Replication of all positive-stranded RNA viruses investigated so far occurs in close association with virus-induced intracellular membrane structures. Dengue virus (DENV), as a member of the family Flaviviridae, also induces such extensive rearrangements of intracellular membranes, called replication complex (RC). These RCs seem to contain viral proteins, viral RNA and host cell factors. However, the biogenesis of the RC and the three-dimensional organisation is to the most part unclear.

from Sven Miller, Ines Romero-Brey, and Ralf Bartenschlager in Frontiers in Dengue Virus Research

Further reading: Dengue Virus

Labels: dengue, dengue fever, dengue virus, Flaviviridae