from Stephen J. W. Busby and Stephen D. Minchin writing in Bacterial Gene Regulation and Transcriptional Networks:
The traditional methods for discovering transcriptional regulatory networks in bacteria, based on genetics and biochemistry, are now being replaced by high throughput pan-genome methods. Experimental approaches include methods involving RNA or methods based on the direct observation of transcription factors. This review places the new methods in context and discusses their potential benefits and drawbacks.
Further reading: Bacterial Gene Regulation and Transcriptional Networks