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Molecular Biology Books

Our high level molecular biology books bring together expert international authors under the skilled editorship of leading scientists to produce state-of-the-art compendiums of current research. Aimed at the research scientist, graduate student, medical reseacher and other professionals, these books are highly recommended for all molecular biology laboratories. Every molecular biology, microbiology and bioscience library should have a copy of each of the following books.
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Epigenetics: Current Research and Emerging Trends
Edited by: Brian P. Chadwick
Published: 2015
Hardback: ISBN 978-1-910190-07-4 £159, $319. Ebook: ISBN 978-1-910190-08-1 £159, $319
The editor of this book has gathered together pioneers in the field of epigenetics to produce a volume of thought-provoking discussions on classic aspects of epigenetics and on the newer, emerging areas. The 17 chapters include topics on the impact of metabolism on the epigenome, how our actions may impact the health of our offspring several generations removed, and how exposure to environmental toxicants can have long-lasting effects on our epigenome with devastating consequences. This up-to-date volume is a major resource essential for those working in the field and is recommended reading for anyone new to this fascinating and fast-moving area of research. read more ...
Microarrays: Current Technology, Innovations and Applications
Edited by: Zhili He
Published: 2014
Hardback: ISBN 978-1-908230-49-2 £159, $319. Ebook: ISBN 978-1-908230-59-1 £159, $319
Written by expert authors this book is focused on current microarray technologies and their applications in environmental microbiology. In the first chapter microarray technologies and applications are briefly introduced and in following chapters microarray probe design, development and evaluation, and data analysis are described in detail. In later chapters, more attention is paid to phylogenetic arrays (e.g., PhyloChip) and functional gene arrays (e.g., GeoChip). These generic tools for analyzing microbial communities from disparate environments, ecosystems, and habitats including soil, water, sediment, animals and humans, are described in detail with examples of specific applications. Also included are microarrays for analyzing microbial communities from specific environments, such as soil, bioleaching ecosystems, and human microbiomes, and microarrays for detecting specific microorganisms (e.g., pathogens) in the environment. The authors also discuss the advantages and limitations of microarray technologies compared to high throughput sequencing technologies. This book is a valuable and useful source of information about microarrays for microbial community analysis and is recommended for anyone working on microbial communities, biofilms or environmental microbiology. read more ...
Proteomics: Targeted Technology, Innovations and Applications
Edited by: Manuel Fuentes and Joshua LaBaer
Published: 2014
Hardback: ISBN 978-1-908230-46-1 £159, $319. Ebook: ISBN 978-1-908230-62-1 £159, $319
In this book a panel of high-profile authors provides an overview of targeted proteomics in biomedical science. The book is focused on current, state-of-the-art technology and applications and is a valuable source of information for everyone working in this field. The first part of the book provides detailed examples of the application of targeted proteomics in biomarker discovery and pathogenesis. The second part is focused on the various tools used in targeted proteomics including bioinformatics approaches while the final section is dedicated to biobanks, a vital aspect of targeted proteomics. This volume is highly recommended for anyone interested in proteomics, disease pathogenesis, clinical protein science and biomarker discovery. read more ...
Applied RNAi: From Fundamental Research to Therapeutic Applications
Edited by: Patrick Arbuthnot and Marc S. Weinberg
Published: 2014
Hardback: ISBN 978-1-908230-43-0 £159, $319. Ebook: ISBN 978-1-908230-67-6 £159, $319
In this book an international panel of RNAi experts critically reviews the most interesting advances in basic applied RNAi research, highlighting the applications in RNAi-based therapies and discussing the technical hurdles that remain. Topics covering the fundamental biological aspects of applied RNAi research include: the role of miRNAs in trinucleotide repeat disorders; miRNAs and HIV pathogenesis; miRNAs for epigenetic gene silencing; the role of miRNAs in virus-related cancers; non-canonical miRNA biogenesis. In the area of RNAi-based therapy, topics include: harnessing RNAi for the treatment of viral infections; optimising the design of exogenous RNAi activators; blocking miRNA function with synthetic agents; somatic cell reprogramming; high-content miRNA-based screening tools and the use of miRNA target sites for control of transgene expression. Essential reading for everyone involved in RNAi research, drug discovery and delivery, biomedical engineering and biomaterials. read more ...
Bioinformatics and Data Analysis in Microbiology
Edited by: Özlem Taştan Bishop
Published: 2014
Hardback: ISBN 978-1-908230-39-3 £159, $319. Ebook: ISBN 978-1-908230-73-7 £159, $319
This book provides invaluable, up-to-date and detailed information on various aspects of bioinformatics data analysis with applications to microbiology. It describes a number of different useful bioinformatics tools, makes links to some wet-lab techniques, explains different approaches to tackle a problem, talks about current challenges and limitations, gives examples of applications of bioinformatics methods to microbiology, and discusses future trends. The chapters include topics such as genome sequencing techniques, assembly, SNP analysis, annotation, comparative genomics, microbial community profiling, metagenomics, phylogenetic microarrays, barcoding and more. Each chapter is written by scientists who are expert in the field, and is peer-reviewed. Bioinformatics and Data Analysis in Microbiology is an essential book for researchers, lecturers and students involved in microbiology, bioinformatics and genome analysis. read more ...
Next-generation Sequencing: Current Technologies and Applications
Edited by: Jianping Xu
Published: 2014
Hardback: ISBN 978-1-908230-33-1 £120, $240. Ebook: ISBN 978-1-908230-95-9 £120, $240
Written by experts from around the world, this book explores the most recent advances in NGS instrumentation and data analysis. The book begins with a comprehensive description of current NGS platforms, their sequencing chemistries, instrument specifications, and general workflows and procedures. A separate chapter is dedicated to low-quantity, single molecule sequencing technology. Further chapters explore the application of NGS technologies in various fields including polymorphism detection, sRNA research, rare variant detection, large variant detection, exome sequencing, plant development studies, microbial metagenomics, and studies on the human microbiome. Practical and cutting-edge, this volume represents an excellent collection of chapters to aid all scientists who wish to apply these innovative research tools. read more ...
Genome Analysis: Current Procedures and Applications
Edited by: Maria S. Poptsova
Published: 2014
Hardback: ISBN 978-1-908230-29-4 £159, $319. Ebook: ISBN 978-1-908230-68-3 £159, $319
In this book, an impressive array of expert authors highlight and review current advances in genome analysis. This volume provides an invaluable, up-to-date and comprehensive overview of the methods currently employed for next-generation sequencing (NGS) data analysis, highlights their problems and limitations, demonstrates the applications and indicates the developing trends in various fields of genome research. The first part of the book is devoted to the methods and applications that arose from, or were significantly advanced by, NGS technologies: the identification of structural variation from DNA-seq data; whole-transcriptome analysis and discovery of small interfering RNAs (siRNAs) from RNA-seq data; motif finding in promoter regions, enhancer prediction and nucleosome sequence code discovery from ChiP-Seq data; identification of methylation patterns in cancer from MeDIP-seq data; transposon identification in NGS data; metagenomics and metatranscriptomics; NGS of viral communities; and causes and consequences of genome instabilities. The second part is devoted to the field of RNA biology with the last three chapters devoted to computational methods of RNA structure prediction including context-free grammar applications. An essential book for everyone involved in sequence data analysis, next-generation sequencing, high-throughput sequencing, RNA structure prediction, bioinformatics and genome analysis. read more ...
RNA Editing: Current Research and Future Trends
Edited by: Stefan Maas
Published: 2013
Hardback: ISBN 978-1-908230-23-2 £159, $319. Ebook: ISBN 978-1-908230-88-1 £159, $319
This major new work presents an up-to-date overview of RNA editing. All the chapters here have been written by experts in the various research areas and describe key recent findings as well as exploring current frontiers in the mechanisms and functional roles of RNA editing. The chapters span the editing of protein coding mRNAs, small regulatory RNAs, tRNAs and non-coding sequences. Also included are studies employing bioinformatics to identify and predict RNA editing sites as well as the evolution of RNA modification. An essential text for anyone interested in RNA editing and modification, RNA structure and function, post-transcriptional regulation, and the regulation of gene expression and a recommended purchase for molecular biology libraries. read more ...
Real-Time PCR: Advanced Technologies and Applications
Edited by: Nick A. Saunders and Martin A. Lee
Published: 2013
Hardback: ISBN 978-1-908230-22-5 £159, $319. Ebook: ISBN 978-1-908230-87-4 £159, $319
This essential manual provides both the novice and experienced user with an invaluable reference to a wide-range of real-time PCR technologies and applications and provides an overview of the theory of this increasingly important technique. Renowned international authors present detailed technical insights into the underlying principles, methods and practice of real-time PCR. The initial chapters cover the important aspects of real-time PCR including choosing an instrument and probe system, set-up, nucleic acid synthesis, sample extraction controls, and validation and data analysis. Further chapters provide a comprehensive overview of important real-time PCR methodologies such as quantification, expression analysis and mutation detection. This is complemented by the final chapters, which address the application of real-time PCR to diagnosis of infectious diseases, biodefence, veterinary science, food authenticity and molecular haplotyping. This timely and authoritative volume serves both as a basic introduction to real-time PCR and as a source of current trends and applications for those already familiar with the technology. The editors also aim to stimulate readers of all levels to develop their own innovative approaches to real-time PCR. An essential book for all laboratories using PCR. read more ...
Bionanotechnology: Biological Self-assembly and its Applications
Edited by: Bernd H. A. Rehm
Published: 2013
Hardback: ISBN 978-1-908230-16-4 £159, $319. Ebook: ISBN 978-1-908230-81-2 £159, $319
Under the expert guidance of Bernd H. A. Rehm, the authors of this book provide a survey of the most striking and successful approaches for the production of biogenic nanodevices considering not only living organisms as manufacturer but also in vitro processes that utilize the self-assembly of isolated biomolecules. The book provides a topical overview of the vast field of bionanotechnology by describing various biological nanostructures, the implied design space and the enormous potential for applications in medicine and technology. Two chapters describe the microbial production of tailor-made self-assembled nanostructures which can be processed into functional nanoparticles. Other chapters comprehensively summarize recent developments in the use of protein-based assemblies for nanodevice and nanomaterials production. Topics include: polymer synthesis, self-assembly and display technology, self-assembly and application of cellulosomal components, protein-aided mineralization of inorganic nanostructures, amyloid fibrils as bionanomaterials, self-assembly and applications of bacteriophages and virus-like particles, plant oil bodies and oleosins-structure function and biotechnological applications, visual restoration using microbial rhodopsins, magnetosomes and liposome-nanoparticle assemblies. This is a recommended book for anyone interested in the fields of nanotechnology, biotechnology, metabolic engineering, molecular biology, genetic engineering and protein design. read more ...
Quantitative Real-time PCR in Applied Microbiology
Edited by: Martin Filion
Published: 2012
Hardback: ISBN 978-1-908230-01-0 £159, $319
Written by experts in the field and aimed specifically at microbiologists, this volume describes and explains the most important aspects of current qPCR strategies, instrumentation and software. Renowned authors cover the application of qPCR technology in various areas of applied microbiology and comment on future trends. Topics covered include instrumentation, fluorescent chemistries, quantification strategies, data analysis software, environmental microbiology, water microbiology, food microbiology, gene expression studies, validation of microbial microarray data and future trends in qPCR technology. The editor and authors have produced an outstanding book that will be invaluable for all microbiologists. A recommended book for all microbiology laboratories. read more ...
Non-coding RNAs and Epigenetic Regulation of Gene Expression: Drivers of Natural Selection
Edited by: Kevin V. Morris
Published: 2012
Hardback: ISBN 978-1-904455-94-3 £159, $319
Many studies have been carried out on the modulation of gene transcription by non-coding RNAs. This book, written by a group of distinguished scientists under the expert guidance of the editor Kevin V. Morris, represents an important overview and summary of the field to date. The thirteen chapters are organized into three sections: Non-coding RNAs: Form, Function and Diversity; Non-coding RNAs: Gene Regulation and Epigenetics; and Non-coding RNAs: Disease and Therapeutics. This up-to-date volume is an essential book for those working in the area and represents a major information resource on current research in the fast-moving fields of epigenetics, the regulation of gene expression, and RNA research. For scientists in other fields it provides a valuable insight into this important and fascinating area of molecular biology. read more ...
Epigenetics: A Reference Manual
Edited by: Jeffrey M. Craig and Nicholas C. Wong
Published: 2011
Hardback: ISBN 978-1-904455-88-2 £180, $360
The editors of this book have assembled top-quality scientists from diverse fields of epigenetics to produce a major new volume. Comprehensive and cutting-edge, the 26 chapters in this book constitute a key reference manual for everyone involved in epigenetics, DNA methylation, cancer epigenetics and related fields. Topics include: early life environment, DNA methylation and behavior, histone acetyltransferase biology, transgenerational epigenetic inheritance, mammalian X inactivation, epigenetic memory in plants, polycomb-group regulation, centromeres and telomeres, DNA sequence contribution to nucleosome distribution, macrosatellite epigenetics, histones, cell-fate specification and reprogramming, DNA methylation in cancer, variant histone H2A and cancer development, RNA modification, paramutation in plants, DNMT3L dependent methylation during gametogenesis, non-coding RNA, bisulphite-enabled technologies, rapid analysis of DNA methylation, microarray mapping, DNA methylation profiling, ChIP-sequencing, genome-wide DNA methylation analysis, and epigenetics in maize. In addition there are useful chapters on bioinformatics in epigenomics, online resources and tools for epigeneticists, and educational resources for epigenetics. This up-to-date reference manual is an essential book for those working in the field and for scientists in other disciplines it represents a major information resource on the fascinating and fast-moving field of epigenetics. read more ...
PCR Troubleshooting and Optimization: The Essential Guide
Edited by: Suzanne Kennedy and Nick Oswald
Published: 2011
Hardback: ISBN 978-1-904455-72-1 £159, $319
This book discusses the strategies for preparing effective controls and standards for PCR, when they should be employed and how to interpret the information they provide. It highlights the significance of optimization for efficiency, precision and sensitivity of PCR methodology and provides essential guidance on how to troubleshoot inefficient reactions. Experts in PCR describe design and optimization techniques, discuss the use of appropriate controls, explain the significance of standard curves and explore the principles and strategies required for effective troubleshooting. Authors highlight the importance of sample preparation and quality, primer design, controlling inhibitors, avoiding amplicon and environmental contamination, optimizing reagent quality and concentration, and modifying the thermal cycling protocol for optimal sensitivity and specificity. In addition, specific chapters discuss the history of PCR, the choice of instrumentation, the applications of PCR in metagenomics, high resolution melting analysis, the MIQE guidelines, and PCR at the microliter scale. The strategies, tips and advice contained in this concise volume enable the scientist to optimize and effectively troubleshoot a wide range of techniques including PCR, reverse transcriptase PCR, real-time PCR and quantitative PCR. An essential book for anyone using PCR technology. read more ...
Molecular Phylogeny of Microorganisms
Edited by: Aharon Oren and R. Thane Papke
Published: 2010
Hardback: ISBN 978-1-904455-67-7 £159, $319
In this book, leading scientists from around the world explore current concepts in molecular phylogeny and their application with respect to microorganisms. The authors describe the different approaches applied today to elucidate the molecular phylogeny of prokaryotes (and eukaryotic protists) and review current phylogenetic methods, techniques and software tools. Topics covered include: a historical overview, computational tools, multilocus sequence analysis, 16S rRNA phylogenetic trees, rooting of the universal tree of life, applications of conserved indels, lateral gene transfer, endosymbiosis and the evolution of plastids. This book is an ideal introduction to molecular phylogeny for all microbiologists and is an essential review of current concepts for experts in the field. A recommended text for all microbiology laboratories. read more ...
Nanotechnology in Water Treatment Applications
Edited by: T. Eugene Cloete, Michele de Kwaadsteniet, Marelize Botes and J. Manuel López-Romero
Published: 2010
Hardback: ISBN 978-1-904455-66-0 £159, $319
This timely volume reviews the current state-of-the-art research and development of different nanomaterials (nanostructured catalytic membranes, nanosorbents, nanocatalysts and bioactive nanoparticles) and their application in water treatment, purification and disinfection. The expert authors have contributed chapters focusing on the cutting-edge research in this emerging technology and its applications in microbiology and water treatment. Topics covered include the detection of microbial pathogens, nanofibers and nanobiocides in water purification, nanozymes for biofilm removal, water and wastewater treatment and reverse osmosis. Also included is a chapter dedicated to the health and environmental concerns for the use of nanotechnology in water treatment. This book is aimed at everyone interested in nanobiotechnology, bioremediation, biodiagnostics, molecular diagnostics and environmental microbiology and is a recommended text for all microbiology laboratories. read more ...
Microbial Population Genetics
Edited by: Jianping Xu
Published: 2010
Hardback: ISBN 978-1-904455-59-2 £159, $319
Written by leading researchers in the field, this invaluable book details the major current advances in microbial population genetics and genomics. Distinguished international scientists introduce fundamental concepts, describe genetic tools and comprehensively review recent data from SNP surveys, whole-genome DNA sequences and microarray hybridizations. Chapters cover broad groups of microorganisms including viruses, bacteria, archaea, fungi, protozoa and algae. A major focus of the book is the application of molecular tools in the study of genetic variation. Topics covered include microbial systematics, comparative microbial genomics, horizontal gene transfer, pathogenic bacteria, nitrogen-fixing bacteria, cyanobacteria, microalgae, fungi, malaria parasites, viral pathogens and metagenomics. An essential volume for everyone interested in population genetics and highly recommended reading for all microbiologists. read more ...
RNA Interference and Viruses: Current Innovations and Future Trends
Edited by: Miguel Angel Martínez
Published: 2010
Hardback: ISBN 978-1-904455-56-1 £159, $319
In this book, expert RNAi specialists from around the world have teamed up to produce a timely and thought-provoking review of the area. The two central themes are: 1) the latest findings on RNAi-virus interactions and 2) progress in the development of RNAi-based antiviral therapeutics. A number of chapters explain general concepts concerned with the role of RNAi in natural antiviral defense mechanisms, other chapters discuss how to improve the efficacy and safety of RNAi-based antiviral drugs, while others describe how this technology is being developed as a new therapeutic tool for fighting specific viruses, including HIV, HCV and respiratory viruses. Authors also outline potential new avenues for research thus providing a stimulus for further research. Essential reading for researchers involved in RNAi or antiviral research and a recommended text for all virology laboratories. read more ...
Metagenomics: Theory, Methods and Applications
Edited by: Diana Marco
Published: 2010
Hardback: ISBN 978-1-904455-54-7 £159, $319
This book addresses in a coherent manner the diverse and multiple aspects of metagenomics and the multiplicity of its potential applications. Renowned authors from around the world have contributed chapters covering the new theoretical insights, the more recent applications, and the dynamically developing methods of data acquisition and analysis. Topics include: Conceptual frameworks, tools and methods, integration of complementary approaches, horizontal gene transfer, analysis of complex microbial communities, public data resources, plant-microbe interactions, bioremediation, industrial bioproducts, archaeal metagenomics, bioprospecting novel genes, the human microbiome, and philosophical themes in metagenomics. The book is essential reading for all researchers currently performing metagenomics studies and is highly recommended for all students and scientists wishing to increase their understanding of this field. read more ...
Lab-on-a-Chip Technology (Vol. 2): Biomolecular Separation and Analysis
Edited by: Keith E. Herold and Avraham Rasooly
Published: 2009
Hardback: ISBN 978-1-904455-47-9 £159, $319
The editors of this book have brought together expert authors from many countries to produce a comprehensive volume focusing on the applications of LOC technology in the biomedical and life sciences. The first section includes chapters on LOC biomolecule separation. Separation of biomolecules is an important element of various clinical laboratories and is required for many "down stream" analytical applications. Various electrophoresis and liquid chromatography applications for proteins and DNA are described as well as methods for cell separation, with an emphasis on blood cell separation, which have many important clinical applications. The second part includes chapters on analysis and manipulation technologies. Authors describe protein, genetic (mainly PCR) and transcriptome analysis with examples from research and clinical applications, as well as cell manipulation and analysis including cell viability analysis and microorganism capturing. A skillful selection of topics of exceptional importance to current science ensures that this book will be of major value to a wide range of molecular biologists, clinical scientists, microbiologists, biochemists and anyone interested in LOC technology or developing applications for LOC devices. read more ...
Lab-on-a-Chip Technology (Vol. 1): Fabrication and Microfluidics
Edited by: Keith E. Herold and Avraham Rasooly
Published: 2009
Hardback: ISBN 978-1-904455-46-2 £159, $319
This invaluable book describes the latest methods and novel technologies being developed for the fabrication of LOC devices and new approaches for fluid control and manipulation. Expert authors from around the world describe and discuss the newest technologies for the prototyping of devices, including replication and direct machining methods of fabrication. Part I of the book covers all aspects of fabrication including laser micromachining, silicon and glass micromachining, PMMA and COC microfluidic substrates, and xurography (LOC prototyping with a cutting plotter). Part II focuses on fluid control and manipulation for LOC systems. As well as providing examples of the use of pumps in microfluidics, topics covered include electrokinetic pumping (electroosmois), electrochemical pumping and electrowetting, and the fabrication of a microchip for rapid polymerase chain reaction (PCR). This comprehensive volume presents the current technologies in the field and includes theoretical and technical information to enable both the understanding of the technology and the reproduction of experiments. The book aims to help the reader to understand current LOC technologies, to perform similar experiments, to design new LOC systems and to develop new methodologies and applications. An essential book for biologists and clinicians using LOC technology and developing applications and also for engineering, chemical and physical science researchers developing analytical technologies. The book will also be useful as a teaching tool for bioengineering, biomedical engineering and biology. read more ...
Real-Time PCR: Current Technology and Applications
Edited by: Julie Logan, Kirstin Edwards and Nick Saunders
Published: 2009
Hardback: ISBN 978-1-904455-39-4 £159, $319
This essential manual presents a comprehensive guide to the most up-to-date technologies and applications as well as providing an overview of the theory of this increasingly important technique. Renowned experts in the field describe and discuss the latest PCR platforms, fluorescent chemistries, validation software, data analysis, and internal and external controls. This timely and authoritative volume also discusses a wide range of RT-PCR applications including: clinical diagnostics, biodefense, RNA expression studies, validation of array data, mutation detection, food authenticity and legislation, NASBA, molecular halotyping, and much more. An essential book for all laboratories using PCR. read more ...
Plant Pathogenic Bacteria: Genomics and Molecular Biology
Edited by: Robert W. Jackson
Published: 2009
Hardback: ISBN 978-1-904455-37-0 £159, $319
In this book, internationally acclaimed experts review the most important developments providing an invaluable, up-to-date summary of the molecular biology and genomics of plant pathogenic bacteria. The book opens with two chapters on bacterial evolution, diversity and taxonomy, topics that have been transformed by molecular biology and genomics analyses. The third chapter delves into the crucially understudied area of pathogen adaptation to the plant apoplast environment. The following seven chapters focus on specific plant pathogens: Agrobacterium, Leifsonia, Pectobacterium, Pseudomonas, Ralstonia, Xanthomonas, and Xylella. The next four chapters review specific, intensively studied areas of research in the plant pathogen field: microbe associated molecular patterns (MAMPs) and innate immunity; use of bacterial virulence factors to suppress plant defence; cyclic di-GMP signalling and the regulation of virulence; and plasmids and the spread of virulence. The final chapter covers the critical area of bioinformatics. With contributions from some of the pioneering bacterial plant pathogen genome sequencers, this book is essential reading for every plant pathogen researcher, from the PhD student to the experienced scientist, as it provides a timely review of the current and most topical areas of research. read more ...
Microbial Production of Biopolymers and Polymer Precursors: Applications and Perspectives
Edited by: Bernd H. A. Rehm
Published: 2009
Hardback: ISBN 978-1-904455-36-3 £159, $319
Written by expert, internationally renowned scientists, this comprehensive volume describes in detail the use of microorganisms for the production of the most important biopolymers and polymer precursors. The authors describe, in depth, the biosynthetic pathways, physical properties and industrial production processes and discuss in detail the genetic and metabolic engineering of microorganisms for biopolymer production. Also highlighted are the applications and potential applications of the biopolymers and microbial biotechnology. Topics include the biochemistry and genetics of biosynthesis of xanthan, alginate, cellulose, cyanophycin, poly(gamma-glutamic acid), levan, hyaluronic acid, organic acids, oligosaccharides and polysaccharides, and polyhydroxyalkanoates. A recommended book for all biotechnology and microbiology laboratories. read more ...
RNA and the Regulation of Gene Expression: A Hidden Layer of Complexity
Edited by: Kevin V. Morris
Published: 2008
Hardback: ISBN 978-1-904455-25-7 £159, $319
The role of RNA in regulating gene expression has become a topic of intense interest. In this book internationally recognized experts in RNA research explore and discuss the methods whereby RNA can regulate gene expression with examples in yeast, Drosophila, mammals, and viral infection, and highlight the application of this knowledge in therapeutics and research. Topics include: gene silencing and gene activation, the hammerhead ribozyme, epigenetic regulation, RNAi, microRNA, and pyknons. This comprehensive publication is intended for readers with teaching or research interests in RNA, the regulation of gene expression, genetics, genomics or molecular biology. read more ...
Epigenetics
Edited by: Jörg Tost
Published: 2008
Hardback: ISBN 978-1-904455-23-3 £159, $319
In this book the molecular mechanisms and biological processes in which epigenetic modifications play a primordial role are described in detail. The first seven chapters describe the different biological mechanisms of the epigenetic machinery including: DNA methylation, histone tails, chromatin structure, nucleosome occupancy, Polycomb group proteins, siRNAs and miRNAs. The following chapters cover the epigenetic systems of plants, the epigenetic profile of embryonic stem cells, cell differentiation, imprinting marks, and random X chromosome inactivation. Further chapters deal with epigenetics in relation to cancers, premature aging, longevity and the developmental origins of disease. The final chapter, describes the fascinating potential transfer of epigenetic information across generations. This up-to-date volume is a major resource for those working in the field and will stimulate readers of all levels to dive into the fascinating and fast moving field of epigenetics. read more ...
Real-Time PCR in Microbiology: From Diagnosis to Characterization
Edited by: Ian M. Mackay
Published: 2007
Hardback: ISBN 978-1-904455-18-9 £159, $319
The editor and authors have produced an excellent book that will be extremely useful for all microbiologists. A recommended book for all microbiology laboratories. read more ...
PCR Troubleshooting: The Essential Guide
Author: Michael L. Altshuler
Published:
Paperback: ISBN 978-1-904455-07-3 £30, $60. Ebook: ISBN 978-1-904455-08-0 £30, $60
A unique PCR troubleshooting guide that is an essential companion for anyone who uses the polymerase chain reaction technique. Aimed at a reader with some experience in PCR the book discusses the many and varied problems encountered with PCR together with tips, advice and procedures to obviate rather than overcome the PCR problems. Written in the language of the laboratory with a little humour and a down-to-earth approach, the book is easy to read and understand. If you fail at PCR, consult this book! The advice in these pages is invaluable and is the sort of advice that is not usually found elsewhere. In the words of the author, remember that there are many other things in life than PCR ... for example, isothermal DNA amplification. read more ...
Frontiers in Computational Genomics
Edited by: Michael Y. Galperin and Eugene V. Koonin
Published: 2003
Hardback: ISBN 978-0-9542464-4-0 £159, $319
Computational biology and bioinformatics form a major, integral part of genomics. From sequence fragment assembly, to gene prediction, to prediction of protein functions and structure, to identification of regulatory signals in DNA, to building phylogenetic trees, it would not be an exaggeration to state that genomics is primarily computational. Major new programs, software and internet facilities have evolved recently that facilitate computational analysis and more novel technologies are currently being developed. Written by experts in the field, this volume highlights research on the emerging, perhaps somewhat controversial, topics in genomics and shows the feedback between the new developments and the established methods of computational biology. An essential book for anyone involved in genomic science or bioinformatics. read more ...
Genomics of GC-Rich Gram-Positive Bacteria
Edited by: Antoine Danchin
Published: 2002
Hardback: ISBN 978-0-9542464-3-3 £159, $319
Eminent scientists have contributed comprehensive reviews on all aspects of the genomics of Rhodococcus, Mycobacteria, Streptomyces and other organisms. The authors provide an insight into the many facets of large-scale functional investigation in a variety of bacteria with the explicit goal to find common rules in the dynamic and structural organisation of these organisms. This volume is the definitive guide to current research in this increasingly important area. read more ...
Genomic Technologies: Present and Future
Edited by: David J. Galas and Stephen J. McCormack
Published: 2002
Hardback: ISBN 978-0-9542464-2-6 £159, $319
The chapters in this book reflect the range of technical advances and their applications that are currently transforming biology. Topics covered include the application of computational methods, the robotics of modern automation methodologies, the new chemical and imaging methods that reveal chromosome structure and elucidate gene function, and the emergence of evolutionary and functional information by comparative genomics. Eminent international scientists describe in detail the new technology necessary to study the entire genome in a holistic manner and all the high throughput and large-scale experimental methodologies currently being used in genomic science. In addition the authors describe the progress of the newest technologies that are currently being developed. Written by experts in the field, this concise yet informative volume covers all aspects of technology pertaining to genomic studies. An essential book for anyone involved in genomic science. Readership: bioscientists, molecular biologists, biotechnologists, geneticists, human, animal and plant geneticists, microbiologists, genome scientists. An essential book for anyone involved in genomic science. read more ...