DNA damage response pathways
HSV-1 and the DNA Damage Response
Category: Virology
from Matthew D. Weitzman and Sandra K. Weller writing in Alphaherpesviruses: Molecular Virology:
The cellular DNA damage machinery responds to virus infection and the foreign genomes that accumulate in the nuclei of infected cells. Many DNA viruses have been shown to manipulate the cellular DNA damage response pathways in order to create environments conducive to their own replication. Some cellular factors are activated during infection while others are inactivated.
Further reading: Alphaherpesviruses: Molecular Virology
The cellular DNA damage machinery responds to virus infection and the foreign genomes that accumulate in the nuclei of infected cells. Many DNA viruses have been shown to manipulate the cellular DNA damage response pathways in order to create environments conducive to their own replication. Some cellular factors are activated during infection while others are inactivated.
Further reading: Alphaherpesviruses: Molecular Virology