PCR | real-time PCR | qPCR
new and forthcoming publications ...
Virology
new and forthcoming publications ...
Genome analysis | Biotechnology
new and forthcoming publications ...
Newsletter

Medical Microbiology Books

Our high level medical microbiology books bring together expert international authors under the skilled editorship of leading scientists to produce state-of-the-art compendiums of current research. Aimed at the research scientist, graduate student, medical reseacher and other professionals, these books are highly recommended for all medical microbiology laboratories. Every medical microbiology, microbiology and bioscience library should have a copy of each of the following books.
Library recommendation form
Pathogenic Neisseria: Genomics, Molecular Biology and Disease Intervention
Edited by: John K. Davies and Charlene M. Kahler
Published: 2014
Hardback: ISBN 978-1-908230-47-8 £159, $319. Ebook: ISBN 978-1-908230-61-4 £159, $319
The human pathogens, Neisseria meningitidis and Neisseria gonorrhoeae are exquisitely adapted to life within the human mucosa, their only natural niche. N. meningitidis is the causative agent of rapidly transmissible meningitis and septic shock. Vaccines developed to control this pathogen can be rendered ineffective by the pathogen's ability to undergo antigenic variation. In contrast, there are no current vaccination prospects for N. gonorrhoeae, the causative agent of sexually transmitted gonorrhoea. Historically infections caused by N. gonorrhoeae were treated with antibiotics. However the recent advent of new strains with resistance to all known antibiotics is causing such treatment regimes to fail, necessitating the need for new and more effective control strategies. In this book leading Neisseria authorities review the most important research on pathogenic Neisseria to provide a timely overview of the field. Topics covered include: the link between pathogenesis and important metabolic pathways; vaccine development; antibiotic resistance; transcriptomics of regulatory networks; regulatory small RNAs; interactions with neutrophils; and advances in humanized mouse models. An essential guide for research scientists, advanced students, clinicians and other professionals working with Neisseria, this book is a recommended text for all microbiology libraries. read more ...
Molecular Diagnostics: Current Research and Applications
Edited by: Jim Huggett and Justin O'Grady
Published: 2014
Hardback: ISBN 978-1-908230-41-6 £159, $319. Ebook: ISBN 978-1-908230-64-5 £159, $319
The editors of this book have commissioned an excellent series of chapters representing two key molecular diagnostic areas: cancer and infectious diseases. The cancer section deals with the challenges in identifying genetic, epigenetic and transcriptomic biomarkers. The infectious disease section describes the current clinical applications of molecular diagnostics for the detection of viral, bacterial and fungal pathogens as well as an example of the use of molecular diagnostics outside the clinic environment. A cautionary tale describing what can go wrong when molecular methods are applied incorrectly is also provided and makes fascinating reading. A substantial component of the book is dedicated to the process of translating a preclinical test to the bedside and describes the progress in the near patient point-of-care molecular diagnostics market. This is a fundamental consideration for successful translation of diagnostics tests from bench to bedside and is crucial for molecular diagnostics to have an impact on patient care. The final chapter offers a prediction of future trends in the molecular diagnostics of infectious diseases. This volume is essential reading for anyone involved in the development or application of molecular diagnostics and is recommended for all clinical diagnostics laboratories. read more ...
Phage Therapy: Current Research and Applications
Edited by: Jan Borysowski, Ryszard Międzybrodzki and Andrzej Górski
Published: 2014
Hardback: ISBN 978-1-908230-40-9 £180, $360. Ebook: ISBN 978-1-908230-74-4 £180, $360
This volume is an essential reference for anyone interested in phage therapy and a highly recommended book for everyone working in the areas of antibacterial resistance, antimicrobial development, bacteriophage research, biocontrol and biodetection. read more ...
Campylobacter Ecology and Evolution
Edited by: Samuel K. Sheppard
Published: 2014
Hardback: ISBN 978-1-908230-36-2 £159, $319. Ebook: ISBN 978-1-908230-98-0 £159, $319
In this book, internationally recognised experts critically review and provide novel insights into important aspects Campylobacter research. The book is divided into four sections: Mechanisms of evolution; Adaptations to host colonisation; Molecular epidemiology; and Ecology in poultry. The topics covered range from the mechanisms of evolution through the processes of host colonisation and within host adaptation, and epidemiology to considerations of their broader biochemical and ecological properties. An important resource summarising our current knowledge of Campylobacter ecology and evolution, this book is essential reading for all researchers working with Campylobacter and related organisms. read more ...
Mollicutes: Molecular Biology and Pathogenesis
Edited by: Glenn F. Browning and Christine Citti
Published: 2014
Hardback: ISBN 978-1-908230-30-0 £159, $319. Ebook: ISBN 978-1-908230-93-5 £159, $319
In this book acknowledged experts critically review the most recent advances in the evolution, genetics and molecular pathogenesis of these important pathogens. Topics covered include: taxonomy; genomic mosaics; molecular genetic tools for mollicutes; identification and characterisation of virulence genes in mycoplasmas; post-translational modification of proteins; multifunctional cytoadherence factors; the glycocalyx; glycosidase activity; phase and antigenic variation in mycoplasmas; spiroplasma transmission from insect to plants; cytoskeletons organization; gliding mechanism of the Mycoplasma pneumoniae subgroup; biofilm formation by mycoplasmas; host immune responses to mycoplasmas; and emerging antimicrobial resistance in mycoplasmas of humans and animals. An essential book for researchers working with mollicutes and recommended reading for everyone interested in bacterial genomics, bacterial pathogenesis and the evolution of bacterial virulence. read more ...
Fusarium: Genomics, Molecular and Cellular Biology
Edited by: Daren W. Brown and Robert H. Proctor
Published: 2013
Hardback: ISBN 978-1-908230-25-6 £159, $319. Ebook: ISBN 978-1-908230-75-1 £159, $319
In this book, an international group of researchers critically reviews the most important current research on the genomics and molecular and cellular biology of Fusarium. The opening chapter provides a fascinating introduction to the organism. Subsequent chapters deal with: sex and fruiting; genome structural dynamics; molecular genetics and genomic approaches to study pathogenesis in wheat; proteomic analysis of the fungus-host interaction; Repeat-induced point mutation, DNA methylation and heterochromatin in Fusarium graminearum (Gibberella zeae); nitrogen regulation network and its impact on secondary metabolism and pathogenicity; diversity of polyketide synthases; and plant responses to Fusarium metabolites. This volume is essential for everyone working with Fusarium and other filamentous fungi. A recommended book for all biology, agriculture and medical libraries. read more ...
Prions: Current Progress in Advanced Research
Edited by: Akikazu Sakudo and Takashi Onodera
Published: 2013
Hardback: ISBN 978-1-908230-24-9 £120, $240. Ebook: ISBN 978-1-908230-89-8 £120, $240
In this book, renowned prion experts review the most recent advances to provide a timely and up-to-date overview of the field. Topics covered include: prion proteins (PrP) and their family members; PrP function; molecular mechanisms of prions diseases; immunological strategies for the prevention and treatment of prion disease; microglial inflammation and prion diseases; methods for prion inactivation; clinical aspects of CJD; the BSE and scrapie prions; chronic wasting disease; future strategies for the prevention and treatment of prion diseases. The book closes with a look to the future of prion research. Essential reading for everyone with an interest in prions and prion diseases. A recommended book for all biology, veterinary and medical libraries. read more ...
Microbial Efflux Pumps: Current Research
Edited by: Edward W. Yu, Qijing Zhang and Melissa H. Brown
Published: 2013
Hardback: ISBN 978-1-908230-21-8 £159, $319. Ebook: ISBN 978-1-908230-86-7 £159, $319
Infectious diseases caused by bacteria remain a leading cause of death worldwide. Many of the antibiotics developed to combat bacterial infections have been rendered almost impotent due to the rapid evolution and spread of antibiotic resistance. A common and major resistance mechanism, the efflux system, enables bacteria to extrude structurally diverse antimicrobials, facilitating survival in toxic environments. The pumps also have important physiological functions, play major roles in bacterial pathogenesis and are distributed widely across diverse bacterial species. In addition a single species may harbour several different types of efflux systems: of these, active efflux has proven to be one of the most successful detoxification mechanisms used by both Gram-positive and -negative pathogens. Unravelling the intricacies of the microbial efflux systems is essential for the development of new strategies to overcome antimicrobial resistance. This has inspired a plethora of multidisciplinary research projects that have focused on the biochemistry, bioinformatics, structural and molecular biology of this fascinating field. With contributions from leading researchers in the field, this book reviews the most important current research and summarizes the most spectacular discoveries. Essential reading for all scientists with an interest in drug and antibiotic resistance in a range of different microorganisms. read more ...
Cytomegaloviruses: From Molecular Pathogenesis to Intervention
Edited by: Matthias J. Reddehase
Published: 2013
Hardback: ISBN 978-1-908230-18-8 £300, $600. Ebook: ISBN 978-1-908230-83-6 £300, $600
This two-volume work, is an updated and upgraded 2nd-edition of 'Cytomegaloviruses: Molecular Biology and Immunology' (2006). The title 'Cytomegaloviruses: From Molecular Pathogenesis to Intervention' reflects its expanded commitment not only to cover cutting-edge basic science but also to include the translation of this to clinical science. In an interdisciplinary approach to understanding CMV disease and outlining options for prevention and treatment, leading international experts provide comprehensive and authoritative reviews on literally every aspect of current research with an unprecedented completeness, integrating research on human CMV and insights gained from experimental animal models. With contributions from over 100 authors, the topics covered in the 46 chapters range from the most contemporary systems biology 'omics' views on virus-host interaction to considerations of the health and economic impact of CMV disease for evaluating the hoped-for benefit from a vaccine. Volume I focuses on basic science laying the foundations of clinical research, starting with the comparative genomics of primate CMVs and ending with the emerging field of humanized mouse models. Volume II is more clinically-oriented, covering the immune response to CMV, the most pressing medical problems in the newborn and in transplantation patients, as well as diagnostics, the management of antiviral drug resistance, the state and future of a CMV vaccine, and the potential of using CMV as a vaccine vector to fight unrelated diseases. The book closes with a critical survey of disputed associations between CMV and atherosclerotic cardiovascular disease, certain tumors such as Glioblastoma Multiforme, and the phenomenon of 'immune senescence' in the elderly. The book is liberally illustrated with more than 200 figures, most of which are in full colour. There are over 60 tables and several thousand references which enhance the book even further making it an invaluable source of information. Essential reading for all virologists with an interest in cytomegaloviruses, for all clinicians in pediatric intensive-care medicine and at transplantation centers, for scientists working on antiviral drug and vaccine development, as well as for public health service and science funding system authorities. read more ...
Oral Microbial Ecology: Current Research and New Perspectives
Edited by: Nicholas S. Jakubovics and Robert J. Palmer Jr.
Published: 2013
Hardback: ISBN 978-1-908230-17-1 £159, $319. Ebook: ISBN 978-1-908230-82-9 £159, $319
Expert authors from around the world provide an update on recent developments in the burgeoning field of oral microbial ecology. The focus of the book is on the most topical areas in oral microbiology and the volume is a major new work in the field. The chapters are arranged into five sections: microbial populations in oral biofilms, the structure of oral biofilms, communication and sensing within biofilms, health to disease - the microbial community perspective, and new approaches for oral biofilm control. Specialist authors contribute chapters on various topics including population biology, detection and culture of novel oral bacteria, bacterial catabolism of salivary substrates, structural organization of oral biofilms, the extracellular polysaccharides matrix, extracellular proteins and DNA in the matrix, a holistic view of inter-species bacterial interactions, environmental sensory perception, microbial community interactions of Streptococcus mutans, biofilms in periodontal health and disease, oral biofilms as a reservoir for pathogens, oral biofilms as a device for therapeutic agents, and probiotics in oral healthcare. The book is an essential text for scientists interested in oral microbiology, bacterial communities and biofilms and is recommended reading for anyone working in the areas of oral health, and the pathogenesis of dental caries and periodontal disease. A recommended book for all microbiology laboratories. read more ...
Rhabdoviruses: Molecular Taxonomy, Evolution, Genomics, Ecology, Host-Vector Interactions, Cytopathology and Control
Edited by: Ralf G. Dietzgen and Ivan V. Kuzmin
Published: 2012
Hardback: ISBN 978-1-908230-11-9 £159, $319
Written by a select group of world-renowned virologists, this book reviews all of the most recent advances in rhabdovirology providing a timely overview of the field. Most contributions are written from a molecular and genomic perspective and contain expert insights upon which to base future research efforts. Topics covered include: morphology, genome organization, transcription, virus replication, taxonomy, characterization, virus evolution, vesiculovirus, lyssavirus, ephemeroviruses, fish novirhabdoviruses, the sigma viruses of Drosophila, virus-host protein interaction of plant-adapted rhabdoviruses, cereal-infecting rhabdoviruses, and rabies prevention and control including lyssavirus vaccine development. The book is a 'must read' for all virologists working on these and related negative sense RNA viruses. A recommended book for all biology, veterinary and medical libraries. read more ...
Malaria Parasites: Comparative Genomics, Evolution and Molecular Biology
Edited by: Jane M. Carlton, Susan L. Perkins and Kirk W. Deitsch
Published: 2013
Hardback: ISBN 978-1-908230-07-2 £159, $319. Ebook: ISBN 978-1-908230-76-8 £159, $319
Since the publication of the first two Plasmodium genome sequences in 2002, numerous other parasite genomes have been sequenced. These include the genomes of several more Plasmodium species as well as those of other apicomplexans, including species of Toxoplasma, Cryptosporidium, Babesia, and Eimeria. This wealth of genome sequence data has provided researchers with a powerful new tool, comparative genomics, which has revolutionised research in this area. In this book, expert authors from around the world comprehensively review the current advances in Plasmodium comparative genomics, highlighting the fascinating new insights into parasite evolution and molecular biology that have ensued. Topics include: Plasmodium taxonomy and phylogeny; the apicomplexan genomic landscape; the 'art' of sequencing Plasmodium genomes; diversity of Plasmodium falciparum and Plasmodium vivax genomes; Plasmodium functional genomics; Plasmodium experimental genetic crosses; P. falciparum epigenetic modification and transcriptional regulation; Plasmodium invasion of host red blood cells; protein export and trafficking by malaria parasites; Plasmodium-mosquito vector interactions; and a practical guide to many of the revolutionary new techniques and molecular tools for Plasmodium research. The book is essential reading for every researcher working with malaria parasites and related organisms, from the PhD student to the experienced scientist, and is a recommended text for all parasitologists. read more ...
Foodborne and Waterborne Bacterial Pathogens: Epidemiology, Evolution and Molecular Biology
Edited by: Shah M. Faruque
Published: 2012
Hardback: ISBN 978-1-908230-06-5 £159, $319
Food- and waterborne pathogens continue to be a major cause of mortality in developing countries and cause significant morbidity in developed nations. Important pathogens include species or strains of Salmonella, Vibrio, Shigella, Escherichia coli, Yersinia, Staphylococcus and Campylobacter. Understanding the molecular basis of pathogenesis, its evolution and spread is critical to the development of new strategies for disease prevention and control. The application of genomic and other omics technologies in recent years has led to a deluge of information in this area, making it difficult for the busy researcher to keep abreast of developments. This timely book aims to capture the essence of the latest developments to provide a timely overview of the field. Written by leading bacteriologists, chapters cover all the important bacteria and review topics such as pathogenic properties, population genetics, virulence genes, evolution, drug resistance, epidemiology, detection, identification and control strategies. Other topics include the molecular basis for enhanced transmissibility of waterborne pathogens, their mode of survival in the environment, and the evolution of new species with increased fitness both as pathogens and environmental organisms. Essential reading for microbiologists working with these and related pathogens. read more ...
Yersinia: Systems Biology and Control
Edited by: Elisabeth Carniel and B. Joseph Hinnebusch
Published: 2012
Hardback: ISBN 978-1-908230-05-8 £159, $319
Three members of the genus Yersinia are important human pathogens, causing diseases ranging from the deadly Plague (Yersinia pestis) to a relatively mild gastroenteritis (Y. enterocolitica and Y. pseudotuberculosis). Plague, a re-emerging disease, is endemic in many parts of the world. The extraordinary pathogenicity of Y. pestis makes it a potential bioterrorist weapon. On the other hand, the two enteropathogenic Yersinia species represent the third most common bacterial cause of gastroenteritis in Europe and probably elsewhere, although their prevalence is largely underestimated. This and the emergence of antibiotic resistant Y. pestis in recent years highlight the urgency to understand the mechanisms of pathogenicity and the need to devise new strategies for the prevention and control of human pathogenic Yersinia. In this book, leading Yersinia researchers review the hot topics in the systems biology and control of these important bacteria. Topics include: transcriptome analysis of the bacterial response to the host and of the host response to a Yersinia infection; proteome analysis of the bacterial and host responses; treatment and antibiotic resistance; vaccines; surveillance and control. Essential reading for everyone working on Yersinia and related organisms and recommended reading for researchers interested in biodefence, microbial genomics and the evolution of microbial virulence. read more ...
Bacterial Spores: Current Research and Applications
Edited by: Ernesto Abel-Santos
Published: 2012
Hardback: ISBN 978-1-908230-00-3 £159, $319
In this book expert authors from around the world contribute comprehensive, up-to-date reviews on the current state of our knowledge of bacterial endospores. Topics covered include: gene regulation of sporulation, fruiting body development in Myxococcus xanthus, sporulation in Streptomyces, structure and composition of the bacterial spore, mechanisms of spore survival, germination of spores, spore peptidoglycan degradation, water and cations flux during sporulation and germination, the spore as an infectious agent, heterogeneity in spore populations, detection of bacterial spores, and the expression of recombinant proteins using spores. An essential text for everyone involved in spore research, the expression of recombinant proteins and pathogen detection, this book is also recommended for all scientists that like to keep up with cutting-edge research in microbiology and biotechnology. read more ...
Small DNA Tumour Viruses
Edited by: Kevin Gaston
Published: 2012
Hardback: ISBN 978-1-904455-99-8 £159, $319
In this timely book leading scientists from around the world review current hot-topics in this area providing a fascinating overview of the molecular biology of these viruses and their interactions with the host. Topics covered include: HPV infections and the production of HPV virion stocks; viral oncoproteins and their functions; the replication and maintenance of viral genomes; virus induced alterations in cellular miRNAs; viral deregulation of DNA damage responses; the initiation of viral DNA replication; induction of genomic instability by viral oncoproteins; targeting of PML proteins and PML nuclear bodies by these viruses; adenoviruses and gene therapy. Essential reading for scientists and researchers working on small DNA tumour viruses and their associated diseases and a recommended text for anyone involved with DNA replication, DNA damage responses and genome instability, virus-host interactions, viral tumourigenesis or antiviral drug development. read more ...
Bacillus: Cellular and Molecular Biology (Second edition)
Edited by: Peter Graumann
Published: 2012
Hardback: ISBN 978-1-904455-97-4 £180, $360
Extensively revised and updated, the new edition of this valuable reference work provides a comprehensive and up-to-date analysis of the current knowledge and new research in Bacillus molecular and cellular biology. Under the expert guidance of the editor Peter Graumann, renowned authors from around the world have contributed critical reviews on the most recent and topical research. Subjects covered include chromosome replication, DNA repair, chromosome segregation, cell division, transcription and translation, RNA-mediated regulation, general and regulatory proteolysis, the actin-like MreB cytoskeleton, the membrane proteome, the cell wall, endospore formation, biofilms, multicellularity and social behaviour, competence and transformation. An essential book for anyone interested in Bacillus and an important reference volume for those working in fields as diverse as medicine, biotechnology, agriculture, food and industry. A recommended book for all microbiology laboratories. read more ...
Microbial Biofilms: Current Research and Applications
Edited by: Gavin Lear and Gillian D. Lewis
Published: 2012
Hardback: ISBN 978-1-904455-96-7 £159, $319
In this book, leading scientists provide an up-to-date review of the latest scientific research on these fascinating microbial communities and predict future trends and growth areas in biofilm-related research. Under the expert guidance of the editors Gavin Lear and Gillian Lewis, authors from around the world have contributed critical reviews on the most topical aspects of current biofilm research. Subjects covered include quorum sensing and social interactions in microbial biofilms, biofilms in disease, plant-associated biofilms, biofilms in the soil, applications in bioremediation, biofilms in wastewater treatment, corrosion and fouling, aquatic biofilms, microbial fuel cells, and catalytic biofilms. The book is essential for everyone interested in biofilms and their applications. It is also highly recommended for environmental microbiologists, soil scientists, medical microbiologists, bioremediation experts and microbiologists working in biocorrosion, biofouling, biodegradation, water microbiology, quorum sensing and many other areas. read more ...
Brucella: Molecular Microbiology and Genomics
Edited by: Ignacio López-Goñi and David O'Callaghan
Published: 2012
Hardback: ISBN 978-1-904455-93-6 £159, $319
Written by highly acclaimed Brucella scientists, this book comprehensively reviews the most important advances in the field. Opening chapters focus on genetic diversity within Brucella, covering both classical and new species. Particular emphasis is given to how comparative genomics has led to advances in molecular diagnostics, taxonomy and phylogeny. Following chapters cover proteomic analysis, transcriptomic analysis, the VirB type IV secretion system, signalling complexes, e.g. the BvrR/BvrS two-component regulatory system and quorum sensing. These chapters highlight the intricate interplay between factors involved in virulence. Another chapter discusses the role of the Brucella cell envelope in bacterial virulence and evasion of host defences. The final two chapters review the current strategies for the development of novel antibacterial agents and improved vaccines. This volume is essential reading for everyone with an interest in Brucella and brucellosis. It is also recommended reading for the wider body of scientists, veterinarians and MDs with an interest in microbial diagnostics, microbial pathogenesis, host-parasite interactions, cellular microbiologists and immunologists and vaccine development scientists. read more ...
Molecular Virology and Control of Flaviviruses
Edited by: Pei-Yong Shi
Published: 2012
Hardback: ISBN 978-1-904455-92-9 £180, $360
The editor of Molecular Virology and Control of Flaviviruses has assembled an up-to-date and cutting-edge anthology from the leading experts in the flavivirus field. Chapters are balanced by contributions from established investigators, who have dedicated their careers to flavivirus research, with those from newcomers who have recently made significant contributions to the flavivirus field. The book opens with a brief introduction then divides into two sections: Molecular Virology (Chapters 2-9) and Virus Prevention (Chapters 10-15). The first section covers: virion structure; virus replication; the NS1 glycoprotein; the NS3 protein; the NS5 protein; innate immunity and flavivirus infection; host responses to flavivirus infection; and flavivirus fitness and transmission. The second section includes: vaccines; antibody therapy; small molecule antiviral development; flavivirus diagnostics; vector-virus interactions; and vector control. The book represents an important update of flavivirus research and will serve as a reference to flavivirus researchers at the graduate level and beyond. A recommended text for all virology libraries. read more ...
Bacterial Pathogenesis: Molecular and Cellular Mechanisms
Edited by: Camille Locht and Michel Simonet
Published: 2012
Hardback: ISBN 978-1-904455-91-2 £180, $360
In this book, a group of distinguished scientists from eight different countries and three continents, under the expert guidance of the editors Camille Locht and Michel Simonet, overview the molecular and cellular mechanisms of bacterial pathogenesis. The fifteen chapters are organized into five sections: approaches to the study of bacterial pathogenesis; bacterial adhesion to the cell surface and extracellular matrix of host tissues; poisoning the host by toxins; cellular invasion by bacterial pathogens; and bacterial evasion of host defences. The authors comprehensively describe the most relevant and up-to-date information on pathogenic features across the bacterial world. Aimed at the entire scientific community from students to senior scientists and physicians, the book is relevant to a broad range of people interested in the mechanisms of bacterial infectious diseases and is a recommended text for all microbiology laboratories. read more ...
Bunyaviridae: Molecular and Cellular Biology
Edited by: Alexander Plyusnin and Richard M. Elliott
Published: 2011
Hardback: ISBN 978-1-904455-90-5 £159, $319
The book is essential reading for everyone working on bunyaviruses and related viruses. A recommended text for all virology libraries. read more ...
Emerging Trends in Antibacterial Discovery: Answering the Call to Arms
Edited by: Alita A. Miller and Paul F. Miller
Published: 2011
Hardback: ISBN 978-1-904455-89-9 £180, $360
In this book, respected international experts summarize the most important concepts and pioneering strategies currently being used to develop novel antibacterials. The book opens with chapters on cellular processes that could be used as novel antibacterial targets. Examples include cell division, efflux pumps, metabolite-sensing riboswitches and bacterial secretion systems. These are followed by excellent chapters on the identification of new, naturally occurring antibacterial agents, including phage and biosynthetically engineered compounds. Understanding the host-microbe interaction and microbial communities and how they can be exploited to develop new antibacterial strategies is discussed in subsequent chapters. Other topics included are: antibacterial vaccines adjuvants, host defence peptides, antibodies, within-host models, and diagnostics. A major reference volume on antibacterial research and how it impacts on public health worldwide, the book is essential reading for everyone working in antibacterial research and is a recommended volume for all microbiology libraries. read more ...
The Biology of Paramyxoviruses
Edited by: Siba K. Samal
Published: 2011
Hardback: ISBN 978-1-904455-85-1 £180, $360
This book provides a timely and comprehensive review of current knowledge of all paramyxoviruses and is written by renowned scientists who have made seminal contributions in their respective paramyxovirus fields of expertise. Topics include: mumps virus, simian virus 5, parainfluenza viruses, Newcastle disease and related avian paramyxoviruses, Sendai virus, Hendra virus, Nipah virus, measles virus, canine distemper virus, rinderpest virus, peste des petits ruminants virus, human respiratory syncytial virus, metapneumoviruses, and new and emerging paramyxoviruses. Each chapter covers our current knowledge on history, genome organization, viral proteins, reverse genetics, epidemiology, pathogenesis, immunity, diagnosis, prevention and control and future challenges. This book is an invaluable reference source of timely information for virologists, microbiologists, immunologists, physicians, veterinarians and scientists working on paramyxoviruses. It is also strongly recommended for all medical and veterinary school libraries. read more ...
Helicobacter pylori
Edited by: Lyudmila Boyanova
Published: 2011
Hardback: ISBN 978-1-904455-84-4 £159, $319
This book highlights recent research and provides in a single volume an up-to-date summary of our current knowledge for microbiologists, clinicians and advanced students working with Helicobacter and for those wishing to enter the field. The authors offer an outstanding collection of reviews on many aspects of Helicobacter research including microbiology, virulence factors, immunology, vaccine research, epidemiology, diseases associated with the infection, antibiotic resistance, and treatment (including the use of non-antibiotic agents). A major reference volume on Helicobacter pylori and how it impacts on public health worldwide, the book is essential reading for those with an interest in the microbiology of H. pylori and is a recommended volume for all microbiology libraries. read more ...
Viruses and Interferon: Current Research
Edited by: Karen Mossman
Published: 2011
Hardback: ISBN 978-1-904455-81-3 £159, $319
In this book, a panel of international experts reviews the current hot-topics, producing a timely overview of this exciting field. The book opens with a chapter that comprehensively reviews the antiviral effects of extracellular double-stranded RNA, the "viral toxin". This is followed by chapters that review the properties of type I and type III interferons, and the role of interferon-stimulated genes. The next five chapters are devoted to understanding the diverse strategies used by clinically relevant human viruses to subvert host interferon responses. The closing chapter provides an interesting overview of the clinical application of interferon as antiviral and anticancer agents. Essential reading for every scientist involved in interferon or antiviral research and a recommended text for all virology laboratories. read more ...
Hepatitis C: Antiviral Drug Discovery and Development
Edited by: Seng-Lai Tan and Yupeng He
Published: 2011
Hardback: ISBN 978-1-904455-78-3 £180, $360
The editors of this book have recruited experts from around the world to produce a timely and well-compiled review of current HCV research with an emphasis on antiviral drug development. The chapters provide in-depth reviews of the most critical areas of research. Topics covered include: the HCV life cycle, HCV assays, HCV resources, HCV databases, HCV infection systems, models of hepatitis C infections, overview of the drug pipeline, clinical trial design, clinical virology and drug development, NS3 protease inhibitors, NS3-NS4A complex inhibitors, NS3 helicase inhibitors, NS4B targets and inhibitors, NS5A inhibitors, nucleoside inhibitors, NS5B polymerase inhibitors, glycoprotein-dependent entry, host cell targets and inhibitors, and innate immunity for HCV antiviral therapy. An essential book for scientists involved with HCV and anyone interested in antiviral drug development. A recommended text for all virology libraries. read more ...
Alphaherpesviruses: Molecular Virology
Edited by: Sandra K. Weller
Published: 2011
Hardback: ISBN 978-1-904455-76-9 £180, $360
Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections. read more ...
Vaccine Design: Innovative Approaches and Novel Strategies
Edited by: Rino Rappuoli and Fabio Bagnoli
Published: 2011
Hardback: ISBN 978-1-904455-74-5 £180, $360
In this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies. The book has been divided into two parts. The first part reviews the technologies and approaches used to identify, generate and test new vaccines. Topics include: new strategies to identify protective antigens, generation of improved adjuvants, use of alternative immunization routes, improving vaccine safety, and finding and establishing the correlates of protection. The second part of the book focuses on the development of new vaccines to replace or complement currently available products or for diseases against which prophylactic strategies are missing. Examples include vaccines against nosocomial infections, streptococci, emerging viral diseases, P. aeruginosa, and bovine mastitis. Essential reading for everyone with an interest in vaccine R & D. read more ...
Salmonella: From Genome to Function
Edited by: Steffen Porwollik
Published: 2011
Hardback: ISBN 978-1-904455-73-8 £159, $319
In this book, internationally acclaimed experts review cutting-edge topics in Salmonella genomics and molecular biology, providing a timely snapshot of the current state of research. Topics include latest approaches to sub-species level classification and phage typing of Salmonella, comparative genomics, the search for genetic determinants for survival of the bacterium in different environments and the evolution of niche specialization by Salmonella. The book also explores the latest genomic information and molecular characterizations of sRNAs and complements of fimbriae, flagella and secreted virulence factors. Moreover, S. Typhi pathogenesis, interactions of the host with intracellular Salmonella and the host's anti-Salmonella immune response are reviewed. The current knowledge on Salmonella biofilm formation and a progress report on using Salmonella as an anti-tumour tool conclude this compendium. Essential reading for all researchers working with Salmonella and related organisms, and recommended reading for other scientists working on bacterial genomics, molecular biology and bacterial molecular and cellular pathogenesis. read more ...
Insect Virology
Edited by: Sassan Asgari and Karyn N. Johnson
Published: 2010
Hardback: ISBN 978-1-904455-71-4 £180, $360
Written by internationally renowned insect virologists, chapters review the current molecular biology of all the major groups of insect pathogenic viruses and suggest future directions for research. The book is divided into three parts: 1) DNA viruses 2) RNA viruses and 3) current hot-topics in insect virology. Virus groups covered include: Ascoviruses, Baculoviruses, Densoviruses, Entomopoxviruses, Hytrosaviruses, Iridoviruses, Nudiviruses, Polydnaviruses, Dicistroviruses, Iflaviruses, Nodaviruses, Tetraviruses and Cypoviruses. The special topics chapters review exciting recent developments in insect virology including RNAi, insect antiviral responses, structural comparison of insect RNA viruses, and viral ecology. The book is essential reading for every insect virologist in both the academic and private sectors. It is also strongly recommended for other virologists, particularly those interested in virus evolution, virus structure, viral vectors, biological control of insects and insect immunity. read more ...
Bifidobacteria: Genomics and Molecular Aspects
Edited by: Baltasar Mayo and Douwe van Sinderen
Published: 2010
Hardback: ISBN 978-1-904455-68-4 £159, $319
This book brings together the expertise and enthusiasm of the leading bifidobacteria experts from around the world to provide a state-of-the art overview of the molecular biology and genomics of this exciting and important microbial genus. Topics include: ecology, genomics, comparative genomics, metabolism, acid and bile resistance, stress response, probiotic properties, antimicrobial activity, interaction with the intestinal mucosa, safety assessment of bifidobacteria, synthesis and utilization of exopolysaccharides and prebiotics, antibiotic resistance/susceptibility profiles, viability and stability in commercial preparations, mobile genetic elements, cloning vectors and genetic manipulation of bifidobacteria. Essential reading for every bifidobacteria researcher, from the PhD student to the experienced scientist, and recommended reading for everyone with an interest in probiotics. read more ...
Caliciviruses: Molecular and Cellular Virology
Edited by: Grant S. Hansman, Xi Jason Jiang and Kim Y. Green
Published: 2010
Hardback: ISBN 978-1-904455-63-9 £159, $319
In this book, a panel of experts distil the most important up-to-date research findings in their respective calicivirus field of study producing timely and comprehensive reviews. Each chapter gives the reader a brief introduction to the topic followed by a descriptive discussion of the past and present research areas. Topics include: norovirus epidemiology; calicivirus contamination of the environment; genome organization and recombination, proteolytic cleavage and viral proteins; viral protein structures; virus-host interactions; calicivirus reverse genetics and replicon systems; feline calicivirus; swine calicivirus; murine norovirus pathogenesis and immunity; murine norovirus translation, replication and reverse genetics; and lagoviruses. This book is essential reading for all virologists working on caliciviruses and related viruses and is recommended for all virology, immunology and molecular biology laboratories. read more ...
Epstein-Barr Virus: Latency and Transformation
Edited by: Erle S. Robertson
Published: 2010
Hardback: ISBN 978-1-904455-62-2 £159, $319Paperback: ISBN 978-1-904455-64-6 £60, $120 In this book, expert EBV virologists comprehensively review this important subject from a genetic, biochemical, immunological, and cell biological perspective. Topics include: latent infections, EBV leader protein, EBNA-1 in viral DNA replication and persistence, EBNA-2 in transcription activation of viral and cellular genes, the nuclear antigen family 3 in regulation of cellular processes, molecular profiles of EBV latently infected cells, latent membrane protein 1 oncoprotein, regulation of latency by LMP2A, role of noncoding RNAs in EBV-induced cell growth and transformation and the regulation of EBV latency by viral lytic proteins. This book is essential reading for all EBV virologists as well as clinical and basic scientists working on oncogenic viruses. read more ...
Anaerobic Parasitic Protozoa: Genomics and Molecular Biology
Edited by: C. Graham Clark, Patricia J. Johnson and Rodney D. Adam
Published: 2010
Hardback: ISBN 978-1-904455-61-5 £159, $319
In this book internationally acclaimed researchers critically review the most important aspects of research on anaerobic parasitic protozoa, providing the first coherent picture of their genomics and molecular biology since the publication of the genomes. Chapters are written from a molecular and genomic perspective and contain speculative models upon which future research efforts can be based. Topics include: the genomes of Entamoeba histolytica, Trichomonas vaginalis, Giardia and other diplomonads; the cytoskeletons of Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis; genomic analyses and manipulation of gene expression in Entamoeba histolytica; nuclear and chromosomal structure and replication in Giardia; and the mitochondrion-like organelles of a fourth anaerobe, Blastocystis. Essential reading for all researchers working with these protozoa and related organisms and with eukaryotic model organisms. Recommended text for all parasitology laboratories. read more ...
Lentiviruses and Macrophages: Molecular and Cellular Interactions
Edited by: Moira Desport
Published: 2010
Hardback: ISBN 978-1-904455-60-8 £159, $319
In this timely book, top lentivirus and macrophage specialists comprehensively review cutting-edge topics in the molecular and cellular biology of the lentivirus-macrophage interaction. Topics include: lentivirus tropism and disease, macrophage biology, macrophage in HIV-1 infection and disease progression, post-entry restrictions to lentiviral replication, HIV-2 tropism and disease, SHIV model of disease, the felid immunodeficiency viruses, EIAV, small ruminant lentiviruses, bovine lentiviruses, coinfections and superinfections. Essential reading for every lentivirologist and retrovirologist, this is also a recommended text for all virology, immunology and molecular biology laboratories. read more ...
Borrelia: Molecular Biology, Host Interaction and Pathogenesis
Edited by: D. Scott Samuels and Justin D. Radolf
Published: 2010
Hardback: ISBN 978-1-904455-58-5 £159, $319
Written by renowned scientists who have made seminal contributions to the field, this book is a comprehensive guide to the pathogenic Borrelia, providing researchers, advanced students, clinicians, and other professionals with an encyclopedic overview of the molecular biology of this important genus and the pathogenesis of diseases caused. Leading authorities have contributed chapters on topics such as Borrelia genomics, DNA replication, gene regulation, transcriptomics, proteomics, metabolism and physiology, cellular structure, motility and chemotaxis, genetic manipulation, evolutionary genetics, ecology, tick interactions, Lyme disease and relapsing fever pathogenesis, animal models, host response, detection, and vaccines. The volume is essential for anyone involved in Borrelia research and is strongly recommended for microbiologists, immunologists, and physicians involved in spirochete research, Lyme borreliosis, or relapsing fever. The book is a recommended reference volume for all microbiology libraries. read more ...
Influenza: Molecular Virology
Edited by: Qinghua Wang and Yizhi Jane Tao
Published: 2010
Hardback: ISBN 978-1-904455-57-8 £159, $319
In this timely book, internationally renowned scientists critically review the current research and the most important discoveries in this highly topical field. Subjects covered include the NS1 protein of influenza A virus, the structure of influenza NS1, influenza B hemagglutinin, influenza A nucleoprotein, influenza A hemagglutinin glycoproteins, the M2 channel, virulence genes of the 1918 pandemic influenza, influenza virus polymerase, gene diagnostic microarrays, and computer-assisted vaccine design. Highly informative and well referenced, this book is essential reading for all influenza specialists and is recommended reading for all virologists, immunologists, molecular biologists, public health scientists and research scientists in pharmaceutical companies. read more ...
RNA Interference and Viruses: Current Innovations and Future Trends
Edited by: Miguel Angel Martínez
Published: 2010
Hardback: ISBN 978-1-904455-56-1 £159, $319
In this book, expert RNAi specialists from around the world have teamed up to produce a timely and thought-provoking review of the area. The two central themes are: 1) the latest findings on RNAi-virus interactions and 2) progress in the development of RNAi-based antiviral therapeutics. A number of chapters explain general concepts concerned with the role of RNAi in natural antiviral defense mechanisms, other chapters discuss how to improve the efficacy and safety of RNAi-based antiviral drugs, while others describe how this technology is being developed as a new therapeutic tool for fighting specific viruses, including HIV, HCV and respiratory viruses. Authors also outline potential new avenues for research thus providing a stimulus for further research. Essential reading for researchers involved in RNAi or antiviral research and a recommended text for all virology laboratories. read more ...
Retroviruses: Molecular Biology, Genomics and Pathogenesis
Edited by: Reinhard Kurth and Norbert Bannert
Published: 2010
Hardback: ISBN 978-1-904455-55-4 £159, $319
Written by the top retroviral specialists, this book reviews the genomics, molecular biology, and pathogenesis of these important viruses, comprehensively covering all the recent advances. Topics include: host and retroelement interactions, endogenous retroviruses, retroviral proteins and genomes, viral entry and uncoating, reverse transcription and integration, transcription, splicing and RNA transport, pathogenesis of oncoviral infections, pathogenesis of immunodeficiency virus infections, retroviral restriction factors molecular vaccines and correlates of protection, gammaretroviral and lentiviral vectors, non-primate mammalian and fish retroviruses, simian exogenous retroviruses, and HTLV and HIV. Essential reading for every retrovirologist and a recommended text for all virology and molecular biology laboratories. read more ...
Metagenomics: Theory, Methods and Applications
Edited by: Diana Marco
Published: 2010
Hardback: ISBN 978-1-904455-54-7 £159, $319
This book addresses in a coherent manner the diverse and multiple aspects of metagenomics and the multiplicity of its potential applications. Renowned authors from around the world have contributed chapters covering the new theoretical insights, the more recent applications, and the dynamically developing methods of data acquisition and analysis. Topics include: Conceptual frameworks, tools and methods, integration of complementary approaches, horizontal gene transfer, analysis of complex microbial communities, public data resources, plant-microbe interactions, bioremediation, industrial bioproducts, archaeal metagenomics, bioprospecting novel genes, the human microbiome, and philosophical themes in metagenomics. The book is essential reading for all researchers currently performing metagenomics studies and is highly recommended for all students and scientists wishing to increase their understanding of this field. read more ...
Aspergillus: Molecular Biology and Genomics
Edited by: Masayuki Machida and Katsuya Gomi
Published: 2010
Hardback: ISBN 978-1-904455-53-0 £159, $319
In this book leading Aspergillus researchers review and summarise the most important aspects of Aspergillus molecular biology and genomics. The book opens with a fascinating overview of the genus Aspergillus. This is followed by in-depth reviews of the Aspergillus molecular systematics, comparative genomics, bioinformatics and systems biology of Aspergillus, transcriptional regulation, genetics and genomics of sexual development of A. nidulans, genomics and secondary metabolism, ecology, development and gene regulation in A. flavus, functional systems biology, and novel industrial applications of A. oryzae genomics. Essential reading for everyone with an interest in Aspergillus and related fungi. read more ...
Neisseria: Molecular Mechanisms of Pathogenesis
Edited by: Caroline Genco and Lee Wetzler
Published: 2010
Hardback: ISBN 978-1-904455-51-6 £159, $319
This important reference volume provides research scientists, advanced students, clinicians, and other professionals with a comprehensive update on the current understanding of the molecular mechanisms of pathogenesis in Neisseria. The editors have assembled a team of highly regarded scientists, over 40 contributors, to describe the latest, up-to-date research, theory and clinical significance of molecular mechanisms in meningococcal disease. Leading authorities have contributed chapters on topics such as gene expression, genomics, biofilms, denitrification, adhesion strategies and mechanisms of cellular invasion. A section on the host response to neisserial infection covers inate immunity, complement, apoptosis, and acquired immunity while a section devoted to clinical correlation deals with vaccine development, epidemiology and antibiotic resistance. The volume is highly recommended for microbiologists, epidemiologists and clinicians involved with Neisseria research or meningococcal disease and is a recommended text for all microbiology libraries. read more ...
Frontiers in Dengue Virus Research
Edited by: Kathryn A. Hanley and Scott C. Weaver
Published: 2010
Hardback: ISBN 978-1-904455-50-9 £159, $319
This book brings together a panel of expert dengue virologists to produce a timely review of the rapidly expanding dengue research literature. In addition authors identify the most pressing questions that remain to be answered, thus providing a stimulus for future research. Topics include: evolutionary history, epidemiology, translation and processing of the viral polyprotein, viral replication, the role of the viral untranslated regions, pathogenesis, host response to DENV, development of animal models, DENV-mosquito interactions, dynamics of dengue virus transmission, emergence of DENV from its ancestral, sylvatic cycle, vaccines, novel anti-dengue drugs, and passive immunotherapy. Essential reading for every dengue virologist and highly recommended for all flavivirus and arbovirus virologists. read more ...
ABC Transporters in Microorganisms: Research, Innovation and Value as Targets against Drug Resistance
Edited by: Alicia Ponte-Sucre
Published: 2009
Hardback: ISBN 978-1-904455-49-3 £159, $319
This concise volume describes the latest, up-to-date theory, methodology and applications of ABC transporters in microorganisms. The topics include the structure, physiology and evolution of ABC transporters, as well as their special characteristics in specific microorganisms including bacteria, yeast, trypanosomes and malaria parasites. In particular the book describes the most recent research and innovations relative to the role of ABC transporters in the design of strategies to circumvent drug resistance in microorganisms. Each chapter comprises an exhaustive review of the particular topic and provides insights into the future of the field both from the scientific and clinical perspective. Essential reading for anyone involved in this field and a recommended volume for all microbiology laboratories. read more ...
Pili and Flagella: Current Research and Future Trends
Edited by: Ken Jarrell
Published: 2009
Hardback: ISBN 978-1-904455-48-6 £159, $319
This book, the first for many years on this important topic, brings together some of the top scientists in the field and describes the current knowledge and latest research on prokaryotic pili and flagella. The emphasis of the chapters is on the molecular biology, genetics, structure, assembly and function of these structures. Topics include biogenesis, structure, and function of various pili in Gram-negative and Gram-positive organisms, flagellar gene expression, structure and assembly, the flagella motor, posttranslational modifications of flagella systems, lateral flagella systems, the origin and evolution of flagella, applications of flagella as a surface display and expression system, and a chapter on the flagella and pili of Archaea. A recommended text for all microbiology laboratories and an essential volume for anyone involved in microbial adhesion, pathogenesis, virulence, structural biology, host colonization and motility. read more ...
Lab-on-a-Chip Technology (Vol. 2): Biomolecular Separation and Analysis
Edited by: Keith E. Herold and Avraham Rasooly
Published: 2009
Hardback: ISBN 978-1-904455-47-9 £159, $319
The editors of this book have brought together expert authors from many countries to produce a comprehensive volume focusing on the applications of LOC technology in the biomedical and life sciences. The first section includes chapters on LOC biomolecule separation. Separation of biomolecules is an important element of various clinical laboratories and is required for many "down stream" analytical applications. Various electrophoresis and liquid chromatography applications for proteins and DNA are described as well as methods for cell separation, with an emphasis on blood cell separation, which have many important clinical applications. The second part includes chapters on analysis and manipulation technologies. Authors describe protein, genetic (mainly PCR) and transcriptome analysis with examples from research and clinical applications, as well as cell manipulation and analysis including cell viability analysis and microorganism capturing. A skillful selection of topics of exceptional importance to current science ensures that this book will be of major value to a wide range of molecular biologists, clinical scientists, microbiologists, biochemists and anyone interested in LOC technology or developing applications for LOC devices. read more ...
Lab-on-a-Chip Technology (Vol. 1): Fabrication and Microfluidics
Edited by: Keith E. Herold and Avraham Rasooly
Published: 2009
Hardback: ISBN 978-1-904455-46-2 £159, $319
This invaluable book describes the latest methods and novel technologies being developed for the fabrication of LOC devices and new approaches for fluid control and manipulation. Expert authors from around the world describe and discuss the newest technologies for the prototyping of devices, including replication and direct machining methods of fabrication. Part I of the book covers all aspects of fabrication including laser micromachining, silicon and glass micromachining, PMMA and COC microfluidic substrates, and xurography (LOC prototyping with a cutting plotter). Part II focuses on fluid control and manipulation for LOC systems. As well as providing examples of the use of pumps in microfluidics, topics covered include electrokinetic pumping (electroosmois), electrochemical pumping and electrowetting, and the fabrication of a microchip for rapid polymerase chain reaction (PCR). This comprehensive volume presents the current technologies in the field and includes theoretical and technical information to enable both the understanding of the technology and the reproduction of experiments. The book aims to help the reader to understand current LOC technologies, to perform similar experiments, to design new LOC systems and to develop new methodologies and applications. An essential book for biologists and clinicians using LOC technology and developing applications and also for engineering, chemical and physical science researchers developing analytical technologies. The book will also be useful as a teaching tool for bioengineering, biomedical engineering and biology. read more ...
Bacterial Polysaccharides: Current Innovations and Future Trends
Edited by: Matthias Ullrich
Published: 2009
Hardback: ISBN 978-1-904455-45-5 £159, $319
In this timely book a cohort of experienced and authoritative experts review the most important innovations in research on and biotechnological applications of bacterial polysaccharides. The book takes an interdisciplinary view that examines this fascinating subject area in detail from molecular biology, genome-, transcriptome- and proteome-wide perspectives, and looks at the ecological aspects and systems biology approaches. Hence the book provides a sound basis for future research directions including high efficiency applications of bacterial polysaccharides in medicine, the food industry, and renewable energy production. Topics include: peptidoglycan, lipopolysaccharide, arabinogalactan, capsule gene expression in Escherichia coli, immune response to polysaccharides, polysaccharides from periodontopathic bacteria, role in dental plaque, biofilms, levan, amylovoran and much more. Essential reading for everyone with an interest in bacterial polysaccharides, from the PhD student to the experienced scientist, as it provides a timely review of the current and most topical areas of research. read more ...
Microbial Toxins: Current Research and Future Trends
Edited by: Thomas Proft
Published: 2009
Hardback: ISBN 978-1-904455-44-8 £159, $319
Essential reading for everyone with an interest in microbial toxins and recommended reading for other scientists with an interest in bioterrorism, microbial pathogenesis, and microbial genomics. read more ...
Acanthamoeba: Biology and Pathogenesis
Author: Naveed Khan
Published: 2009
Hardback: ISBN 978-1-904455-43-1 £159, $319
This compilation will serve as an essential reference for parasitologists, microbiologists, immunologists, and physicians in the field of basic and medical microbiology, as well as an invaluable reference for new and experienced researchers who wish to understand this organism better. This book is the definitive guide to current research on this increasingly important organism. read more ...
Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis
Edited by: Karl Wooldridge
Published: 2009
Hardback: ISBN 978-1-904455-42-4 £159, $319
This extensive publication on bacterial secreted proteins, the secretory systems of bacteria and the vital role of secreted proteins in bacterial pathogenesis will be of immense value to all microbiologists, molecular biologists, public health scientists and researchers engaged in the study of pathogenesis, drug design and vaccine development. A skillful selection of topics and a panel of acknowledged experts as authors have ensured that this volume will become an important reference source for many years to come. The book is divided into two sections. The first section describes the various protein secretion systems including mechanisms for secretion across the cytoplasmic membrane of Gram-negative and Gram-positive bacteria, specialized mechanisms for secretion across the Gram-negative outer membrane, systems for transport across both membranes of Gram-negative bacteria, protein secretion systems in Gram-positive bacteria, the secretion of surface fimbrae/pili and a chapter on the less well defined pathways. Section 2 describes the protein secretion mechanisms and secreted proteins of a number of important human, veterinary and plant pathogens and their role in the pathogenicity of these organisms. The pathogens covered have been selected on the basis that there is active research on protein secretion by these pathogens and they employ a diverse array of secreted proteins and protein secretion systems. Each chapter of the book can be read in isolation, particularly the chapters in section 2. The book constitutes a broad and in-depth description of the current knowledge of bacterial protein secretion and its role in pathogenesis. A recommended reference volume for all microbiology libraries. read more ...
Lactobacillus Molecular Biology: From Genomics to Probiotics
Edited by: Åsa Ljungh and Torkel Wadström
Published: 2009
Hardback: ISBN 978-1-904455-41-7 £159, $319
This major new work focuses on recent research on the molecular biology and genomics of Lactobacillus. Written by an international team of scientists the volume is an essential reference for all medical researchers, dairy technologists, microbiologists and biotechnologists in the academic and industrial sectors. Topics covered include phylogenetics, taxonomy, comparative genomics, functional genomics, the intestinal microflora, surface proteins, stress responses, interaction with the immune system, probiotics, anti-cancer potential, and much more. Essential reading for all scientists involved with lactic acid bacteria or probiotic research and a recommended book for all microbiology laboratories. read more ...
Mycobacterium: Genomics and Molecular Biology
Edited by: Tanya Parish and Amanda Brown
Published: 2009
Hardback: ISBN 978-1-904455-40-0 £159, $319
A valuable reference text for all microbiology laboratories and essential reading for all scientists and researchers involved with mycobacteria. read more ...
Clostridia: Molecular Biology in the Post-genomic Era
Edited by: Holger Brüggemann and Gerhard Gottschalk
Published: 2009
Hardback: ISBN 978-1-904455-38-7 £159, $319
In this book internationally recognised Clostridium experts critically review the most important aspects of clostridial research, providing the first coherent picture of the organism's molecular and cellular biology in this post-genomic era. The first major focus of the book is the genetics and molecular biology of the major clostridial toxins including: botulinum and tetanus neurotoxins, C. difficile large exotoxins, C. perfringens enterotoxin, pore-forming and binary bacterial toxins. Other topics include: molecular epidemiology of C. botulinum and C. difficile, metabolic networks in C. acetobutylicum, development of genetic knock-out systems for clostridia, surface structures, anti tumor potential of clostridia, and antibiotic resistance determinants in C. difficile. Essential reading for every clostridia researcher, from the PhD student to the experienced scientist, as it provides a timely review of current research. read more ...
Plasmids: Current Research and Future Trends
Edited by: Georg Lipps
Published: 2008
Hardback: ISBN 978-1-904455-35-6 £159, $319
Written by acknowledged experts in the field, this volume provides an up to date treatment of the structure, function and application of plasmids with a particular emphasis on current and future trends. The book is aimed primarily at research scientists, graduate students and professional scientists but will also be of great interest to all molecular biologists and microbiologists involved in research or teaching. Chapters include a historical perspective on E. coli plasmids and the scientific background of the plasmids used routinely in laboratories to clone genes and to express proteins; an overview on the plasmids of archaea and eukarya; bioinformatic tools; horizontal gene transfer and the process of DNA transfer. Two entire chapters are devoted to the important medical applications of plasmids, including the correction of gene defects and vaccines to treat cancer or infectious diseases. An essential book for all molecular biology laboratories. read more ...
Pasteurellaceae: Biology, Genomics and Molecular Aspects
Edited by: Peter Kuhnert and Henrik Christensen
Published: 2008
Hardback: ISBN 978-1-904455-34-9 £159, $319
Pasteurellaceae comprise a large and diverse family of Gram-negative bacteria with members ranging from important pathogens such as Haemophilus influenzae to commensals of the animal and human mucosa. Information on the biology of these organisms has mushroomed in recent years, driven by the development of novel genetic and molecular methodologies. Since 1995, the family has been expanded from three genera to the current thirteen through the use of new genetic-based classification and identification technologies. Many members of the Pasteurellaceae family make excellent natural models for the study of bacterial pathogenesis and host-pathogen-interactions thus giving valuable insights into related human diseases. Research in this area is at a very exciting stage. In this timely book, leading international Pasteurellaceae scientists critically review the most important current research providing an up-to-date review of the molecular biology, genomics and virulence of these fascinating organisms. Topics covered include taxonomy and biodiversity, phylogeny, comparative genomics, competence, DNA uptake and transformation, proteomics and protein secretion, RTX toxins, lipopolysaccharides, biofilms, quorum sensing, antimicrobial resistance, diagnosis, and OMP and iron uptake. Each chapter is independent and can be read in isolation and as a whole the book provides an important resource summarising our current knowledge of Pasteurellaceae genomics and molecular biology. Essential reading for everyone working on Pasteurellaceae and related organisms. read more ...
Vibrio cholerae: Genomics and Molecular Biology
Edited by: Shah M. Faruque and G. Balakrish Nair
Published: 2008
Hardback: ISBN 978-1-904455-33-2 £159, $319
Written by leading V. cholerae experts, the chapters review the most important cutting-edge genetic facets of V. cholerae including its genomic organization, population genetics, molecular epidemiology, and synchronized regulation of gene expression. Other topics include the molecular basis for enhanced transmissibility of cholera during epidemics, survival of the pathogen in the environment, and above all the evolution of the species to attain increased fitness both as a pathogen and an environmental organism. Essential reading for everyone with an interest in Vibrio and recommended reading for other scientists working in microbial pathogenesis, microbial genomics and antimicrobial research. read more ...
Pathogenic Fungi: Insights in Molecular Biology
Edited by: Gioconda San-Blas and Richard A. Calderone
Published: 2008
Hardback: ISBN 978-1-904455-32-5 £159, $319
In this book a panel of expert international mycologists critically review the most important cutting-edge topics. Chapters are written from a molecular and genomic perspective and through the provision of extensive reference sections positively encourage readers to pursue the subject in greater detail. Topics include: gene expression and regulation, heterozygosity in Candida, molecular diagnosis, regulation of the host-fungal interaction, the development of anti-fungals, signal transduction, and mechanisms of multi-drug resistance. Essential reading for everyone with an interest in pathogenic fungi including: mycologists, biotechnologists, molecular biologists, and pharmaceutical and biotechnology companies. read more ...
Helicobacter pylori: Molecular Genetics and Cellular Biology
Edited by: Yoshio Yamaoka
Published: 2008
Hardback: ISBN 978-1-904455-31-8 £159, $319
A useful introduction to the subject for new researchers and an invaluable reference for the experienced researcher, this book is essential reading for all researchers working with Helicobacter and related organisms. read more ...
Corynebacteria: Genomics and Molecular Biology
Edited by: Andreas Burkovski
Published: 2008
Hardback: ISBN 978-1-904455-30-1 £159, $319
This volume brings together the expertise and enthusiasm of today's leading experts to provide a description of the current state-of-the-art molecular biology toolbox available for Corynebacterium research, including global analyses techniques such as comparative genomics, transcriptome, proteome and metabolome analysis as well as the most recent knowledge on Corynebacterium promoter structures and vector systems. Furthermore, topics such as regulatory networks controlling carbon, nitrogen, phosphorus, sulphur and iron metabolism, cell wall structure, proteolysis and environmental stress response are covered. Essential reading for all Corynebacterium scientists and everyone with an interest in global analysis techniques, global regulation and systems biology. read more ...
Staphylococcus: Molecular Genetics
Edited by: Jodi Lindsay
Published: 2008
Hardback: ISBN 978-1-904455-29-5 £159, $319
This volume, the first to focus on staphylococcal genetics, brings together the expertise and enthusiasm of an international panel of leading staphylococcal researchers to provide a state-of-the art overview of the field. Topics include the sequencing projects, including spin-off microarray and systems biology tools, epidemiology, evolution, manipulation of the genome, diagnostics, gene expression due to global regulators and environmental triggers, cell-wall synthesis, coagulase-negative species, and animal pathogens. It is designed for two major audiences. Firstly, to introduce the subject to new researchers, including those unfamiliar with genetics. Secondly, for established researchers, for whom it will serve as an invaluable reference and summary of a large field, as well as presenting the latest advances and future trends written by those who are developing them. Essential reading for anyone involved in Staphylococcus research. read more ...
Leishmania: After The Genome
Edited by: Peter J. Myler and Nicolas Fasel
Published: 2008
Hardback: ISBN 978-1-904455-28-8 £159, $319
Leishmania is a vector-borne pathogenic parasite found in 88 countries worldwide and is the causative agent of leishmaniasis. The different Leishmania species infect macrophages and dendritic cells of the host immune system, causing symptoms that range from disfiguring cutaneous and mucocutaneous lesions, widespread destruction of mucous membranes, or visceral disease affecting the haemopoetic organs. The recent publication of the complete genome sequences of three different Leishmania species provides new insights into this leading pathogen and presents scientists with an exciting resource to improve the understanding of its complex molecular and cellular biology. In this book, internationally recognised Leishmania experts critically review the most important aspects of current Leishmania research, providing the first coherent picture of the organism's molecular and cellular biology since the publication of the genome sequence. Chapters are written from a molecular and genomic perspective and discuss in depth Leishmania-specific aspects of trypanosomatid biology and pathology. Topics include: diagnosis and epidemiology, genome structure and content, regulation of gene expression, the Leishmania proteome, the Leishmania metabolome, Leishmania differentiation, interaction with the sand fly vector, drug discovery, drug resistance, and much more. Essential reading for all researchers working with Leishmania, trypanosomes and protozoa. A recommended book for all biology and medical libraries. read more ...
Legionella: Molecular Microbiology
Edited by: Klaus Heuner and Michele Swanson
Published: 2008
Hardback: ISBN 978-1-904455-26-4 £159, $319
Legionellosis is a disease of significant medical and public interest. Legionella is commonly found in aquatic habitats where its ability to survive and to multiply within different protozoa equips the bacterium to be transmissible and pathogenic to humans. In addition Legionella has become a favored model system to analyse the mechanisms of bacterial survival, acquisition of nutrients and intracellular replication. Following the recent publication of the genome sequences of four L. pneumophila strains it is now feasible to investigate the whole genome in silico, the transcriptome via micro arrays and the proteome by two-dimensional gel electrophoresis. Research in the fields of clinical features, diagnosis, treatment and epidemiology continues to generate new data. The topics covered by this volume range from the history of the identification of Legionella and clinical disease treatment, to the microbe's gene expression and secretion systems as well as its strategies for intracellular multiplication and nutrient acquisition. The main focus of the book is the current state of many of the most critical features of Legionella. Internationally renowned authors have contributed chapters describing and discussing the latest research findings with an emphasis on molecular aspects. The editors and authors have produced an excellent book that will be an extremely useful reference source. This comprehensive publication is aimed at readers with teaching or research interests in microbiology, genetics, genomics, infectious diseases or clinical research. A recommended book for all microbiology and clinical research laboratories. read more ...
Molecular Oral Microbiology
Edited by: Anthony H. Rogers
Published: 2008
Hardback: ISBN 978-1-904455-24-0 £159, $319
A panel of experts discuss the molecular biology of micro-organisms involved in the two major dental diseases: caries and periodontal disease. Research has focused on factors which might modulate the interaction between the resident oral bacteria and the host. Chapters deal with the interactions of oral micro-organisms with one another and with the host; the innate defence mechanisms of the host; and the development of vaccines against oral diseases. Topics include oral microbial taxonomy, identification and typing, applied genomics, horizontal gene transfer, cell-cell communication, cariogenic bacteria, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, host-pathogen interaction, host defense mechanisms, and vaccination against oral infections. Essential reading for students and researchers in the field of oral biology and oral microbiology and a recommended book for all microbiology laboratories. read more ...
Epigenetics
Edited by: Jörg Tost
Published: 2008
Hardback: ISBN 978-1-904455-23-3 £159, $319
In this book the molecular mechanisms and biological processes in which epigenetic modifications play a primordial role are described in detail. The first seven chapters describe the different biological mechanisms of the epigenetic machinery including: DNA methylation, histone tails, chromatin structure, nucleosome occupancy, Polycomb group proteins, siRNAs and miRNAs. The following chapters cover the epigenetic systems of plants, the epigenetic profile of embryonic stem cells, cell differentiation, imprinting marks, and random X chromosome inactivation. Further chapters deal with epigenetics in relation to cancers, premature aging, longevity and the developmental origins of disease. The final chapter, describes the fascinating potential transfer of epigenetic information across generations. This up-to-date volume is a major resource for those working in the field and will stimulate readers of all levels to dive into the fascinating and fast moving field of epigenetics. read more ...
Animal Viruses: Molecular Biology
Edited by: Thomas C. Mettenleiter and Francisco Sobrino
Published: 2008
Hardback: ISBN 978-1-904455-22-6 £159, $319
In this book an international panel of leading virologists provide a state-of-the-art overview of the field, comprehensively detailing the current understanding of viruses, their replication, evolution and interaction with the host. The authors emphasize strategic and methodological aspects of current research, and provide key related references. Topics include foot-and-mouth disease virus, Pestivirus, Arteriviridae, Coronaviruses (including SARS), Herpesviridae, Paramyxoviridae, influenza viruses, Reoviridae, porcine circoviruses, Asfarviridae and much more. An essential text for all virology laboratories. read more ...
Segmented Double-stranded RNA Viruses: Structure and Molecular Biology
Edited by: John T. Patton
Published: 2008
Hardback: ISBN 978-1-904455-21-9 £159, $319
This timely book brings together all of the key recent research on this disparate group of viruses, providing for the first time a single resource reviewing dsRNA viral structure and molecular biology. Written by well respected and experienced virologists, topics include: the structures of orthoreoviruses, rotavirus, phytoreoviruses, and bluetongue virus, entry into the bacterial cell, crystal structure of reovirus polymerase λ3, assembly of the reovirus genome, genomic RNA packaging and replication in the Cystoviridae, and much more. Essential reading for all dsRNA virologists and all other virologists with an interest in molecular and structural biology. read more ...
Acinetobacter Molecular Biology
Edited by: Ulrike Gerischer
Published: 2008
Hardback: ISBN 978-1-904455-20-2 £159, $319
This concise volume reviews the most current and topical aspects of Acinetobacter genetics and molecular biology and is aimed at a readership of research scientists, graduate students and other specialists. Expert international authors have contributed chapters on diverse topics including taxonomy, lipopolysaccharides, catabolism of aromatic compounds, transformation systems, transcriptional regulation, applications in biotechnology, the molecular basis for virulence and pathogenicity, molecular epidemiology, and antibiotic resistance. This book is highly recommended for anyone involved in Acinetobacter research. read more ...
Pseudomonas: Genomics and Molecular Biology
Edited by: Pierre Cornelis
Published: 2008
Hardback: ISBN 978-1-904455-19-6 £159, $319
The genome sequences of several pseudomonads have become available in recent years and researchers are beginning to use the data to make new discoveries about this bacterium. This concise volume reviews the most current and topical aspects of Pseudomonas molecular biology and genomics and is aimed at a readership of research scientists, graduate students and other specialists. Renowned international authors have contributed chapters on diverse topics including taxonomy, genome diversity, oligonucleotide usage, polysaccharides, pathogenesis, virulence, biofilms, antibiotic resistance and iron uptake. In addition an entire chapter is devoted to the genetic tools being developed to take full advantage of the wealth of information generated by the genome sequencing efforts. This book is essential reading for anyone involved in Pseudomonas research. read more ...
Real-Time PCR in Microbiology: From Diagnosis to Characterization
Edited by: Ian M. Mackay
Published: 2007
Hardback: ISBN 978-1-904455-18-9 £159, $319
The editor and authors have produced an excellent book that will be extremely useful for all microbiologists. A recommended book for all microbiology laboratories. read more ...
Coronaviruses: Molecular and Cellular Biology
Edited by: Volker Thiel
Published: 2007
Hardback: ISBN 978-1-904455-16-5 £159, $319
In this timely book, internationally renowned experts review literally every aspect of cutting edge coronavirus research providing the first coherent picture of the molecular and cellular biology since the outbreak of SARS in 2003. The book is divided into two sections: Part I focuses on the molecular biology of the virus itself and includes topics such as coronavirus binding and entry, replicase gene function, cis-acting RNA elements, coronavirus discontinuous transcription, reverse genetics, genome packaging and molecular evolution. In Part II of the book, the focus is on molecular and cellular pathogenesis and infection control. This section includes reviews of the three prototype viruses, namely avian infectious bronchitis virus, feline coronavirus and mouse hepatitis virus. Other topics include SARS-CoV virus pathogenesis, SARS-CoV interaction with the host INF and antiviral cytokines, the newly recognized bat coronaviruses and human coronavirus NL63, and strategies for coronavirus vaccine development and the development of novel antiviral coronavirus agents. Essential reading for all coronavirologists as well as scientists working on other viruses of the respiratory and/or gastrointestinal tract. read more ...
The Cyanobacteria: Molecular Biology, Genomics and Evolution
Edited by: Antonia Herrero and Enrique Flores
Published: 2008
Hardback: ISBN 978-1-904455-15-8 £159, $319
This volume brings together the expertise and enthusiasm of an international panel of leading cyanobacterial researchers to provide a state-of-the art overview of the field. Topics covered include: evolution, comparative genomics, gene transfer, molecular ecology and environmental genomics, stress responses, bioactive compounds, circadian clock, structure of the photosynthetic apparatus, membrane systems, carbon acquisition, nitrogen assimilation and C/N balance sensing and much more. Essential for anyone with an interest in cyanobacteria, bacterial photosynthesis, bacterial nitrogen fixation, and symbiosis. read more ...
Candida: Comparative and Functional Genomics
Edited by: Christophe d'Enfert and Bernhard Hube
Published: 2007
Hardback: ISBN 978-1-904455-13-4 £159, $319
In this timely book international experts provide comprehensive and authoritative reviews of these important organisms. Topics covered include: genome dynamics of C. albicans; molecular epidemiological and population studies of C. albicans; the parasexual cycle in C. albicans; comparative genomics of the hemiascomycetes group and of different Candida species; databases and the challenges that their curators are facing; transcriptome analysis; proteomics; molecular evolution of the genetic code; stress responses; regulation of morphogenesis; cell wall biology; interaction with host cells; analysis of gene function; antifungal resistance mechanisms and much more. Essential reading for all Candida genome and molecular biology researchers and a recommended text for scientists working on fungal genomics and molecular biology. read more ...
AIDS Vaccine Development: Challenges and Opportunities
Edited by: Wayne Koff, Patricia Kahn and Ian D. Gust
Published:
Paperback: ISBN 978-1-904455-11-0 £49, $99
This book reviews the scientific challenges that have impeded the search for an effective AIDS vaccine and discusses current novel research that is accelerating progress. In a series of mini-reviews by the world's leading experts in AIDS vaccine research the book is essential reading for everyone interested in the current progress and future direction of AIDS vaccine development. read more ...
Pathogenic Treponema: Molecular and Cellular Biology
Edited by: Justin D. Radolf and Sheila A. Lukehart
Published: 2006
Hardback: ISBN 978-1-904455-10-3 £159, $319
This volume is the first comprehensive review of treponemal research to be published in more than twenty years. Written by leading experts in the field, this book presents the current state of research on these organisms that affect the health of millions of people worldwide. The structure and metabolism of the treponemes are explored in light of the comparative genomics data now available. The newest information concerning their pathogenic mechanisms, as well as the complex innate and adaptive immune responses they elicit, are detailed. A number of chapters illustrate how our knowledge of syphilis has grown in the molecular era despite the continuing inability to propagate its elusive etiologic agent. The book also provides an historical perspective on treponemal research that will be of considerable interest. This compilation will serve as an essential reference for microbiologists, immunologists, and physicians who deal with these organisms on a day-by-day basis or who wish to understand them better in the context of contemporary microbiology. Topics covered include the phylogenic diversity, comparative genomics, metabolism and cultivation, motility, antigenic variation, immunology of syphilis, the use cultivatable treponemes as surrogates for T. pallidum, oral treponemes, and much much more. Essential reading for all scientists and researchers working on trepenomes and other spirochetes and a recommended reference book for all microbiology laboratories. read more ...
Alpha Herpesviruses: Molecular and Cellular Biology
Edited by: R. M. Sandri-Goldin
Published: 2006
Hardback: ISBN 978-1-904455-09-7 £180, $360
Written by internationally recognized experts, this book highlights the more provocative and exciting findings in herpesvirus research. Each chapter is a review of a specific area with an emphasis on recent advances and the latest developments. Topics include: multifunctional proteins, advances in DNA replication, new information on the regulation of gene expression, the emergence of new technologies, recent technological advances in fluorescent probes, the induction of apoptosis, the disruption of interferon, vaccine development and drug design. With a specific focus on new and topical herpesvirus research, this book is essential reading for everyone with an interest in herpesviruses and recommended reading for other scientists working in viral pathogenesis, viral genomics and antiviral research. read more ...
PCR Troubleshooting: The Essential Guide
Author: Michael L. Altshuler
Published:
Paperback: ISBN 978-1-904455-07-3 £30, $60. Ebook: ISBN 978-1-904455-08-0 £30, $60
A unique PCR troubleshooting guide that is an essential companion for anyone who uses the polymerase chain reaction technique. Aimed at a reader with some experience in PCR the book discusses the many and varied problems encountered with PCR together with tips, advice and procedures to obviate rather than overcome the PCR problems. Written in the language of the laboratory with a little humour and a down-to-earth approach, the book is easy to read and understand. If you fail at PCR, consult this book! The advice in these pages is invaluable and is the sort of advice that is not usually found elsewhere. In the words of the author, remember that there are many other things in life than PCR ... for example, isothermal DNA amplification. read more ...
Influenza Virology: Current Topics
Edited by: Yoshihiro Kawaoka
Published: 2006
Hardback: ISBN 978-1-904455-06-6 £159, $319
Despite extensive, coordinated efforts by various agencies and disciplines, both national and international, we are ill-equipped for a new influenza pandemic. In fact it is highly unlikely that adequate supplies of vaccine for the H5N1 viruses will be prepared prior to the occurrence of the next pandemic. Many countries are stockpiling influenza drugs, with the hope that the inevitable emergence of drug-resistant viruses will not nullify those efforts immediately. To combat the outbreaks that will undoubtedly occur in the near future a better understanding of influenza virus itself, the virus-host interaction, and mechanisms of drug resistance is urgently needed.
In this timely book world renowned scientists (including the 1996 Nobel Prize Winner, Peter Doherty) critically review the most important issues in this rapidly expanding field. Topics covered include analysis of influenza RNP, viral entry and intracellular transport, epidemiology, host range and pathogenicity, antivirals, vaccines, H5 viruses, and much more. Essential reading for all influenza virologists, molecular biologists, public health scientists and research scientists in pharmaceutical companies.
read more ...
Microbial Subversion of Immunity: Current Topics
Edited by: Peter J. Lachmann and M.B.A. Oldstone
Published: 2006
Hardback: ISBN 978-1-904455-05-9 £159, $319
In this book internationally renowned scientists critically review the current cutting-edge research in this area. Topics covered include the subversion of complement, NK cell function, mucosal innate immune response, evasion/subversion mechanisms used by bacteria, helminths, viruses, and the measles model system. Containing over 1,700 references, this book is an essential resource book for researchers in the fields of microbiology, immunology, pharmacology and molecular medicine. read more ...
Papillomavirus Research: From Natural History To Vaccines and Beyond
Edited by: M. Saveria Campo
Published: 2006
Hardback: ISBN 978-1-904455-04-2 £159, $319
In this timely book leading scientists review current aspects of papillomavirus research providing a fascinating insight into papillomavirus molecular biology, interactions with the host, immunology and vaccine development. Topics covered include epidemiology and taxonomy, phylogenetic analyses, gene expression, regulation of DNA replication, transcription factor proteins, organotypic raft cultures, virus-like particles, and much more. Essential reading for scientists and researchers working on papillomavirus and a recommended text for anyone involved with antiviral drug and vaccine development. read more ...
Epstein-Barr Virus
Edited by: Erle S. Robertson
Published: 2005
Hardback: ISBN 978-1-904455-03-5 £159, $319
Epstein-Barr virus (EBV) is a human gamma herpes virus that remains one of the most successful viral parasites known to man. It is the etiological agent of infectious mononucleosis and is the major biological cofactor contributing to a number of human cancers including B-cell neoplasms (e.g. Burkitt's lymphoma, Hodgkin's disease and immunoblastic lymphomas), certain forms of T-cell lymphoma, and some epithelial tumours (e.g. nasopharyngeal carcinomas and gastric carcinomas). The virus has the unique ability to persist in the infected, apparently healthy host for life. Understanding the molecular interaction between EBV and its human host, the ability of the virus to modulate the host immune system, its ability to "hide" in B-memory cells and factors that trigger viral reactivation are fundamental to understanding the cellular and molecular pathogenesis of the virus. This is critical for the development of strategies for the prevention and control of infection and disease. In this book, world renowned EBV experts provide a critical and comprehensive review of every aspect of this important virus. By integrating genetic, immunologic, and cell biologic approaches to elucidate pathogenesis, penetrating new insights into the molecular and cellular interaction between EBV and its human host have emerged. Topics covered include: Discovery, history and seroepidemiology, EBV and the immune response, EBV genetics, EBV infection and persistence, latency, lytic proteins and reactivation control, vaccine approaches, animal models, and the future of EBV studies. This is essential reading for all EBV virologists as well as clinical and research scientists working on oncogenic viruses. read more ...
Cytomegaloviruses: Molecular Biology and Immunology
Edited by: Matthias J. Reddehase
Published: 2006
Hardback: ISBN 978-1-904455-02-8 £159, $319
In this book leading international experts provide comprehensive and authoritative reviews on every aspect of current research. By integrating viral genomics, proteomics, immunology and molecular biology with the emerging knowledge of the genomics of the host organism, penetrating new insights into the virus-host interaction are provided. The focus of the book is on the molecular and genomic aspects and the authors provide an insight into the current understanding of the subject and the future direction of research. Topics covered include disease mechanisms, genomics, proteomics, BAC mutagenesis, virus entry and activation of innate immunity, regulation of viral gene expression, regulation of viral mRNA export, animal models of infection, novel therapeutics, vaccine development, antivirals, and much more. The book is liberally illustrated with many figures in full colour and is set is a clear, easy-to-follow layout. Essential reading for all virologists with an interest in cytomegaloviruses and a recommended text for scientists working on antiviral drug and vaccine development. read more ...
Probiotics and Prebiotics: Scientific Aspects
Edited by: Gerald W. Tannock
Published: 2005
Hardback: ISBN 978-1-904455-01-1 £159, $319
Probiotics are products aimed at delivering living bacterial cells to the gut ecosystem of humans and other animals, whereas prebiotics are non-digestible carbohydrates delivered in food to the large bowel to provide fermentable substrates for selected bacteria. Food scientists and nutritionists have accepted, relatively uncritically, the concepts underlying the use of probiotics and prebiotics in the promotion of health. Microbiologists and medical practitioners have viewed these products more sceptically. Much more scientific and medical validation of probiotic/prebiotic use is required. This will entail the use of sophisticated analytical methodologies. Knowledge of the gut microbiota has increased dramatically during the past decade thanks largely to the results obtained from the application of nucleic acid-based methodologies. Because of the availability of improved technologies, detailed studies of the two principal kinds of probiotic/prebiotic bacteria, members of the genera Lactobacillus and Bifidobacterium, can be made. While well-established scientists continue to make important contributions to probiotic/prebiotic research, it is notable that younger scholars are playing a vital role in developing scientific concepts related to the field. Several of these emerging leaders have contributed chapters to this book that therefore represents a state-of-the-art compendium of fundamental science related to early 21st century probiotic/prebiotic research. read more ...
Foodborne Pathogens: Microbiology and Molecular Biology
Edited by: Pina M. Fratamico, Arun K. Bhunia, and James L. Smith
Published: 2005
Hardback: ISBN 978-1-904455-00-4 £159, $319. Paperback: ISBN 978-1-898486-52-7 £99, $199
Foodborne pathogens continue to cause major public health problems worldwide. These organisms are the leading causes of illness and death in less developed countries, killing approximately 1.8 million people annually. In developed countries Foodborne pathogens are responsible for millions of cases of infectious gastrointestinal diseases each year, costing billions of dollars in medical care and lost productivity. In addition, new Foodborne diseases are likely to emerge driven by factors such as pathogen evolution, changes in agricultural and food manufacturing practices, and changes to the human host status. A third problem is that there are growing concerns that terrorists could use pathogens to contaminate food and water supplies in attempts to incapacitate thousands of people and disrupt economic growth. Fuelled by these concerns research into the genomics, molecular biology and microbiology of the most important Foodborne pathogens has escalated to unprecedented levels in recent years. Written by leaders in the field, this book represents a cutting edge summary of all the latest advances, providing the first coherent picture of the current status. Opening chapters tackle topics such as pathogen detection (molecular, biosensor), molecular typing, viable but non-culturable organisms, predictive modeling, and stress responses. The next section covers groups of organisms: enteric viruses, protozoan parasites, and mycotoxins. This is followed by chapters on specific bacteria: Yersinia enterocolitica, Vibrio spp., Staphylococcus aureus, Campylobacter Infections, Listeria monocytogenes, Salmonella spp., Shigella spp., Escherichia coli, Clostridium botulinum, Clostridium perfringens and Bacillus cereus. The final chapters provide a fascinating review of the ability of pathogens to contaminate a food supply and provide an overview of emerging Foodborne pathogens. The book is essential reading for all microbiologists and food scientists and of particular interest to anyone involved in food safety. read more ...
HIV Chemotherapy: A Critical Review
Edited by: Salvatore T. Butera
Published: 2005
Hardback: ISBN 978-0-9542464-9-5 £159, $319
Since the beginning of the AIDS pandemic in the early 1980's nearly 50 million people have been infected and over 16 million of those have died of AIDS. Combination anti-HIV therapy has dramatically reduced mortality rates and increased life expectancy in infected individuals. However it has not eradicated AIDS: the endemic is merely contained in industrialized nations and continues unabated in developing countries, e.g. Africa and parts of Asia. Since current anti-HIV drugs are virostatic rather than virotoxic, infected individuals must remain on drug therapy for life. This is a major problem since all of the existing anti-HIV drugs have side effects, some of which are serious and potentially fatal. In addition, the naturally occurring and extensive genetic variation found in HIV has led to the emergence of drug-resistant viruses. These challenges have prompted the urgent search for novel, molecular-based drugs and therapeutic strategies that target the different stages of viral infection of and interaction with the host. This is a book aimed at the scientist in the research laboratory. Written by expert international authors, the book is an essential reference for scientists working on AIDS, HIV and other retroviruses. Expert AIDS researchers critically review every aspect of this highly topical subject. The opening chapters deal with the management of HIV infections and include a fascinating review of current molecular strategies to protect and strengthen the host immune system at the cellular level. Chapters 6 and 7 summarises the strategies required for the implementation of effective anti-HIV therapies in developing countries (90% of worldwide AIDS cases). Two excellent chapters (4 and 5) comprehensively review the genetics of viral drug resistance, and current drug-resistance testing technologies. The remaining chapters provide cutting-edge reviews of the latest viral and cellular targets for anti-HIV chemotherapy, the development of iRNA based therapeutics and molecular based strategies that target latent virus reservoirs in infected individuals. Essential reading for scientists and clinicians working on AIDS, HIV, and other retroviruses as well as all health care professionals interested in expanding their current understanding of the subject. read more ...
Pathogenic Fungi: Host Interactions and Emerging Strategies for Control
Edited by: Gioconda San-Blas and Richard A. Calderone
Published: 2004
Hardback: ISBN 978-0-9542464-8-8 £159, $319
During the past decade we have witnessed a mushrooming of papers in the area of medical mycology; detailing major advances in areas such as genomics, molecular and cellular biology, molecular epidemiology, immune response and vaccine development, and strategies to combat infections in humans. This sheer volume of information makes it extremely difficult for the busy research scientist and/or teacher of medical mycology to keep abreast of all the latest advances. This book, together with its companion volume Pathogenic Fungi: Structural Biology and Taxonomy, brings together expert international authors who critically review current topics, and through the provision of extensive reference sections positively encourage readers to pursue the subject in greater detail. The book is divided into two sections: "Fungal Interactions with the Host" and "Antifungal Antibiotics". The emphasis of the first section is focused on the two-way recognition systems that exist between the host and the fungus. Experts in fungal-host interactions discuss new initiatives for alternatives to drug therapy through the development of vaccines and passive antibody therapy. In the "Antifungal Antibiotics" section, new target development, molecular modelling, and drug resistance, both at the individual organism level, and in a biofilm, are featured. Essential reading for everyone with an interest in medical mycology including: mycologists, biotechnologists, molecular biologists, and pharmaceutical and biotechnology companies. read more ...
Pathogenic Fungi: Structural Biology and Taxonomy
Edited by: Gioconda San-Blas and Richard A. Calderone
Published: 2004
Hardback: ISBN 978-0-9542464-7-1 £159, $319
During the past decade we have witnessed a mushrooming of papers in the area of medical mycology; detailing major advances in areas such as genomics, molecular and cellular biology, molecular epidemiology, immune response and vaccine development, and strategies to combat infections in humans. This sheer volume of information makes it extremely difficult for the busy research scientist and/or teacher of medical mycology to keep abreast of all the latest advances. This book, together with its companion volume "Pathogenic Fungi: Host Interactions and Emerging Strategies for Control", brings together expert international authors who critically review current topics, and through the provision of extensive reference sections positively encourage readers to pursue the subject in greater detail. The book is divided into two sections: "Fungal Dimorphism and Pathogenicity" and "New Taxonomic Tools". The first section focuses on morphogenesis, the cell cycle, and the cell wall of human pathogens. These play a major role in elucidating fungal relationships, both with the environment and with the host. Experts in fungal structural biology contribute in-depth reviews on a variety of topics with a focus on molecular and biochemical analysis. The final chapter in this section presents a fascinating review of how mathematical modelling can be used to understand the building of three-dimensional cell structures in the morphogenetic process. The second section, entitled "New Taxonomic Tools", presents novel approaches to aid the understanding of strain variability, the significance of environmental and patient strains, and the relatedness of "uncultured" fungi. In addition the use of molecular tools for the taxonomic classification of previously unclassifiable fungi is featured. Essential reading for everyone with an interest in medical mycology including: mycologists, biotechnologists, molecular biologists, and pharmaceutical and biotechnology companies. read more ...
Malaria Parasites: Genomes and Molecular Biology
Edited by: A.P. Waters and C.J. Janse
Published: 2004
Hardback: ISBN 978-0-9542464-6-4 £159, $319
The completion of the Plasmodium falciparum genome sequence in late 2002 hearlded a new era in malaria research. The search began in earnest for new drugs and vaccines to combat malaria, a disease which afflicts up to 500 million people worldwide and is responsible for the deaths of more than one million people each year. The new genomic data is aiding a greater understanding of the living parasite and its interaction with the insect vector and human host. In this book internationally renown experts provide up-to-date reviews of the most important aspects of post-genomic malaria research. Topics covered include: the P. falciparum genome and model parasites, bioinformatics and genome databases, microsatellite analysis, analysis of chromosome structure, cell cycle to RNA polymerase I and II mediated gene expression, role of the nuclear genome, the parasite surface and cell biology, and much more. The book is essential reading for all parasitologists and scientists with an interest in malaria. read more ...
MRSA: Current Perspectives
Edited by: Ad C. Fluit and Franz-Josef Schmitz
Published: 2003
Hardback: ISBN 978-0-9542464-5-7 £159, $319
Since their discovery in the 1960s, methicillin-resistant S. aureus (MRSA) strains continue to present unique challenges to clinicians, microbiologists, and the molecular biologists around the world. These organisms are typically resistant to several other antimicrobial agents, including aminoglycosides, chloramphenicol, clindamycin, fluoroquinolones and macrolides and are susceptible only to vancomycin. In fact there is increasing evidence that this susceptibility will soon disappear. In this book, internationally renown authors comprehensively review all aspects of MRSA research. Topics covered include strategies for the detection and typing of MRSA strains, epidemiological characterisation, molecular evolution of MRSA, vancomycin resistant S. aureus, mechanisms of methicillin resistance, virulence mechanisms in MRSA pathogenesis, recommended treatment of MRSA infections and options for the prevention and control of MRSA infections. An essential text for all scientists and clinicians with an interest in the Staphylococcus aureus or antibiotic resistance. read more ...
Genomics of GC-Rich Gram-Positive Bacteria
Edited by: Antoine Danchin
Published: 2002
Hardback: ISBN 978-0-9542464-3-3 £159, $319
Eminent scientists have contributed comprehensive reviews on all aspects of the genomics of Rhodococcus, Mycobacteria, Streptomyces and other organisms. The authors provide an insight into the many facets of large-scale functional investigation in a variety of bacteria with the explicit goal to find common rules in the dynamic and structural organisation of these organisms. This volume is the definitive guide to current research in this increasingly important area. read more ...
Probiotics and Prebiotics: Where are We Going?
Edited by: Gerald W. Tannock,
Published: 2002
Hardback: ISBN 978-0-9542464-1-9 £159, $319
This new volume follows from and complements the bestselling book *Probiotics: A Critical Review* (also edited by G. W. Tannock). The new book expands and enlarges on all aspects of this highly topical subject. Leading international experts describe in detail current research and applications and in particular focus on novel issues and developing technology, and comment on the future potential of this important and exciting topic. Probiotics and Prebiotics: Where Are We Going? contains state-of-the-art commentaries on all aspects of the intestinal microflora and probiotics and provides an authoritative review of important aspects of probiotic and prebiotic research. Written by leading experts in the field, each chapter affords a critical insight to a particular topic, reviews current research, discusses future direction and aims to stimulate discussion. Topics covered include the genomics of probiotic microorganisms, the developing technologies for analysis of gut microorganisms, evaluation and future potential of prebiotic substances, and the potential for disease prevention in the host by probiotic organisms. An essential text for all microbiologists, health professionals, biotechnologists, pharmaceutial companies, dairy and food scientists. read more ...