Molecular Biology Today (2002). 3: 31-37.

Random Analysis of Presence and Absence of Two- and Three-Amino-Acid Sequences and Distributions of Amino Acids, Two- and Three-Amino-Acid Sequences in Bovine p53 Protein

Guang Wu and Shaomin Yan

In this study we use five probabilistic procedures to analyse the bovine p53 protein. (1) We count each kind of two-, three- and multi-amino-acid sequences along bovine p53 protein from one terminal to the other and calculate their frequencies and probabilities. (2) We compare the amino-acid sequences in bovine p53 protein with the theoretical amino-acid sequences and determine which theoretical amino-acid sequences are present and absent. (3) We use the random principle to predict the frequencies of presence and absence of amino-acid sequences in bovine p53 protein from its amino acid composition and compare the predicted frequencies with the counted frequencies. (4) We use the random principle to predict the probability that an amino acid follows a preceding amino acid and compare the predicted probabilities with the probabilities occurred in bovine p53 protein. (5) We use the random principle to predict the distributions of amino acids, two- and three-amino-acid sequences in bovine p53 protein and compare the predicted distributions with the measured distributions.