Vaccine Delivery Strategies
Publisher: Horizon Scientific Press
Editor: Guido Dietrich Biotech AG, Berne, Switzerland and W. Goebel University of Wuerzburg, Wuerzburg, Germany
Publication date: October 2002
ISBN-10: 1-898486-48-4 (hbk)
ISBN-13: 978-1-898486-48-0 (hbk)
Price: GB £111 or US $222
Pages: xiv + 404
Chapter abstracts . Book reviews . How to Order
Since it's discovery by Jenner in 1796, vaccination continues to be one of the most powerful tools available in the fight against infectious diseases. However modern vaccinology faces two major challenges. The first is the inadequate use of existing vaccines, for example due to concerns over vaccine safety, or due to insufficient availability of vaccines in certain parts of the world. The second major challenge is the development of vaccines against diseases for which none exists to date (e.g. AIDS, hepatitis C virus). Therefore new and better vaccines have to be developed and crucial to the success of a vaccine is the delivery strategy to be used.
Written by leading experts in the field, this book examines the current state of research of all the most important and modern vaccine delivery systems available to date. The immunological principles upon which these systems are based, their potential applications and current clinical status are detailed. Topics covered include: bacterial polysaccharide conjugate vaccines, virosomes and liposomes, bacterial ghosts, attenuated Salmonella and Shigella vaccines, vaccines against tumors, edible vaccines and much more.
An essential text for all vaccinologists, microbiologists, health professionals, biotechnologists, and pharmaceutial companies
Key Features:
* Detailed Discussions of Cutting Edge Technologies * International Contributors * Useful Index * Up-To-Date * Broad Coverage * Expert Authors
Chapter List:
Part I Vaccine Delivery by Nonliving Systems
Chapter 1. Bacterial Polysaccharide Conjugate Vaccines
M. Frosch
Chapter 2. Novel Adjuvants
M. Pizza, D. O'Hagan, and R. Rappuoli
Chapter 3. Transcutaneous Immunization
G. Glenn
Chapter 4. Virosomes and Liposomes in Vaccinology
R. Zurbriggen
Chapter 5. Enhancing DNA Vaccine Efficacy by Stress Protein-Facilitated Antigen Expression
R. Schirmbeck, and J. Reimann
Chapter 6. CpG Motifs in Vaccination
S. Zimmermann, K. Heeg
Chapter 7. Bacterial Ghosts as Carrier and Targeting Systems for Antigen Delivery
W. Jechlinger, W. Haidinger, S. Paukner, P. Mayrhofer, E. Riedmann, J. Marchart, U. Mayr, C. Haller, G. Kohl, P., Walcher, P. Kudela, J. Bizik, D. Felnerova, E. M.B. Denner, A. Indra, A. Haslberger, M. Szostak, S. Resch, F. Eko, T. Schukovskaya, V. Kutyrev, A. Hensel, S. Friederichs, T. Schlapp, and W. Lubitz
Part II Vaccine Delivery by Live Systems
Chapter 8.
Attenuated Salmonella and Shigella Live Vectors
M.M. Levine, J.E. Galen, E.Barry, M.F. Pasetti, C.O. Tacket, and M.B. Sztein
Chapter 9. Use of the a-Hemolysin Secretion System (TypeI) of Escherichia coli in Vaccine Development
I. Gentschev, G. Dietrich, J. Hess, and W. Goebel
Chapter 10. Use of Type III Secretion Systems toInduce MHC Class I-Restricted Immune Responses
H. Rüssmann
Chapter 11. Live Mycobacterial Vaccine Candidates
J. Hess
Chapter 12.
Delivery of Protein Antigens and DNA Vaccines by Listeria monocytogenes
G. Dietrich, I. Gentschev, and W. Goebel
Chapter 13. Transfer of Eukaryotic Expression Plasmids to Mammalian Host Cells by Gram-negative Bacteria
S. Weiss, and T. Chakraborty
Chapter 14.
Recombinant Intra-cellular Bacteria as Carriers for Tumor Antigens
G.R. Gunn, III, A.C. Zubair, and Y. Paterson
Chapter 15.
Dendritic Cell-Based Vaccination against Tumors and Infectious Diseases
C. Berberich, Wolfgang Strittmatter, and H. Moll
Chapter 16. Edible Vaccines
J. Yu, J. E. Carter, and W.H.R. Langridge
(EAN: 9781898486480)
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