Tuesday, May 01, 2007
Dynamics of DNA Double-Strand Break Repair in Bacillus subtilis
Humberto Sanchez, Begoña Carrasco, Silvia Ayora and Juan C. Alonso
All organisms have developed a variety of repair mechanisms, with recombination being the ultimate step for DNA repair and for promoting re-establishment of replication forks that are stalled or collapsed. This review summarises our current knowledge on the cellular response to DNA damage in Bacillus subtilis cells. Cytological approaches now confirm previous observations from genetic and biochemical analyses, which suggested that recombinational repair, and especially double-strand break repair, is choreographed by multi-protein complexes that are organised into focal assemblies tightly regulated and coordinated with other essential processes, such as DNA replication, and chromosomal segregation.
More information from: Bacillus: Cellular and Molecular Biology
All organisms have developed a variety of repair mechanisms, with recombination being the ultimate step for DNA repair and for promoting re-establishment of replication forks that are stalled or collapsed. This review summarises our current knowledge on the cellular response to DNA damage in Bacillus subtilis cells. Cytological approaches now confirm previous observations from genetic and biochemical analyses, which suggested that recombinational repair, and especially double-strand break repair, is choreographed by multi-protein complexes that are organised into focal assemblies tightly regulated and coordinated with other essential processes, such as DNA replication, and chromosomal segregation.
More information from: Bacillus: Cellular and Molecular Biology
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