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J. Mol. Micro. Biotechnol. 3: 381-384
Regulation of Galactoside Transport by the PTS
Masayuki Kuroda, Thomas H. Wilson, and Tomofusa Tsuchiya
Inducer exclusion, regulation of activity of transporter, is mediated by phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). To elucidate the molecular mechanism of the inducer exclusion, numerous biochemical and genetic studies have been performed. It is now well known that non-phosphorylated IIAGlc inhibits the transport via direct binding to the transporter. Analysis of inducer exclusion resistant mutants of lactose transporter and melibiose transporter in Escherichia coli and Salmonella typhimurium revealed amino acid residues that are involved in the interaction with IIAGlc. It is concluded that there are multiple interaction sites for IIAGlc in these transporters.
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