Sequence analysis and experimentally determined three-dimensional structures of structural and nonstructural proteins from a range of caliciviruses help to provide a molecular framework for understanding many aspects of their replication strategies. Structures of intact virions, virus-like particles and capsid fragments, as well as capsid-receptor complexes help to explain basic mechanisms of capsid assembly and receptor recognition. Structural studies of the recombinant viral proteinase and polymerase in complex with substrates and inhibitors provide a basis for understanding substrate recognition and enzymatic mechanisms, thus setting the stage for the design of new antiviral compounds.

Further reading: Caliciviruses: Molecular and Cellular Virology

Labels: Caliciviridae, Calicivirus, Caliciviruses, Lagovirus, Norovirus, Sapovirus, Vesivirus