Diplomonads are a group of mitochondrion-lacking, binucleated flagellates found in anaerobic or micro-aerophilic environments. Most research on diplomonads has focused on Giardia, which is a major cause of water-borne enteric disease in humans and other animals. The first diplomonad to have its genome sequenced was a Giardia isolate (WB) and the 11.7 million basepair genome is compact in structure and content with simplified basic cellular machineries and metabolism. Currently the genomes of several other Giardia isolates and diplomonads (the fish pathogens Spironucleus vortens and S. salmonicida) are being sequenced.
from Anaerobic Parasitic Protozoa: Genomics and Molecular Biology
Further reading:Labels: Binucleated flagellates, Diplomonads, Giardia, Giardia lamblia, Spironucleus, Spironucleus salmonicida, Spironucleus vortens, Water-borne enteric disease
In a forthcoming book on
anaerobic protozoa, internationally acclaimed researchers critically review the most important aspects of research on anaerobic parasitic protozoa, providing the first coherent picture of their genomics and molecular biology since the publication of the genomes.
Chapters are written from a molecular and genomic perspective and contain speculative models upon which future research efforts can be based. Topics include: the genomes of
Entamoeba histolytica,
Trichomonas vaginalis,
Giardia and other diplomonads; the cytoskeletons of
Entamoeba histolytica,
Giardia lamblia and
Trichomonas vaginalis; genomic analyses and manipulation of gene expression in
Entamoeba histolytica; nuclear and chromosomal structure and replication in
Giardia; and the mitochondrion-like organelles of a fourth anaerobe,
Blastocystis.
from Anaerobic Parasitic Protozoa: Genomics and Molecular BiologyFurther reading:Labels: Blastocystis, Diplomonads, Entamoeba histolytica, Giardia, Giardia lamblia, Mitochondrion-like organelles, Trichomonas vaginalis
Anaerobic parasitic protozoa cause medically and economically important diseases such as dysentery, sexually transmitted infections, and gastroenteritis that affect millions of people worldwide annually. Recently the genomes of the three key anaerobic protozoa,
Trichomonas,
Giardia and
Entamoeba, have been determined. The availability of these genomic data and the use of post-genomic analyses have provided fascinating new insights into the biology of these important parasites. They will be important for the design of novel anti-protozoan drugs and the development of effective vaccines.
from Anaerobic Parasitic Protozoa: Genomics and Molecular BiologyFurther reading:Labels: Anaerobic protozoa, Anti-protozoan drugs, Dysentery, Entamoeba, Gastroenteritis, Giardia, Parasitic protozoa, Trichomonas
Anaerobic parasitic protozoa cause medically and economically important diseases such as dysentery, sexually transmitted infections, and gastroenteritis that affect millions of people worldwide annually. Recently the genomes of the three key anaerobic protozoa, Trichomonas, Giardia and Entamoeba, have been determined. The availability of these genomic data and the use of post-genomic analyses have provided fascinating new insights into the biology of these important parasites. They will be important for the design of novel anti-protozoan drugs and the development of effective vaccines.
A new book on
Anaerobic Parasitic Protozoa critically reviews the most important aspects of research on anaerobic parasitic protozoa, providing the first coherent picture of their genomics and molecular biology since the publication of the genomes. Chapters are written from a molecular and genomic perspective and contain speculative models upon which future research efforts can be based. Topics include: the genomes of
Entamoeba histolytica,
Trichomonas vaginalis,
Giardia and other diplomonads; the cytoskeletons of
Entamoeba histolytica,
Giardia lamblia and
Trichomonas vaginalis; genomic analyses and manipulation of gene expression in
Entamoeba histolytica; nuclear and chromosomal structure and replication in
Giardia; and the mitochondrion-like organelles of a fourth anaerobe,
Blastocystis. Recommended text for all parasitology laboratories.
Further reading:
Anaerobic Parasitic ProtozoaLabels: Blastocystis, Entamoeba, Giardia, new book, parasites, parasitic infections, parasitology, parasitology books, Trichomonas