See also:
Animal Viruses: Molecular Biology Coronaviruses Influenza Virology Alpha Herpesviruses Double-stranded RNA Viruses
Foot-and-Mouth Disease Virus
from Animal Viruses: Molecular Biology
Encarnacion Martinez-Salas, Margarita Saiz and Francisco Sobrino
Foot-and-mouth disease virus (FMDV) is the prototypic member of the Aphthovirus genus in the Picornaviridae family. This picornavirus is the etiological agent of an acute systemic vesicular disease that affects cattle worldwide. Here we have addressed several aspects dealing with the molecular biology of this highly variable and transmissible virus that are relevant to understand the viral infectious cycle. Particular emphasis has been given to the peculiarities of its genome organization, as well as its control of gene expression. Soon after infection, the single stranded positive RNA that constitutes the viral genome is efficiently translated using a cap-independent mechanism driven by the internal ribosome entry site element (IRES). This process occurs concomitantly with the inhibition of cellular protein synthesis, caused by the expression of viral proteases. Processing of the viral polyprotein is achieved cotranslationally by viral encoded proteases, giving rise to the different mature viral proteins. Viral RNA as well as viral proteins interact with different components of the host cell, acting as key determinants of viral pathogenesis. In depth knowledge of the molecular basis of the viral cycle is needed to control viral pathogenesis and disease spreading.
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Edited by: Thomas C. Mettenleiter and Francisco Sobrino
Published: 2008
ISBN: 978-1-904455-22-6
Price: GB £150 or US $300
An international panel of leading virologists provide a state-of-the-art overview of the field, comprehensively detailing the current understanding of viruses, their replication, evolution and interaction with the host. read more ...
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Edited by: John T. Patton
Published: 2008
ISBN: 978-1-904455-21-9
Price: GB £150 or US $300
This timely book brings together all of the key recent research on this disparate group of viruses, providing for the first time a single resource reviewing dsRNA viral structure and molecular biology. Written by well respected and experienced virologists, topics include: the structures of orthoreoviruses, rotavirus, phytoreoviruses, and bluetongue virus, entry into the bacterial cell, crystal structure of reovirus polymerase λ3, assembly of the reovirus genome, genomic RNA packaging and replication in the Cystoviridae, and much more. Essential reading for all dsRNA virologists and all other virologists with an interest in molecular and structural biology. read more ...
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Edited by: Volker Thiel
Published: 2007
ISBN: 978-1-904455-16-5
Price: GB £150 or US $300
In this timely book, internationally renowned experts review literally every aspect of cutting edge coronavirus research providing the first coherent picture of the molecular and cellular biology since the outbreak of SARS in 2003. The book is divided into two sections: Part I focuses on the molecular biology of the virus itself and includes topics such as coronavirus binding and entry, replicase gene function, cis-acting RNA elements, coronavirus discontinuous transcription, reverse genetics, genome packaging and molecular evolution. In Part II of the book, the focus is on molecular and cellular pathogenesis and infection control. read more ...
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Featured book: Animal Viruses: Molecular Biology
Edited by: Thomas C. Mettenleiter and Francisco Sobrino
An international panel of leading virologists provide a state-of-the-art overview of the field, comprehensively detailing the current understanding of viruses, their replication, evolution and interaction with the host. The authors emphasize strategic and methodological aspects of current research, and provide key related references. Topics include foot-and-mouth disease virus, Pestivirus, Arteriviridae, Coronaviruses (including SARS), Herpesviridae, Paramyxoviridae, influenza viruses, Reoviridae, porcine circoviruses, Asfarviridae and much more.
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