Peptidoglycan biosynthesis is a target for various antibiotics. Therefore, a large number of resistance mechanisms have evolved. Resistance strategies include changing the peptide structure of peptidoglycan. For example, replacing the terminal d-Ala-d-Ala with d-Ala-d-Lac confers resistance against vancomycin- and penicillininsensitive l,d-transpeptidases and leads to l,d- instead of d,d-cross-links. Activation of the 'cell-wall stress stimulon' by antibiotics results in overexpression of peptidoglycan biosynthesis-associated genes, suggesting a higher biosynthesis rate in order to cope with damages of the cell wall.
from Ute Bertsche
in Bacterial PolysaccharidesFurther reading:
Bacterial Polysaccharides: Current Innovations and Future TrendsLabels: antibiotic resistance, peptidoglycan