from Matthew Reeves and John Sinclair writing in Cytomegaloviruses: From Molecular Pathogenesis to Intervention:
The myeloid lineage is now accepted to be an important site in vivo for the carriage of latent HCMV genomes, but the mechanisms underlying how the latent state is maintained and how latent virus reactivates are still far from clear. In this review, we discuss how analyses of promoter binding proteins and post-translational modifications of histones on viral promoters during virus infection have led to an understanding that the higher-order chromatin structure around the viral major immediate-early promoter region has profound effects on the control of viral latency and reactivation. We further discuss the role of chromatin during lytic infection and how this may also give insights into the cellular mechanisms important for the establishment and control of latent infection.
Further reading: Cytomegaloviruses: From Molecular Pathogenesis to Intervention