Toxoplasma: Molecular and Cellular Biology
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Publisher: Horizon Bioscience
Editor: James W. Ajioka and Dominique Soldati of the Department of Pathology, Cambridge University, Tennis Court Road, UK and the Department of Microbiology and Molecular Medicine, University of Geneva, Switzerland respectively
Publication date: July 2007
ISBN: 978-1-904933-34-2 (hardback)
ISBN: 978-1-904933-35-9 (ebook)
Pages: xx + 626 (plus 6 colour plates)
Chapter abstracts . How to Order . Download PDF of entire book
Toxoplasma gondii, once an obscure protozoan parasite, has recently become the focus of intense research, both as a serious pathogen in its own right and as a model member of the phylum Apicomplexa. This parasite causes congenital birth defects, is an important opportunistic pathogen associated with AIDS, and a serious veterinary concern. In addition the experimental accessibility of this parasite has allowed its development into an outstanding model for studying related species, including Plasmodium (the causative agent of malaria), Cryptosporidium (a devastating AIDS pathogen for which no effective therapy is available), and numerous veterinary pathogens.
Written by internationally acclaimed researchers, this is the first book to provide a comprehensive coverage of this important parasite from both the host and pathogen perspectives. The book is divided into six main themes ranging from pathogenesis in humans to molecular details of parasite motility and invasion. Part 1 reviews the life cycle and ultrastructure of the parasite and provides a general framework for the subsequent chapters. The second part covers pathogenesis and immunity. The third section covers both Mendelian and molecular genetics and the latest genomic sequencing results, providing a fascinating insight into how host-pathogen interactions may shape the parasite's genome organization, population structure and evolution. The fourth section discusses the core cell biology of the parasite, exploring the relationship between cell cycle, gene expression, nutrient metabolism and developmental interconversion. The final two sections cover the novel sub-cellular and molecular devices of the parasite cell, the organelles and molecular processes characteristic of apicomplexan parasites, molecular motility, and invasion and occupancy of the host cell.
The authors of this book describe in detail the biological characteristics that make T. gondii and related apicomplexans the most common and successful group of parasites on earth. Essential reading for all researchers working with Toxoplasma and related apicomplexans.
Chapter List:
Part 1 - Overview
Chapter 1: The Life Cycle of Toxoplasma gondii
J. P. Dubey
Chapter 2: Ultrastructure
J.-F. Dubremetz and D. J. P. Ferguson
Part 2 - Pathogenesis, Immunology and Virulence
Chapter 3: Epidemiology, Diagnostics and Chemotherapy
Eskild Petersen
Chapter 4: Ocular Toxoplasmosis: Clinical Features, Pathology, Pathogenesis, Animal Models and Immune Responses
Fiona Roberts, Annie Kuo, Leigh Jones, Rima McLeod and Craig Roberts
Chapter 5: Congenital Toxoplasmosis
A.W. Pfaff, O. Liesenfeld and E. Candolfi
Chapter 6: Innate Recognition and the Regulation of Protective Immunity to Toxoplasma gondii
Marion Pepper and Christopher A. Hunter
Chapter 7: Mechanisms of Immune Evasion
Eric Y. Denkers, Chiang W. Lee, Leesun Kim and Barbara A. Butcher
Chapter 8: Apoptosis and Its Impact on the Parasite-host Interaction
Carsten G. K. Lüder
Chapter 9: Pathogenicity and Virulence in Toxoplasma gondii
Sonya Taylor, Asis Khan, Chunlei Su, and L. David Sibley
Chapter 10: Cellular Response to Infection
Ashley Fouts and John C. Boothroyd
Part 3 - Genome and Genetics
Chapter 11: Genetics and Genome Organization of Toxoplasma gondii
Asis Khan, Sonya Taylor, Chunlei Su, L. David Sibley, Ian Paulsen, and James W. Ajioka
Chapter 12: Evolution and Comparative Genomics of Toxoplasma gondii
Jessica Kissinger and Chih-Horng Kuo
Chapter 13: Population Genetics, Sex and the Emergence of Clonal Lines of Toxoplasma gondii
Michael E. Grigg
Chapter 14: Manipulating the Genome
Marc-Jan Gubbels, Jolly Mazumdar, Giel van Dooren, and Boris Striepen
Part 4 - Growth, Development and Metabolism
Chapter 15: Cell Cycle Control/Parasite Division
Michael W. White, Jay R. Radke, Magnolia Conde de Felipe, and Margaret Lehmann
Chapter 16: Gene Regulation and Bradyzoite Development
Stanislas Tomavo and Louis M. Weiss
Chapter 17: Biology of Bradyzoites
Florence Dzierszinski and Laura J. Knoll
Chapter 18: Chromatin Remodeling
William J. Sullivan, Jr.
Chapter 19: Lipid Synthesis and Uptake
Isabelle Coppens
Chapter 20: Nucleotides and Amino Acids
Barbara A. Fox, Kshitiz Chaudhary, and David J. Bzik
Part 5 - Organelles: Sorting, Content and Function
Chapter 21: Protein Targeting to the Apicoplast
Marilyn Parsons Amy DeRocher, and Jean Feagin
Chapter 22: The Metabolic Functions of the Mitochondrion and the Apicoplast
Frank Seeber and Dominique Soldati
Chapter 23: Microneme Protein Repertoire and Function
M.-H. Huynh and V.B. Carruthers
Chapter 24: Proteomic Analysis of the Rhoptry Organelles of Toxoplasma gondii
J.M. Wastling and P.J. Bradley
Chapter 25: Dense Granules of the Infectious Stages of Toxoplasma gondii: Their Central Role in the Host/Parasite Relationship
Corinne Mercier, Marie-France Cesbron-Delauw and David J.P. Ferguson
Chapter 26: Calcium Homeostasis and Acidocalcisomes in Toxoplasma gondii
Silvia N.J. Moreno, Kildare Miranda and Wanderley de Souza
Part 6 - Cytoskeleton, Signaling, Motility and Invasion
Chapter 27: Tubulin, Microtubules and Microtubule-Associated Structures in Toxoplasma gondii
Naomi S. Morrissette
Chapter 28: Molecular Motors
Bernardo J. Foth and Dominique Soldati
Chapter 29: Actin Dynamics and Motility in Apicomplexans
Jennifer L. Gordon, Nivedita Sahoo, Simren Mehta, L. David Sibley
Chapter 30: Proteases of Toxoplasma gondii
Artemio Jongco and Kami Kim
Chapter 31: The Toxoplasma gondii Parasitophorous Vacuole Membrane: Transactions at the Parasite Host Interface.
Angela M. Martin and Anthony P. Sinai
(EAN: 9781904933342)
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