Microbiology news and views
J. Mol. Micro. Biotechnol. 3: 225-236
Inhibition of Efflux Pumps as a Novel Approach to Combat Drug Resistance in Bacteria
Olga Lomovskaya and Will Watkins
Efflux mechanisms have become broadly recognized as major components of resistance to many classes
of antibiotics. Some efflux pumps selectively extrude specific antibiotics, while others, referred to as
multidrug resistance (MDR) pumps, expel a variety of structurally diverse compounds with differing antibacterial
modes of action. There are numerous potentially beneficial consequences of the inhibition of efflux pumps in
improving the clinical performance of various antibiotics, and several companies and research laboratories have
initiated programs to discover and develop efflux pump inhibitors. This review will summarize recent achievements
in this new, very exciting and equally challenging field.
Full article [pdf]
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