Group B Streptococcus Vaccine
Toward the Development of a Universal Vaccine Against Group B Streptococcus
from Roberta Cozzi, John L. Telford and Domenico Maione writing in Vaccine Design: Innovative Approaches and Novel Strategies
Group B Streptococcus (GBS) is one of the most common cause of life-threatening bacterial infections in infants and is also an emerging pathogen among adult humans, especially in the elderly, immunocompromised and diabetic adults. Capsular polysaccharide based vaccines of the most common serotypes present in the United States and Europe are in an advanced stage of development but they are not effective against serotypes present in other parts of the world. Many protein antigens have been studied for the discovery of an effective universal vaccine that could overcome serotype specificity. Thanks to reverse vaccinology and new technologies, a vaccine combination based on the pilus proteins has been discovered for the development of a universal GBS vaccine that is potentially capable of preventing all GBS infections.
Further reading: Vaccine Design: Innovative Approaches and Novel Strategies | Pili and Flagella: Current Research and Future Trends
from Roberta Cozzi, John L. Telford and Domenico Maione writing in Vaccine Design: Innovative Approaches and Novel Strategies
Group B Streptococcus (GBS) is one of the most common cause of life-threatening bacterial infections in infants and is also an emerging pathogen among adult humans, especially in the elderly, immunocompromised and diabetic adults. Capsular polysaccharide based vaccines of the most common serotypes present in the United States and Europe are in an advanced stage of development but they are not effective against serotypes present in other parts of the world. Many protein antigens have been studied for the discovery of an effective universal vaccine that could overcome serotype specificity. Thanks to reverse vaccinology and new technologies, a vaccine combination based on the pilus proteins has been discovered for the development of a universal GBS vaccine that is potentially capable of preventing all GBS infections.
Further reading: Vaccine Design: Innovative Approaches and Novel Strategies | Pili and Flagella: Current Research and Future Trends