Helicobacter pylori: Molecular and Cellular Biology Book Reviews
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Review by CAB International. March 2001 This book is aimed at graduate students and to scientists not yet familiar with this area. In addition the aim is to provide a source of topical summaries of recent developments within this highly active area of research to Helicobacter experts. The book begins with background chapters covering the history, taxonomy and epidemiology of
H. pylori infection. It continues with chapters on host responses, including immunity, apoptosis and animal models followed by chapters on virulence factors and vaccine development. The final section summarizes genome analyses, molecular typing and population genetics. Chapters are independent and can be read in any desired sequence.
Microbiology Today 29: 53. February 2002 A novel, obscure gastric bacterium in the 1980s, Helicobacter pylori was, the Editors of this book point out, exceeded in publication numbers only by E. coli and Salmonella among bacterial pathogens in PubMed searches in mid-2000. It has now been the subject of one of the most searching postgenomic explorations of a bacterium yet reported, a global survey of protein-protein interactions [J.C. Rain et al., Nature (2001)409, 211-215], underpinned by not one but two genome sequences. This book is therefore a timely summary of current understanding of the most prevalent bacterial pathogen of humans worldwide. Expert reviews from international authors cover its history and taxonomy, host responses to infection, pathogenicity and virulence, and genetics. The result is a compilation of microbiological (as distinct from clinical) data, valuable to the expert and interesting to the general reader, which should become a standard reference on this fascinating pathogen.
CAB International
Review by
Charles Penn University of Birmingham, U.K.