Microbiology news and views
J. Mol. Micro. Biotechnol. 3: 145-150
Comparative Genomics of Microbial Drug Efflux Systems
Ian T. Paulsen, Joan Chen, Karen E. Nelson, and Milton H. Saier, Jr
The complete genome sequences of 36 microorganisms have now been published and this wealth of
genome data has enabled the development of comparative genomic and functional genomic approaches to
investigate the biology of these organisms. Comparative genomic analyses of membrane transport systems have
revealed that transporter substrate specificities correlate with an organism's lifestyle. The types and numbers of
predicted drug efflux systems vary dramatically amongst sequenced organisms. Microarray and gene knockout
studies to date have suggested that predicted drug efflux genes often appear to be a) non-essential and b) expressed
at detectable levels under standard laboratory growth conditions.
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