboratories. read more ...

Molecular Oral Microbiology Buy now!

Edited by: Anthony H. Rogers
Published: 2008   ISBN: 978-1-904455-24-0
Price: GB £159 or US $319
A panel of experts discuss the molecular biology of micro-organisms involved in the two major dental diseases: caries and periodontal disease. Research has focused on factors which might modulate the interaction between the resident oral bacteria and the host. Chapters deal with the interactions of oral micro-organisms with one another and with the host; the innate defence mechanisms of the host; and the development of vaccines against oral diseases. Topics include oral microbial taxonomy, identification and typing, applied genomics, horizontal gene transfer, cell-cell communication, cariogenic bacteria, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, host-pathogen interaction, host defense mechanisms, and vaccination against oral infections. Essential reading for students and researchers in the field of oral biology and oral microbiology and a recommended book for all microbiology laboratories. read more ...

Acinetobacter Molecular Biology Buy now!

Edited by: Ulrike Gerischer
Published: 2008   ISBN: 978-1-904455-20-2
Price: GB £159 or US $319
This concise volume reviews the most current and topical aspects of Acinetobacter genetics and molecular biology and is aimed at a readership of research scientists, graduate students and other specialists. Expert international authors have contributed chapters on diverse topics including taxonomy, lipopolysaccharides, catabolism of aromatic compounds, transformation systems, transcriptional regulation, applications in biotechnology, the molecular basis for virulence and pathogenicity, molecular epidemiology, and antibiotic resistance. This book is highly recommended for anyone involved in Acinetobacter research. read more ...

Pseudomonas: Genomics and Molecular Biology Buy now!

Edited by: Pierre Cornelis
Published: 2008   ISBN: 978-1-904455-19-6
Price: GB £159 or US $319
The genome sequences of several pseudomonads have become available in recent years and researchers are beginning to use the data to make new discoveries about this bacterium. This concise volume reviews the most current and topical aspects of Pseudomonas molecular biology and genomics and is aimed at a readership of research scientists, graduate students and other specialists. Renowned international authors have contributed chapters on diverse topics including taxonomy, genome diversity, oligonucleotide usage, polysaccharides, pathogenesis, virulence, biofilms, antibiotic resistance and iron uptake. In addition an entire chapter is devoted to the genetic tools being developed to take full advantage of the wealth of information generated by the genome sequencing efforts. This book is essential reading for anyone involved in Pseudomonas research. read more ...

Microbial Biodegradation: Genomics and Molecular Biology Buy now!

Edited by: Eduardo Díaz
Published: 2008   ISBN: 978-1-904455-17-2
Price: GB £159 or US $319
In this timely book expert international authors critically review all of the most important topics in this exciting field. Although other books covering this are currently available, this book is unique in that it is the first to review the area from a molecular biology and genomics perspective. Topics covered include: aerobic and anaerobic biodegradation of aromatic compounds, molecular detection methods (e.g. microautoradiography, mRNA analyses, etc.), genome-based predictive modelling, elucidation of regulatory networks, bioavailability, chemotaxis and transport issues, functional genomic analyses, natural attenuation, community fingerprinting and metagenomics, biotreatment, and biocatalysts engineering. Essential reading for microbial degradation and bioremediation scientists and of general interest for microbiologists working in field of environmental microbiology. read more ...

The Cyanobacteria: Molecular Biology, Genomics and Evolution Buy now!

Edited by: Antonia Herrero and Enrique Flores
Published: 2008   ISBN: 978-1-904455-15-8
Price: GB £159 or US $319
This volume brings together the expertise and enthusiasm of an international panel of leading cyanobacterial researchers to provide a state-of-the art overview of the field. Topics covered include: evolution, comparative genomics, gene transfer, molecular ecology and environmental genomics, stress responses, bioactive compounds, circadian clock, structure of the photosynthetic apparatus, membrane systems, carbon acquisition, nitrogen assimilation and C/N balance sensing and much more. Essential for anyone with an interest in cyanobacteria, bacterial photosynthesis, bacterial nitrogen fixation, and symbiosis. read more ...

Bacteriophage: Genetics and Molecular Biology Buy now!

Edited by: Stephen Mc Grath and Douwe van Sinderen
Published: 2007   ISBN: 978-1-904455-14-1
Price: GB £159 or US $319
Written by eminent international researchers actively involved in the disparate areas of bacteriophage research this book focuses on the current rapid developments in this exciting field. The book opens with an excellent chapter that provides a broad overview of the topics and also highlights the multifaceted nature of bacteriophage research. This is followed by a series of reviews that focus on the current most cutting-edge topics including bioinformatics and genomics, phage in the environment, bacteriophage in medicine, transfer of phage DNA to the host, contribution to host phenotype and much more. Essential reading for all phage researchers and of interest to molecular biologists and microbiologists working on bacteria in academia, biotechnology and pharmaceutical companies, and in the food and other industries read more ...

Candida: Comparative and Functional Genomics Buy now!

Edited by: Christophe d'Enfert and Bernhard Hube
Published: 2007   ISBN: 978-1-904455-13-4
Price: GB £159 or US $319
In this timely book international experts provide comprehensive and authoritative reviews of these important organisms. Topics covered include: genome dynamics of C. albicans; molecular epidemiological and population studies of C. albicans; the parasexual cycle in C. albicans; comparative genomics of the hemiascomycetes group and of different Candida species; databases and the challenges that their curators are facing; transcriptome analysis; proteomics; molecular evolution of the genetic code; stress responses; regulation of morphogenesis; cell wall biology; interaction with host cells; analysis of gene function; antifungal resistance mechanisms and much more. Essential reading for all Candida genome and molecular biology researchers and a recommended text for scientists working on fungal genomics and molecular biology. read more ...

Bacillus: Cellular and Molecular Biology Buy now!

Edited by: Peter Graumann
Published: 2007   ISBN: 978-1-904455-12-7
Price: GB £159 or US $319
Download flyer Bacillus subtilis is one of the best understood prokaryotes in terms of molecular biology and cell biology. Its superb genetic amenability and relatively large size have provided powerful tools to investigate a bacterium in all possible aspects. Recent improvements in technology have provided novel and amazing insights into the dynamic structure of this single cell organism. The organism is a model for differentiation, gene/protein regulation and cell cycle events in bacteria. This book presents an overview of the most recent exciting new research fields and provides a picture of the major cytological aspects of a model bacterium. The authors present the most recent knowledge on topics such as the replication and segregation of the chromosome, cell division, replication and growth, the cell cycle, transcription, translation, regulation, the actin cyctoskeleton, the cell membrane and cell wall, biofilm formation and sporulation. Also covered are DNA repair, the regulation of transcription through RNA molecules, and the regulation of protein activity through proteolysis. The authors seamlessly merge the fields of bacterial cell biology and molecular biology to provide an integral view of the bacterial cell, providing an understanding of the way a bacterial cell functions as a whole entity and in 3D, i.e. how it is spatially organized, and even how bacterial cells communicate with each other, or give their life for the sake of the whole community. An essential book for anyone interested in Bacillus, cell biology or bacterial genetics and molecular biology. read more ...

Pathogenic Treponema: Molecular and Cellular Biology Buy now!

Edited by: Justin D. Radolf and Sheila A. Lukehart
Published: 2006   ISBN: 978-1-904455-10-3
Price: GB £159 or US $319
This volume is the first comprehensive review of treponemal research to be published in more than twenty years. Written by leading experts in the field, this book presents the current state of research on these organisms that affect the health of millions of people worldwide. The structure and metabolism of the treponemes are explored in light of the comparative genomics data now available. The newest information concerning their pathogenic mechanisms, as well as the complex innate and adaptive immune responses they elicit, are detailed. A number of chapters illustrate how our knowledge of syphilis has grown in the molecular era despite the continuing inability to propagate its elusive etiologic agent. The book also provides an historical perspective on treponemal research that will be of considerable interest. This compilation will serve as an essential reference for microbiologists, immunologists, and physicians who deal with these organisms on a day-by-day basis or who wish to understand them better in the context of contemporary microbiology. Topics covered include the phylogenic diversity, comparative genomics, metabolism and cultivation, motility, antigenic variation, immunology of syphilis, the use cultivatable treponemes as surrogates for T. pallidum, oral treponemes, and much much more. Essential reading for all scientists and researchers working on trepenomes and other spirochetes and a recommended reference book for all microbiology laboratories. read more ...

Microbial Subversion of Immunity: Current Topics Buy now!

Edited by: Peter J. Lachmann
Published: 2006   ISBN: 978-1-904455-05-9
Price: GB £159 or US $319
In this book internationally renowned scientists critically review the current cutting-edge research in this area. Topics covered include the subversion of complement, NK cell function, mucosal innate immune response, evasion/subversion mechanisms used by bacteria, helminths, viruses, and the measles model system. Containing over 1,700 references, this book is an essential resource book for researchers in the fields of microbiology, immunology, pharmacology and molecular medicine. read more ...

Probiotics and Prebiotics: Scientific Aspects Buy now!

Edited by: Gerald W. Tannock
Published: 2005   ISBN: 978-1-904455-01-1
Price: GB £159 or US $319
Food scientists and nutritionists have accepted, relatively uncritically, the concepts underlying the use of probiotics and prebiotics in the promotion of health. Microbiologists and medical practitioners have viewed these products more sceptically. Much more scientific and medical validation of probiotic or prebiotic use is required. This will entail the use of sophisticated analytical methodologies. Knowledge of the gut microbiota has increased dramatically during the past decade thanks largely to the results obtained from the application of nucleic acid-based methodologies. Because of the availability of improved technologies, detailed studies of the two principal kinds of probiotic or prebiotic bacteria, Lactobacillus and Bifidobacterium, can be made. Emerging leaders have contributed chapters to this book that therefore represents a state of the art compendium of fundamental science related to early 21st century probiotic or prebiotic research. read more ...

Foodborne Pathogens: Microbiology and Molecular Biology Buy now!

Edited by: Pina M. Fratamico, Arun K. Bhunia, and James L. Smith
Published: 2005   ISBN: 978-1-904455-00-4
Price: GB £159 or US $319
Written by leaders in the field, this book represents a cutting edge summary of all the latest advances, providing the first coherent picture of the current status. Opening chapters tackle topics such as pathogen detection (molecular, biosensor), molecular typing, viable but non-culturable organisms, predictive modeling, and stress responses. The next section covers groups of organisms: enteric viruses, protozoan parasites, and mycotoxins. This is followed by chapters on specific bacteria: Yersinia enterocolitica, Vibrio spp., Staphylococcus aureus, Campylobacter Infections, Listeria monocytogenes, Salmonella spp., Shigella spp., Escherichia coli, Clostridium botulinum, Clostridium perfringens and Bacillus cereus. The final chapters provide a fascinating review of the ability of pathogens to contaminate a food supply and provide an overview of emerging foodborne pathogens. read more ...

MRSA: Current Perspectives Buy now!

Edited by: Ad C. Fluit and Franz-Josef Schmitz
Published: 2003   ISBN: 978-0-9542464-5-7
Price: GB £159 or US $319
Methicillin-resistant S. aureus (MRSA) strains continue to present unique challenges to clinicians, microbiologists, and the molecular biologists around the world. These organisms are typically resistant to several other antimicrobial agents, including aminoglycosides, chloramphenicol, clindamycin, fluoroquinolones and macrolides and are susceptible only to vancomycin. Internationally renown authors comprehensively review all aspects of MRSA research. Topics covered include strategies for the detection and typing of MRSA strains, epidemiological characterisation, molecular evolution of MRSA, vancomycin resistant S. aureus, mechanisms of methicillin resistance, virulence mechanisms in MRSA pathogenesis, recommended treatment of MRSA infections and options for the prevention and control of MRSA infections. read more ...

Genomics of GC-Rich Gram-Positive Bacteria Buy now!

Edited by: Antoine Danchin
Published: 2002   ISBN: 978-0-9542464-3-3
Price: GB £159 or US $319
Eminent scientists have contributed comprehensive reviews on all aspects of the genomics of Rhodococcus, Mycobacteria, Streptomyces and other organisms. The authors provide an insight into the many facets of large-scale functional investigation in a variety of bacteria with the explicit goal to find common rules in the dynamic and structural organisation of these organisms. This volume is the definitive guide to current research in this increasingly important area. read more ...

Probiotics and Prebiotics: Where are We Going? Buy now!

Edited by: Gerald W. Tannock,
Published: 2002   ISBN: 978-0-9542464-1-9
Price: GB £159 or US $319
Contains state-of-the-art commentaries on all aspects of the intestinal microflora and probiotics and provides an authoritative review of important aspects of probiotic and prebiotic research. Written by leading experts in the field, each chapter affords a critical insight to a particular topic, reviews current research, discusses future direction and aims to stimulate discussion. Topics covered include the genomics of probiotic microorganisms, the developing technologies for analysis of gut microorganisms, evaluation and future potential of prebiotic substances, and the potential for disease prevention in the host by probiotic organisms. read more ...