Caister Academic Press

Cytomegaloviruses: From Molecular Pathogenesis to Intervention | Book

"intended for a wide audience" Ref. Res. Book News
Publisher: Caister Academic Press
Edited by: Matthias J. Reddehase
Institute for Virology, University Medical Center of the Johannes Gutenberg-University, 55131 Mainz, Germany
Pages: 1046
Publication date: April 2013Buy book
ISBN: 978-1-908230-18-8
Price: GB £300 or US $600
Publication date: October 2013Buy ebook
ISBN: 978-1-908230-83-6
Price: GB £300 or US $600

Human Cytomegalovirus (CMV), a member of the herpesvirus family, is an under-rated health risk. Low public awareness results from the relatively mild symptoms it causes in otherwise healthy people whose immune system is intact, with primary infection thus usually going unnoticed. During pregnancy, however, transmission from the mother to the fetus is currently the most frequent viral cause of birth defects with life-long neurological sequelae, sensorineural hearing loss in particular. People at risk also include the growing number of immunocompromised patients requiring either a solid organ graft or receiving a hematopoietic cell graft for the treatment of hematopoietic malignancies that are refractory to standard therapies. Under the condition of weakened immune surveillance in these patients, latent CMV hidden in transplanted donor cells or in the recipients' own tissues can awake to cause a destructive infection resulting in graft loss and multiple end-organ disease, of which viral pneumonia is the most feared.

This two-volume work, is an updated and upgraded 2nd-edition of 'Cytomegaloviruses: Molecular Biology and Immunology' (2006). The title 'Cytomegaloviruses: From Molecular Pathogenesis to Intervention' reflects its expanded commitment not only to cover cutting-edge basic science but also to include the translation of this to clinical science. In an interdisciplinary approach to understanding CMV disease and outlining options for prevention and treatment, leading international experts provide comprehensive and authoritative reviews on literally every aspect of current research with an unprecedented completeness, integrating research on human CMV and insights gained from experimental animal models. With contributions from over 100 authors, the topics covered in the 46 chapters range from the most contemporary systems biology 'omics' views on virus-host interaction to considerations of the health and economic impact of CMV disease for evaluating the hoped-for benefit from a vaccine. Volume I focuses on basic science laying the foundations of clinical research, starting with the comparative genomics of primate CMVs and ending with the emerging field of humanized mouse models. Volume II is more clinically-oriented, covering the immune response to CMV, the most pressing medical problems in the newborn and in transplantation patients, as well as diagnostics, the management of antiviral drug resistance, the state and future of a CMV vaccine, and the potential of using CMV as a vaccine vector to fight unrelated diseases. The book closes with a critical survey of disputed associations between CMV and atherosclerotic cardiovascular disease, certain tumors such as Glioblastoma Multiforme, and the phenomenon of 'immune senescence' in the elderly.

The book is liberally illustrated with more than 200 figures, most of which are in full colour. There are over 60 tables and several thousand references which enhance the book even further making it an invaluable source of information. Essential reading for all virologists with an interest in cytomegaloviruses, for all clinicians in pediatric intensive-care medicine and at transplantation centers, for scientists working on antiviral drug and vaccine development, as well as for public health service and science funding system authorities.


"intended for a wide audience of virologists, clinicians in intensive care medicine and transplantation centres, researchers involved with antiviral drug and vaccine development, and public health and science funding authorities" from Ref. Res. Book News (June 2013).

Chapter I.1
Comparative Genomics of Primate Cytomegaloviruses
Andrew J. Davison, Mary Holton, Aidan Dolan, Derrick J. Dargan, Derek Gatherer and Gary S. Hayward
Chapter I.2
Molecular Evolution of Murine Cytomegalovirus Genomes
Alec J. Redwood, Geoffrey R. Shellam and Lee M. Smith
Chapter I.3
Manipulating CMV Genomes by BAC Mutagenesis: Strategies and Applications
Zsolt Ruzsics, Eva M. Borst, Jens B. Bosse, Wolfram Brune and Martin Messerle
Chapter I.4
Human Cytomegalovirus Metabolomics
Joshua D. Rabinowitz and Thomas Shenk
Chapter I.5
Cytomegalovirus-encoded miRNAs
Meaghan H. Hancock, Igor Landais, Lauren M. Hook, Finn Grey, Rebecca Tirabassi and Jay A. Nelson
Chapter I.6
Cytomegalovirus Proteomics
Patrizia Caposio, Daniel N. Streblow and Jay A. Nelson
Chapter I.7
A Systems Pathway View of Cytomegalovirus Infection
Peter Ghazal, Alexander Mazein, Steven Watterson, Ana Angulo and Kai A. Kropp
Chapter I.8
Virus Entry and Activation of Innate Defense
Adam L. Feire and Teresa Compton
Chapter I.9
Pre-immediate Early Tegument Protein Functions
Robert F. Kalejta
Chapter I.10
Major Immediate-Early Enhancer and Its Gene Products
Jeffery L. Meier and Mark F. Stinski
Chapter I.11
Multifaceted Regulation of Human Cytomegalovirus Gene Expression
Marco Thomas, Nina Reuter and Thomas Stamminger
Chapter I.12
Intracellular Sorting and Trafficking of Cytomegalovirus Proteins during Permissive Infection
Anamaris M. Colberg-Poley and Chad D. Williamson
Chapter I.13
Morphogenesis of the Cytomegalovirus Virion and Subviral Particles
Wade Gibson and Elke Bogner
Chapter I.14
Exploitation of Host Cell Cycle Regulatory Pathways by HCMV
Deborah H. Spector
Chapter I.15
Cell Death Pathways Controlled by Cytomegaloviruses
A. Louise McCormick and Edward S. Mocarski
Chapter I.16
Cytomegaloviruses and Interferons
Mirko Trilling and Hartmut Hengel
Chapter I.17
Cytomegalovirus Inter-Strain Variance in Cell-Type Tropism
Barbara Adler and Christian Sinzger
Chapter I.18
Molecular Basis of Cytomegalovirus Host Species Specificity
Wolfram Brune
Chapter I.19
Epigenetic Regulation of Human Cytomegalovirus Gene Expression: Impact on Latency and Reactivation
Matthew Reeves and John Sinclair
Chapter I.20
Transcription Associated with Human Cytomegalovirus Latency
Barry Slobedman, Selmir Avdic and Allison Abendroth
Chapter I.21
Myeloid Cell Recruitment and Function in Cytomegalovirus Dissemination and Immunity
Lisa P. Daley-Bauer and Edward S. Mocarski
Chapter I.22
Immune Surveillance of Cytomegalovirus Latency and Reactivation in Murine Models: Link to 'Memory Inflation'
Christof K. Seckert, Marion Grieβl, Julia K. Büttner, Kirsten Freitag and Niels A.W. Lemmermann and Mary A. Hummel, Xue-Feng Liu and Michael I. Abecassis and Ana Angulo and Martin Messerle and Charles H. Cook and Matthias J. Reddehase
Chapter I.23
Humanized Mouse Models of Cytomegalovirus Pathogenesis and Latency
M. Shane Smith, Daniel N. Streblow, Patrizia Caposio, and Jay A. Nelson

Chapter Abstracts: Volume I     Volume II

Volume II

Chapter II.1
Synopsis of Clinical Aspects of Human Cytomegalovirus Disease
Suresh B. Boppana and William J. Britt
Chapter II.2
The Epidemiology and Public Health Impact of Congenital Cytomegalovirus Infection
Michael J. Cannon, Scott D. Grosse and Karen B. Fowler
Chapter II.2- Addendum
The Economic Impact of Congenital CMV Infection: Methods and Estimates
Scott D. Grosse, Ismael R. Ortega-Sanchez, Stephanie R. Bialek and Sheila C. Dollard
Chapter II.3
Clinical Cytomegalovirus Research: Congenital Infection
Stuart P. Adler and Giovanni Nigro
Chapter II.4
Cytomegalovirus Replication in the Developing Human Placenta
Lenore Pereira, Takako Tabata, Matthew Petitt and June Fang-Hoover
Chapter II.5
The Guinea Pig Model of Congenital Cytomegalovirus Infection
Alistair McGregor, Michael A. McVoy and Mark R. Schleiss
Chapter II.6
Murine Model of Neonatal Cytomegalovirus Infection
William J. Britt, Djurdjica Cekinović and Stipan Jonjić
Chapter II.7
Adaptive Cellular Immunity to Human Cytomegalovirus
Mark R. Wills, Gavin M. Mason and J. G. Patrick Sissons
Chapter II.8
Natural Killer Cells and Human Cytomegalovirus
Gavin W. G. Wilkinson, Rebecca J. Aicheler and Eddie C. Y. Wang
Chapter II.9
Innate Immunity to Cytomegalovirus in the Murine Model
Silvia Vidal, Astrid Krmpotić, Michal Pyzik and Stipan Jonjić
Chapter II.10
Protective Humoral Immunity
Michael Mach, Anna-Katharina Wiegers, Nadja Spindler and Thomas Winkler
Chapter II.11
Immunoregulatory Cytokine Networks Discovered and Characterized during Murine Cytomegalovirus Infections
Marc Dalod and Christine A. Biron
Chapter II.12
Host Genetic Models in Cytomegalovirus Immunology
Chris A. Benedict, Karine Crozat, Mariapia Degli-Esposti and Marc Dalod
Chapter II.13
Clinical Cytomegalovirus Research: Thoracic Organ Transplantation
Robin K. Avery
Chapter II.14
Clinical Cytomegalovirus Research: Liver and Kidney Transplantation
Vincent C. Emery, Richard S.B. Milne and Paul D. Griffiths
Chapter II.15
The Rat Model of Cytomegalovirus Infection and Vascular Disease
Sebastian Voigt, Jakob Ettinger and Daniel N. Streblow
Chapter II.16
Clinical Cytomegalovirus Research: Hematopoietic Cell Transplantation
Sachiko Seo and Michael Boeckh
Chapter II.17
Murine Model for Cytoimmunotherapy of CMV Disease after Hematopoietic Cell Transplantation
Rafaela Holtappels, Stefan Ebert, Jürgen Podlech, Annette Fink, Verena Böhm, Niels A.W. Lemmermann, Kirsten Freitag, Angélique Renzaho, Doris Thomas and Matthias J. Reddehase
Chapter II.18
State of the Art and Trends in Cytomegalovirus Diagnostics
Maria Grazia Revello and Giuseppe Gerna
Chapter II.19
Antiviral Therapy, Drug Resistance, and Computed Resistance Profiling
Detlef Michel, Meike Chevillotte and Thomas Mertens
Chapter II.20
Cytomegalovirus Vaccine: On the Way to the Future?
Stanley A. Plotkin and Bodo Plachter
Chapter II.21
Vaccine Vectors Using the Unique Biology and Immunology of Cytomegalovirus
Michael A. Jarvis, Scott G. Hansen, Jay A. Nelson, Louis J. Picker and Klaus Früh
Chapter II.22
Non-Human-Primate Models of Cytomegalovirus Infection, Prevention, and Therapy
Klaus Früh, Daniel Malouli, Kristie L. Oxford and Peter A. Barry
Chapter II.23
Putative Disease Associations with Cytomegalovirus: a Critical Survey
Ann B. Hill
Résumé and Visions: From CMV Today to CMV Tomorrow
Ulrich H. Koszinowski

How to buy this book

(EAN: 9781908230188 9781908230836 Subjects: [microbiology] [virology] [medical microbiology] [genomics] )