Retroviruses comprise a diverse family of enveloped RNA viruses, remarkable for their use of reverse transcription of viral RNA into linear double stranded DNA during replication and the subsequent integration of this DNA into the genome of the host cell. Members of this family include important pathogens such as HIV-1, feline leukemia, and several cancer-causing viruses.

Research into retroviruses led to the discovery of oncogenes, a major advance in the field of cancer genetics. Studies of retroviruses have contributed greatly to our understanding of mechanisms that regulate eukaryotic gene expression.

Retroviruses are proving to be valuable research tools in molecular biology and have been used successfully in gene therapy (e.g. to treat X-linked severe combined immunodeficiency).

Further reading: Retroviruses: Molecular Biology, Genomics and Pathogenesis

Labels: Lentiviral, lentivirus, lentiviruses, Retroviral, Retrovirus, retroviruses

September 21 - 23, 2009 Frontiers of Retrovirology: complex retroviruses, retroelements and their hosts
Montpellier, France Further information
This conference will bring together leading human retrovirus researchers to review current progress and to chart future challenges. Internationally renowned speakers will present their insights into the principles guiding the life cycle of endogenous retroelements, complex human retroviruses, and their pathogenic interactions with the hosts. Cutting edge presentations will be delivered by internationally renowned researchers. Short oral platform presentations and posters will be selected from registrants. A limited number of scholarships will be available.
Suggested reading: Virology Books

Labels: retroelements, retrovirology, retroviruses