Recent studies regarding the utility of RNAi to specifically inhibit virus replication have opened new possibilities for the development of novel therapies against viral infection. However, viruses appear to be capable of escaping RNAi inhibition in mammalian cells. Viral mechanisms for escaping RNAi may include suppression of RNAi, mutational escape from RNAi, and modulation of the cell's microRNA (miRNA) /RNAi profile.

Further reading:

• RNA Interference and Viruses: Current Innovations and Future Trends
• RNA and the Regulation of Gene Expression: A Hidden Layer of Complexity

Labels: MicroRNA, RNAi