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Genomics Books

Our high level genomics books bring together expert international authors under the skilled editorship of leading scientists to produce state-of-the-art compendiums of current research. Aimed at the research scientist, graduate student, medical reseacher and other professionals, these books are highly recommended for all genomics laboratories. Every genomics, microbiology and bioscience library should have a copy of each of the following books.
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Epigenetics: Current Research and Emerging Trends
Edited by: Brian P. Chadwick
Published: 2015
Hardback: ISBN 978-1-910190-07-4 £159, $319. Ebook: ISBN 978-1-910190-08-1 £159, $319
The editor of this book has gathered together pioneers in the field of epigenetics to produce a volume of thought-provoking discussions on classic aspects of epigenetics and on the newer, emerging areas. The 17 chapters include topics on the impact of metabolism on the epigenome, how our actions may impact the health of our offspring several generations removed, and how exposure to environmental toxicants can have long-lasting effects on our epigenome with devastating consequences. This up-to-date volume is a major resource essential for those working in the field and is recommended reading for anyone new to this fascinating and fast-moving area of research. read more ...
Corynebacterium glutamicum: From Systems Biology to Biotechnological Applications
Edited by: Andreas Burkovski
Published: 2015
Hardback: ISBN 978-1-910190-05-0 £159, $319. Ebook: ISBN 978-1-910190-06-7 £159, $319
This book provides a comprehensive overview of current knowledge and research on C. glutamicum systems biology and biotechnological applications. Written by a team of prominent scientists under the expert editorship of Andreas Burkovski, the topics covered include: proteomics; flux analysis technology for metabolic analysis; metabolic engineering for alternative carbon source utilization; manipulation of nitrogen metabolism; transport, degradation and assimilation of aromatic compounds and their regulation; engineering for production of organic acids and alcohols; microbial factory for the production of polyesters; biotechnological application under oxygen deprivation; the secretory production of heterologous proteins; genetically-encoded biosensors. Packed with practical information and state-of-the-art science this concise volume is an essential handbook for everyone working with Corynebacterium and related organisms in academia, biotechnology companies, and the pharmaceutical industry and is a recommended volume for all microbiology libraries. read more ...
Antifungals: From Genomics to Resistance and the Development of Novel Agents
Edited by: Alix T. Coste and Patrick Vandeputte
Published: 2015
Hardback: ISBN 978-1-910190-01-2 £159, $319. Ebook: ISBN 978-1-910190-02-9 £159, $319
In this book a panel of high-profile authors provides an overview of current antifungal research. Chapters are written from a molecular and genomic perspective and contain speculative models upon which to base future research efforts. Topics include: the molecular mechanisms responsible for antifungal resistance to the classical molecules, azoles, polyenes, and echinocandins; fungal biofilms; fungal-specific biological pathways that constitute potential new targets; strategy to potentiate existing antifungal agents; Impact of high throughput screenings of chemical compound collections; modulating the host response; antifungal vaccines; and animals models. This volume is an essential reference for everyone with an interest in fungal pathogenesis. A recommended book for all biology and medical libraries. read more ...
Bacteria-Plant Interactions: Advanced Research and Future Trends
Edited by: Jesús Murillo, Robert W. Jackson, Boris A. Vinatzer and Dawn L. Arnold
Published: 2015
Hardback: ISBN 978-1-908230-58-4 £159, $319. Ebook: ISBN 978-1-910190-00-5 £159, $319
In this book a team of respected scientists review the most important current topics to provide a timely overview. The topics covered include: type III secretion systems and their role in the bacterial-host interaction; the Pseudomonas and Erwinia model systems and their application to other studies; the emerging plant pathogen Acidovorax; the Gram-positive phytopathogens Clavibacter, Streptomyces, and Rhodococcus; colonisation of plants by human bacterial pathogens; Pseudomonas biocontrol approaches; and phage therapy. Essential reading for every plant pathogen researcher, from the PhD student to the experienced scientist, and recommended reading for researchers working on foodborne pathogens and bacterial pathogenesis. read more ...
Metagenomics of the Microbial Nitrogen Cycle: Theory, Methods and Applications
Edited by: Diana Marco
Published: 2014
Hardback: ISBN 978-1-908230-48-5 £159, $319. Ebook: ISBN 978-1-908230-60-7 £159, $319
Written by renowned researchers specialised in the most relevant and emerging topics in the field, this book provides comprehensive information on the new theoretical, methodological and applied aspects of metagenomics and other 'omics' approaches used to study the microbial N cycle. Recommended for microbiologists, environmental scientists and anyone interested in microbial communities, metagenomics, metatranscriptomics and metaproteomics of the microbial N cycle. This volume provides a thorough account of the contributions of metagenomics to microbial N cycle background theory, reviews state-of-the-art investigative methods and explores new applications in water treatment, agricultural practices and climate change, among others. read more ...
Pathogenic Neisseria: Genomics, Molecular Biology and Disease Intervention
Edited by: John K. Davies and Charlene M. Kahler
Published: 2014
Hardback: ISBN 978-1-908230-47-8 £159, $319. Ebook: ISBN 978-1-908230-61-4 £159, $319
The human pathogens, Neisseria meningitidis and Neisseria gonorrhoeae are exquisitely adapted to life within the human mucosa, their only natural niche. N. meningitidis is the causative agent of rapidly transmissible meningitis and septic shock. Vaccines developed to control this pathogen can be rendered ineffective by the pathogen's ability to undergo antigenic variation. In contrast, there are no current vaccination prospects for N. gonorrhoeae, the causative agent of sexually transmitted gonorrhoea. Historically infections caused by N. gonorrhoeae were treated with antibiotics. However the recent advent of new strains with resistance to all known antibiotics is causing such treatment regimes to fail, necessitating the need for new and more effective control strategies. In this book leading Neisseria authorities review the most important research on pathogenic Neisseria to provide a timely overview of the field. Topics covered include: the link between pathogenesis and important metabolic pathways; vaccine development; antibiotic resistance; transcriptomics of regulatory networks; regulatory small RNAs; interactions with neutrophils; and advances in humanized mouse models. An essential guide for research scientists, advanced students, clinicians and other professionals working with Neisseria, this book is a recommended text for all microbiology libraries. read more ...
Proteomics: Targeted Technology, Innovations and Applications
Edited by: Manuel Fuentes and Joshua LaBaer
Published: 2014
Hardback: ISBN 978-1-908230-46-1 £159, $319. Ebook: ISBN 978-1-908230-62-1 £159, $319
In this book a panel of high-profile authors provides an overview of targeted proteomics in biomedical science. The book is focused on current, state-of-the-art technology and applications and is a valuable source of information for everyone working in this field. The first part of the book provides detailed examples of the application of targeted proteomics in biomarker discovery and pathogenesis. The second part is focused on the various tools used in targeted proteomics including bioinformatics approaches while the final section is dedicated to biobanks, a vital aspect of targeted proteomics. This volume is highly recommended for anyone interested in proteomics, disease pathogenesis, clinical protein science and biomarker discovery. read more ...
Biofuels: From Microbes to Molecules
Edited by: Xuefeng Lu
Published: 2014
Hardback: ISBN 978-1-908230-45-4 £159, $319. Ebook: ISBN 978-1-908230-63-8 £159, $319
In this book a panel of international experts reviews the most important hot-topics in this area to provide a timely overview. The production of different biofuel molecules including hydrogen, methane, ethanol, butanol, higher chain alcohols, isoprenoids and fatty acid derivatives, from genetically engineered microbes, is comprehensively covered. Special focus is given to the use of metabolic engineering of microbes, including bacteria, yeast and microalgae, to enhance biofuel production. In addition authors discuss current research progress, technical challenges and future development trends for biofuel production. Essential reading for research scientists, graduate students, and other specialists interested in microbial biofuels, the book is also recommended reading for environmental microbiologists, chemists and engineers. read more ...
Human Pathogenic Fungi: Molecular Biology and Pathogenic Mechanisms
Edited by: Derek J. Sullivan and Gary P. Moran
Published: 2014
Hardback: ISBN 978-1-908230-44-7 £180, $360. Ebook: ISBN 978-1-908230-66-9 £180, $360
In this book a panel of high profile authors critically reviews the most important research to provide a timely overview. The extensive reference sections in each chapter positively encourage readers to pursue the subject in greater detail. The book is divided into two sections: The first six chapters review the transformative effect of applying state-of-the-art tools and innovative approaches to research, particularly in the area of comparative biology. The second section consists of eight chapters, each dedicated to the molecular and cellular biology of a major fungal pathogen of humans: Candida, Aspergillus, Cryptococcus, dermatophytes, Histoplasma, Blastomyces, Pneumocystis and Paracoccidoides. These chapters provide a timely snapshot of the current state of research. This volume is an essential reference for students, researchers and clinicians with an interest in fungal pathogenesis. read more ...
Applied RNAi: From Fundamental Research to Therapeutic Applications
Edited by: Patrick Arbuthnot and Marc S. Weinberg
Published: 2014
Hardback: ISBN 978-1-908230-43-0 £159, $319. Ebook: ISBN 978-1-908230-67-6 £159, $319
In this book an international panel of RNAi experts critically reviews the most interesting advances in basic applied RNAi research, highlighting the applications in RNAi-based therapies and discussing the technical hurdles that remain. Topics covering the fundamental biological aspects of applied RNAi research include: the role of miRNAs in trinucleotide repeat disorders; miRNAs and HIV pathogenesis; miRNAs for epigenetic gene silencing; the role of miRNAs in virus-related cancers; non-canonical miRNA biogenesis. In the area of RNAi-based therapy, topics include: harnessing RNAi for the treatment of viral infections; optimising the design of exogenous RNAi activators; blocking miRNA function with synthetic agents; somatic cell reprogramming; high-content miRNA-based screening tools and the use of miRNA target sites for control of transgene expression. Essential reading for everyone involved in RNAi research, drug discovery and delivery, biomedical engineering and biomaterials. read more ...
Pathogenic Escherichia coli: Molecular and Cellular Microbiology
Edited by: Stefano Morabito
Published: 2014
Hardback: ISBN 978-1-908230-37-9 £159, $319. Ebook: ISBN 978-1-908230-99-7 £159, $319
This book reviews the most important recent findings of the studies on pathogenic E. coli providing a timely overview of the field. Topics covered include: epidemiology of the disease in humans and animals and the biological mechanisms that shaped the pathogenic types of E. coli; shiga toxins; subtilase cytotoxin; cell cycle modulating toxins; the heat stable and heat labile enterotoxins; haemolysins; structural, molecular and functional characteristics of A/E lesions; colonization factor antigens of ETEC; enteroaggregative adhesion; host cell invasion; and the development of vaccinal strategies to confront the burden of disease. Chapters are written from a molecular and cellular biology standpoint but also include discussions of the findings with a wider perspective including considerations on public health and the impact on animal productions. Essential reading for everyone working on these and related pathogens. read more ...
Burkholderia: From Genomes to Function
Edited by: Tom Coenye and Eshwar Mahenthiralingam
Published: 2014
Hardback: ISBN 978-1-908230-35-5 £159, $319. Ebook: ISBN 978-1-908230-97-3 £159, $319
In this book leading international investigators review key advances in Burkholderia research to provide timely overview. The topics covered include: genomic taxonomy and biodiversity, comparative genomics, molecular epidemiology, transcriptomics, proteomics, molecular pathogenesis of virulence in B. mallei/B. pseudomallei and the Burkholderia cepacia complex, molecular basis of phytopathogenicity and antibiotic resistance, signalling and biofilms, and the genomic biology of Burkholderia phages. The theme underpinning each chapter is the use of DNA/protein sequence data and post-genomic technologies to understand Burkholderia biology. Essential reading for everyone working with these and related bacteria. read more ...
Next-generation Sequencing: Current Technologies and Applications
Edited by: Jianping Xu
Published: 2014
Hardback: ISBN 978-1-908230-33-1 £120, $240. Ebook: ISBN 978-1-908230-95-9 £120, $240
Written by experts from around the world, this book explores the most recent advances in NGS instrumentation and data analysis. The book begins with a comprehensive description of current NGS platforms, their sequencing chemistries, instrument specifications, and general workflows and procedures. A separate chapter is dedicated to low-quantity, single molecule sequencing technology. Further chapters explore the application of NGS technologies in various fields including polymorphism detection, sRNA research, rare variant detection, large variant detection, exome sequencing, plant development studies, microbial metagenomics, and studies on the human microbiome. Practical and cutting-edge, this volume represents an excellent collection of chapters to aid all scientists who wish to apply these innovative research tools. read more ...
Omics in Soil Science
Edited by: Paolo Nannipieri, Giacomo Pietramellara and Giancarlo Renella
Published: 2014
Hardback: ISBN 978-1-908230-32-4 £159, $319. Ebook: ISBN 978-1-908230-94-2 £159, $319
This volume presents the state-of-the-art of omic applications in soil science, a field that is advancing rapidly on many fronts. Distinguished authors describe the application of metagenomics, metatranscriptomics and proteomics to soil science. In particular the book covers the current and emerging omics techniques and the contribution of these approaches to a better assessment of soil functionality. The authors also explore the specific problems encountered in the application of various omics technologies to soil science and the future research requirements necessary to overcome the current limitations in this area. Topics covered include soil functional genomics, soil metagenomics, soil microbial ecology, soil metatranscriptomics, soil proteomics, soil volatilomics and soil proteogenomics. Omics techniques are also discussed in comparison with classical techniques. This book is both a practical guide and a recommended reference volume for all soil scientists. read more ...
Mollicutes: Molecular Biology and Pathogenesis
Edited by: Glenn F. Browning and Christine Citti
Published: 2014
Hardback: ISBN 978-1-908230-30-0 £159, $319. Ebook: ISBN 978-1-908230-93-5 £159, $319
In this book acknowledged experts critically review the most recent advances in the evolution, genetics and molecular pathogenesis of these important pathogens. Topics covered include: taxonomy; genomic mosaics; molecular genetic tools for mollicutes; identification and characterisation of virulence genes in mycoplasmas; post-translational modification of proteins; multifunctional cytoadherence factors; the glycocalyx; glycosidase activity; phase and antigenic variation in mycoplasmas; spiroplasma transmission from insect to plants; cytoskeletons organization; gliding mechanism of the Mycoplasma pneumoniae subgroup; biofilm formation by mycoplasmas; host immune responses to mycoplasmas; and emerging antimicrobial resistance in mycoplasmas of humans and animals. An essential book for researchers working with mollicutes and recommended reading for everyone interested in bacterial genomics, bacterial pathogenesis and the evolution of bacterial virulence. read more ...
Genome Analysis: Current Procedures and Applications
Edited by: Maria S. Poptsova
Published: 2014
Hardback: ISBN 978-1-908230-29-4 £159, $319. Ebook: ISBN 978-1-908230-68-3 £159, $319
In this book, an impressive array of expert authors highlight and review current advances in genome analysis. This volume provides an invaluable, up-to-date and comprehensive overview of the methods currently employed for next-generation sequencing (NGS) data analysis, highlights their problems and limitations, demonstrates the applications and indicates the developing trends in various fields of genome research. The first part of the book is devoted to the methods and applications that arose from, or were significantly advanced by, NGS technologies: the identification of structural variation from DNA-seq data; whole-transcriptome analysis and discovery of small interfering RNAs (siRNAs) from RNA-seq data; motif finding in promoter regions, enhancer prediction and nucleosome sequence code discovery from ChiP-Seq data; identification of methylation patterns in cancer from MeDIP-seq data; transposon identification in NGS data; metagenomics and metatranscriptomics; NGS of viral communities; and causes and consequences of genome instabilities. The second part is devoted to the field of RNA biology with the last three chapters devoted to computational methods of RNA structure prediction including context-free grammar applications. An essential book for everyone involved in sequence data analysis, next-generation sequencing, high-throughput sequencing, RNA structure prediction, bioinformatics and genome analysis. read more ...
Cytomegaloviruses: From Molecular Pathogenesis to Intervention
Edited by: Matthias J. Reddehase
Published: 2013
Hardback: ISBN 978-1-908230-18-8 £300, $600. Ebook: ISBN 978-1-908230-83-6 £300, $600
This two-volume work, is an updated and upgraded 2nd-edition of 'Cytomegaloviruses: Molecular Biology and Immunology' (2006). The title 'Cytomegaloviruses: From Molecular Pathogenesis to Intervention' reflects its expanded commitment not only to cover cutting-edge basic science but also to include the translation of this to clinical science. In an interdisciplinary approach to understanding CMV disease and outlining options for prevention and treatment, leading international experts provide comprehensive and authoritative reviews on literally every aspect of current research with an unprecedented completeness, integrating research on human CMV and insights gained from experimental animal models. With contributions from over 100 authors, the topics covered in the 46 chapters range from the most contemporary systems biology 'omics' views on virus-host interaction to considerations of the health and economic impact of CMV disease for evaluating the hoped-for benefit from a vaccine. Volume I focuses on basic science laying the foundations of clinical research, starting with the comparative genomics of primate CMVs and ending with the emerging field of humanized mouse models. Volume II is more clinically-oriented, covering the immune response to CMV, the most pressing medical problems in the newborn and in transplantation patients, as well as diagnostics, the management of antiviral drug resistance, the state and future of a CMV vaccine, and the potential of using CMV as a vaccine vector to fight unrelated diseases. The book closes with a critical survey of disputed associations between CMV and atherosclerotic cardiovascular disease, certain tumors such as Glioblastoma Multiforme, and the phenomenon of 'immune senescence' in the elderly. The book is liberally illustrated with more than 200 figures, most of which are in full colour. There are over 60 tables and several thousand references which enhance the book even further making it an invaluable source of information. Essential reading for all virologists with an interest in cytomegaloviruses, for all clinicians in pediatric intensive-care medicine and at transplantation centers, for scientists working on antiviral drug and vaccine development, as well as for public health service and science funding system authorities. read more ...
Bacterial Gene Regulation and Transcriptional Networks
Edited by: M. Madan Babu
Published: 2013
Hardback: ISBN 978-1-908230-14-0 £159, $319. Ebook: ISBN 978-1-908230-79-9 £159, $319
Along with the strategic guidance of M. Madan Babu (Cambridge, UK) authors from around the world have joined forces to review and discuss the latest research observations and current theories in this highly topical and important area of microbiology. The first few chapters describe the components required for transcriptional regulation, elucidate their complexity and discuss the genome-scale theories that currently prevail by investigating a large number of completely sequenced microbial genomes. Other chapters discuss how transcriptional regulation and gene circuits can be used by bacteria to sense signals and generate phenotypic variation. The next chapters introduce experimental and computational methods for investigating transcriptional regulatory networks on a genomic scale. Later chapters explore the transcriptional complexity of specific organisms, discuss current understanding of the genome-scale regulatory networks and the importance of key transcription factors. Specific organisms covered include Escherichia coli, Bacillus subtilis, Helicobacter pylori, Mycobacterium tuberculosis, Pseudomonas aeruginosa and Cyanobacteria. This book constitutes a major work on bacterial gene regulation and is a recommended purchase for all institutions and organisations interested in microbiology. read more ...
Neurospora: Genomics and Molecular Biology
Edited by: Durgadas P. Kasbekar and Kevin McCluskey
Published: 2013
Hardback: ISBN 978-1-908230-12-6 £159, $319. Ebook: ISBN 978-1-908230-77-5 £159, $319
In this book, internationally recognised Neurospora experts critically review the most important research and demonstrate the breadth of applications to industrial biology, biofuels, agriculture, and human health. The opening chapter is an introduction to the organism. Following chapters cover topics such as: carotenoid biosynthesis, polysaccharide deconstruction, genome biology, genome recombination, gene regulation, signal transduction, self-recognition, development, circadian rhythms and mutation. The book closes with a fascinating look at the history and future trends for research on Neurospora gene and genome analysis. This volume is essential for everyone working with Neurospora and other filamentous fungi. A recommended book for all biology, agriculture and medical libraries. read more ...
Horizontal Gene Transfer in Microorganisms
Edited by: M. Pilar Francino
Published: 2012
Hardback: ISBN 978-1-908230-10-2 £159, $319. Ebook: ISBN 978-1-908230-72-0 £159, $319
Under the expert guidance of the editor, M. Pilar Francino, expert authors from around the world have contributed novel work and comprehensive, up-to-date reviews on the most topical aspects of horizontal gene transfer in microorganisms. Topics include: gene survival in emergent genomes, evolution of prokaryotic pangenomes, horizontal transfer of host-adaptability systems, barriers to horizontal gene transfer, evolution of horizontally transferred genes, lateral gene transfer in natural ecosystems, maintenance of plasmids among bacteria, mobile genetic elements in metagenomes, and the evolution of antibiotic resistance genes. Aimed primarily at research scientists, graduate students and other experts, this book is a major resource for anyone interested in horizontal gene transfer, microbial evolution or antibiotic resistance in bacteria. A recommended book for all microbiology laboratories. read more ...
Malaria Parasites: Comparative Genomics, Evolution and Molecular Biology
Edited by: Jane M. Carlton, Susan L. Perkins and Kirk W. Deitsch
Published: 2013
Hardback: ISBN 978-1-908230-07-2 £159, $319. Ebook: ISBN 978-1-908230-76-8 £159, $319
Since the publication of the first two Plasmodium genome sequences in 2002, numerous other parasite genomes have been sequenced. These include the genomes of several more Plasmodium species as well as those of other apicomplexans, including species of Toxoplasma, Cryptosporidium, Babesia, and Eimeria. This wealth of genome sequence data has provided researchers with a powerful new tool, comparative genomics, which has revolutionised research in this area. In this book, expert authors from around the world comprehensively review the current advances in Plasmodium comparative genomics, highlighting the fascinating new insights into parasite evolution and molecular biology that have ensued. Topics include: Plasmodium taxonomy and phylogeny; the apicomplexan genomic landscape; the 'art' of sequencing Plasmodium genomes; diversity of Plasmodium falciparum and Plasmodium vivax genomes; Plasmodium functional genomics; Plasmodium experimental genetic crosses; P. falciparum epigenetic modification and transcriptional regulation; Plasmodium invasion of host red blood cells; protein export and trafficking by malaria parasites; Plasmodium-mosquito vector interactions; and a practical guide to many of the revolutionary new techniques and molecular tools for Plasmodium research. The book is essential reading for every researcher working with malaria parasites and related organisms, from the PhD student to the experienced scientist, and is a recommended text for all parasitologists. read more ...
Small DNA Tumour Viruses
Edited by: Kevin Gaston
Published: 2012
Hardback: ISBN 978-1-904455-99-8 £159, $319
In this timely book leading scientists from around the world review current hot-topics in this area providing a fascinating overview of the molecular biology of these viruses and their interactions with the host. Topics covered include: HPV infections and the production of HPV virion stocks; viral oncoproteins and their functions; the replication and maintenance of viral genomes; virus induced alterations in cellular miRNAs; viral deregulation of DNA damage responses; the initiation of viral DNA replication; induction of genomic instability by viral oncoproteins; targeting of PML proteins and PML nuclear bodies by these viruses; adenoviruses and gene therapy. Essential reading for scientists and researchers working on small DNA tumour viruses and their associated diseases and a recommended text for anyone involved with DNA replication, DNA damage responses and genome instability, virus-host interactions, viral tumourigenesis or antiviral drug development. read more ...
Bacillus: Cellular and Molecular Biology (Second edition)
Edited by: Peter Graumann
Published: 2012
Hardback: ISBN 978-1-904455-97-4 £180, $360
Extensively revised and updated, the new edition of this valuable reference work provides a comprehensive and up-to-date analysis of the current knowledge and new research in Bacillus molecular and cellular biology. Under the expert guidance of the editor Peter Graumann, renowned authors from around the world have contributed critical reviews on the most recent and topical research. Subjects covered include chromosome replication, DNA repair, chromosome segregation, cell division, transcription and translation, RNA-mediated regulation, general and regulatory proteolysis, the actin-like MreB cytoskeleton, the membrane proteome, the cell wall, endospore formation, biofilms, multicellularity and social behaviour, competence and transformation. An essential book for anyone interested in Bacillus and an important reference volume for those working in fields as diverse as medicine, biotechnology, agriculture, food and industry. A recommended book for all microbiology laboratories. read more ...
Non-coding RNAs and Epigenetic Regulation of Gene Expression: Drivers of Natural Selection
Edited by: Kevin V. Morris
Published: 2012
Hardback: ISBN 978-1-904455-94-3 £159, $319
Many studies have been carried out on the modulation of gene transcription by non-coding RNAs. This book, written by a group of distinguished scientists under the expert guidance of the editor Kevin V. Morris, represents an important overview and summary of the field to date. The thirteen chapters are organized into three sections: Non-coding RNAs: Form, Function and Diversity; Non-coding RNAs: Gene Regulation and Epigenetics; and Non-coding RNAs: Disease and Therapeutics. This up-to-date volume is an essential book for those working in the area and represents a major information resource on current research in the fast-moving fields of epigenetics, the regulation of gene expression, and RNA research. For scientists in other fields it provides a valuable insight into this important and fascinating area of molecular biology. read more ...
Brucella: Molecular Microbiology and Genomics
Edited by: Ignacio López-Goñi and David O'Callaghan
Published: 2012
Hardback: ISBN 978-1-904455-93-6 £159, $319
Written by highly acclaimed Brucella scientists, this book comprehensively reviews the most important advances in the field. Opening chapters focus on genetic diversity within Brucella, covering both classical and new species. Particular emphasis is given to how comparative genomics has led to advances in molecular diagnostics, taxonomy and phylogeny. Following chapters cover proteomic analysis, transcriptomic analysis, the VirB type IV secretion system, signalling complexes, e.g. the BvrR/BvrS two-component regulatory system and quorum sensing. These chapters highlight the intricate interplay between factors involved in virulence. Another chapter discusses the role of the Brucella cell envelope in bacterial virulence and evasion of host defences. The final two chapters review the current strategies for the development of novel antibacterial agents and improved vaccines. This volume is essential reading for everyone with an interest in Brucella and brucellosis. It is also recommended reading for the wider body of scientists, veterinarians and MDs with an interest in microbial diagnostics, microbial pathogenesis, host-parasite interactions, cellular microbiologists and immunologists and vaccine development scientists. read more ...
Emerging Trends in Antibacterial Discovery: Answering the Call to Arms
Edited by: Alita A. Miller and Paul F. Miller
Published: 2011
Hardback: ISBN 978-1-904455-89-9 £180, $360
In this book, respected international experts summarize the most important concepts and pioneering strategies currently being used to develop novel antibacterials. The book opens with chapters on cellular processes that could be used as novel antibacterial targets. Examples include cell division, efflux pumps, metabolite-sensing riboswitches and bacterial secretion systems. These are followed by excellent chapters on the identification of new, naturally occurring antibacterial agents, including phage and biosynthetically engineered compounds. Understanding the host-microbe interaction and microbial communities and how they can be exploited to develop new antibacterial strategies is discussed in subsequent chapters. Other topics included are: antibacterial vaccines adjuvants, host defence peptides, antibodies, within-host models, and diagnostics. A major reference volume on antibacterial research and how it impacts on public health worldwide, the book is essential reading for everyone working in antibacterial research and is a recommended volume for all microbiology libraries. read more ...
Epigenetics: A Reference Manual
Edited by: Jeffrey M. Craig and Nicholas C. Wong
Published: 2011
Hardback: ISBN 978-1-904455-88-2 £180, $360
The editors of this book have assembled top-quality scientists from diverse fields of epigenetics to produce a major new volume. Comprehensive and cutting-edge, the 26 chapters in this book constitute a key reference manual for everyone involved in epigenetics, DNA methylation, cancer epigenetics and related fields. Topics include: early life environment, DNA methylation and behavior, histone acetyltransferase biology, transgenerational epigenetic inheritance, mammalian X inactivation, epigenetic memory in plants, polycomb-group regulation, centromeres and telomeres, DNA sequence contribution to nucleosome distribution, macrosatellite epigenetics, histones, cell-fate specification and reprogramming, DNA methylation in cancer, variant histone H2A and cancer development, RNA modification, paramutation in plants, DNMT3L dependent methylation during gametogenesis, non-coding RNA, bisulphite-enabled technologies, rapid analysis of DNA methylation, microarray mapping, DNA methylation profiling, ChIP-sequencing, genome-wide DNA methylation analysis, and epigenetics in maize. In addition there are useful chapters on bioinformatics in epigenomics, online resources and tools for epigeneticists, and educational resources for epigenetics. This up-to-date reference manual is an essential book for those working in the field and for scientists in other disciplines it represents a major information resource on the fascinating and fast-moving field of epigenetics. read more ...
Metagenomics: Current Innovations and Future Trends
Edited by: Diana Marco
Published: 2011
Hardback: ISBN 978-1-904455-87-5 £159, $319
This book covers the most innovative and recent advances in theoretical, methodological and applied areas of metagenomics. Topics covered include metagenomics integration with complementary technologies, bacterial genealogy, viral metagenomics, the regulation of prokaryotic communities, functional metagenomics, systems biology, next-generation sequencing, stable isotope probing, DNA sequencing of uncultured microbes, cyberinfrastructure resource, identification of novel viruses, metagenomics of fungal communities, the human microbiome, microbial bioremediation, metagenomic enzyme discovery, quorum-sensing, plant-pathogen interactions, and metagenomics of belowground microbial communities. The book is aimed at researchers and environmental managers involved in metagenomics, students starting research in this field and teachers interested in the new developments. read more ...
Lactic Acid Bacteria and Bifidobacteria: Current Progress in Advanced Research
Edited by: Kenji Sonomoto and Atsushi Yokota
Published: 2011
Hardback: ISBN 978-1-904455-82-0 £159, $319
In this comprehensive book, expert international authors review the most recent cutting-edge research in these areas. Topics include: Lactobacillus genomics; Bifidobacterium gene manipulation technologies; metabolism of human milk oligosaccharides in bifidobacteria; proton-motive metabolic cycles; oxidative stress and oxygen metabolism; Bifidobacterium response to O2; bile acid stress in LAB and bifidobacteria; protein structure quality control; bacteriocin classification and diversity; lactococcal bacteriocins; lactobacilli bacteriocins; other bacteriocins; production of optically pure lactic acid; antihypertensive metabolites from LAB; the anti-H. pylori effect of Lactobacillus gasseri; probiotics for allergic rhinitis; probiotics health claims in Japan and Europe. Essential reading for every researcher working with LAB, bifidobacteria and probiotics, from the PhD student to the experienced scientist. read more ...
Streptomyces: Molecular Biology and Biotechnology
Edited by: Paul Dyson
Published: 2011
Hardback: ISBN 978-1-904455-77-6 £159, $319
With contributions from some of the leading scientists in the field, this volume documents recent research and development in streptomycetes genomics, physiology and metabolism. With a focus on biotechnology and genomics, the book provides an excellent source of up-to-date information. Topics include: genome architecture, conjugative genetic elements, differentiation, protein secretion, central carbon metabolic pathways, regulation of nitrogen assimilation, phosphate control of metabolism, gamma-butyrolactones and their role in antibiotic regulation, clavulanic acid and clavams, genome-guided exploration, gene clusters for bioactive natural products, genomics of cytochromes p450. Essential reading for research scientists, biotechnologists, graduate students and other professionals involved in streptomycetes research, antibiotic and antimicrobial development, drug discovery, soil microbiology and related fields. A recommended text for all microbiology laboratories. read more ...
Salmonella: From Genome to Function
Edited by: Steffen Porwollik
Published: 2011
Hardback: ISBN 978-1-904455-73-8 £159, $319
In this book, internationally acclaimed experts review cutting-edge topics in Salmonella genomics and molecular biology, providing a timely snapshot of the current state of research. Topics include latest approaches to sub-species level classification and phage typing of Salmonella, comparative genomics, the search for genetic determinants for survival of the bacterium in different environments and the evolution of niche specialization by Salmonella. The book also explores the latest genomic information and molecular characterizations of sRNAs and complements of fimbriae, flagella and secreted virulence factors. Moreover, S. Typhi pathogenesis, interactions of the host with intracellular Salmonella and the host's anti-Salmonella immune response are reviewed. The current knowledge on Salmonella biofilm formation and a progress report on using Salmonella as an anti-tumour tool conclude this compendium. Essential reading for all researchers working with Salmonella and related organisms, and recommended reading for other scientists working on bacterial genomics, molecular biology and bacterial molecular and cellular pathogenesis. read more ...
PCR Troubleshooting and Optimization: The Essential Guide
Edited by: Suzanne Kennedy and Nick Oswald
Published: 2011
Hardback: ISBN 978-1-904455-72-1 £159, $319
This book discusses the strategies for preparing effective controls and standards for PCR, when they should be employed and how to interpret the information they provide. It highlights the significance of optimization for efficiency, precision and sensitivity of PCR methodology and provides essential guidance on how to troubleshoot inefficient reactions. Experts in PCR describe design and optimization techniques, discuss the use of appropriate controls, explain the significance of standard curves and explore the principles and strategies required for effective troubleshooting. Authors highlight the importance of sample preparation and quality, primer design, controlling inhibitors, avoiding amplicon and environmental contamination, optimizing reagent quality and concentration, and modifying the thermal cycling protocol for optimal sensitivity and specificity. In addition, specific chapters discuss the history of PCR, the choice of instrumentation, the applications of PCR in metagenomics, high resolution melting analysis, the MIQE guidelines, and PCR at the microliter scale. The strategies, tips and advice contained in this concise volume enable the scientist to optimize and effectively troubleshoot a wide range of techniques including PCR, reverse transcriptase PCR, real-time PCR and quantitative PCR. An essential book for anyone using PCR technology. read more ...
Insect Virology
Edited by: Sassan Asgari and Karyn N. Johnson
Published: 2010
Hardback: ISBN 978-1-904455-71-4 £180, $360
Written by internationally renowned insect virologists, chapters review the current molecular biology of all the major groups of insect pathogenic viruses and suggest future directions for research. The book is divided into three parts: 1) DNA viruses 2) RNA viruses and 3) current hot-topics in insect virology. Virus groups covered include: Ascoviruses, Baculoviruses, Densoviruses, Entomopoxviruses, Hytrosaviruses, Iridoviruses, Nudiviruses, Polydnaviruses, Dicistroviruses, Iflaviruses, Nodaviruses, Tetraviruses and Cypoviruses. The special topics chapters review exciting recent developments in insect virology including RNAi, insect antiviral responses, structural comparison of insect RNA viruses, and viral ecology. The book is essential reading for every insect virologist in both the academic and private sectors. It is also strongly recommended for other virologists, particularly those interested in virus evolution, virus structure, viral vectors, biological control of insects and insect immunity. read more ...
Bifidobacteria: Genomics and Molecular Aspects
Edited by: Baltasar Mayo and Douwe van Sinderen
Published: 2010
Hardback: ISBN 978-1-904455-68-4 £159, $319
This book brings together the expertise and enthusiasm of the leading bifidobacteria experts from around the world to provide a state-of-the art overview of the molecular biology and genomics of this exciting and important microbial genus. Topics include: ecology, genomics, comparative genomics, metabolism, acid and bile resistance, stress response, probiotic properties, antimicrobial activity, interaction with the intestinal mucosa, safety assessment of bifidobacteria, synthesis and utilization of exopolysaccharides and prebiotics, antibiotic resistance/susceptibility profiles, viability and stability in commercial preparations, mobile genetic elements, cloning vectors and genetic manipulation of bifidobacteria. Essential reading for every bifidobacteria researcher, from the PhD student to the experienced scientist, and recommended reading for everyone with an interest in probiotics. read more ...
Molecular Phylogeny of Microorganisms
Edited by: Aharon Oren and R. Thane Papke
Published: 2010
Hardback: ISBN 978-1-904455-67-7 £159, $319
In this book, leading scientists from around the world explore current concepts in molecular phylogeny and their application with respect to microorganisms. The authors describe the different approaches applied today to elucidate the molecular phylogeny of prokaryotes (and eukaryotic protists) and review current phylogenetic methods, techniques and software tools. Topics covered include: a historical overview, computational tools, multilocus sequence analysis, 16S rRNA phylogenetic trees, rooting of the universal tree of life, applications of conserved indels, lateral gene transfer, endosymbiosis and the evolution of plastids. This book is an ideal introduction to molecular phylogeny for all microbiologists and is an essential review of current concepts for experts in the field. A recommended text for all microbiology laboratories. read more ...
Anaerobic Parasitic Protozoa: Genomics and Molecular Biology
Edited by: C. Graham Clark, Patricia J. Johnson and Rodney D. Adam
Published: 2010
Hardback: ISBN 978-1-904455-61-5 £159, $319
In this book internationally acclaimed researchers critically review the most important aspects of research on anaerobic parasitic protozoa, providing the first coherent picture of their genomics and molecular biology since the publication of the genomes. Chapters are written from a molecular and genomic perspective and contain speculative models upon which future research efforts can be based. Topics include: the genomes of Entamoeba histolytica, Trichomonas vaginalis, Giardia and other diplomonads; the cytoskeletons of Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis; genomic analyses and manipulation of gene expression in Entamoeba histolytica; nuclear and chromosomal structure and replication in Giardia; and the mitochondrion-like organelles of a fourth anaerobe, Blastocystis. Essential reading for all researchers working with these protozoa and related organisms and with eukaryotic model organisms. Recommended text for all parasitology laboratories. read more ...
Microbial Population Genetics
Edited by: Jianping Xu
Published: 2010
Hardback: ISBN 978-1-904455-59-2 £159, $319
Written by leading researchers in the field, this invaluable book details the major current advances in microbial population genetics and genomics. Distinguished international scientists introduce fundamental concepts, describe genetic tools and comprehensively review recent data from SNP surveys, whole-genome DNA sequences and microarray hybridizations. Chapters cover broad groups of microorganisms including viruses, bacteria, archaea, fungi, protozoa and algae. A major focus of the book is the application of molecular tools in the study of genetic variation. Topics covered include microbial systematics, comparative microbial genomics, horizontal gene transfer, pathogenic bacteria, nitrogen-fixing bacteria, cyanobacteria, microalgae, fungi, malaria parasites, viral pathogens and metagenomics. An essential volume for everyone interested in population genetics and highly recommended reading for all microbiologists. read more ...
Borrelia: Molecular Biology, Host Interaction and Pathogenesis
Edited by: D. Scott Samuels and Justin D. Radolf
Published: 2010
Hardback: ISBN 978-1-904455-58-5 £159, $319
Written by renowned scientists who have made seminal contributions to the field, this book is a comprehensive guide to the pathogenic Borrelia, providing researchers, advanced students, clinicians, and other professionals with an encyclopedic overview of the molecular biology of this important genus and the pathogenesis of diseases caused. Leading authorities have contributed chapters on topics such as Borrelia genomics, DNA replication, gene regulation, transcriptomics, proteomics, metabolism and physiology, cellular structure, motility and chemotaxis, genetic manipulation, evolutionary genetics, ecology, tick interactions, Lyme disease and relapsing fever pathogenesis, animal models, host response, detection, and vaccines. The volume is essential for anyone involved in Borrelia research and is strongly recommended for microbiologists, immunologists, and physicians involved in spirochete research, Lyme borreliosis, or relapsing fever. The book is a recommended reference volume for all microbiology libraries. read more ...
RNA Interference and Viruses: Current Innovations and Future Trends
Edited by: Miguel Angel Martínez
Published: 2010
Hardback: ISBN 978-1-904455-56-1 £159, $319
In this book, expert RNAi specialists from around the world have teamed up to produce a timely and thought-provoking review of the area. The two central themes are: 1) the latest findings on RNAi-virus interactions and 2) progress in the development of RNAi-based antiviral therapeutics. A number of chapters explain general concepts concerned with the role of RNAi in natural antiviral defense mechanisms, other chapters discuss how to improve the efficacy and safety of RNAi-based antiviral drugs, while others describe how this technology is being developed as a new therapeutic tool for fighting specific viruses, including HIV, HCV and respiratory viruses. Authors also outline potential new avenues for research thus providing a stimulus for further research. Essential reading for researchers involved in RNAi or antiviral research and a recommended text for all virology laboratories. read more ...
Retroviruses: Molecular Biology, Genomics and Pathogenesis
Edited by: Reinhard Kurth and Norbert Bannert
Published: 2010
Hardback: ISBN 978-1-904455-55-4 £159, $319
Written by the top retroviral specialists, this book reviews the genomics, molecular biology, and pathogenesis of these important viruses, comprehensively covering all the recent advances. Topics include: host and retroelement interactions, endogenous retroviruses, retroviral proteins and genomes, viral entry and uncoating, reverse transcription and integration, transcription, splicing and RNA transport, pathogenesis of oncoviral infections, pathogenesis of immunodeficiency virus infections, retroviral restriction factors molecular vaccines and correlates of protection, gammaretroviral and lentiviral vectors, non-primate mammalian and fish retroviruses, simian exogenous retroviruses, and HTLV and HIV. Essential reading for every retrovirologist and a recommended text for all virology and molecular biology laboratories. read more ...
Metagenomics: Theory, Methods and Applications
Edited by: Diana Marco
Published: 2010
Hardback: ISBN 978-1-904455-54-7 £159, $319
This book addresses in a coherent manner the diverse and multiple aspects of metagenomics and the multiplicity of its potential applications. Renowned authors from around the world have contributed chapters covering the new theoretical insights, the more recent applications, and the dynamically developing methods of data acquisition and analysis. Topics include: Conceptual frameworks, tools and methods, integration of complementary approaches, horizontal gene transfer, analysis of complex microbial communities, public data resources, plant-microbe interactions, bioremediation, industrial bioproducts, archaeal metagenomics, bioprospecting novel genes, the human microbiome, and philosophical themes in metagenomics. The book is essential reading for all researchers currently performing metagenomics studies and is highly recommended for all students and scientists wishing to increase their understanding of this field. read more ...
Aspergillus: Molecular Biology and Genomics
Edited by: Masayuki Machida and Katsuya Gomi
Published: 2010
Hardback: ISBN 978-1-904455-53-0 £159, $319
In this book leading Aspergillus researchers review and summarise the most important aspects of Aspergillus molecular biology and genomics. The book opens with a fascinating overview of the genus Aspergillus. This is followed by in-depth reviews of the Aspergillus molecular systematics, comparative genomics, bioinformatics and systems biology of Aspergillus, transcriptional regulation, genetics and genomics of sexual development of A. nidulans, genomics and secondary metabolism, ecology, development and gene regulation in A. flavus, functional systems biology, and novel industrial applications of A. oryzae genomics. Essential reading for everyone with an interest in Aspergillus and related fungi. read more ...
Environmental Molecular Microbiology
Edited by: Wen-Tso Liu and Janet K. Jansson
Published: 2010
Hardback: ISBN 978-1-904455-52-3 £159, $319
This book highlights the current state-of-the-art of environmental molecular microbiology. International experts have contributed chapters that describe the various technologies and their applications in environmental microbiology. The first half of the book focuses on the microbial diversity and phylogeny of microorganisms in the environment and describes the molecular toolbox currently available for the study of the composition and diversity of microbial communities and their functions. Topics include the use of the 16S rRNA gene as a phylogenetic marker, metagenomics, metaproteomics, microarrays, and molecular fingerprinting. The second half focuses on the application of these approaches in various environments including soil, marine water, plants, humans and wastewater treatment. The last chapter of the book discusses the genetics and environmental implications of microbial biofilms. An essential book for advanced students, research scientists, environmental agencies and industries involved in any aspect of environmental microbiology. read more ...
Lactobacillus Molecular Biology: From Genomics to Probiotics
Edited by: Åsa Ljungh and Torkel Wadström
Published: 2009
Hardback: ISBN 978-1-904455-41-7 £159, $319
This major new work focuses on recent research on the molecular biology and genomics of Lactobacillus. Written by an international team of scientists the volume is an essential reference for all medical researchers, dairy technologists, microbiologists and biotechnologists in the academic and industrial sectors. Topics covered include phylogenetics, taxonomy, comparative genomics, functional genomics, the intestinal microflora, surface proteins, stress responses, interaction with the immune system, probiotics, anti-cancer potential, and much more. Essential reading for all scientists involved with lactic acid bacteria or probiotic research and a recommended book for all microbiology laboratories. read more ...
Mycobacterium: Genomics and Molecular Biology
Edited by: Tanya Parish and Amanda Brown
Published: 2009
Hardback: ISBN 978-1-904455-40-0 £159, $319
A valuable reference text for all microbiology laboratories and essential reading for all scientists and researchers involved with mycobacteria. read more ...
Clostridia: Molecular Biology in the Post-genomic Era
Edited by: Holger Brüggemann and Gerhard Gottschalk
Published: 2009
Hardback: ISBN 978-1-904455-38-7 £159, $319
In this book internationally recognised Clostridium experts critically review the most important aspects of clostridial research, providing the first coherent picture of the organism's molecular and cellular biology in this post-genomic era. The first major focus of the book is the genetics and molecular biology of the major clostridial toxins including: botulinum and tetanus neurotoxins, C. difficile large exotoxins, C. perfringens enterotoxin, pore-forming and binary bacterial toxins. Other topics include: molecular epidemiology of C. botulinum and C. difficile, metabolic networks in C. acetobutylicum, development of genetic knock-out systems for clostridia, surface structures, anti tumor potential of clostridia, and antibiotic resistance determinants in C. difficile. Essential reading for every clostridia researcher, from the PhD student to the experienced scientist, as it provides a timely review of current research. read more ...
Plant Pathogenic Bacteria: Genomics and Molecular Biology
Edited by: Robert W. Jackson
Published: 2009
Hardback: ISBN 978-1-904455-37-0 £159, $319
In this book, internationally acclaimed experts review the most important developments providing an invaluable, up-to-date summary of the molecular biology and genomics of plant pathogenic bacteria. The book opens with two chapters on bacterial evolution, diversity and taxonomy, topics that have been transformed by molecular biology and genomics analyses. The third chapter delves into the crucially understudied area of pathogen adaptation to the plant apoplast environment. The following seven chapters focus on specific plant pathogens: Agrobacterium, Leifsonia, Pectobacterium, Pseudomonas, Ralstonia, Xanthomonas, and Xylella. The next four chapters review specific, intensively studied areas of research in the plant pathogen field: microbe associated molecular patterns (MAMPs) and innate immunity; use of bacterial virulence factors to suppress plant defence; cyclic di-GMP signalling and the regulation of virulence; and plasmids and the spread of virulence. The final chapter covers the critical area of bioinformatics. With contributions from some of the pioneering bacterial plant pathogen genome sequencers, this book is essential reading for every plant pathogen researcher, from the PhD student to the experienced scientist, as it provides a timely review of the current and most topical areas of research. read more ...
Microbial Production of Biopolymers and Polymer Precursors: Applications and Perspectives
Edited by: Bernd H. A. Rehm
Published: 2009
Hardback: ISBN 978-1-904455-36-3 £159, $319
Written by expert, internationally renowned scientists, this comprehensive volume describes in detail the use of microorganisms for the production of the most important biopolymers and polymer precursors. The authors describe, in depth, the biosynthetic pathways, physical properties and industrial production processes and discuss in detail the genetic and metabolic engineering of microorganisms for biopolymer production. Also highlighted are the applications and potential applications of the biopolymers and microbial biotechnology. Topics include the biochemistry and genetics of biosynthesis of xanthan, alginate, cellulose, cyanophycin, poly(gamma-glutamic acid), levan, hyaluronic acid, organic acids, oligosaccharides and polysaccharides, and polyhydroxyalkanoates. A recommended book for all biotechnology and microbiology laboratories. read more ...
Pasteurellaceae: Biology, Genomics and Molecular Aspects
Edited by: Peter Kuhnert and Henrik Christensen
Published: 2008
Hardback: ISBN 978-1-904455-34-9 £159, $319
Pasteurellaceae comprise a large and diverse family of Gram-negative bacteria with members ranging from important pathogens such as Haemophilus influenzae to commensals of the animal and human mucosa. Information on the biology of these organisms has mushroomed in recent years, driven by the development of novel genetic and molecular methodologies. Since 1995, the family has been expanded from three genera to the current thirteen through the use of new genetic-based classification and identification technologies. Many members of the Pasteurellaceae family make excellent natural models for the study of bacterial pathogenesis and host-pathogen-interactions thus giving valuable insights into related human diseases. Research in this area is at a very exciting stage. In this timely book, leading international Pasteurellaceae scientists critically review the most important current research providing an up-to-date review of the molecular biology, genomics and virulence of these fascinating organisms. Topics covered include taxonomy and biodiversity, phylogeny, comparative genomics, competence, DNA uptake and transformation, proteomics and protein secretion, RTX toxins, lipopolysaccharides, biofilms, quorum sensing, antimicrobial resistance, diagnosis, and OMP and iron uptake. Each chapter is independent and can be read in isolation and as a whole the book provides an important resource summarising our current knowledge of Pasteurellaceae genomics and molecular biology. Essential reading for everyone working on Pasteurellaceae and related organisms. read more ...
Vibrio cholerae: Genomics and Molecular Biology
Edited by: Shah M. Faruque and G. Balakrish Nair
Published: 2008
Hardback: ISBN 978-1-904455-33-2 £159, $319
Written by leading V. cholerae experts, the chapters review the most important cutting-edge genetic facets of V. cholerae including its genomic organization, population genetics, molecular epidemiology, and synchronized regulation of gene expression. Other topics include the molecular basis for enhanced transmissibility of cholera during epidemics, survival of the pathogen in the environment, and above all the evolution of the species to attain increased fitness both as a pathogen and an environmental organism. Essential reading for everyone with an interest in Vibrio and recommended reading for other scientists working in microbial pathogenesis, microbial genomics and antimicrobial research. read more ...
Helicobacter pylori: Molecular Genetics and Cellular Biology
Edited by: Yoshio Yamaoka
Published: 2008
Hardback: ISBN 978-1-904455-31-8 £159, $319
A useful introduction to the subject for new researchers and an invaluable reference for the experienced researcher, this book is essential reading for all researchers working with Helicobacter and related organisms. read more ...
Corynebacteria: Genomics and Molecular Biology
Edited by: Andreas Burkovski
Published: 2008
Hardback: ISBN 978-1-904455-30-1 £159, $319
This volume brings together the expertise and enthusiasm of today's leading experts to provide a description of the current state-of-the-art molecular biology toolbox available for Corynebacterium research, including global analyses techniques such as comparative genomics, transcriptome, proteome and metabolome analysis as well as the most recent knowledge on Corynebacterium promoter structures and vector systems. Furthermore, topics such as regulatory networks controlling carbon, nitrogen, phosphorus, sulphur and iron metabolism, cell wall structure, proteolysis and environmental stress response are covered. Essential reading for all Corynebacterium scientists and everyone with an interest in global analysis techniques, global regulation and systems biology. read more ...
Staphylococcus: Molecular Genetics
Edited by: Jodi Lindsay
Published: 2008
Hardback: ISBN 978-1-904455-29-5 £159, $319
This volume, the first to focus on staphylococcal genetics, brings together the expertise and enthusiasm of an international panel of leading staphylococcal researchers to provide a state-of-the art overview of the field. Topics include the sequencing projects, including spin-off microarray and systems biology tools, epidemiology, evolution, manipulation of the genome, diagnostics, gene expression due to global regulators and environmental triggers, cell-wall synthesis, coagulase-negative species, and animal pathogens. It is designed for two major audiences. Firstly, to introduce the subject to new researchers, including those unfamiliar with genetics. Secondly, for established researchers, for whom it will serve as an invaluable reference and summary of a large field, as well as presenting the latest advances and future trends written by those who are developing them. Essential reading for anyone involved in Staphylococcus research. read more ...
Leishmania: After The Genome
Edited by: Peter J. Myler and Nicolas Fasel
Published: 2008
Hardback: ISBN 978-1-904455-28-8 £159, $319
Leishmania is a vector-borne pathogenic parasite found in 88 countries worldwide and is the causative agent of leishmaniasis. The different Leishmania species infect macrophages and dendritic cells of the host immune system, causing symptoms that range from disfiguring cutaneous and mucocutaneous lesions, widespread destruction of mucous membranes, or visceral disease affecting the haemopoetic organs. The recent publication of the complete genome sequences of three different Leishmania species provides new insights into this leading pathogen and presents scientists with an exciting resource to improve the understanding of its complex molecular and cellular biology. In this book, internationally recognised Leishmania experts critically review the most important aspects of current Leishmania research, providing the first coherent picture of the organism's molecular and cellular biology since the publication of the genome sequence. Chapters are written from a molecular and genomic perspective and discuss in depth Leishmania-specific aspects of trypanosomatid biology and pathology. Topics include: diagnosis and epidemiology, genome structure and content, regulation of gene expression, the Leishmania proteome, the Leishmania metabolome, Leishmania differentiation, interaction with the sand fly vector, drug discovery, drug resistance, and much more. Essential reading for all researchers working with Leishmania, trypanosomes and protozoa. A recommended book for all biology and medical libraries. read more ...
Archaea: New Models for Prokaryotic Biology
Edited by: Paul Blum
Published: 2008
Hardback: ISBN 978-1-904455-27-1 £159, $319
A conventional view delineates cellular life into only two basic types called prokaryotes and eukaryotes. The prokaryotes are further subdivided into the Bacteria and the Archaea based on small subunit ribosomal RNA comparisons and conserved mechanisms for information processing. The study of archaeal prokaryotes has matured rapidly in part initiated by genomic science as well as a continuing interest in the biochemistry and metabolism of extremophiles. The authors present an expanding pattern of new information relevant to both the general and the technical reader. The book focuses on molecular biology and genomics and topics include the biology of metals, redox chemistry, respiration, sugar catabolism, nucleic acid modification, DNA replication, repair and recombination, transcriptomics, signal transduction and peptide antibiotics. Throughout the well referenced text the emphasis is on emerging topics in specific fields providing the reader with a vision of the future in the expanding world of Archaea. Essential reading for all archaea researchers and everyone with an interest in prokaryote molecular and cellular biology. A recommended book for all microbiology libraries. read more ...
Legionella: Molecular Microbiology
Edited by: Klaus Heuner and Michele Swanson
Published: 2008
Hardback: ISBN 978-1-904455-26-4 £159, $319
Legionellosis is a disease of significant medical and public interest. Legionella is commonly found in aquatic habitats where its ability to survive and to multiply within different protozoa equips the bacterium to be transmissible and pathogenic to humans. In addition Legionella has become a favored model system to analyse the mechanisms of bacterial survival, acquisition of nutrients and intracellular replication. Following the recent publication of the genome sequences of four L. pneumophila strains it is now feasible to investigate the whole genome in silico, the transcriptome via micro arrays and the proteome by two-dimensional gel electrophoresis. Research in the fields of clinical features, diagnosis, treatment and epidemiology continues to generate new data. The topics covered by this volume range from the history of the identification of Legionella and clinical disease treatment, to the microbe's gene expression and secretion systems as well as its strategies for intracellular multiplication and nutrient acquisition. The main focus of the book is the current state of many of the most critical features of Legionella. Internationally renowned authors have contributed chapters describing and discussing the latest research findings with an emphasis on molecular aspects. The editors and authors have produced an excellent book that will be an extremely useful reference source. This comprehensive publication is aimed at readers with teaching or research interests in microbiology, genetics, genomics, infectious diseases or clinical research. A recommended book for all microbiology and clinical research laboratories. read more ...
RNA and the Regulation of Gene Expression: A Hidden Layer of Complexity
Edited by: Kevin V. Morris
Published: 2008
Hardback: ISBN 978-1-904455-25-7 £159, $319
The role of RNA in regulating gene expression has become a topic of intense interest. In this book internationally recognized experts in RNA research explore and discuss the methods whereby RNA can regulate gene expression with examples in yeast, Drosophila, mammals, and viral infection, and highlight the application of this knowledge in therapeutics and research. Topics include: gene silencing and gene activation, the hammerhead ribozyme, epigenetic regulation, RNAi, microRNA, and pyknons. This comprehensive publication is intended for readers with teaching or research interests in RNA, the regulation of gene expression, genetics, genomics or molecular biology. read more ...
Molecular Oral Microbiology
Edited by: Anthony H. Rogers
Published: 2008
Hardback: ISBN 978-1-904455-24-0 £159, $319
A panel of experts discuss the molecular biology of micro-organisms involved in the two major dental diseases: caries and periodontal disease. Research has focused on factors which might modulate the interaction between the resident oral bacteria and the host. Chapters deal with the interactions of oral micro-organisms with one another and with the host; the innate defence mechanisms of the host; and the development of vaccines against oral diseases. Topics include oral microbial taxonomy, identification and typing, applied genomics, horizontal gene transfer, cell-cell communication, cariogenic bacteria, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, host-pathogen interaction, host defense mechanisms, and vaccination against oral infections. Essential reading for students and researchers in the field of oral biology and oral microbiology and a recommended book for all microbiology laboratories. read more ...
Epigenetics
Edited by: Jörg Tost
Published: 2008
Hardback: ISBN 978-1-904455-23-3 £159, $319
In this book the molecular mechanisms and biological processes in which epigenetic modifications play a primordial role are described in detail. The first seven chapters describe the different biological mechanisms of the epigenetic machinery including: DNA methylation, histone tails, chromatin structure, nucleosome occupancy, Polycomb group proteins, siRNAs and miRNAs. The following chapters cover the epigenetic systems of plants, the epigenetic profile of embryonic stem cells, cell differentiation, imprinting marks, and random X chromosome inactivation. Further chapters deal with epigenetics in relation to cancers, premature aging, longevity and the developmental origins of disease. The final chapter, describes the fascinating potential transfer of epigenetic information across generations. This up-to-date volume is a major resource for those working in the field and will stimulate readers of all levels to dive into the fascinating and fast moving field of epigenetics. read more ...
Segmented Double-stranded RNA Viruses: Structure and Molecular Biology
Edited by: John T. Patton
Published: 2008
Hardback: ISBN 978-1-904455-21-9 £159, $319
This timely book brings together all of the key recent research on this disparate group of viruses, providing for the first time a single resource reviewing dsRNA viral structure and molecular biology. Written by well respected and experienced virologists, topics include: the structures of orthoreoviruses, rotavirus, phytoreoviruses, and bluetongue virus, entry into the bacterial cell, crystal structure of reovirus polymerase λ3, assembly of the reovirus genome, genomic RNA packaging and replication in the Cystoviridae, and much more. Essential reading for all dsRNA virologists and all other virologists with an interest in molecular and structural biology. read more ...
Acinetobacter Molecular Biology
Edited by: Ulrike Gerischer
Published: 2008
Hardback: ISBN 978-1-904455-20-2 £159, $319
This concise volume reviews the most current and topical aspects of Acinetobacter genetics and molecular biology and is aimed at a readership of research scientists, graduate students and other specialists. Expert international authors have contributed chapters on diverse topics including taxonomy, lipopolysaccharides, catabolism of aromatic compounds, transformation systems, transcriptional regulation, applications in biotechnology, the molecular basis for virulence and pathogenicity, molecular epidemiology, and antibiotic resistance. This book is highly recommended for anyone involved in Acinetobacter research. read more ...
Pseudomonas: Genomics and Molecular Biology
Edited by: Pierre Cornelis
Published: 2008
Hardback: ISBN 978-1-904455-19-6 £159, $319
The genome sequences of several pseudomonads have become available in recent years and researchers are beginning to use the data to make new discoveries about this bacterium. This concise volume reviews the most current and topical aspects of Pseudomonas molecular biology and genomics and is aimed at a readership of research scientists, graduate students and other specialists. Renowned international authors have contributed chapters on diverse topics including taxonomy, genome diversity, oligonucleotide usage, polysaccharides, pathogenesis, virulence, biofilms, antibiotic resistance and iron uptake. In addition an entire chapter is devoted to the genetic tools being developed to take full advantage of the wealth of information generated by the genome sequencing efforts. This book is essential reading for anyone involved in Pseudomonas research. read more ...
Microbial Biodegradation: Genomics and Molecular Biology
Edited by: Eduardo Díaz
Published: 2008
Hardback: ISBN 978-1-904455-17-2 £159, $319
In this timely book expert international authors critically review all of the most important topics in this exciting field. Although other books covering this are currently available, this book is unique in that it is the first to review the area from a molecular biology and genomics perspective. Topics covered include: aerobic and anaerobic biodegradation of aromatic compounds, molecular detection methods (e.g. microautoradiography, mRNA analyses, etc.), genome-based predictive modelling, elucidation of regulatory networks, bioavailability, chemotaxis and transport issues, functional genomic analyses, natural attenuation, community fingerprinting and metagenomics, biotreatment, and biocatalysts engineering. Essential reading for microbial degradation and bioremediation scientists and of general interest for microbiologists working in field of environmental microbiology. read more ...
Coronaviruses: Molecular and Cellular Biology
Edited by: Volker Thiel
Published: 2007
Hardback: ISBN 978-1-904455-16-5 £159, $319
In this timely book, internationally renowned experts review literally every aspect of cutting edge coronavirus research providing the first coherent picture of the molecular and cellular biology since the outbreak of SARS in 2003. The book is divided into two sections: Part I focuses on the molecular biology of the virus itself and includes topics such as coronavirus binding and entry, replicase gene function, cis-acting RNA elements, coronavirus discontinuous transcription, reverse genetics, genome packaging and molecular evolution. In Part II of the book, the focus is on molecular and cellular pathogenesis and infection control. This section includes reviews of the three prototype viruses, namely avian infectious bronchitis virus, feline coronavirus and mouse hepatitis virus. Other topics include SARS-CoV virus pathogenesis, SARS-CoV interaction with the host INF and antiviral cytokines, the newly recognized bat coronaviruses and human coronavirus NL63, and strategies for coronavirus vaccine development and the development of novel antiviral coronavirus agents. Essential reading for all coronavirologists as well as scientists working on other viruses of the respiratory and/or gastrointestinal tract. read more ...
The Cyanobacteria: Molecular Biology, Genomics and Evolution
Edited by: Antonia Herrero and Enrique Flores
Published: 2008
Hardback: ISBN 978-1-904455-15-8 £159, $319
This volume brings together the expertise and enthusiasm of an international panel of leading cyanobacterial researchers to provide a state-of-the art overview of the field. Topics covered include: evolution, comparative genomics, gene transfer, molecular ecology and environmental genomics, stress responses, bioactive compounds, circadian clock, structure of the photosynthetic apparatus, membrane systems, carbon acquisition, nitrogen assimilation and C/N balance sensing and much more. Essential for anyone with an interest in cyanobacteria, bacterial photosynthesis, bacterial nitrogen fixation, and symbiosis. read more ...
Bacteriophage: Genetics and Molecular Biology
Edited by: Stephen Mc Grath and Douwe van Sinderen
Published: 2007
Hardback: ISBN 978-1-904455-14-1 £159, $319
Written by eminent international researchers actively involved in the disparate areas of bacteriophage research this book focuses on the current rapid developments in this exciting field. The book opens with an excellent chapter that provides a broad overview of the topics and also highlights the multifaceted nature of bacteriophage research. This is followed by a series of reviews that focus on the current most cutting-edge topics including bioinformatics and genomics, phage in the environment, bacteriophage in medicine, transfer of phage DNA to the host, contribution to host phenotype and much more. Essential reading for all phage researchers and of interest to molecular biologists and microbiologists working on bacteria in academia, biotechnology and pharmaceutical companies, and in the food and other industries read more ...
Candida: Comparative and Functional Genomics
Edited by: Christophe d'Enfert and Bernhard Hube
Published: 2007
Hardback: ISBN 978-1-904455-13-4 £159, $319
In this timely book international experts provide comprehensive and authoritative reviews of these important organisms. Topics covered include: genome dynamics of C. albicans; molecular epidemiological and population studies of C. albicans; the parasexual cycle in C. albicans; comparative genomics of the hemiascomycetes group and of different Candida species; databases and the challenges that their curators are facing; transcriptome analysis; proteomics; molecular evolution of the genetic code; stress responses; regulation of morphogenesis; cell wall biology; interaction with host cells; analysis of gene function; antifungal resistance mechanisms and much more. Essential reading for all Candida genome and molecular biology researchers and a recommended text for scientists working on fungal genomics and molecular biology. read more ...
Bacillus: Cellular and Molecular Biology
Edited by: Peter Graumann
Published: 2007
Hardback: ISBN 978-1-904455-12-7 £159, $319
This book presents an overview of the most recent exciting new research fields and provides a picture of the major cytological aspects of a model bacterium. The authors present the most recent knowledge on topics such as the replication and segregation of the chromosome, cell division, replication and growth, the cell cycle, transcription, translation, regulation, the actin cyctoskeleton, the cell membrane and cell wall, biofilm formation and sporulation. Also covered are DNA repair, the regulation of transcription through RNA molecules, and the regulation of protein activity through proteolysis. The authors seamlessly merge the fields of bacterial cell biology and molecular biology to provide an integral view of the bacterial cell, providing an understanding of the way a bacterial cell functions as a whole entity and in 3D, i.e. how it is spatially organized, and even how bacterial cells communicate with each other, or give their life for the sake of the whole community. An essential book for anyone interested in Bacillus, cell biology or bacterial genetics and molecular biology. read more ...
PCR Troubleshooting: The Essential Guide
Author: Michael L. Altshuler
Published:
Paperback: ISBN 978-1-904455-07-3 £30, $60. Ebook: ISBN 978-1-904455-08-0 £30, $60
A unique PCR troubleshooting guide that is an essential companion for anyone who uses the polymerase chain reaction technique. Aimed at a reader with some experience in PCR the book discusses the many and varied problems encountered with PCR together with tips, advice and procedures to obviate rather than overcome the PCR problems. Written in the language of the laboratory with a little humour and a down-to-earth approach, the book is easy to read and understand. If you fail at PCR, consult this book! The advice in these pages is invaluable and is the sort of advice that is not usually found elsewhere. In the words of the author, remember that there are many other things in life than PCR ... for example, isothermal DNA amplification. read more ...
Malaria Parasites: Genomes and Molecular Biology
Edited by: A.P. Waters and C.J. Janse
Published: 2004
Hardback: ISBN 978-0-9542464-6-4 £159, $319
The completion of the Plasmodium falciparum genome sequence in late 2002 hearlded a new era in malaria research. The search began in earnest for new drugs and vaccines to combat malaria, a disease which afflicts up to 500 million people worldwide and is responsible for the deaths of more than one million people each year. The new genomic data is aiding a greater understanding of the living parasite and its interaction with the insect vector and human host. In this book internationally renown experts provide up-to-date reviews of the most important aspects of post-genomic malaria research. Topics covered include: the P. falciparum genome and model parasites, bioinformatics and genome databases, microsatellite analysis, analysis of chromosome structure, cell cycle to RNA polymerase I and II mediated gene expression, role of the nuclear genome, the parasite surface and cell biology, and much more. The book is essential reading for all parasitologists and scientists with an interest in malaria. read more ...
Frontiers in Computational Genomics
Edited by: Michael Y. Galperin and Eugene V. Koonin
Published: 2003
Hardback: ISBN 978-0-9542464-4-0 £159, $319
Computational biology and bioinformatics form a major, integral part of genomics. From sequence fragment assembly, to gene prediction, to prediction of protein functions and structure, to identification of regulatory signals in DNA, to building phylogenetic trees, it would not be an exaggeration to state that genomics is primarily computational. Major new programs, software and internet facilities have evolved recently that facilitate computational analysis and more novel technologies are currently being developed. Written by experts in the field, this volume highlights research on the emerging, perhaps somewhat controversial, topics in genomics and shows the feedback between the new developments and the established methods of computational biology. An essential book for anyone involved in genomic science or bioinformatics. read more ...
Genomics of GC-Rich Gram-Positive Bacteria
Edited by: Antoine Danchin
Published: 2002
Hardback: ISBN 978-0-9542464-3-3 £159, $319
Eminent scientists have contributed comprehensive reviews on all aspects of the genomics of Rhodococcus, Mycobacteria, Streptomyces and other organisms. The authors provide an insight into the many facets of large-scale functional investigation in a variety of bacteria with the explicit goal to find common rules in the dynamic and structural organisation of these organisms. This volume is the definitive guide to current research in this increasingly important area. read more ...
Genomic Technologies: Present and Future
Edited by: David J. Galas and Stephen J. McCormack
Published: 2002
Hardback: ISBN 978-0-9542464-2-6 £159, $319
The chapters in this book reflect the range of technical advances and their applications that are currently transforming biology. Topics covered include the application of computational methods, the robotics of modern automation methodologies, the new chemical and imaging methods that reveal chromosome structure and elucidate gene function, and the emergence of evolutionary and functional information by comparative genomics. Eminent international scientists describe in detail the new technology necessary to study the entire genome in a holistic manner and all the high throughput and large-scale experimental methodologies currently being used in genomic science. In addition the authors describe the progress of the newest technologies that are currently being developed. Written by experts in the field, this concise yet informative volume covers all aspects of technology pertaining to genomic studies. An essential book for anyone involved in genomic science. Readership: bioscientists, molecular biologists, biotechnologists, geneticists, human, animal and plant geneticists, microbiologists, genome scientists. An essential book for anyone involved in genomic science. read more ...