Neisseria book review
I am pleased to provide the following excerpt from a book review of Neisseria: Molecular Mechanisms of Pathogenesis:
"an excellent, comprehensive and updated review ... The editors, both experienced in the Neisseria field, have recruited 43 contributors from five different countries. Many of these individuals are well-recognized experts, front-line researchers and/or key opinion leaders in their topics. They provide, evaluate and discuss detailed up-to-date understanding, the significance of different findings, theories, hypotheses and conclusions, and future directions in a research, clinical and public health perspective. The volume is valuable and timely ... Most chapters ... are excellent, comprehensive, important, updated, well-written, and contain many relevant references and informative figures/tables summarizing the key information ... the 'future trends' are valuably emphasized in most chapters. Some chapters even recommend good web resources for further reading ... the editors of the present volume have collated an impressive group of well-recognized experts that provide exceedingly interesting, comprehensive and up-to-date understanding regarding molecular mechanisms of pathogenesis in Neisseria, as well as an excellent bibliography for further reading. The volume is valuable, timely and can be highly recommended for researchers, microbiologists, molecular biologists, epidemiologists, clinicians, vaccine manufacturers and students, who are involved and/ or interested in any topic involving pathogenic Neisseria species." from Magnus Unemo (Orebro, Sweden) writing in Expert Rev. Anti Infect. Ther. (2010) 8: 871–875. read more ...
"an excellent, comprehensive and updated review ... The editors, both experienced in the Neisseria field, have recruited 43 contributors from five different countries. Many of these individuals are well-recognized experts, front-line researchers and/or key opinion leaders in their topics. They provide, evaluate and discuss detailed up-to-date understanding, the significance of different findings, theories, hypotheses and conclusions, and future directions in a research, clinical and public health perspective. The volume is valuable and timely ... Most chapters ... are excellent, comprehensive, important, updated, well-written, and contain many relevant references and informative figures/tables summarizing the key information ... the 'future trends' are valuably emphasized in most chapters. Some chapters even recommend good web resources for further reading ... the editors of the present volume have collated an impressive group of well-recognized experts that provide exceedingly interesting, comprehensive and up-to-date understanding regarding molecular mechanisms of pathogenesis in Neisseria, as well as an excellent bibliography for further reading. The volume is valuable, timely and can be highly recommended for researchers, microbiologists, molecular biologists, epidemiologists, clinicians, vaccine manufacturers and students, who are involved and/ or interested in any topic involving pathogenic Neisseria species." from Magnus Unemo (Orebro, Sweden) writing in Expert Rev. Anti Infect. Ther. (2010) 8: 871–875. read more ...
 | Edited by: Caroline Genco and Lee Wetzler "excellent, comprehensive ... valuable and timely ... highly recommended" (Expert Rev. Anti Infect. Ther.)ISBN: 978-1-904455-51-6 Publisher: Caister Academic Press Publication Date: January 2010 Cover: hardback |
Serogroup B Meningococcus Vaccine
The First Vaccine Obtained Through Reverse Vaccinology: The Serogroup B Meningococcus Vaccine
from Jeannette Adu-Bobie, Beatrice Aricò, Marzia M. Giuliani and Davide Serruto writing in Vaccine Design: Innovative Approaches and Novel Strategies
Neisseria meningitidis was isolated over one hundred years when Anton Weicshelbaum identified the causative agent of cerebrospinal meningitis. Since its isolation in 1887, N. meningitidis has been recognized to cause endemic cases, case clusters, epidemics and pandemics of meningitis and devastating septicaemia. Despite over one century since its discovery, scientists have yet to identify a universal vaccine for this deadly bacterium. Although vaccines exist for several serogroups of pathogenic N. meningitidis, serotype B (MenB) has eluded scientists for decades, until the advent of genomics. The genome era has completely changed the way to design vaccines. The availability of the complete genome of microorganisms combined with a novel advanced technology has introduced a new prospective in vaccine research. This novel approach is now known as "Reverse Vaccinology" and N. meningitidis can be considered the first successful example of its application. A recent review describes the successful story of the development of the serogroup B vaccine, starting from the analysis of genome and finishing with the results obtained in clinical trials.
Further reading: Vaccine Design: Innovative Approaches and Novel Strategies | Neisseria: Molecular Mechanisms of Pathogenesis
from Jeannette Adu-Bobie, Beatrice Aricò, Marzia M. Giuliani and Davide Serruto writing in Vaccine Design: Innovative Approaches and Novel Strategies
Neisseria meningitidis was isolated over one hundred years when Anton Weicshelbaum identified the causative agent of cerebrospinal meningitis. Since its isolation in 1887, N. meningitidis has been recognized to cause endemic cases, case clusters, epidemics and pandemics of meningitis and devastating septicaemia. Despite over one century since its discovery, scientists have yet to identify a universal vaccine for this deadly bacterium. Although vaccines exist for several serogroups of pathogenic N. meningitidis, serotype B (MenB) has eluded scientists for decades, until the advent of genomics. The genome era has completely changed the way to design vaccines. The availability of the complete genome of microorganisms combined with a novel advanced technology has introduced a new prospective in vaccine research. This novel approach is now known as "Reverse Vaccinology" and N. meningitidis can be considered the first successful example of its application. A recent review describes the successful story of the development of the serogroup B vaccine, starting from the analysis of genome and finishing with the results obtained in clinical trials.
Further reading: Vaccine Design: Innovative Approaches and Novel Strategies | Neisseria: Molecular Mechanisms of Pathogenesis
Vaccination
Category: Immunology | Vaccines
Vaccination
from Fabio Bagnoli and Rino Rappuoli writing in Vaccine Design: Innovative Approaches and Novel Strategies
Vaccination, together with the wider availability of potable water, has had the most profound positive effect on the quality of public health of any measure: during the past century, these products essentially eliminated most infectious diseases causing mortality in infants and children. Vaccines against diphtheria, tetanus, polio, measles, mumps, rubella, pneumococcus, hepatitis B and meningitis (Haemophilus influenzae and serogroup C meningococcus) have reduced the incidence and mortality of these diseases by > 97-99% (Fabio Bagnoli and Rino Rappuoli). Nevertheless, perception of vaccines in the public opinion is not completely positive. Many people are still skeptical about the real need of vaccines. This behavior has been particularly evident during the influenza A (H1N1) pandemic in 2009.
Further reading: Vaccine Design: Innovative Approaches and Novel Strategies
from Fabio Bagnoli and Rino Rappuoli writing in Vaccine Design: Innovative Approaches and Novel Strategies
Vaccination, together with the wider availability of potable water, has had the most profound positive effect on the quality of public health of any measure: during the past century, these products essentially eliminated most infectious diseases causing mortality in infants and children. Vaccines against diphtheria, tetanus, polio, measles, mumps, rubella, pneumococcus, hepatitis B and meningitis (Haemophilus influenzae and serogroup C meningococcus) have reduced the incidence and mortality of these diseases by > 97-99% (Fabio Bagnoli and Rino Rappuoli). Nevertheless, perception of vaccines in the public opinion is not completely positive. Many people are still skeptical about the real need of vaccines. This behavior has been particularly evident during the influenza A (H1N1) pandemic in 2009.
Further reading: Vaccine Design: Innovative Approaches and Novel Strategies