Neisseria book review
I am pleased to provide the following excerpt from a book review of Neisseria: Molecular Mechanisms of Pathogenesis:
"an excellent, comprehensive and updated review ... The editors, both experienced in the Neisseria field, have recruited 43 contributors from five different countries. Many of these individuals are well-recognized experts, front-line researchers and/or key opinion leaders in their topics. They provide, evaluate and discuss detailed up-to-date understanding, the significance of different findings, theories, hypotheses and conclusions, and future directions in a research, clinical and public health perspective. The volume is valuable and timely ... Most chapters ... are excellent, comprehensive, important, updated, well-written, and contain many relevant references and informative figures/tables summarizing the key information ... the 'future trends' are valuably emphasized in most chapters. Some chapters even recommend good web resources for further reading ... the editors of the present volume have collated an impressive group of well-recognized experts that provide exceedingly interesting, comprehensive and up-to-date understanding regarding molecular mechanisms of pathogenesis in Neisseria, as well as an excellent bibliography for further reading. The volume is valuable, timely and can be highly recommended for researchers, microbiologists, molecular biologists, epidemiologists, clinicians, vaccine manufacturers and students, who are involved and/ or interested in any topic involving pathogenic Neisseria species." from Magnus Unemo (Orebro, Sweden) writing in Expert Rev. Anti Infect. Ther. (2010) 8: 871–875. read more ...
"an excellent, comprehensive and updated review ... The editors, both experienced in the Neisseria field, have recruited 43 contributors from five different countries. Many of these individuals are well-recognized experts, front-line researchers and/or key opinion leaders in their topics. They provide, evaluate and discuss detailed up-to-date understanding, the significance of different findings, theories, hypotheses and conclusions, and future directions in a research, clinical and public health perspective. The volume is valuable and timely ... Most chapters ... are excellent, comprehensive, important, updated, well-written, and contain many relevant references and informative figures/tables summarizing the key information ... the 'future trends' are valuably emphasized in most chapters. Some chapters even recommend good web resources for further reading ... the editors of the present volume have collated an impressive group of well-recognized experts that provide exceedingly interesting, comprehensive and up-to-date understanding regarding molecular mechanisms of pathogenesis in Neisseria, as well as an excellent bibliography for further reading. The volume is valuable, timely and can be highly recommended for researchers, microbiologists, molecular biologists, epidemiologists, clinicians, vaccine manufacturers and students, who are involved and/ or interested in any topic involving pathogenic Neisseria species." from Magnus Unemo (Orebro, Sweden) writing in Expert Rev. Anti Infect. Ther. (2010) 8: 871–875. read more ...
 | Edited by: Caroline Genco and Lee Wetzler "excellent, comprehensive ... valuable and timely ... highly recommended" (Expert Rev. Anti Infect. Ther.)ISBN: 978-1-904455-51-6 Publisher: Caister Academic Press Publication Date: January 2010 Cover: hardback |
Serogroup B Meningococcus Vaccine
The First Vaccine Obtained Through Reverse Vaccinology: The Serogroup B Meningococcus Vaccine
from Jeannette Adu-Bobie, Beatrice Aricò, Marzia M. Giuliani and Davide Serruto writing in Vaccine Design: Innovative Approaches and Novel Strategies
Neisseria meningitidis was isolated over one hundred years when Anton Weicshelbaum identified the causative agent of cerebrospinal meningitis. Since its isolation in 1887, N. meningitidis has been recognized to cause endemic cases, case clusters, epidemics and pandemics of meningitis and devastating septicaemia. Despite over one century since its discovery, scientists have yet to identify a universal vaccine for this deadly bacterium. Although vaccines exist for several serogroups of pathogenic N. meningitidis, serotype B (MenB) has eluded scientists for decades, until the advent of genomics. The genome era has completely changed the way to design vaccines. The availability of the complete genome of microorganisms combined with a novel advanced technology has introduced a new prospective in vaccine research. This novel approach is now known as "Reverse Vaccinology" and N. meningitidis can be considered the first successful example of its application. A recent review describes the successful story of the development of the serogroup B vaccine, starting from the analysis of genome and finishing with the results obtained in clinical trials.
Further reading: Vaccine Design: Innovative Approaches and Novel Strategies | Neisseria: Molecular Mechanisms of Pathogenesis
from Jeannette Adu-Bobie, Beatrice Aricò, Marzia M. Giuliani and Davide Serruto writing in Vaccine Design: Innovative Approaches and Novel Strategies
Neisseria meningitidis was isolated over one hundred years when Anton Weicshelbaum identified the causative agent of cerebrospinal meningitis. Since its isolation in 1887, N. meningitidis has been recognized to cause endemic cases, case clusters, epidemics and pandemics of meningitis and devastating septicaemia. Despite over one century since its discovery, scientists have yet to identify a universal vaccine for this deadly bacterium. Although vaccines exist for several serogroups of pathogenic N. meningitidis, serotype B (MenB) has eluded scientists for decades, until the advent of genomics. The genome era has completely changed the way to design vaccines. The availability of the complete genome of microorganisms combined with a novel advanced technology has introduced a new prospective in vaccine research. This novel approach is now known as "Reverse Vaccinology" and N. meningitidis can be considered the first successful example of its application. A recent review describes the successful story of the development of the serogroup B vaccine, starting from the analysis of genome and finishing with the results obtained in clinical trials.
Further reading: Vaccine Design: Innovative Approaches and Novel Strategies | Neisseria: Molecular Mechanisms of Pathogenesis
Neisseria Book Review
Category: Bacteria | Book Review
I am pleased to provide the following excerpt from a book review of Neisseria: Molecular Mechanisms of Pathogenesis:
"focuses effectively on (the) molecular approach to neisserial pathogenicity ... authoritative reviews of gene regulation, anaerobic survival, genome plasticity, epidemiology, vaccine development and the development of antibiotic resistance ... well-referenced" from Jeff Cole (University of Birmingham, UK) writing in Microbiology Today read more ...
"focuses effectively on (the) molecular approach to neisserial pathogenicity ... authoritative reviews of gene regulation, anaerobic survival, genome plasticity, epidemiology, vaccine development and the development of antibiotic resistance ... well-referenced" from Jeff Cole (University of Birmingham, UK) writing in Microbiology Today read more ...
| Edited by: Caroline Genco and Lee Wetzler "authoritative reviews" (Microbiology Today)ISBN: 978-1-904455-51-6 Publisher: Caister Academic Press Publication Date: January 2010 Cover: hardback |
Neisseria Book Review
I am pleased to provide the following excerpt from a book review of Neisseria: Molecular Mechanisms of Pathogenesis:
"written by outstanding and internationally highly recognized experts in the Neisseria research field ... The chapters are of the highest scientific quality including links to central primary publications on the different topics ... an excellent monography for the specialist" from Arzneimittelforschung/Drug Research (2010) 60: 226-227 read more ...
"written by outstanding and internationally highly recognized experts in the Neisseria research field ... The chapters are of the highest scientific quality including links to central primary publications on the different topics ... an excellent monography for the specialist" from Arzneimittelforschung/Drug Research (2010) 60: 226-227 read more ...
| Edited by: Caroline Genco and Lee Wetzler "a comprehensive update" (Society for Microbial Ecology and Disease)ISBN: 978-1-904455-51-6 Publisher: Caister Academic Press Publication Date: January 2010 Cover: Hardback |
Antibiotic Resistance in Neisseria
Category: Antibiotic Resistance
from William M. Shafer, Jason P. Folster and Robert A. Nicholas in Neisseria: Molecular Mechanisms of Pathogenesis
Diseases caused by the pathogenic Neisseria (N. gonorrhoeae and N. meningitidis) have been successfully treated with antibiotics for the past 70 years. However, a disturbing trend worldwide is the increasing prevalence of strains with resistance to inexpensive and widely available antibiotics (e.g., penicillin, tetracycline and ciprofloxacin) and the emergence of strains exhibiting decreased susceptibility to effective antibiotics that are expensive and not always available (e.g. third-generation cephalosporins and the newer macrolides).
A recent publication reports that the global problem of antibiotic resistance will continue (and worsen) in the foreseeable future. By understanding the mechanisms of antibiotic resistance in gonococci and meningococci, resistance to antibiotics currently in clinical practice can be anticipated and the design of novel antimicrobials to circumvent this problem can be undertaken more rationally. The authors review the genetic and physiologic basis by which the pathogenic Neisseria developed resistance to historically important antibiotics and how resistance to newer antibiotics is emerging.
Neisseria: Molecular Mechanisms of Pathogenesis
Diseases caused by the pathogenic Neisseria (N. gonorrhoeae and N. meningitidis) have been successfully treated with antibiotics for the past 70 years. However, a disturbing trend worldwide is the increasing prevalence of strains with resistance to inexpensive and widely available antibiotics (e.g., penicillin, tetracycline and ciprofloxacin) and the emergence of strains exhibiting decreased susceptibility to effective antibiotics that are expensive and not always available (e.g. third-generation cephalosporins and the newer macrolides).
A recent publication reports that the global problem of antibiotic resistance will continue (and worsen) in the foreseeable future. By understanding the mechanisms of antibiotic resistance in gonococci and meningococci, resistance to antibiotics currently in clinical practice can be anticipated and the design of novel antimicrobials to circumvent this problem can be undertaken more rationally. The authors review the genetic and physiologic basis by which the pathogenic Neisseria developed resistance to historically important antibiotics and how resistance to newer antibiotics is emerging.
Neisseria: Molecular Mechanisms of Pathogenesis