JMMB Abstract

J. Mol. Micro. Biotechnol. 4: 217-222

Members of the Fur Protein Family Regulate Iron and Zinc Transport in E. coli and Characteristics of the Fur-Regulated FhuF Protein

Klaus Hantke

The regulator Fur represses with Fe²⁺ as cofactor iron uptake genes. The fhuF gene reacts very sensitive to minor changes of Fe²⁺ and Fur. It is assumed that FhuF helps in the mobilisation of iron out of the hydroxamate siderophores transported into the cell. Analysis of the protein revealed an unusual [2Fe-2S] cluster bound to a Cys-Cys-X₁₀-Cys-X₂-Cys motif in FhuF. suf genes responsible for the synthesis of the iron sulfur center were identified.

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Members of the Fur Protein Family Regulate Iron and Zinc Transport in E. coli and Characteristics of the Fur-Regulated FhuF Protein

Klaus Hantke

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