Development of Novel Antimicrobial Agents: Emerging Strategies

Publisher: Horizon Scientific Press
Editor: Karl Lohner,Graz, Austria
Publication date: January 2001
ISBN-10: 1-898486-23-9 (hbk)
ISBN-13: 978-1-898486-23-7 (hbk)
Price: GB £111 or US $222
Pages: xii + 284

Chapter abstracts . Book reviews . How to Order

We face a world-wide rapid increase in pathogenic bacteria which are multi-resistant to antibiotics. Since the development of the first commercially available antibiotic penicillin in the 1940s, the high expectations by man in the healing power of these "wonder drugs" has not been fulfilled due to the evolution of antibiotic resistance in bacteria. The problem has increased dramatically in recent years with the emergence of multi-resistant strains of bacteria. Infections caused by these bacteria (often prevalent in hospitals) cannot be treated by currently available antibiotics.

There is therefore a pressing need to develop new antibiotics and novel antimicrobial agents. This book presents current research on the development of new classes of antibiotics with novel mechanisms of action. Leading international researchers from academia and industry present this unique collection of highly acclaimed reviews covering every aspect of this important topic. The authors also discuss stategies for the containment of antimicrobial resistance, and advocate a more sophisticated and prudent use of antibiotics.

Chapter List

•   Chapter 1. Are We on the Threshold of the Post-Antibiotic Era?
Karl Lohner and Erich Staudegger

•   Chapter 2. Origins and Evolution of Antibiotic and Multiple Antibiotic Resistance in Bacteria
Ruth M. Hall and Christina M. Collis

•   Chapter 3. Antimicrobial Peptide Resistance Mechanisms in Bacteria
Arden Aspedon and Eduardo A. Groisman

•   Chapter 4. Genetic Engineering of Novel Macrolide Antibiotics
Robert McDaniel and Leonard Katz

•   Chapter 5. Granulysin, A Novel Mediator of Antimicrobial Activity of Cytolytic T-cells
Steffen Stenger, Alan M. Krensky and Robert L. Modlin

•   Chapter 6. The Immunostimulatory Properties of Bacterial DNA
David S. Pisetsky

•   Chapter 7. Bacteria-Mediated DNA Transfer for Gene Therapy and Genetic Vaccination
Siegfried Weiss and Trinad Chakraborty

•   Chapter 8. Potential Mucosal Adjuvants For Human Use
Mari Ohmura, Raymond J. Jackson, Yoshifumi Takeda and Jerry R. McGhee

•   Chapter 9. Attenuated Bacteria as Delivery Vehicles for H. pylori Vaccines
Thomas G. Blanchard and Steven J. Czinn

•   Chapter 10. Development of an Adhesin Vaccine to Prevent Urinary Tract Infection
Matthew A. Mulvey, Scott J. Hultgren and Solomon Langermann

•   Chapter 11. Antimicrobial Peptides in Innate Immunity
Tomas Ganz and Robert I. Lehrer

•   Chapter 12. The Role of Membrane Lipid Composition in Cell Targeting of Antimicrobial Peptides
Karl Lohner

•   Chapter 13. Molecular Mechanisms of Membrane Perturbation by Antimicrobial Peptides
Katsumi Matsuzaki

•   Chapter 14. Molecular Mechanism of Cell Selectivity by Linear Amphipatic a-helical and Diasteriomeric Antimicrobial Peptides
Ziv Oren and Yechiel Shai

•   Chapter 15. Molecular Interactions Involved in Bactericidal Activities of Lantibiotics
Ulrike Pag and Hans-Georg Sahl

•   Chapter 16. Cyclic Cystine-Knot ß-Stranded Antimicrobial Peptides: Occurrence, Design and Synthesis
James P. Tam, Yi-An Lu, Jin-Long Yang and Qitao Yu

•   Chapter 17. Synthetic Combinatorial Libraries: An Emerging Approach Toward the Identification of Novel Antibiotics
Sylvie E. Blondelle

•   Chapter 18. The Commercial Development of the Antimicrobial Peptide Pexiganan
Michael A. Zasloff

How to buy this book

(EAN: 9781898486237)

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