Molecular chaperone proteins
Molecular Chaperones and Alphaherpesvirus Infection
Category: Virology
from Christine M. Livingston, Christos Kyratsous, Saul Silverstein and Sandra K. Weller writing in Alphaherpesviruses: Molecular Virology:
Molecular chaperone proteins have long been recognized to play diverse and important roles in the life cycles of viruses from bacteriophage to SV40 to herpesviruses. The alphaherpesviruses HSV-1 and VZV not only interact with and reorganize cellular chaperones and co-chaperones but alphaherpesviruses also encode their own molecular chaperones. Cellular chaperones such as Hsp70, Hsc70 and Hsp90 are required for efficient production of infectious virus in that they play essential roles in nuclear transport of viral proteins, protein quality control and maintenance of cellular homeostasis during viral infection. These findings raise the possibility that molecular chaperones could be utilized as effective targets for antiviral therapy. A recent review reviews the evidence that replication of the human alphaherpesviruses herpes simplex virus type 1 and 2 (HSV-1 and 2) and varicella zoster virus (VZV) requires the activities of cellular and viral molecular chaperones.
Further reading: Alphaherpesviruses: Molecular Virology
Molecular chaperone proteins have long been recognized to play diverse and important roles in the life cycles of viruses from bacteriophage to SV40 to herpesviruses. The alphaherpesviruses HSV-1 and VZV not only interact with and reorganize cellular chaperones and co-chaperones but alphaherpesviruses also encode their own molecular chaperones. Cellular chaperones such as Hsp70, Hsc70 and Hsp90 are required for efficient production of infectious virus in that they play essential roles in nuclear transport of viral proteins, protein quality control and maintenance of cellular homeostasis during viral infection. These findings raise the possibility that molecular chaperones could be utilized as effective targets for antiviral therapy. A recent review reviews the evidence that replication of the human alphaherpesviruses herpes simplex virus type 1 and 2 (HSV-1 and 2) and varicella zoster virus (VZV) requires the activities of cellular and viral molecular chaperones.
Further reading: Alphaherpesviruses: Molecular Virology