Genome Analysis: Current Procedures and Applications Buy now!

Edited by: Maria S. Poptsova
Published: 2014   ISBN: 978-1-908230-29-4
Price: GB £159 or US $319
In this book, an impressive array of expert authors highlight and review current advances in genome analysis. This volume provides an invaluable, up-to-date and comprehensive overview of the methods currently employed for next-generation sequencing (NGS) data analysis, highlights their problems and limitations, demonstrates the applications and indicates the developing trends in various fields of genome research. The first part of the book is devoted to the methods and applications that arose from, or were significantly advanced by, NGS technologies: the identification of structural variation from DNA-seq data; whole-transcriptome analysis and discovery of small interfering RNAs (siRNAs) from RNA-seq data; motif finding in promoter regions, enhancer prediction and nucleosome sequence code discovery from ChiP-Seq data; identification of methylation patterns in cancer from MeDIP-seq data; transposon identification in NGS data; metagenomics and metatranscriptomics; NGS of viral communities; and causes and consequences of genome instabilities. The second part is devoted to the field of RNA biology with the last three chapters devoted to computational methods of RNA structure prediction including context-free grammar applications. An essential book for everyone involved in sequence data analysis, next-generation sequencing, high-throughput sequencing, RNA structure prediction, bioinformatics and genome analysis. read more ...

Bacterial Toxins: Genetics, Cellular Biology and Practical Applications Buy now!

Edited by: Thomas Proft
Published: 2013   ISBN: 978-1-908230-28-7
Price: GB £159 or US $319
This timely volume serves as an update on the most important recent advances in the genetics, cellular biology and practical applications of the most important bacterial toxins. Written by internationally respected scientists from eight different countries, topics reviewed include: the molecular basis and risk factors for verotoxin pathogenesis; molecular mechanisms of Helicobacter pylori CagA translocation and function; structure and mechanisms of action of pore-forming toxins; bacterial enterotoxins as immunomodulators and vaccine adjuvants; mobile genetic elements as carriers for bacterial virulence genes; the novel family of staphylococcal superantigen-like toxins (SSLs); new insights into the use of botulinum neurotoxins as therapeutics; microbial toxins as tools in cell biology; the role of the large clostridial cytotoxins in C. difficile disease. Essential reading for everyone with an interest in bacterial toxins and recommended book for researchers interested in microbial genomics and microbial pathogenesis. read more ...

Bacterial Membranes: Structural and Molecular Biology Buy now!

Edited by: Han Remaut and Rémi Fronzes
Published: 2014   ISBN: 978-1-908230-27-0
Price: GB £180 or US $360
Written by specialists in the field, this book provides a comprehensive overview of the structural and molecular biology of cellular processes that occur at or near bacterial membranes. The authors present and discuss recent progress on the function and involvement of membranes in bacterial physiology enabling a greater understanding of the molecular details of the cell envelope, its biogenesis and function. Topics covered include: cell wall growth, shape and division, the outer membrane of Gram-negative bacteria, outer membrane protein biosynthesis, bacterial lipoproteins, mycobacteria, lipid composition, ABC transporters, transport across the outer membrane, drug passage across membranes, bacterial membrane proteins, secretion systems, signal transduction, signalling mechanisms, bacterial membranes in adhesion and pathogenesis, and membranes as a drug target. This cutting-edge text will provide a valuable resource for all those working in this field and is recommended for all microbiology libraries. read more ...

Fusarium: Genomics, Molecular and Cellular Biology Buy now!

Edited by: Daren W. Brown and Robert H. Proctor
Published: 2013   ISBN: 978-1-908230-25-6
Price: GB £159 or US $319
In this book, an international group of researchers critically reviews the most important current research on the genomics and molecular and cellular biology of Fusarium. The opening chapter provides a fascinating introduction to the organism. Subsequent chapters deal with: sex and fruiting; genome structural dynamics; molecular genetics and genomic approaches to study pathogenesis in wheat; proteomic analysis of the fungus-host interaction; Repeat-induced point mutation, DNA methylation and heterochromatin in Fusarium graminearum (Gibberella zeae); nitrogen regulation network and its impact on secondary metabolism and pathogenicity; diversity of polyketide synthases; and plant responses to Fusarium metabolites. This volume is essential for everyone working with Fusarium and other filamentous fungi. A recommended book for all biology, agriculture and medical libraries. read more ...

Prions: Current Progress in Advanced Research Buy now!

Edited by: Akikazu Sakudo and Takashi Onodera
Published: 2013   ISBN: 978-1-908230-24-9
Price: GB £120 or US $240
In this book, renowned prion experts review the most recent advances to provide a timely and up-to-date overview of the field. Topics covered include: prion proteins (PrP) and their family members; PrP function; molecular mechanisms of prions diseases; immunological strategies for the prevention and treatment of prion disease; microglial inflammation and prion diseases; methods for prion inactivation; clinical aspects of CJD; the BSE and scrapie prions; chronic wasting disease; future strategies for the prevention and treatment of prion diseases. The book closes with a look to the future of prion research. Essential reading for everyone with an interest in prions and prion diseases. A recommended book for all biology, veterinary and medical libraries. read more ...

RNA Editing: Current Research and Future Trends Buy now!

Edited by: Stefan Maas
Published: 2013   ISBN: 978-1-908230-23-2
Price: GB £159 or US $319
This major new work presents an up-to-date overview of RNA editing. All the chapters here have been written by experts in the various research areas and describe key recent findings as well as exploring current frontiers in the mechanisms and functional roles of RNA editing. The chapters span the editing of protein coding mRNAs, small regulatory RNAs, tRNAs and non-coding sequences. Also included are studies employing bioinformatics to identify and predict RNA editing sites as well as the evolution of RNA modification. An essential text for anyone interested in RNA editing and modification, RNA structure and function, post-transcriptional regulation, and the regulation of gene expression and a recommended purchase for molecular biology libraries. read more ...

Real-Time PCR: Advanced Technologies and Applications Buy now!

Edited by: Nick A. Saunders and Martin A. Lee
Published: 2013   ISBN: 978-1-908230-22-5
Price: GB £159 or US $319
This essential manual provides both the novice and experienced user with an invaluable reference to a wide-range of real-time PCR technologies and applications and provides an overview of the theory of this increasingly important technique. Renowned international authors present detailed technical insights into the underlying principles, methods and practice of real-time PCR. The initial chapters cover the important aspects of real-time PCR including choosing an instrument and probe system, set-up, nucleic acid synthesis, sample extraction controls, and validation and data analysis. Further chapters provide a comprehensive overview of important real-time PCR methodologies such as quantification, expression analysis and mutation detection. This is complemented by the final chapters, which address the application of real-time PCR to diagnosis of infectious diseases, biodefence, veterinary science, food authenticity and molecular haplotyping. This timely and authoritative volume serves both as a basic introduction to real-time PCR and as a source of current trends and applications for those already familiar with the technology. The editors also aim to stimulate readers of all levels to develop their own innovative approaches to real-time PCR. An essential book for all laboratories using PCR. read more ...

Microbial Efflux Pumps: Current Research Buy now!

Edited by: Edward W. Yu, Qijing Zhang and Melissa H. Brown
Published: 2013   ISBN: 978-1-908230-21-8
Price: GB £159 or US $319
Infectious diseases caused by bacteria remain a leading cause of death worldwide. Many of the antibiotics developed to combat bacterial infections have been rendered almost impotent due to the rapid evolution and spread of antibiotic resistance. A common and major resistance mechanism, the efflux system, enables bacteria to extrude structurally diverse antimicrobials, facilitating survival in toxic environments. The pumps also have important physiological functions, play major roles in bacterial pathogenesis and are distributed widely across diverse bacterial species. In addition a single species may harbour several different types of efflux systems: of these, active efflux has proven to be one of the most successful detoxification mechanisms used by both Gram-positive and -negative pathogens. Unravelling the intricacies of the microbial efflux systems is essential for the development of new strategies to overcome antimicrobial resistance. This has inspired a plethora of multidisciplinary research projects that have focused on the biochemistry, bioinformatics, structural and molecular biology of this fascinating field. With contributions from leading researchers in the field, this book reviews the most important current research and summarizes the most spectacular discoveries. Essential reading for all scientists with an interest in drug and antibiotic resistance in a range of different microorganisms. read more ...

Oral Microbial Ecology: Current Research and New Perspectives Buy now!

Edited by: Nicholas S. Jakubovics and Robert J. Palmer Jr.
Published: 2013   ISBN: 978-1-908230-17-1
Price: GB £159 or US $319
Expert authors from around the world provide an update on recent developments in the burgeoning field of oral microbial ecology. The focus of the book is on the most topical areas in oral microbiology and the volume is a major new work in the field. The chapters are arranged into five sections: microbial populations in oral biofilms, the structure of oral biofilms, communication and sensing within biofilms, health to disease - the microbial community perspective, and new approaches for oral biofilm control. Specialist authors contribute chapters on various topics including population biology, detection and culture of novel oral bacteria, bacterial catabolism of salivary substrates, structural organization of oral biofilms, the extracellular polysaccharides matrix, extracellular proteins and DNA in the matrix, a holistic view of inter-species bacterial interactions, environmental sensory perception, microbial community interactions of Streptococcus mutans, biofilms in periodontal health and disease, oral biofilms as a reservoir for pathogens, oral biofilms as a device for therapeutic agents, and probiotics in oral healthcare. The book is an essential text for scientists interested in oral microbiology, bacterial communities and biofilms and is recommended reading for anyone working in the areas of oral health, and the pathogenesis of dental caries and periodontal disease. A recommended book for all microbiology laboratories. read more ...

Real-Time PCR in Food Science: Current Technology and Applications Buy now!

Edited by: David Rodríguez-Lázaro
Published: 2013   ISBN: 978-1-908230-15-7
Price: GB £159 or US $319
Written by experts in the field, this book is an indispensable manual for scientists in the food industry. The first section, Real-Time PCR Basics, provides an introduction to real-time PCR, discusses the use of PCR diagnostics in food science, describes the principles and methods of sample preparation, and covers the verification and control of PCR procedures. The eleven chapters in the second section, Food Microbiology, cover the use of real-time PCR to detect various pathogens including Salmonella, Listeria, E. coli, Campylobacter, Yersinia, Staphylococcus, Clostridium, viruses and parasites. Also included is a chapter on the standardisation of real-time PCR methods in food microbiology. The final section, Food Quality, covers the use of real-time PCR for the analysis of GMOs, food allergens and for the identification of animal or plant species. An invaluable book for anyone involved in food science or the detection of foodborne pathogens and a recommended volume for all microbiology laboratories. read more ...

Bacterial Gene Regulation and Transcriptional Networks Buy now!

Edited by: M. Madan Babu
Published: 2013   ISBN: 978-1-908230-14-0
Price: GB £159 or US $319
Along with the strategic guidance of M. Madan Babu (Cambridge, UK) authors from around the world have joined forces to review and discuss the latest research observations and current theories in this highly topical and important area of microbiology. The first few chapters describe the components required for transcriptional regulation, elucidate their complexity and discuss the genome-scale theories that currently prevail by investigating a large number of completely sequenced microbial genomes. Other chapters discuss how transcriptional regulation and gene circuits can be used by bacteria to sense signals and generate phenotypic variation. The next chapters introduce experimental and computational methods for investigating transcriptional regulatory networks on a genomic scale. Later chapters explore the transcriptional complexity of specific organisms, discuss current understanding of the genome-scale regulatory networks and the importance of key transcription factors. Specific organisms covered include Escherichia coli, Bacillus subtilis, Helicobacter pylori, Mycobacterium tuberculosis, Pseudomonas aeruginosa and Cyanobacteria. This book constitutes a major work on bacterial gene regulation and is a recommended purchase for all institutions and organisations interested in microbiology. read more ...

Rhabdoviruses: Molecular Taxonomy, Evolution, Genomics, Ecology, Host-Vector Interactions, Cytopathology and Control Buy now!

Edited by: Ralf G. Dietzgen and Ivan V. Kuzmin
Published: 2012   ISBN: 978-1-908230-11-9
Price: GB £159 or US $319
Written by a select group of world-renowned virologists, this book reviews all of the most recent advances in rhabdovirology providing a timely overview of the field. Most contributions are written from a molecular and genomic perspective and contain expert insights upon which to base future research efforts. Topics covered include: morphology, genome organization, transcription, virus replication, taxonomy, characterization, virus evolution, vesiculovirus, lyssavirus, ephemeroviruses, fish novirhabdoviruses, the sigma viruses of Drosophila, virus-host protein interaction of plant-adapted rhabdoviruses, cereal-infecting rhabdoviruses, and rabies prevention and control including lyssavirus vaccine development. The book is a 'must read' for all virologists working on these and related negative sense RNA viruses. A recommended book for all biology, veterinary and medical libraries. read more ...

Horizontal Gene Transfer in Microorganisms Buy now!

Edited by: M. Pilar Francino
Published: 2012   ISBN: 978-1-908230-10-2
Price: GB £159 or US $319
Under the expert guidance of the editor, M. Pilar Francino, expert authors from around the world have contributed novel work and comprehensive, up-to-date reviews on the most topical aspects of horizontal gene transfer in microorganisms. Topics include: gene survival in emergent genomes, evolution of prokaryotic pangenomes, horizontal transfer of host-adaptability systems, barriers to horizontal gene transfer, evolution of horizontally transferred genes, lateral gene transfer in natural ecosystems, maintenance of plasmids among bacteria, mobile genetic elements in metagenomes, and the evolution of antibiotic resistance genes. Aimed primarily at research scientists, graduate students and other experts, this book is a major resource for anyone interested in horizontal gene transfer, microbial evolution or antibiotic resistance in bacteria. A recommended book for all microbiology laboratories. read more ...

Two-Component Systems in Bacteria Buy now!

Edited by: Roy Gross and Dagmar Beier
Published: 2012   ISBN: 978-1-908230-08-9
Price: GB £180 or US $360
In this book, expert authors from around the world present the current knowledge on two-component systems in bacteria and critically evaluate the vast amount of exciting new information that has been brought to light in recent years. The eighteen chapters cover various topics including the structure-function analysis of two-component systems, the sensing mechanisms, essential or atypical two-component systems and signaling networks, two-component systems in stress responses, two-component systems in developmental processes, and two-component systems in virulence and symbiosis. The aim of this book is to provide a comprehensive overview of the area for graduate students, academic scientists and researchers in the pharmaceutical industry. This major reference work is essential reading for everyone working on bacterial regulation or antimicrobial drug design and a recommended volume for all microbiology libraries. read more ...

Malaria Parasites: Comparative Genomics, Evolution and Molecular Biology Buy now!

Edited by: Jane M. Carlton, Susan L. Perkins and Kirk W. Deitsch
Published: 2013   ISBN: 978-1-908230-07-2
Price: GB £159 or US $319
Since the publication of the first two Plasmodium genome sequences in 2002, numerous other parasite genomes have been sequenced. These include the genomes of several more Plasmodium species as well as those of other apicomplexans, including species of Toxoplasma, Cryptosporidium, Babesia, and Eimeria. This wealth of genome sequence data has provided researchers with a powerful new tool, comparative genomics, which has revolutionised research in this area. In this book, expert authors from around the world comprehensively review the current advances in Plasmodium comparative genomics, highlighting the fascinating new insights into parasite evolution and molecular biology that have ensued. Topics include: Plasmodium taxonomy and phylogeny; the apicomplexan genomic landscape; the 'art' of sequencing Plasmodium genomes; diversity of Plasmodium falciparum and Plasmodium vivax genomes; Plasmodium functional genomics; Plasmodium experimental genetic crosses; P. falciparum epigenetic modification and transcriptional regulation; Plasmodium invasion of host red blood cells; protein export and trafficking by malaria parasites; Plasmodium-mosquito vector interactions; and a practical guide to many of the revolutionary new techniques and molecular tools for Plasmodium research. The book is essential reading for every researcher working with malaria parasites and related organisms, from the PhD student to the experienced scientist, and is a recommended text for all parasitologists. read more ...

Foodborne and Waterborne Bacterial Pathogens: Epidemiology, Evolution and Molecular Biology Buy now!

Edited by: Shah M. Faruque
Published: 2012   ISBN: 978-1-908230-06-5
Price: GB £159 or US $319
Food- and waterborne pathogens continue to be a major cause of mortality in developing countries and cause significant morbidity in developed nations. Important pathogens include species or strains of Salmonella, Vibrio, Shigella, Escherichia coli, Yersinia, Staphylococcus and Campylobacter. Understanding the molecular basis of pathogenesis, its evolution and spread is critical to the development of new strategies for disease prevention and control. The application of genomic and other omics technologies in recent years has led to a deluge of information in this area, making it difficult for the busy researcher to keep abreast of developments. This timely book aims to capture the essence of the latest developments to provide a timely overview of the field. Written by leading bacteriologists, chapters cover all the important bacteria and review topics such as pathogenic properties, population genetics, virulence genes, evolution, drug resistance, epidemiology, detection, identification and control strategies. Other topics include the molecular basis for enhanced transmissibility of waterborne pathogens, their mode of survival in the environment, and the evolution of new species with increased fitness both as pathogens and environmental organisms. Essential reading for microbiologists working with these and related pathogens. read more ...

Yersinia: Systems Biology and Control Buy now!

Edited by: Elisabeth Carniel and B. Joseph Hinnebusch
Published: 2012   ISBN: 978-1-908230-05-8
Price: GB £159 or US $319
Three members of the genus Yersinia are important human pathogens, causing diseases ranging from the deadly Plague (Yersinia pestis) to a relatively mild gastroenteritis (Y. enterocolitica and Y. pseudotuberculosis). Plague, a re-emerging disease, is endemic in many parts of the world. The extraordinary pathogenicity of Y. pestis makes it a potential bioterrorist weapon. On the other hand, the two enteropathogenic Yersinia species represent the third most common bacterial cause of gastroenteritis in Europe and probably elsewhere, although their prevalence is largely underestimated. This and the emergence of antibiotic resistant Y. pestis in recent years highlight the urgency to understand the mechanisms of pathogenicity and the need to devise new strategies for the prevention and control of human pathogenic Yersinia. In this book, leading Yersinia researchers review the hot topics in the systems biology and control of these important bacteria. Topics include: transcriptome analysis of the bacterial response to the host and of the host response to a Yersinia infection; proteome analysis of the bacterial and host responses; treatment and antibiotic resistance; vaccines; surveillance and control. Essential reading for everyone working on Yersinia and related organisms and recommended reading for researchers interested in biodefence, microbial genomics and the evolution of microbial virulence. read more ...

Stress Response in Microbiology Buy now!

Edited by: Jose M. Requena
Published: 2012   ISBN: 978-1-908230-04-1
Price: GB £180 or US $360
In this book, expert authors from around the world summarise the current knowledge on microbial stress response and comprehensively review the recent findings that have greatly advanced the understanding of stress response systems. Each chapter is devoted to a particular organism or group of organisms including Gram-negative bacteria, Streptococcus,Neisseria, Listeria monocytogenes, Bacillus cereus, Salmonella, Yersinia, Vibrio, Mycobacterium, mycoplasmas, yeast, Plasmodium falciparum, Toxoplasma gondii, Leishmania, Trypanosoma cruzi, Trypanosoma brucei and Entamoeba histolytica. In addition to providing an up-to-date review of current trends the authors also describe the challenges for future research and provide comprehensive reference sections. The volume represents a major collection of information and knowledge across a wide range of microorganisms and is essential reading for anyone with an interest in stress response. A highly recommended book for anyone interested in stress response, regulatory networks, environmental microbiology or the pathogenicity of microorganisms. read more ...

Bacterial Regulatory Networks Buy now!

Edited by: Alain A.M. Filloux
Published: 2012   ISBN: 978-1-908230-03-4
Price: GB £180 or US $360
Renowned authors under the expert guidance of the editor Alain A.M. Filloux, have contributed authoritative, up-to-date reviews of the current research and theories on regulatory networks in bacteria. The volume contains critical reviews written by the leading research scientists in this topical field. The authors fully explore various regulatory networks, discuss variations of common themes and provide fresh insights into bacterial regulatory mechanisms. Topics include: the sigma network in Escherichia coli, control of bacterial virulence, ECF sigma factors, quorum sensing, cyclic di-GMP, RNA-mediated regulation, the H-NS regulator, two-component regulatory systems, bacterial chemotaxis, regulation of iron homeostasis, anaerobic regulatory networks, bacterial bistable regulatory networks, and evolution of transcription factors and regulatory networks. This book is essential reading for everyone interested in gene expression and regulation in bacteria and is a recommended text for all microbiology libraries. read more ...

Systems Microbiology: Current Topics and Applications Buy now!

Edited by: Brian D. Robertson and Brendan W. Wren
Published: 2012   ISBN: 978-1-908230-02-7
Price: GB £159 or US $319
This volume contains cutting-edge reviews by world-leading experts on the systems biology of microorganisms. As well as covering theoretical approaches and mathematical modelling this book includes case studies on single microbial species of bacteria and archaea, and explores the systems analysis of microbial phenomena such as chemotaxis and phagocytosis. Topics covered include mathematical models for systems biology, systems biology of Escherichia coli metabolism, bacterial chemotaxis, systems biology of infection, host-microbe interactions, phagocytosis, system-level study of metabolism in Mycobacterium tuberculosis, and the systems biology of Sulfolobus. This book is a major resource for anyone interested in systems biology and a recommended text for all microbiology laboratories. read more ...

Quantitative Real-time PCR in Applied Microbiology Buy now!

Edited by: Martin Filion
Published: 2012   ISBN: 978-1-908230-01-0
Price: GB £159 or US $319
Written by experts in the field and aimed specifically at microbiologists, this volume describes and explains the most important aspects of current qPCR strategies, instrumentation and software. Renowned authors cover the application of qPCR technology in various areas of applied microbiology and comment on future trends. Topics covered include instrumentation, fluorescent chemistries, quantification strategies, data analysis software, environmental microbiology, water microbiology, food microbiology, gene expression studies, validation of microbial microarray data and future trends in qPCR technology. The editor and authors have produced an outstanding book that will be invaluable for all microbiologists. A recommended book for all microbiology laboratories. read more ...

Bacterial Spores: Current Research and Applications Buy now!

Edited by: Ernesto Abel-Santos
Published: 2012   ISBN: 978-1-908230-00-3
Price: GB £159 or US $319
In this book expert authors from around the world contribute comprehensive, up-to-date reviews on the current state of our knowledge of bacterial endospores. Topics covered include: gene regulation of sporulation, fruiting body development in Myxococcus xanthus, sporulation in Streptomyces, structure and composition of the bacterial spore, mechanisms of spore survival, germination of spores, spore peptidoglycan degradation, water and cations flux during sporulation and germination, the spore as an infectious agent, heterogeneity in spore populations, detection of bacterial spores, and the expression of recombinant proteins using spores. An essential text for everyone involved in spore research, the expression of recombinant proteins and pathogen detection, this book is also recommended for all scientists that like to keep up with cutting-edge research in microbiology and biotechnology. read more ...

Small DNA Tumour Viruses Buy now!

Edited by: Kevin Gaston
Published: 2012   ISBN: 978-1-904455-99-8
Price: GB £159 or US $319
In this timely book leading scientists from around the world review current hot-topics in this area providing a fascinating overview of the molecular biology of these viruses and their interactions with the host. Topics covered include: HPV infections and the production of HPV virion stocks; viral oncoproteins and their functions; the replication and maintenance of viral genomes; virus induced alterations in cellular miRNAs; viral deregulation of DNA damage responses; the initiation of viral DNA replication; induction of genomic instability by viral oncoproteins; targeting of PML proteins and PML nuclear bodies by these viruses; adenoviruses and gene therapy. Essential reading for scientists and researchers working on small DNA tumour viruses and their associated diseases and a recommended text for anyone involved with DNA replication, DNA damage responses and genome instability, virus-host interactions, viral tumourigenesis or antiviral drug development. read more ...

Extremophiles: Microbiology and Biotechnology Buy now!

Edited by: Roberto Paul Anitori
Published: 2012   ISBN: 978-1-904455-98-1
Price: GB £159 or US $319
This book highlights the current and topical areas of research in this rapidly growing field. Expert authors from around the world provide the latest insights into the mechanisms these fascinating organisms use to survive. The topics covered include the ability of acidophiles to maintain a neutral intracellular pH, the way that psychrophiles "loosen up" their proteins at low temperatures, and other equally ingenious adaptations and metabolic strategies that extremophiles use to survive and flourish under extreme conditions. The book also covers the established biotechnological uses of extremophiles and the most recent and novel applications including the exploitation of these organisms for enzyme production, their potential use in the generation of sustainable energy and in the oil industry. Aimed at research scientists, students, microbiologists and biotechnologists this book is essential reading for scientists working with extremophiles and a recommended reference text for anyone interested in the microbiology of these organisms, as well as bioprospecting, biomining, biofuels and extremozymes. read more ...

Bacillus: Cellular and Molecular Biology (Second edition) Buy now!

Edited by: Peter Graumann
Published: 2012   ISBN: 978-1-904455-97-4
Price: GB £180 or US $360
Extensively revised and updated, the new edition of this valuable reference work provides a comprehensive and up-to-date analysis of the current knowledge and new research in Bacillus molecular and cellular biology. Under the expert guidance of the editor Peter Graumann, renowned authors from around the world have contributed critical reviews on the most recent and topical research. Subjects covered include chromosome replication, DNA repair, chromosome segregation, cell division, transcription and translation, RNA-mediated regulation, general and regulatory proteolysis, the actin-like MreB cytoskeleton, the membrane proteome, the cell wall, endospore formation, biofilms, multicellularity and social behaviour, competence and transformation. An essential book for anyone interested in Bacillus and an important reference volume for those working in fields as diverse as medicine, biotechnology, agriculture, food and industry. A recommended book for all microbiology laboratories. read more ...

Microbial Biofilms: Current Research and Applications Buy now!

Edited by: Gavin Lear and Gillian D. Lewis
Published: 2012   ISBN: 978-1-904455-96-7
Price: GB £159 or US $319
In this book, leading scientists provide an up-to-date review of the latest scientific research on these fascinating microbial communities and predict future trends and growth areas in biofilm-related research. Under the expert guidance of the editors Gavin Lear and Gillian Lewis, authors from around the world have contributed critical reviews on the most topical aspects of current biofilm research. Subjects covered include quorum sensing and social interactions in microbial biofilms, biofilms in disease, plant-associated biofilms, biofilms in the soil, applications in bioremediation, biofilms in wastewater treatment, corrosion and fouling, aquatic biofilms, microbial fuel cells, and catalytic biofilms. The book is essential for everyone interested in biofilms and their applications. It is also highly recommended for environmental microbiologists, soil scientists, medical microbiologists, bioremediation experts and microbiologists working in biocorrosion, biofouling, biodegradation, water microbiology, quorum sensing and many other areas. read more ...

Bacterial Glycomics: Current Research, Technology and Applications Buy now!

Edited by: Christopher W. Reid, Susan M. Twine, and Anne N. Reid
Published: 2012   ISBN: 978-1-904455-95-0
Price: GB £159 or US $319
Written by a team of acknowledged experts, this book provides an up-to-date overview of our current understanding of bacterial glycomes, describes the main analytical methods in use and discusses recent and novel applications. The book is divided into three sections. The first section includes overviews of microbial glyconjugates, lipopolysaccharide, capsular polysaccharide, lipoarabinomannan biosynthesis, cell wall metabolism, and glycosylation of bacterial and archaeal proteins. The second section reviews the analytical approaches used in the characterization of the bacterial glycome. The final section describes applications of bacterial glycomics, including metabolic oligosaccharide labeling, the synthesis of bioactive glycans and the potential for glycoconjugate vaccines. Essential reading for microbiologists working in polysaccharide and carbohydrate research, the book is also recommended for carbohydrate experts, microbiologists, immunologists and researchers in many other fields of life sciences. read more ...

Brucella: Molecular Microbiology and Genomics Buy now!

Edited by: Ignacio López-Goñi and David O'Callaghan
Published: 2012   ISBN: 978-1-904455-93-6
Price: GB £159 or US $319
Written by highly acclaimed Brucella scientists, this book comprehensively reviews the most important advances in the field. Opening chapters focus on genetic diversity within Brucella, covering both classical and new species. Particular emphasis is given to how comparative genomics has led to advances in molecular diagnostics, taxonomy and phylogeny. Following chapters cover proteomic analysis, transcriptomic analysis, the VirB type IV secretion system, signalling complexes, e.g. the BvrR/BvrS two-component regulatory system and quorum sensing. These chapters highlight the intricate interplay between factors involved in virulence. Another chapter discusses the role of the Brucella cell envelope in bacterial virulence and evasion of host defences. The final two chapters review the current strategies for the development of novel antibacterial agents and improved vaccines. This volume is essential reading for everyone with an interest in Brucella and brucellosis. It is also recommended reading for the wider body of scientists, veterinarians and MDs with an interest in microbial diagnostics, microbial pathogenesis, host-parasite interactions, cellular microbiologists and immunologists and vaccine development scientists. read more ...

Bacterial Pathogenesis: Molecular and Cellular Mechanisms Buy now!

Edited by: Camille Locht and Michel Simonet
Published: 2012   ISBN: 978-1-904455-91-2
Price: GB £180 or US $360
In this book, a group of distinguished scientists from eight different countries and three continents, under the expert guidance of the editors Camille Locht and Michel Simonet, overview the molecular and cellular mechanisms of bacterial pathogenesis. The fifteen chapters are organized into five sections: approaches to the study of bacterial pathogenesis; bacterial adhesion to the cell surface and extracellular matrix of host tissues; poisoning the host by toxins; cellular invasion by bacterial pathogens; and bacterial evasion of host defences. The authors comprehensively describe the most relevant and up-to-date information on pathogenic features across the bacterial world. Aimed at the entire scientific community from students to senior scientists and physicians, the book is relevant to a broad range of people interested in the mechanisms of bacterial infectious diseases and is a recommended text for all microbiology laboratories. read more ...

Emerging Trends in Antibacterial Discovery: Answering the Call to Arms Buy now!

Edited by: Alita A. Miller and Paul F. Miller
Published: 2011   ISBN: 978-1-904455-89-9
Price: GB £180 or US $360
In this book, respected international experts summarize the most important concepts and pioneering strategies currently being used to develop novel antibacterials. The book opens with chapters on cellular processes that could be used as novel antibacterial targets. Examples include cell division, efflux pumps, metabolite-sensing riboswitches and bacterial secretion systems. These are followed by excellent chapters on the identification of new, naturally occurring antibacterial agents, including phage and biosynthetically engineered compounds. Understanding the host-microbe interaction and microbial communities and how they can be exploited to develop new antibacterial strategies is discussed in subsequent chapters. Other topics included are: antibacterial vaccines adjuvants, host defence peptides, antibodies, within-host models, and diagnostics. A major reference volume on antibacterial research and how it impacts on public health worldwide, the book is essential reading for everyone working in antibacterial research and is a recommended volume for all microbiology libraries. read more ...

Epigenetics: A Reference Manual Buy now!

Edited by: Jeffrey M. Craig and Nicholas C. Wong
Published: 2011   ISBN: 978-1-904455-88-2
Price: GB £180 or US $360
The editors of this book have assembled top-quality scientists from diverse fields of epigenetics to produce a major new volume. Comprehensive and cutting-edge, the 26 chapters in this book constitute a key reference manual for everyone involved in epigenetics, DNA methylation, cancer epigenetics and related fields. Topics include: early life environment, DNA methylation and behavior, histone acetyltransferase biology, transgenerational epigenetic inheritance, mammalian X inactivation, epigenetic memory in plants, polycomb-group regulation, centromeres and telomeres, DNA sequence contribution to nucleosome distribution, macrosatellite epigenetics, histones, cell-fate specification and reprogramming, DNA methylation in cancer, variant histone H2A and cancer development, RNA modification, paramutation in plants, DNMT3L dependent methylation during gametogenesis, non-coding RNA, bisulphite-enabled technologies, rapid analysis of DNA methylation, microarray mapping, DNA methylation profiling, ChIP-sequencing, genome-wide DNA methylation analysis, and epigenetics in maize. In addition there are useful chapters on bioinformatics in epigenomics, online resources and tools for epigeneticists, and educational resources for epigenetics. This up-to-date reference manual is an essential book for those working in the field and for scientists in other disciplines it represents a major information resource on the fascinating and fast-moving field of epigenetics. read more ...

Metagenomics: Current Innovations and Future Trends Buy now!

Edited by: Diana Marco
Published: 2011   ISBN: 978-1-904455-87-5
Price: GB £159 or US $319
This book covers the most innovative and recent advances in theoretical, methodological and applied areas of metagenomics. Topics covered include metagenomics integration with complementary technologies, bacterial genealogy, viral metagenomics, the regulation of prokaryotic communities, functional metagenomics, systems biology, next-generation sequencing, stable isotope probing, DNA sequencing of uncultured microbes, cyberinfrastructure resource, identification of novel viruses, metagenomics of fungal communities, the human microbiome, microbial bioremediation, metagenomic enzyme discovery, quorum-sensing, plant-pathogen interactions, and metagenomics of belowground microbial communities. The book is aimed at researchers and environmental managers involved in metagenomics, students starting research in this field and teachers interested in the new developments. read more ...

Nitrogen Cycling in Bacteria: Molecular Analysis Buy now!

Edited by: James W. B. Moir
Published: 2011   ISBN: 978-1-904455-86-8
Price: GB £159 or US $319
This timely book aims to provide comprehensive reviews of current nitrogen cycle research and to give a broader perspective on the state of our understanding of this key biogeochemical cycle. With contributions from expert authors from around the world, topics covered include: the archaean N-cycle; redox complexes N-cycle; organisation of respiratory chains in N-cycle processes; Mo-nitrogenase; nitrogen assimilation in bacteria; alternative routes to dinitrogen; nitrite and nitrous oxide reductases; assembly of respiratory proteins; nitric oxide metabolism; denitrification in legume-associated endosymbiotic bacteria; nitrous oxide production in the terrestrial environment; bacterial nitrogen cycling in humans. This book will serve as a valuable reference work for everyone working in this field and will also be of interest to researchers studying symbioses, environmental microbiology, plant metabolism, infection events and other prokaryote-eukaryote interactions. read more ...

Helicobacter pylori Buy now!

Edited by: Lyudmila Boyanova
Published: 2011   ISBN: 978-1-904455-84-4
Price: GB £159 or US $319
This book highlights recent research and provides in a single volume an up-to-date summary of our current knowledge for microbiologists, clinicians and advanced students working with Helicobacter and for those wishing to enter the field. The authors offer an outstanding collection of reviews on many aspects of Helicobacter research including microbiology, virulence factors, immunology, vaccine research, epidemiology, diseases associated with the infection, antibiotic resistance, and treatment (including the use of non-antibiotic agents). A major reference volume on Helicobacter pylori and how it impacts on public health worldwide, the book is essential reading for those with an interest in the microbiology of H. pylori and is a recommended volume for all microbiology libraries. read more ...

Microbial Bioremediation of Non-metals: Current Research Buy now!

Edited by: Anna-Irini Koukkou
Published: 2011   ISBN: 978-1-904455-83-7
Price: GB £159 or US $319
Topics covered include: enzymatic biodegradation reactions; the impact of bioturbation on hydrocarbon dynamics in marine sediments; the structure, function and biodiversity of ring-hydroxylating dioxygenases involved in PAH biodegradation; strategies to engineer PCB-degrading bacteria; PCB-degrading plant-microbe systems strategies; the structure, regulation and diversity of microbial genes encoding biodegradative enzymes. In addition there are excellent reviews detailing the application of the state-of-the-art molecular technologies to study biodegradative processes. Technologies covered are community fingerprinting, molecular detection of degradative genes, and metagenomics for the analysis and monitoring of microorganisms in situ. These are complemented well by the fascinating reviews of the catabolic plasmids and mobile genetic elements involved in bioremediation, including discussions on the origin and evolution of these catabolic pathways to different genera. In addition the best procedures for the evaluation and design of relevant in situ remediation strategies are examined and classical ex-situ technologies such Landfarming, Composting, Biopiling and Slurry-phase bioremediation are described. This book is a vital reference resource for research scientists, graduate students, and other specialists interested on microbial bioremediation of organic pollutants and is recommended reading for environmental microbiologists, chemists and engineers. read more ...

Lactic Acid Bacteria and Bifidobacteria: Current Progress in Advanced Research Buy now!

Edited by: Kenji Sonomoto and Atsushi Yokota
Published: 2011   ISBN: 978-1-904455-82-0
Price: GB £159 or US $319
In this comprehensive book, expert international authors review the most recent cutting-edge research in these areas. Topics include: Lactobacillus genomics; Bifidobacterium gene manipulation technologies; metabolism of human milk oligosaccharides in bifidobacteria; proton-motive metabolic cycles; oxidative stress and oxygen metabolism; Bifidobacterium response to O₂; bile acid stress in LAB and bifidobacteria; protein structure quality control; bacteriocin classification and diversity; lactococcal bacteriocins; lactobacilli bacteriocins; other bacteriocins; production of optically pure lactic acid; antihypertensive metabolites from LAB; the anti-H. pylori effect of Lactobacillus gasseri; probiotics for allergic rhinitis; probiotics health claims in Japan and Europe. Essential reading for every researcher working with LAB, bifidobacteria and probiotics, from the PhD student to the experienced scientist. read more ...

Viruses and Interferon: Current Research Buy now!

Edited by: Karen Mossman
Published: 2011   ISBN: 978-1-904455-81-3
Price: GB £159 or US $319
In this book, a panel of international experts reviews the current hot-topics, producing a timely overview of this exciting field. The book opens with a chapter that comprehensively reviews the antiviral effects of extracellular double-stranded RNA, the "viral toxin". This is followed by chapters that review the properties of type I and type III interferons, and the role of interferon-stimulated genes. The next five chapters are devoted to understanding the diverse strategies used by clinically relevant human viruses to subvert host interferon responses. The closing chapter provides an interesting overview of the clinical application of interferon as antiviral and anticancer agents. Essential reading for every scientist involved in interferon or antiviral research and a recommended text for all virology laboratories. read more ...

Hepatitis C: Antiviral Drug Discovery and Development Buy now!

Edited by: Seng-Lai Tan and Yupeng He
Published: 2011   ISBN: 978-1-904455-78-3
Price: GB £180 or US $360
The editors of this book have recruited experts from around the world to produce a timely and well-compiled review of current HCV research with an emphasis on antiviral drug development. The chapters provide in-depth reviews of the most critical areas of research. Topics covered include: the HCV life cycle, HCV assays, HCV resources, HCV databases, HCV infection systems, models of hepatitis C infections, overview of the drug pipeline, clinical trial design, clinical virology and drug development, NS3 protease inhibitors, NS3-NS4A complex inhibitors, NS3 helicase inhibitors, NS4B targets and inhibitors, NS5A inhibitors, nucleoside inhibitors, NS5B polymerase inhibitors, glycoprotein-dependent entry, host cell targets and inhibitors, and innate immunity for HCV antiviral therapy. An essential book for scientists involved with HCV and anyone interested in antiviral drug development. A recommended text for all virology libraries. read more ...

Streptomyces: Molecular Biology and Biotechnology Buy now!

Edited by: Paul Dyson
Published: 2011   ISBN: 978-1-904455-77-6
Price: GB £159 or US $319
With contributions from some of the leading scientists in the field, this volume documents recent research and development in streptomycetes genomics, physiology and metabolism. With a focus on biotechnology and genomics, the book provides an excellent source of up-to-date information. Topics include: genome architecture, conjugative genetic elements, differentiation, protein secretion, central carbon metabolic pathways, regulation of nitrogen assimilation, phosphate control of metabolism, gamma-butyrolactones and their role in antibiotic regulation, clavulanic acid and clavams, genome-guided exploration, gene clusters for bioactive natural products, genomics of cytochromes p450. Essential reading for research scientists, biotechnologists, graduate students and other professionals involved in streptomycetes research, antibiotic and antimicrobial development, drug discovery, soil microbiology and related fields. A recommended text for all microbiology laboratories. read more ...

Alphaherpesviruses: Molecular Virology Buy now!

Edited by: Sandra K. Weller
Published: 2011   ISBN: 978-1-904455-76-9
Price: GB £180 or US $360
Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections. read more ...

Recent Advances in Plant Virology Buy now!

Edited by: Carole Caranta, Miguel A. Aranda, Mark Tepfer and J.J. Lopez-Moya
Published: 2011   ISBN: 978-1-904455-75-2
Price: GB £180 or US $360
Viruses that infect plants are responsible for reduction in both yield and quality of crops around the world, and are thus of great economic importance. This has provided the impetus for the extensive research into the molecular and cellular biology of these pathogens and into their interaction with their plant hosts and their vectors. However interest in plant viruses extends beyond their ability to damage crops. Many plant viruses, for example tobacco mosaic virus, have been used as model systems to provide basic understanding of how viruses express genes and replicate. Others permitted the elucidation of the processes underlying RNA silencing, now recognised as a core epigenetic mechanism underpinning numerous areas of biology. This book attests to the huge diversity of research in plant molecular virology. Written by world authorities in the field, the book opens with two chapters on the translation and replication of viral RNA. Following chapters cover topics such as viral movement within and between plants, plant responses to viral infection, antiviral control measures, virus evolution, and newly emerging plant viruses. To close there are two chapters on biotechnological applications of plant viruses. Throughout the book the focus is on the most recent, cutting-edge research, making this book essential reading for everyone, from researchers and scholars to students, working with plant viruses. read more ...

Vaccine Design: Innovative Approaches and Novel Strategies Buy now!

Edited by: Rino Rappuoli and Fabio Bagnoli
Published: 2011   ISBN: 978-1-904455-74-5
Price: GB £180 or US $360
In this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies. The book has been divided into two parts. The first part reviews the technologies and approaches used to identify, generate and test new vaccines. Topics include: new strategies to identify protective antigens, generation of improved adjuvants, use of alternative immunization routes, improving vaccine safety, and finding and establishing the correlates of protection. The second part of the book focuses on the development of new vaccines to replace or complement currently available products or for diseases against which prophylactic strategies are missing. Examples include vaccines against nosocomial infections, streptococci, emerging viral diseases, P. aeruginosa, and bovine mastitis. Essential reading for everyone with an interest in vaccine R & D. read more ...

Salmonella: From Genome to Function Buy now!

Edited by: Steffen Porwollik
Published: 2011   ISBN: 978-1-904455-73-8
Price: GB £159 or US $319
In this book, internationally acclaimed experts review cutting-edge topics in Salmonella genomics and molecular biology, providing a timely snapshot of the current state of research. Topics include latest approaches to sub-species level classification and phage typing of Salmonella, comparative genomics, the search for genetic determinants for survival of the bacterium in different environments and the evolution of niche specialization by Salmonella. The book also explores the latest genomic information and molecular characterizations of sRNAs and complements of fimbriae, flagella and secreted virulence factors. Moreover, S. Typhi pathogenesis, interactions of the host with intracellular Salmonella and the host's anti-Salmonella immune response are reviewed. The current knowledge on Salmonella biofilm formation and a progress report on using Salmonella as an anti-tumour tool conclude this compendium. Essential reading for all researchers working with Salmonella and related organisms, and recommended reading for other scientists working on bacterial genomics, molecular biology and bacterial molecular and cellular pathogenesis. read more ...

PCR Troubleshooting and Optimization: The Essential Guide Buy now!

Edited by: Suzanne Kennedy and Nick Oswald
Published: 2011   ISBN: 978-1-904455-72-1
Price: GB £159 or US $319
This book discusses the strategies for preparing effective controls and standards for PCR, when they should be employed and how to interpret the information they provide. It highlights the significance of optimization for efficiency, precision and sensitivity of PCR methodology and provides essential guidance on how to troubleshoot inefficient reactions. Experts in PCR describe design and optimization techniques, discuss the use of appropriate controls, explain the significance of standard curves and explore the principles and strategies required for effective troubleshooting. Authors highlight the importance of sample preparation and quality, primer design, controlling inhibitors, avoiding amplicon and environmental contamination, optimizing reagent quality and concentration, and modifying the thermal cycling protocol for optimal sensitivity and specificity. In addition, specific chapters discuss the history of PCR, the choice of instrumentation, the applications of PCR in metagenomics, high resolution melting analysis, the MIQE guidelines, and PCR at the microliter scale. The strategies, tips and advice contained in this concise volume enable the scientist to optimize and effectively troubleshoot a wide range of techniques including PCR, reverse transcriptase PCR, real-time PCR and quantitative PCR. An essential book for anyone using PCR technology. read more ...

Insect Virology Buy now!

Edited by: Sassan Asgari and Karyn N. Johnson
Published: 2010   ISBN: 978-1-904455-71-4
Price: GB £180 or US $360
Written by internationally renowned insect virologists, chapters review the current molecular biology of all the major groups of insect pathogenic viruses and suggest future directions for research. The book is divided into three parts: 1) DNA viruses 2) RNA viruses and 3) current hot-topics in insect virology. Virus groups covered include: Ascoviruses, Baculoviruses, Densoviruses, Entomopoxviruses, Hytrosaviruses, Iridoviruses, Nudiviruses, Polydnaviruses, Dicistroviruses, Iflaviruses, Nodaviruses, Tetraviruses and Cypoviruses. The special topics chapters review exciting recent developments in insect virology including RNAi, insect antiviral responses, structural comparison of insect RNA viruses, and viral ecology. The book is essential reading for every insect virologist in both the academic and private sectors. It is also strongly recommended for other virologists, particularly those interested in virus evolution, virus structure, viral vectors, biological control of insects and insect immunity. read more ...

Environmental Microbiology: Current Technology and Water Applications Buy now!

Edited by: Keya Sen and Nicholas J. Ashbolt
Published: 2011   ISBN: 978-1-904455-70-7
Price: GB £159 or US $319
Authors have included comparative tables and figures that address detection sensitivity, specificity, ease of use and other criteria. The value of the book emanates from its explanation of the principles of techniques and the comparison of related techniques. In addition the reader is introduced to key references and important web sites where further details of the technology can be found. An essential book for water microbiologists, environmental microbiologists and regulators and recommended reading for all microbiologists and environmental scientists. read more ...

Sensory Mechanisms in Bacteria: Molecular Aspects of Signal Recognition Buy now!

Edited by: Stephen Spiro and Ray Dixon
Published: 2010   ISBN: 978-1-904455-69-1
Price: GB £159 or US $319
In this unique book, an international team of experts reviews a selection of important model systems, providing a timely snapshot of the current state of research in the field. The book opens with an introductory chapter that reviews the diversity of signal recognition mechanisms, illustrating the breadth of the field. Subsequent chapters include descriptions of the sensing of ligands (α-ketoglutarate, adenylate energy charge, glutamine and xenobiotic compounds), chemoreceptors, iron-sulfur cluster-based sensors, metal-dependent and metal-responsive sensors, thiol-based sensors, and PDZ domains as sensors of other proteins. This book provides essential reading for everyone with an interest in sensory mechanisms, regulatory networks and responses to environmental stress in bacteria. read more ...

Bifidobacteria: Genomics and Molecular Aspects Buy now!

Edited by: Baltasar Mayo and Douwe van Sinderen
Published: 2010   ISBN: 978-1-904455-68-4
Price: GB £159 or US $319
This book brings together the expertise and enthusiasm of the leading bifidobacteria experts from around the world to provide a state-of-the art overview of the molecular biology and genomics of this exciting and important microbial genus. Topics include: ecology, genomics, comparative genomics, metabolism, acid and bile resistance, stress response, probiotic properties, antimicrobial activity, interaction with the intestinal mucosa, safety assessment of bifidobacteria, synthesis and utilization of exopolysaccharides and prebiotics, antibiotic resistance/susceptibility profiles, viability and stability in commercial preparations, mobile genetic elements, cloning vectors and genetic manipulation of bifidobacteria. Essential reading for every bifidobacteria researcher, from the PhD student to the experienced scientist, and recommended reading for everyone with an interest in probiotics. read more ...

Molecular Phylogeny of Microorganisms Buy now!

Edited by: Aharon Oren and R. Thane Papke
Published: 2010   ISBN: 978-1-904455-67-7
Price: GB £159 or US $319
In this book, leading scientists from around the world explore current concepts in molecular phylogeny and their application with respect to microorganisms. The authors describe the different approaches applied today to elucidate the molecular phylogeny of prokaryotes (and eukaryotic protists) and review current phylogenetic methods, techniques and software tools. Topics covered include: a historical overview, computational tools, multilocus sequence analysis, 16S rRNA phylogenetic trees, rooting of the universal tree of life, applications of conserved indels, lateral gene transfer, endosymbiosis and the evolution of plastids. This book is an ideal introduction to molecular phylogeny for all microbiologists and is an essential review of current concepts for experts in the field. A recommended text for all microbiology laboratories. read more ...

Nanotechnology in Water Treatment Applications Buy now!

Edited by: T. Eugene Cloete, Michele de Kwaadsteniet, Marelize Botes and J. Manuel López-Romero
Published: 2010   ISBN: 978-1-904455-66-0
Price: GB £159 or US $319
This timely volume reviews the current state-of-the-art research and development of different nanomaterials (nanostructured catalytic membranes, nanosorbents, nanocatalysts and bioactive nanoparticles) and their application in water treatment, purification and disinfection. The expert authors have contributed chapters focusing on the cutting-edge research in this emerging technology and its applications in microbiology and water treatment. Topics covered include the detection of microbial pathogens, nanofibers and nanobiocides in water purification, nanozymes for biofilm removal, water and wastewater treatment and reverse osmosis. Also included is a chapter dedicated to the health and environmental concerns for the use of nanotechnology in water treatment. This book is aimed at everyone interested in nanobiotechnology, bioremediation, biodiagnostics, molecular diagnostics and environmental microbiology and is a recommended text for all microbiology laboratories. read more ...

Iron Uptake and Homeostasis in Microorganisms Buy now!

Edited by: Pierre Cornelis and Simon C. Andrews
Published: 2010   ISBN: 978-1-904455-65-3
Price: GB £159 or US $319
In this book, an international team of authors presents a comprehensive collection of reviews on iron uptake and metabolism in various microorganisms including rhizobia, Bordetella, Shigella, E. coli, Erwinia, Vibrio, Aeromonas, Francisella, Bacteroides, Campylobacter, cyanobacteria, Bacillus, staphylococci and yeasts. An entire chapter is dedicated to siderophores and another to heme uptake. The volume provides an expert and timely summary of current knowledge, with a focus on molecular and genetic aspects, and highlights some of the most exciting recent developments. Aimed at research scientists, advanced students and other specialists, this book is highly recommended for everyone interested in iron uptake and metabolism, microbial pathogenesis and microbial ecology. read more ...

Caliciviruses: Molecular and Cellular Virology Buy now!

Edited by: Grant S. Hansman, Xi Jason Jiang and Kim Y. Green
Published: 2010   ISBN: 978-1-904455-63-9
Price: GB £159 or US $319
In this book, a panel of experts distil the most important up-to-date research findings in their respective calicivirus field of study producing timely and comprehensive reviews. Each chapter gives the reader a brief introduction to the topic followed by a descriptive discussion of the past and present research areas. Topics include: norovirus epidemiology; calicivirus contamination of the environment; genome organization and recombination, proteolytic cleavage and viral proteins; viral protein structures; virus-host interactions; calicivirus reverse genetics and replicon systems; feline calicivirus; swine calicivirus; murine norovirus pathogenesis and immunity; murine norovirus translation, replication and reverse genetics; and lagoviruses. This book is essential reading for all virologists working on caliciviruses and related viruses and is recommended for all virology, immunology and molecular biology laboratories. read more ...

Anaerobic Parasitic Protozoa: Genomics and Molecular Biology Buy now!

Edited by: C. Graham Clark, Patricia J. Johnson and Rodney D. Adam
Published: 2010   ISBN: 978-1-904455-61-5
Price: GB £159 or US $319
In this book internationally acclaimed researchers critically review the most important aspects of research on anaerobic parasitic protozoa, providing the first coherent picture of their genomics and molecular biology since the publication of the genomes. Chapters are written from a molecular and genomic perspective and contain speculative models upon which future research efforts can be based. Topics include: the genomes of Entamoeba histolytica, Trichomonas vaginalis, Giardia and other diplomonads; the cytoskeletons of Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis; genomic analyses and manipulation of gene expression in Entamoeba histolytica; nuclear and chromosomal structure and replication in Giardia; and the mitochondrion-like organelles of a fourth anaerobe, Blastocystis. Essential reading for all researchers working with these protozoa and related organisms and with eukaryotic model organisms. Recommended text for all parasitology laboratories. read more ...

Lentiviruses and Macrophages: Molecular and Cellular Interactions Buy now!

Edited by: Moira Desport
Published: 2010   ISBN: 978-1-904455-60-8
Price: GB £159 or US $319
In this timely book, top lentivirus and macrophage specialists comprehensively review cutting-edge topics in the molecular and cellular biology of the lentivirus-macrophage interaction. Topics include: lentivirus tropism and disease, macrophage biology, macrophage in HIV-1 infection and disease progression, post-entry restrictions to lentiviral replication, HIV-2 tropism and disease, SHIV model of disease, the felid immunodeficiency viruses, EIAV, small ruminant lentiviruses, bovine lentiviruses, coinfections and superinfections. Essential reading for every lentivirologist and retrovirologist, this is also a recommended text for all virology, immunology and molecular biology laboratories. read more ...

Microbial Population Genetics Buy now!

Edited by: Jianping Xu
Published: 2010   ISBN: 978-1-904455-59-2
Price: GB £159 or US $319
Written by leading researchers in the field, this invaluable book details the major current advances in microbial population genetics and genomics. Distinguished international scientists introduce fundamental concepts, describe genetic tools and comprehensively review recent data from SNP surveys, whole-genome DNA sequences and microarray hybridizations. Chapters cover broad groups of microorganisms including viruses, bacteria, archaea, fungi, protozoa and algae. A major focus of the book is the application of molecular tools in the study of genetic variation. Topics covered include microbial systematics, comparative microbial genomics, horizontal gene transfer, pathogenic bacteria, nitrogen-fixing bacteria, cyanobacteria, microalgae, fungi, malaria parasites, viral pathogens and metagenomics. An essential volume for everyone interested in population genetics and highly recommended reading for all microbiologists. read more ...

Borrelia: Molecular Biology, Host Interaction and Pathogenesis Buy now!

Edited by: D. Scott Samuels and Justin D. Radolf
Published: 2010   ISBN: 978-1-904455-58-5
Price: GB £159 or US $319
Written by renowned scientists who have made seminal contributions to the field, this book is a comprehensive guide to the pathogenic Borrelia, providing researchers, advanced students, clinicians, and other professionals with an encyclopedic overview of the molecular biology of this important genus and the pathogenesis of diseases caused. Leading authorities have contributed chapters on topics such as Borrelia genomics, DNA replication, gene regulation, transcriptomics, proteomics, metabolism and physiology, cellular structure, motility and chemotaxis, genetic manipulation, evolutionary genetics, ecology, tick interactions, Lyme disease and relapsing fever pathogenesis, animal models, host response, detection, and vaccines. The volume is essential for anyone involved in Borrelia research and is strongly recommended for microbiologists, immunologists, and physicians involved in spirochete research, Lyme borreliosis, or relapsing fever. The book is a recommended reference volume for all microbiology libraries. read more ...

Influenza: Molecular Virology Buy now!

Edited by: Qinghua Wang and Yizhi Jane Tao
Published: 2010   ISBN: 978-1-904455-57-8
Price: GB £159 or US $319
In this timely book, internationally renowned scientists critically review the current research and the most important discoveries in this highly topical field. Subjects covered include the NS1 protein of influenza A virus, the structure of influenza NS1, influenza B hemagglutinin, influenza A nucleoprotein, influenza A hemagglutinin glycoproteins, the M2 channel, virulence genes of the 1918 pandemic influenza, influenza virus polymerase, gene diagnostic microarrays, and computer-assisted vaccine design. Highly informative and well referenced, this book is essential reading for all influenza specialists and is recommended reading for all virologists, immunologists, molecular biologists, public health scientists and research scientists in pharmaceutical companies. read more ...

RNA Interference and Viruses: Current Innovations and Future Trends Buy now!

Edited by: Miguel Angel Martínez
Published: 2010   ISBN: 978-1-904455-56-1
Price: GB £159 or US $319
In this book, expert RNAi specialists from around the world have teamed up to produce a timely and thought-provoking review of the area. The two central themes are: 1) the latest findings on RNAi-virus interactions and 2) progress in the development of RNAi-based antiviral therapeutics. A number of chapters explain general concepts concerned with the role of RNAi in natural antiviral defense mechanisms, other chapters discuss how to improve the efficacy and safety of RNAi-based antiviral drugs, while others describe how this technology is being developed as a new therapeutic tool for fighting specific viruses, including HIV, HCV and respiratory viruses. Authors also outline potential new avenues for research thus providing a stimulus for further research. Essential reading for researchers involved in RNAi or antiviral research and a recommended text for all virology laboratories. read more ...

Retroviruses: Molecular Biology, Genomics and Pathogenesis Buy now!

Edited by: Reinhard Kurth and Norbert Bannert
Published: 2010   ISBN: 978-1-904455-55-4
Price: GB £159 or US $319
Written by the top retroviral specialists, this book reviews the genomics, molecular biology, and pathogenesis of these important viruses, comprehensively covering all the recent advances. Topics include: host and retroelement interactions, endogenous retroviruses, retroviral proteins and genomes, viral entry and uncoating, reverse transcription and integration, transcription, splicing and RNA transport, pathogenesis of oncoviral infections, pathogenesis of immunodeficiency virus infections, retroviral restriction factors molecular vaccines and correlates of protection, gammaretroviral and lentiviral vectors, non-primate mammalian and fish retroviruses, simian exogenous retroviruses, and HTLV and HIV. Essential reading for every retrovirologist and a recommended text for all virology and molecular biology laboratories. read more ...

Metagenomics: Theory, Methods and Applications Buy now!

Edited by: Diana Marco
Published: 2010   ISBN: 978-1-904455-54-7
Price: GB £159 or US $319
This book addresses in a coherent manner the diverse and multiple aspects of metagenomics and the multiplicity of its potential applications. Renowned authors from around the world have contributed chapters covering the new theoretical insights, the more recent applications, and the dynamically developing methods of data acquisition and analysis. Topics include: Conceptual frameworks, tools and methods, integration of complementary approaches, horizontal gene transfer, analysis of complex microbial communities, public data resources, plant-microbe interactions, bioremediation, industrial bioproducts, archaeal metagenomics, bioprospecting novel genes, the human microbiome, and philosophical themes in metagenomics. The book is essential reading for all researchers currently performing metagenomics studies and is highly recommended for all students and scientists wishing to increase their understanding of this field. read more ...

Aspergillus: Molecular Biology and Genomics Buy now!

Edited by: Masayuki Machida and Katsuya Gomi
Published: 2010   ISBN: 978-1-904455-53-0
Price: GB £159 or US $319
In this book leading Aspergillus researchers review and summarise the most important aspects of Aspergillus molecular biology and genomics. The book opens with a fascinating overview of the genus Aspergillus. This is followed by in-depth reviews of the Aspergillus molecular systematics, comparative genomics, bioinformatics and systems biology of Aspergillus, transcriptional regulation, genetics and genomics of sexual development of A. nidulans, genomics and secondary metabolism, ecology, development and gene regulation in A. flavus, functional systems biology, and novel industrial applications of A. oryzae genomics. Essential reading for everyone with an interest in Aspergillus and related fungi. read more ...

Environmental Molecular Microbiology Buy now!

Edited by: Wen-Tso Liu and Janet K. Jansson
Published: 2010   ISBN: 978-1-904455-52-3
Price: GB £159 or US $319
This book highlights the current state-of-the-art of environmental molecular microbiology. International experts have contributed chapters that describe the various technologies and their applications in environmental microbiology. The first half of the book focuses on the microbial diversity and phylogeny of microorganisms in the environment and describes the molecular toolbox currently available for the study of the composition and diversity of microbial communities and their functions. Topics include the use of the 16S rRNA gene as a phylogenetic marker, metagenomics, metaproteomics, microarrays, and molecular fingerprinting. The second half focuses on the application of these approaches in various environments including soil, marine water, plants, humans and wastewater treatment. The last chapter of the book discusses the genetics and environmental implications of microbial biofilms. An essential book for advanced students, research scientists, environmental agencies and industries involved in any aspect of environmental microbiology. read more ...

Neisseria: Molecular Mechanisms of Pathogenesis Buy now!

Edited by: Caroline Genco and Lee Wetzler
Published: 2010   ISBN: 978-1-904455-51-6
Price: GB £159 or US $319
This important reference volume provides research scientists, advanced students, clinicians, and other professionals with a comprehensive update on the current understanding of the molecular mechanisms of pathogenesis in Neisseria. The editors have assembled a team of highly regarded scientists, over 40 contributors, to describe the latest, up-to-date research, theory and clinical significance of molecular mechanisms in meningococcal disease. Leading authorities have contributed chapters on topics such as gene expression, genomics, biofilms, denitrification, adhesion strategies and mechanisms of cellular invasion. A section on the host response to neisserial infection covers inate immunity, complement, apoptosis, and acquired immunity while a section devoted to clinical correlation deals with vaccine development, epidemiology and antibiotic resistance. The volume is highly recommended for microbiologists, epidemiologists and clinicians involved with Neisseria research or meningococcal disease and is a recommended text for all microbiology libraries. read more ...

ABC Transporters in Microorganisms Buy now!

Edited by: Alicia Ponte-Sucre
Published: 2009   ISBN: 978-1-904455-49-3
Price: GB £159 or US $319
This concise volume describes the latest, up-to-date theory, methodology and applications of ABC transporters in microorganisms. The topics include the structure, physiology and evolution of ABC transporters, as well as their special characteristics in specific microorganisms including bacteria, yeast, trypanosomes and malaria parasites. In particular the book describes the most recent research and innovations relative to the role of ABC transporters in the design of strategies to circumvent drug resistance in microorganisms. Each chapter comprises an exhaustive review of the particular topic and provides insights into the future of the field both from the scientific and clinical perspective. Essential reading for anyone involved in this field and a recommended volume for all microbiology laboratories. read more ...

Pili and Flagella: Current Research and Future Trends Buy now!

Edited by: Ken Jarrell
Published: 2009   ISBN: 978-1-904455-48-6
Price: GB £159 or US $319
This book, the first for many years on this important topic, brings together some of the top scientists in the field and describes the current knowledge and latest research on prokaryotic pili and flagella. The emphasis of the chapters is on the molecular biology, genetics, structure, assembly and function of these structures. Topics include biogenesis, structure, and function of various pili in Gram-negative and Gram-positive organisms, flagellar gene expression, structure and assembly, the flagella motor, posttranslational modifications of flagella systems, lateral flagella systems, the origin and evolution of flagella, applications of flagella as a surface display and expression system, and a chapter on the flagella and pili of Archaea. A recommended text for all microbiology laboratories and an essential volume for anyone involved in microbial adhesion, pathogenesis, virulence, structural biology, host colonization and motility. read more ...

Lab-on-a-Chip Technology (Vol. 2): Biomolecular Separation and Analysis Buy now!

Edited by: Keith E. Herold and Avraham Rasooly
Published: 2009   ISBN: 978-1-904455-47-9
Price: GB £159 or US $319
The editors of this book have brought together expert authors from many countries to produce a comprehensive volume focusing on the applications of LOC technology in the biomedical and life sciences. The first section includes chapters on LOC biomolecule separation. Separation of biomolecules is an important element of various clinical laboratories and is required for many "down stream" analytical applications. Various electrophoresis and liquid chromatography applications for proteins and DNA are described as well as methods for cell separation, with an emphasis on blood cell separation, which have many important clinical applications. The second part includes chapters on analysis and manipulation technologies. Authors describe protein, genetic (mainly PCR) and transcriptome analysis with examples from research and clinical applications, as well as cell manipulation and analysis including cell viability analysis and microorganism capturing. A skillful selection of topics of exceptional importance to current science ensures that this book will be of major value to a wide range of molecular biologists, clinical scientists, microbiologists, biochemists and anyone interested in LOC technology or developing applications for LOC devices. read more ...

Lab-on-a-Chip Technology (Vol. 1): Fabrication and Microfluidics Buy now!

Edited by: Keith E. Herold and Avraham Rasooly
Published: 2009   ISBN: 978-1-904455-46-2
Price: GB £159 or US $319
This invaluable book describes the latest methods and novel technologies being developed for the fabrication of LOC devices and new approaches for fluid control and manipulation. Expert authors from around the world describe and discuss the newest technologies for the prototyping of devices, including replication and direct machining methods of fabrication. Part I of the book covers all aspects of fabrication including laser micromachining, silicon and glass micromachining, PMMA and COC microfluidic substrates, and xurography (LOC prototyping with a cutting plotter). Part II focuses on fluid control and manipulation for LOC systems. As well as providing examples of the use of pumps in microfluidics, topics covered include electrokinetic pumping (electroosmois), electrochemical pumping and electrowetting, and the fabrication of a microchip for rapid polymerase chain reaction (PCR). This comprehensive volume presents the current technologies in the field and includes theoretical and technical information to enable both the understanding of the technology and the reproduction of experiments. The book aims to help the reader to understand current LOC technologies, to perform similar experiments, to design new LOC systems and to develop new methodologies and applications. An essential book for biologists and clinicians using LOC technology and developing applications and also for engineering, chemical and physical science researchers developing analytical technologies. The book will also be useful as a teaching tool for bioengineering, biomedical engineering and biology. read more ...

Bacterial Polysaccharides: Current Innovations and Future Trends Buy now!

Edited by: Matthias Ullrich
Published: 2009   ISBN: 978-1-904455-45-5
Price: GB £159 or US $319
In this timely book a cohort of experienced and authoritative experts review the most important innovations in research on and biotechnological applications of bacterial polysaccharides. The book takes an interdisciplinary view that examines this fascinating subject area in detail from molecular biology, genome-, transcriptome- and proteome-wide perspectives, and looks at the ecological aspects and systems biology approaches. Hence the book provides a sound basis for future research directions including high efficiency applications of bacterial polysaccharides in medicine, the food industry, and renewable energy production. Topics include: peptidoglycan, lipopolysaccharide, arabinogalactan, capsule gene expression in Escherichia coli, immune response to polysaccharides, polysaccharides from periodontopathic bacteria, role in dental plaque, biofilms, levan, amylovoran and much more. Essential reading for everyone with an interest in bacterial polysaccharides, from the PhD student to the experienced scientist, as it provides a timely review of the current and most topical areas of research. read more ...

Microbial Toxins: Current Research and Future Trends Buy now!

Edited by: Thomas Proft
Published: 2009   ISBN: 978-1-904455-44-8
Price: GB £159 or US $319
Essential reading for everyone with an interest in microbial toxins and recommended reading for other scientists with an interest in bioterrorism, microbial pathogenesis, and microbial genomics. read more ...

Acanthamoeba: Biology and Pathogenesis Buy now!

Author: Naveed Khan
Published: 2009   ISBN: 978-1-904455-43-1
Price: GB £159 or US $319
This compilation will serve as an essential reference for parasitologists, microbiologists, immunologists, and physicians in the field of basic and medical microbiology, as well as an invaluable reference for new and experienced researchers who wish to understand this organism better. This book is the definitive guide to current research on this increasingly important organism. read more ...

Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis Buy now!

Edited by: Karl Wooldridge
Published: 2009   ISBN: 978-1-904455-42-4
Price: GB £159 or US $319
This extensive publication on bacterial secreted proteins, the secretory systems of bacteria and the vital role of secreted proteins in bacterial pathogenesis will be of immense value to all microbiologists, molecular biologists, public health scientists and researchers engaged in the study of pathogenesis, drug design and vaccine development. A skillful selection of topics and a panel of acknowledged experts as authors have ensured that this volume will become an important reference source for many years to come. The book is divided into two sections. The first section describes the various protein secretion systems including mechanisms for secretion across the cytoplasmic membrane of Gram-negative and Gram-positive bacteria, specialized mechanisms for secretion across the Gram-negative outer membrane, systems for transport across both membranes of Gram-negative bacteria, protein secretion systems in Gram-positive bacteria, the secretion of surface fimbrae/pili and a chapter on the less well defined pathways. Section 2 describes the protein secretion mechanisms and secreted proteins of a number of important human, veterinary and plant pathogens and their role in the pathogenicity of these organisms. The pathogens covered have been selected on the basis that there is active research on protein secretion by these pathogens and they employ a diverse array of secreted proteins and protein secretion systems. Each chapter of the book can be read in isolation, particularly the chapters in section 2. The book constitutes a broad and in-depth description of the current knowledge of bacterial protein secretion and its role in pathogenesis. A recommended reference volume for all microbiology libraries. read more ...

Lactobacillus Molecular Biology: From Genomics to Probiotics Buy now!

Edited by: Åsa Ljungh and Torkel Wadström
Published: 2009   ISBN: 978-1-904455-41-7
Price: GB £159 or US $319
This major new work focuses on recent research on the molecular biology and genomics of Lactobacillus. Written by an international team of scientists the volume is an essential reference for all medical researchers, dairy technologists, microbiologists and biotechnologists in the academic and industrial sectors. Topics covered include phylogenetics, taxonomy, comparative genomics, functional genomics, the intestinal microflora, surface proteins, stress responses, interaction with the immune system, probiotics, anti-cancer potential, and much more. Essential reading for all scientists involved with lactic acid bacteria or probiotic research and a recommended book for all microbiology laboratories. read more ...

Mycobacterium: Genomics and Molecular Biology Buy now!

Edited by: Tanya Parish and Amanda Brown
Published: 2009   ISBN: 978-1-904455-40-0
Price: GB £159 or US $319
A valuable reference text for all microbiology laboratories and essential reading for all scientists and researchers involved with mycobacteria. read more ...

Real-Time PCR: Current Technology and Applications Buy now!

Edited by: Julie Logan, Kirstin Edwards and Nick Saunders
Published: 2009   ISBN: 978-1-904455-39-4
Price: GB £159 or US $319
This essential manual presents a comprehensive guide to the most up-to-date technologies and applications as well as providing an overview of the theory of this increasingly important technique. Renowned experts in the field describe and discuss the latest PCR platforms, fluorescent chemistries, validation software, data analysis, and internal and external controls. This timely and authoritative volume also discusses a wide range of RT-PCR applications including: clinical diagnostics, biodefense, RNA expression studies, validation of array data, mutation detection, food authenticity and legislation, NASBA, molecular halotyping, and much more. An essential book for all laboratories using PCR. read more ...

Clostridia: Molecular Biology in the Post-genomic Era Buy now!

Edited by: Holger Brüggemann and Gerhard Gottschalk
Published: 2009   ISBN: 978-1-904455-38-7
Price: GB £159 or US $319
In this book internationally recognised Clostridium experts critically review the most important aspects of clostridial research, providing the first coherent picture of the organism's molecular and cellular biology in this post-genomic era. The first major focus of the book is the genetics and molecular biology of the major clostridial toxins including: botulinum and tetanus neurotoxins, C. difficile large exotoxins, C. perfringens enterotoxin, pore-forming and binary bacterial toxins. Other topics include: molecular epidemiology of C. botulinum and C. difficile, metabolic networks in C. acetobutylicum, development of genetic knock-out systems for clostridia, surface structures, anti tumor potential of clostridia, and antibiotic resistance determinants in C. difficile. Essential reading for every clostridia researcher, from the PhD student to the experienced scientist, as it provides a timely review of current research. read more ...

Plant Pathogenic Bacteria: Genomics and Molecular Biology Buy now!

Edited by: Robert W. Jackson
Published: 2009   ISBN: 978-1-904455-37-0
Price: GB £159 or US $319
In this book, internationally acclaimed experts review the most important developments providing an invaluable, up-to-date summary of the molecular biology and genomics of plant pathogenic bacteria. The book opens with two chapters on bacterial evolution, diversity and taxonomy, topics that have been transformed by molecular biology and genomics analyses. The third chapter delves into the crucially understudied area of pathogen adaptation to the plant apoplast environment. The following seven chapters focus on specific plant pathogens: Agrobacterium, Leifsonia, Pectobacterium, Pseudomonas, Ralstonia, Xanthomonas, and Xylella. The next four chapters review specific, intensively studied areas of research in the plant pathogen field: microbe associated molecular patterns (MAMPs) and innate immunity; use of bacterial virulence factors to suppress plant defence; cyclic di-GMP signalling and the regulation of virulence; and plasmids and the spread of virulence. The final chapter covers the critical area of bioinformatics. With contributions from some of the pioneering bacterial plant pathogen genome sequencers, this book is essential reading for every plant pathogen researcher, from the PhD student to the experienced scientist, as it provides a timely review of the current and most topical areas of research. read more ...

Microbial Production of Biopolymers and Polymer Precursors: Applications and Perspectives Buy now!

Edited by: Bernd H. A. Rehm
Published: 2009   ISBN: 978-1-904455-36-3
Price: GB £159 or US $319
Written by expert, internationally renowned scientists, this comprehensive volume describes in detail the use of microorganisms for the production of the most important biopolymers and polymer precursors. The authors describe, in depth, the biosynthetic pathways, physical properties and industrial production processes and discuss in detail the genetic and metabolic engineering of microorganisms for biopolymer production. Also highlighted are the applications and potential applications of the biopolymers and microbial biotechnology. Topics include the biochemistry and genetics of biosynthesis of xanthan, alginate, cellulose, cyanophycin, poly(gamma-glutamic acid), levan, hyaluronic acid, organic acids, oligosaccharides and polysaccharides, and polyhydroxyalkanoates. A recommended book for all biotechnology and microbiology laboratories. read more ...

Plasmids: Current Research and Future Trends Buy now!

Edited by: Georg Lipps
Published: 2008   ISBN: 978-1-904455-35-6
Price: GB £159 or US $319
Written by acknowledged experts in the field, this volume provides an up to date treatment of the structure, function and application of plasmids with a particular emphasis on current and future trends. The book is aimed primarily at research scientists, graduate students and professional scientists but will also be of great interest to all molecular biologists and microbiologists involved in research or teaching. Chapters include a historical perspective on E. coli plasmids and the scientific background of the plasmids used routinely in laboratories to clone genes and to express proteins; an overview on the plasmids of archaea and eukarya; bioinformatic tools; horizontal gene transfer and the process of DNA transfer. Two entire chapters are devoted to the important medical applications of plasmids, including the correction of gene defects and vaccines to treat cancer or infectious diseases. An essential book for all molecular biology laboratories. read more ...

Pasteurellaceae: Biology, Genomics and Molecular Aspects Buy now!

Edited by: Peter Kuhnert and Henrik Christensen
Published: 2008   ISBN: 978-1-904455-34-9
Price: GB £159 or US $319
Pasteurellaceae comprise a large and diverse family of Gram-negative bacteria with members ranging from important pathogens such as Haemophilus influenzae to commensals of the animal and human mucosa. Information on the biology of these organisms has mushroomed in recent years, driven by the development of novel genetic and molecular methodologies. Since 1995, the family has been expanded from three genera to the current thirteen through the use of new genetic-based classification and identification technologies. Many members of the Pasteurellaceae family make excellent natural models for the study of bacterial pathogenesis and host-pathogen-interactions thus giving valuable insights into related human diseases. Research in this area is at a very exciting stage. In this timely book, leading international Pasteurellaceae scientists critically review the most important current research providing an up-to-date review of the molecular biology, genomics and virulence of these fascinating organisms. Topics covered include taxonomy and biodiversity, phylogeny, comparative genomics, competence, DNA uptake and transformation, proteomics and protein secretion, RTX toxins, lipopolysaccharides, biofilms, quorum sensing, antimicrobial resistance, diagnosis, and OMP and iron uptake. Each chapter is independent and can be read in isolation and as a whole the book provides an important resource summarising our current knowledge of Pasteurellaceae genomics and molecular biology. Essential reading for everyone working on Pasteurellaceae and related organisms. read more ...

Vibrio cholerae: Genomics and Molecular Biology Buy now!

Edited by: Shah M. Faruque and G. Balakrish Nair
Published: 2008   ISBN: 978-1-904455-33-2
Price: GB £159 or US $319
Written by leading V. cholerae experts, the chapters review the most important cutting-edge genetic facets of V. cholerae including its genomic organization, population genetics, molecular epidemiology, and synchronized regulation of gene expression. Other topics include the molecular basis for enhanced transmissibility of cholera during epidemics, survival of the pathogen in the environment, and above all the evolution of the species to attain increased fitness both as a pathogen and an environmental organism. Essential reading for everyone with an interest in Vibrio and recommended reading for other scientists working in microbial pathogenesis, microbial genomics and antimicrobial research. read more ...

Pathogenic Fungi: Insights in Molecular Biology Buy now!

Edited by: Gioconda San-Blas and Richard A. Calderone
Published: 2008   ISBN: 978-1-904455-32-5
Price: GB £159 or US $319
In this book a panel of expert international mycologists critically review the most important cutting-edge topics. Chapters are written from a molecular and genomic perspective and through the provision of extensive reference sections positively encourage readers to pursue the subject in greater detail. Topics include: gene expression and regulation, heterozygosity in Candida, molecular diagnosis, regulation of the host-fungal interaction, the development of anti-fungals, signal transduction, and mechanisms of multi-drug resistance. Essential reading for everyone with an interest in pathogenic fungi including: mycologists, biotechnologists, molecular biologists, and pharmaceutical and biotechnology companies. read more ...

Helicobacter pylori: Molecular Genetics and Cellular Biology Buy now!

Edited by: Yoshio Yamaoka
Published: 2008   ISBN: 978-1-904455-31-8
Price: GB £159 or US $319
A useful introduction to the subject for new researchers and an invaluable reference for the experienced researcher, this book is essential reading for all researchers working with Helicobacter and related organisms. read more ...

Corynebacteria: Genomics and Molecular Biology Buy now!

Edited by: Andreas Burkovski
Published: 2008   ISBN: 978-1-904455-30-1
Price: GB £159 or US $319
This volume brings together the expertise and enthusiasm of today's leading experts to provide a description of the current state-of-the-art molecular biology toolbox available for Corynebacterium research, including global analyses techniques such as comparative genomics, transcriptome, proteome and metabolome analysis as well as the most recent knowledge on Corynebacterium promoter structures and vector systems. Furthermore, topics such as regulatory networks controlling carbon, nitrogen, phosphorus, sulphur and iron metabolism, cell wall structure, proteolysis and environmental stress response are covered. Essential reading for all Corynebacterium scientists and everyone with an interest in global analysis techniques, global regulation and systems biology. read more ...

Staphylococcus: Molecular Genetics Buy now!

Edited by: Jodi Lindsay
Published: 2008   ISBN: 978-1-904455-29-5
Price: GB £159 or US $319
This volume, the first to focus on staphylococcal genetics, brings together the expertise and enthusiasm of an international panel of leading staphylococcal researchers to provide a state-of-the art overview of the field. Topics include the sequencing projects, including spin-off microarray and systems biology tools, epidemiology, evolution, manipulation of the genome, diagnostics, gene expression due to global regulators and environmental triggers, cell-wall synthesis, coagulase-negative species, and animal pathogens. It is designed for two major audiences. Firstly, to introduce the subject to new researchers, including those unfamiliar with genetics. Secondly, for established researchers, for whom it will serve as an invaluable reference and summary of a large field, as well as presenting the latest advances and future trends written by those who are developing them. Essential reading for anyone involved in Staphylococcus research. read more ...

Leishmania: After The Genome Buy now!

Edited by: Peter J. Myler and Nicolas Fasel
Published: 2008   ISBN: 978-1-904455-28-8
Price: GB £159 or US $319
Leishmania is a vector-borne pathogenic parasite found in 88 countries worldwide and is the causative agent of leishmaniasis. The different Leishmania species infect macrophages and dendritic cells of the host immune system, causing symptoms that range from disfiguring cutaneous and mucocutaneous lesions, widespread destruction of mucous membranes, or visceral disease affecting the haemopoetic organs. The recent publication of the complete genome sequences of three different Leishmania species provides new insights into this leading pathogen and presents scientists with an exciting resource to improve the understanding of its complex molecular and cellular biology. In this book, internationally recognised Leishmania experts critically review the most important aspects of current Leishmania research, providing the first coherent picture of the organism's molecular and cellular biology since the publication of the genome sequence. Chapters are written from a molecular and genomic perspective and discuss in depth Leishmania-specific aspects of trypanosomatid biology and pathology. Topics include: diagnosis and epidemiology, genome structure and content, regulation of gene expression, the Leishmania proteome, the Leishmania metabolome, Leishmania differentiation, interaction with the sand fly vector, drug discovery, drug resistance, and much more. Essential reading for all researchers working with Leishmania, trypanosomes and protozoa. A recommended book for all biology and medical libraries. read more ...

Archaea: New Models for Prokaryotic Biology Buy now!

Edited by: Paul Blum
Published: 2008   ISBN: 978-1-904455-27-1
Price: GB £159 or US $319
A conventional view delineates cellular life into only two basic types called prokaryotes and eukaryotes. The prokaryotes are further subdivided into the Bacteria and the Archaea based on small subunit ribosomal RNA comparisons and conserved mechanisms for information processing. The study of archaeal prokaryotes has matured rapidly in part initiated by genomic science as well as a continuing interest in the biochemistry and metabolism of extremophiles. The authors present an expanding pattern of new information relevant to both the general and the technical reader. The book focuses on molecular biology and genomics and topics include the biology of metals, redox chemistry, respiration, sugar catabolism, nucleic acid modification, DNA replication, repair and recombination, transcriptomics, signal transduction and peptide antibiotics. Throughout the well referenced text the emphasis is on emerging topics in specific fields providing the reader with a vision of the future in the expanding world of Archaea. Essential reading for all archaea researchers and everyone with an interest in prokaryote molecular and cellular biology. A recommended book for all microbiology libraries. read more ...

Legionella: Molecular Microbiology Buy now!

Edited by: Klaus Heuner and Michele Swanson
Published: 2008   ISBN: 978-1-904455-26-4
Price: GB £159 or US $319
Legionellosis is a disease of significant medical and public interest. Legionella is commonly found in aquatic habitats where its ability to survive and to multiply within different protozoa equips the bacterium to be transmissible and pathogenic to humans. In addition Legionella has become a favored model system to analyse the mechanisms of bacterial survival, acquisition of nutrients and intracellular replication. Following the recent publication of the genome sequences of four L. pneumophila strains it is now feasible to investigate the whole genome in silico, the transcriptome via micro arrays and the proteome by two-dimensional gel electrophoresis. Research in the fields of clinical features, diagnosis, treatment and epidemiology continues to generate new data. The topics covered by this volume range from the history of the identification of Legionella and clinical disease treatment, to the microbe's gene expression and secretion systems as well as its strategies for intracellular multiplication and nutrient acquisition. The main focus of the book is the current state of many of the most critical features of Legionella. Internationally renowned authors have contributed chapters describing and discussing the latest research findings with an emphasis on molecular aspects. The editors and authors have produced an excellent book that will be an extremely useful reference source. This comprehensive publication is aimed at readers with teaching or research interests in microbiology, genetics, genomics, infectious diseases or clinical research. A recommended book for all microbiology and clinical research laboratories. read more ...

RNA and the Regulation of Gene Expression: A Hidden Layer of Complexity Buy now!

Edited by: Kevin V. Morris
Published: 2008   ISBN: 978-1-904455-25-7
Price: GB £159 or US $319
The role of RNA in regulating gene expression has become a topic of intense interest. In this book internationally recognized experts in RNA research explore and discuss the methods whereby RNA can regulate gene expression with examples in yeast, Drosophila, mammals, and viral infection, and highlight the application of this knowledge in therapeutics and research. Topics include: gene silencing and gene activation, the hammerhead ribozyme, epigenetic regulation, RNAi, microRNA, and pyknons. This comprehensive publication is intended for readers with teaching or research interests in RNA, the regulation of gene expression, genetics, genomics or molecular biology. read more ...

Molecular Oral Microbiology Buy now!

Edited by: Anthony H. Rogers
Published: 2008   ISBN: 978-1-904455-24-0
Price: GB £159 or US $319
A panel of experts discuss the molecular biology of micro-organisms involved in the two major dental diseases: caries and periodontal disease. Research has focused on factors which might modulate the interaction between the resident oral bacteria and the host. Chapters deal with the interactions of oral micro-organisms with one another and with the host; the innate defence mechanisms of the host; and the development of vaccines against oral diseases. Topics include oral microbial taxonomy, identification and typing, applied genomics, horizontal gene transfer, cell-cell communication, cariogenic bacteria, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, host-pathogen interaction, host defense mechanisms, and vaccination against oral infections. Essential reading for students and researchers in the field of oral biology and oral microbiology and a recommended book for all microbiology laboratories. read more ...

Epigenetics Buy now!

Edited by: Jörg Tost
Published: 2008   ISBN: 978-1-904455-23-3
Price: GB £159 or US $319
In this book the molecular mechanisms and biological processes in which epigenetic modifications play a primordial role are described in detail. The first seven chapters describe the different biological mechanisms of the epigenetic machinery including: DNA methylation, histone tails, chromatin structure, nucleosome occupancy, Polycomb group proteins, siRNAs and miRNAs. The following chapters cover the epigenetic systems of plants, the epigenetic profile of embryonic stem cells, cell differentiation, imprinting marks, and random X chromosome inactivation. Further chapters deal with epigenetics in relation to cancers, premature aging, longevity and the developmental origins of disease. The final chapter, describes the fascinating potential transfer of epigenetic information across generations. This up-to-date volume is a major resource for those working in the field and will stimulate readers of all levels to dive into the fascinating and fast moving field of epigenetics. read more ...

Animal Viruses: Molecular Biology Buy now!

Edited by: Thomas C. Mettenleiter and Francisco Sobrino
Published: 2008   ISBN: 978-1-904455-22-6
Price: GB £159 or US $319
In this book an international panel of leading virologists provide a state-of-the-art overview of the field, comprehensively detailing the current understanding of viruses, their replication, evolution and interaction with the host. The authors emphasize strategic and methodological aspects of current research, and provide key related references. Topics include foot-and-mouth disease virus, Pestivirus, Arteriviridae, Coronaviruses (including SARS), Herpesviridae, Paramyxoviridae, influenza viruses, Reoviridae, porcine circoviruses, Asfarviridae and much more. An essential text for all virology laboratories. read more ...

Segmented Double-stranded RNA Viruses: Structure and Molecular Biology Buy now!

Edited by: John T. Patton
Published: 2008   ISBN: 978-1-904455-21-9
Price: GB £159 or US $319
This timely book brings together all of the key recent research on this disparate group of viruses, providing for the first time a single resource reviewing dsRNA viral structure and molecular biology. Written by well respected and experienced virologists, topics include: the structures of orthoreoviruses, rotavirus, phytoreoviruses, and bluetongue virus, entry into the bacterial cell, crystal structure of reovirus polymerase λ3, assembly of the reovirus genome, genomic RNA packaging and replication in the Cystoviridae, and much more. Essential reading for all dsRNA virologists and all other virologists with an interest in molecular and structural biology. read more ...

Acinetobacter Molecular Biology Buy now!

Edited by: Ulrike Gerischer
Published: 2008   ISBN: 978-1-904455-20-2
Price: GB £159 or US $319
This concise volume reviews the most current and topical aspects of Acinetobacter genetics and molecular biology and is aimed at a readership of research scientists, graduate students and other specialists. Expert international authors have contributed chapters on diverse topics including taxonomy, lipopolysaccharides, catabolism of aromatic compounds, transformation systems, transcriptional regulation, applications in biotechnology, the molecular basis for virulence and pathogenicity, molecular epidemiology, and antibiotic resistance. This book is highly recommended for anyone involved in Acinetobacter research. read more ...

Pseudomonas: Genomics and Molecular Biology Buy now!

Edited by: Pierre Cornelis
Published: 2008   ISBN: 978-1-904455-19-6
Price: GB £159 or US $319
The genome sequences of several pseudomonads have become available in recent years and researchers are beginning to use the data to make new discoveries about this bacterium. This concise volume reviews the most current and topical aspects of Pseudomonas molecular biology and genomics and is aimed at a readership of research scientists, graduate students and other specialists. Renowned international authors have contributed chapters on diverse topics including taxonomy, genome diversity, oligonucleotide usage, polysaccharides, pathogenesis, virulence, biofilms, antibiotic resistance and iron uptake. In addition an entire chapter is devoted to the genetic tools being developed to take full advantage of the wealth of information generated by the genome sequencing efforts. This book is essential reading for anyone involved in Pseudomonas research. read more ...

Real-Time PCR in Microbiology: From Diagnosis to Characterization Buy now!

Edited by: Ian M. Mackay
Published: 2007   ISBN: 978-1-904455-18-9
Price: GB £159 or US $319
The editor and authors have produced an excellent book that will be extremely useful for all microbiologists. A recommended book for all microbiology laboratories. read more ...

Microbial Biodegradation: Genomics and Molecular Biology Buy now!

Edited by: Eduardo Díaz
Published: 2008   ISBN: 978-1-904455-17-2
Price: GB £159 or US $319
In this timely book expert international authors critically review all of the most important topics in this exciting field. Although other books covering this are currently available, this book is unique in that it is the first to review the area from a molecular biology and genomics perspective. Topics covered include: aerobic and anaerobic biodegradation of aromatic compounds, molecular detection methods (e.g. microautoradiography, mRNA analyses, etc.), genome-based predictive modelling, elucidation of regulatory networks, bioavailability, chemotaxis and transport issues, functional genomic analyses, natural attenuation, community fingerprinting and metagenomics, biotreatment, and biocatalysts engineering. Essential reading for microbial degradation and bioremediation scientists and of general interest for microbiologists working in field of environmental microbiology. read more ...

Coronaviruses: Molecular and Cellular Biology Buy now!

Edited by: Volker Thiel
Published: 2007   ISBN: 978-1-904455-16-5
Price: GB £159 or US $319
In this timely book, internationally renowned experts review literally every aspect of cutting edge coronavirus research providing the first coherent picture of the molecular and cellular biology since the outbreak of SARS in 2003. The book is divided into two sections: Part I focuses on the molecular biology of the virus itself and includes topics such as coronavirus binding and entry, replicase gene function, cis-acting RNA elements, coronavirus discontinuous transcription, reverse genetics, genome packaging and molecular evolution. In Part II of the book, the focus is on molecular and cellular pathogenesis and infection control. This section includes reviews of the three prototype viruses, namely avian infectious bronchitis virus, feline coronavirus and mouse hepatitis virus. Other topics include SARS-CoV virus pathogenesis, SARS-CoV interaction with the host INF and antiviral cytokines, the newly recognized bat coronaviruses and human coronavirus NL63, and strategies for coronavirus vaccine development and the development of novel antiviral coronavirus agents. Essential reading for all coronavirologists as well as scientists working on other viruses of the respiratory and/or gastrointestinal tract. read more ...

The Cyanobacteria: Molecular Biology, Genomics and Evolution Buy now!

Edited by: Antonia Herrero and Enrique Flores
Published: 2008   ISBN: 978-1-904455-15-8
Price: GB £159 or US $319
This volume brings together the expertise and enthusiasm of an international panel of leading cyanobacterial researchers to provide a state-of-the art overview of the field. Topics covered include: evolution, comparative genomics, gene transfer, molecular ecology and environmental genomics, stress responses, bioactive compounds, circadian clock, structure of the photosynthetic apparatus, membrane systems, carbon acquisition, nitrogen assimilation and C/N balance sensing and much more. Essential for anyone with an interest in cyanobacteria, bacterial photosynthesis, bacterial nitrogen fixation, and symbiosis. read more ...

Bacteriophage: Genetics and Molecular Biology Buy now!

Edited by: Stephen Mc Grath and Douwe van Sinderen
Published: 2007   ISBN: 978-1-904455-14-1
Price: GB £159 or US $319
Written by eminent international researchers actively involved in the disparate areas of bacteriophage research this book focuses on the current rapid developments in this exciting field. The book opens with an excellent chapter that provides a broad overview of the topics and also highlights the multifaceted nature of bacteriophage research. This is followed by a series of reviews that focus on the current most cutting-edge topics including bioinformatics and genomics, phage in the environment, bacteriophage in medicine, transfer of phage DNA to the host, contribution to host phenotype and much more. Essential reading for all phage researchers and of interest to molecular biologists and microbiologists working on bacteria in academia, biotechnology and pharmaceutical companies, and in the food and other industries read more ...

Candida: Comparative and Functional Genomics Buy now!

Edited by: Christophe d'Enfert and Bernhard Hube
Published: 2007   ISBN: 978-1-904455-13-4
Price: GB £159 or US $319
In this timely book international experts provide comprehensive and authoritative reviews of these important organisms. Topics covered include: genome dynamics of C. albicans; molecular epidemiological and population studies of C. albicans; the parasexual cycle in C. albicans; comparative genomics of the hemiascomycetes group and of different Candida species; databases and the challenges that their curators are facing; transcriptome analysis; proteomics; molecular evolution of the genetic code; stress responses; regulation of morphogenesis; cell wall biology; interaction with host cells; analysis of gene function; antifungal resistance mechanisms and much more. Essential reading for all Candida genome and molecular biology researchers and a recommended text for scientists working on fungal genomics and molecular biology. read more ...

Bacillus: Cellular and Molecular Biology Buy now!

Edited by: Peter Graumann
Published: 2007   ISBN: 978-1-904455-12-7
Price: GB £159 or US $319
Download flyer Bacillus subtilis is one of the best understood prokaryotes in terms of molecular biology and cell biology. Its superb genetic amenability and relatively large size have provided powerful tools to investigate a bacterium in all possible aspects. Recent improvements in technology have provided novel and amazing insights into the dynamic structure of this single cell organism. The organism is a model for differentiation, gene/protein regulation and cell cycle events in bacteria. This book presents an overview of the most recent exciting new research fields and provides a picture of the major cytological aspects of a model bacterium. The authors present the most recent knowledge on topics such as the replication and segregation of the chromosome, cell division, replication and growth, the cell cycle, transcription, translation, regulation, the actin cyctoskeleton, the cell membrane and cell wall, biofilm formation and sporulation. Also covered are DNA repair, the regulation of transcription through RNA molecules, and the regulation of protein activity through proteolysis. The authors seamlessly merge the fields of bacterial cell biology and molecular biology to provide an integral view of the bacterial cell, providing an understanding of the way a bacterial cell functions as a whole entity and in 3D, i.e. how it is spatially organized, and even how bacterial cells communicate with each other, or give their life for the sake of the whole community. An essential book for anyone interested in Bacillus, cell biology or bacterial genetics and molecular biology. read more ...

Pathogenic Treponema: Molecular and Cellular Biology Buy now!

Edited by: Justin D. Radolf and Sheila A. Lukehart
Published: 2006   ISBN: 978-1-904455-10-3
Price: GB £159 or US $319
This volume is the first comprehensive review of treponemal research to be published in more than twenty years. Written by leading experts in the field, this book presents the current state of research on these organisms that affect the health of millions of people worldwide. The structure and metabolism of the treponemes are explored in light of the comparative genomics data now available. The newest information concerning their pathogenic mechanisms, as well as the complex innate and adaptive immune responses they elicit, are detailed. A number of chapters illustrate how our knowledge of syphilis has grown in the molecular era despite the continuing inability to propagate its elusive etiologic agent. The book also provides an historical perspective on treponemal research that will be of considerable interest. This compilation will serve as an essential reference for microbiologists, immunologists, and physicians who deal with these organisms on a day-by-day basis or who wish to understand them better in the context of contemporary microbiology. Topics covered include the phylogenic diversity, comparative genomics, metabolism and cultivation, motility, antigenic variation, immunology of syphilis, the use cultivatable treponemes as surrogates for T. pallidum, oral treponemes, and much much more. Essential reading for all scientists and researchers working on trepenomes and other spirochetes and a recommended reference book for all microbiology laboratories. read more ...

Alpha Herpesviruses: Molecular and Cellular Biology Buy now!

Edited by: R. M. Sandri-Goldin
Published: 2006   ISBN: 978-1-904455-09-7
Price: GB £180 or US $360
Written by internationally recognized experts, this book highlights the more provocative and exciting findings in herpesvirus research. Each chapter is a review of a specific area with an emphasis on recent advances and the latest developments. Topics include: multifunctional proteins, advances in DNA replication, new information on the regulation of gene expression, the emergence of new technologies, recent technological advances in fluorescent probes, the induction of apoptosis, the disruption of interferon, vaccine development and drug design. With a specific focus on new and topical herpesvirus research, this book is essential reading for everyone with an interest in herpesviruses and recommended reading for other scientists working in viral pathogenesis, viral genomics and antiviral research. read more ...

PCR Troubleshooting: The Essential Guide Buy now!

Author: Michael L. Altshuler
Published: 2006   ISBN: 978-1-904455-07-3
Price: GB £30 or US $60
A unique PCR troubleshooting guide that is an essential companion for anyone who uses the polymerase chain reaction technique. Aimed at a reader with some experience in PCR the book discusses the many and varied problems encountered with PCR together with tips, advice and procedures to obviate rather than overcome the PCR problems. Written in the language of the laboratory with a little humour and a down-to-earth approach, the book is easy to read and understand. If you fail at PCR, consult this book! The advice in these pages is invaluable and is the sort of advice that is not usually found elsewhere. In the words of the author, remember that there are many other things in life than PCR ... for example, isothermal DNA amplification. read more ...

Papillomavirus Research: From Natural History To Vaccines and Beyond Buy now!

Edited by: M. Saveria Campo
Published: 2006   ISBN: 978-1-904455-04-2
Price: GB £159 or US $319
In this timely book leading scientists review current aspects of papillomavirus research providing a fascinating insight into papillomavirus molecular biology, interactions with the host, immunology and vaccine development. Topics covered include epidemiology and taxonomy, phylogenetic analyses, gene expression, regulation of DNA replication, transcription factor proteins, organotypic raft cultures, virus-like particles, and much more. Essential reading for scientists and researchers working on papillomavirus and a recommended text for anyone involved with antiviral drug and vaccine development. read more ...

Epstein-Barr Virus Buy now!

Edited by: Erle S. Robertson
Published: 2005   ISBN: 978-1-904455-03-5
Price: GB £159 or US $319
World renowned EBV experts provide a critical and comprehensive review of every aspect of this important virus. By integrating genetic, immunologic, and cell biologic approaches to elucidate pathogenesis, penetrating new insights into the molecular and cellular interaction between EBV and its human host have emerged. Topics covered include: Discovery, history and seroepidemiology, EBV and the immune response, EBV genetics, EBV infection and persistence, latency, lytic proteins and reactivation control, vaccine approaches, animal models, and the future of EBV studies. This is essential reading for all EBV virologists as well as clinical and research scientists working on oncogenic viruses. read more ...

Cytomegaloviruses: Molecular Biology and Immunology Buy now!

Edited by: Matthias J. Reddehase
Published: 2006   ISBN: 978-1-904455-02-8
Price: GB £159 or US $319
In this book leading international experts provide comprehensive and authoritative reviews on every aspect of current research. By integrating viral genomics, proteomics, immunology and molecular biology with the emerging knowledge of the genomics of the host organism, penetrating new insights into the virus-host interaction are provided. The focus of the book is on the molecular and genomic aspects and the authors provide an insight into the current understanding of the subject and the future direction of research. Topics covered include disease mechanisms, genomics, proteomics, BAC mutagenesis, virus entry and activation of innate immunity, regulation of viral gene expression, regulation of viral mRNA export, animal models of infection, novel therapeutics, vaccine development, antivirals, and much more. The book is liberally illustrated with many figures in full colour and is set is a clear, easy-to-follow layout. Essential reading for all virologists with an interest in cytomegaloviruses and a recommended text for scientists working on antiviral drug and vaccine development. read more ...

Probiotics and Prebiotics: Scientific Aspects Buy now!

Edited by: Gerald W. Tannock
Published: 2005   ISBN: 978-1-904455-01-1
Price: GB £159 or US $319
Food scientists and nutritionists have accepted, relatively uncritically, the concepts underlying the use of probiotics and prebiotics in the promotion of health. Microbiologists and medical practitioners have viewed these products more sceptically. Much more scientific and medical validation of probiotic or prebiotic use is required. This will entail the use of sophisticated analytical methodologies. Knowledge of the gut microbiota has increased dramatically during the past decade thanks largely to the results obtained from the application of nucleic acid-based methodologies. Because of the availability of improved technologies, detailed studies of the two principal kinds of probiotic or prebiotic bacteria, Lactobacillus and Bifidobacterium, can be made. Emerging leaders have contributed chapters to this book that therefore represents a state of the art compendium of fundamental science related to early 21st century probiotic or prebiotic research. read more ...

Foodborne Pathogens: Microbiology and Molecular Biology Buy now!

Edited by: Pina M. Fratamico, Arun K. Bhunia, and James L. Smith
Published: 2005   ISBN: 978-1-904455-00-4
Price: GB £159 or US $319
Written by leaders in the field, this book represents a cutting edge summary of all the latest advances, providing the first coherent picture of the current status. Opening chapters tackle topics such as pathogen detection (molecular, biosensor), molecular typing, viable but non-culturable organisms, predictive modeling, and stress responses. The next section covers groups of organisms: enteric viruses, protozoan parasites, and mycotoxins. This is followed by chapters on specific bacteria: Yersinia enterocolitica, Vibrio spp., Staphylococcus aureus, Campylobacter Infections, Listeria monocytogenes, Salmonella spp., Shigella spp., Escherichia coli, Clostridium botulinum, Clostridium perfringens and Bacillus cereus. The final chapters provide a fascinating review of the ability of pathogens to contaminate a food supply and provide an overview of emerging foodborne pathogens. read more ...

HIV Chemotherapy: A Critical Review Buy now!

Edited by: Salvatore T. Butera
Published: 2005   ISBN: 978-0-9542464-9-5
Price: GB £159 or US $319
Expert AIDS researchers critically review every aspect of this highly topical subject. Chapters deal with the management of HIV infections, strategies to protect and strengthen the host immune system at the cellular level, strategies required for the implementation of effective anti-HIV therapies in developing countries, the genetics of viral drug resistance, current drug-resistance testing technologies, the latest viral and cellular targets for anti-HIV chemotherapy, the development of iRNA based therapeutics and molecular based strategies that target latent virus reservoirs in infected individuals. Essential reading for scientists and clinicians working on AIDS, HIV, and other retroviruses as well as all health care professionals interested in expanding their current understanding of the subject. read more ...

Pathogenic Fungi Buy now!

Edited by: Gioconda San-Blas and Richard A. Calderone
Published: 2004   ISBN: 978-0-9542464-8-8
Price: GB £159 or US $319
This book, together with its companion volume "Pathogenic Fungi: Structural Biology and Taxonomy", brings together expert international authors who critically review current topics, and through the provision of extensive reference sections positively encourage readers to pursue the subject in greater detail. The book is divided into two sections: "Fungal Interactions with the Host" and "Antifungal Antibiotics". The emphasis of the first section is focused on the two-way recognition systems that exist between the host and the fungus. Experts in fungal-host interactions discuss new initiatives for alternatives to drug therapy through the development of vaccines and passive antibody therapy. In the "Antifungal Antibiotics" section, new target development, molecular modelling, and drug resistance, both at the individual organism level, and in a biofilm, are featured. read more ...

Pathogenic Fungi Buy now!

Edited by: Gioconda San-Blas and Richard A. Calderone
Published: 2004   ISBN: 978-0-9542464-7-1
Price: GB £159 or US $319
Expert international authors critically review current topics and positively encourage readers to pursue the subject in greater detail.The book is divided into two sections: "Fungal Dimorphism and Pathogenicity" and "New Taxonomic Tools". The first section focuses on morphogenesis, the cell cycle, and the cell wall of human pathogens. These play a major role in elucidating fungal relationships, both with the environment and with the host. Experts in fungal structural biology contribute in-depth reviews on a variety of topics with a focus on molecular and biochemical analysis. The final chapter presents a review of how mathematical modelling is used to understand the building of three-dimensional cell structures in the morphogenetic process. The second section presents novel approaches to aid the understanding of strain variability, the significance of environmental and patient strains, and the relatedness of "uncultured" fungi. In addition the use of molecular tools forthe taxonomic classification of previously unclassifiable fungi is featured. read more ...

Malaria Parasites: Genomes and Molecular Biology Buy now!

Edited by: A.P. Waters and C.J. Janse
Published: 2004   ISBN: 978-0-9542464-6-4
Price: GB £159 or US $319
The completion of the Plasmodium falciparum genome sequence in late 2002 hearlded a new era in malaria research. The search could begin in earnest for new drugs and vaccines to combat malaria, a disease which afflicts up to 500 million people worldwide and is responsible for the deaths of more than one million people each year. More importantly, it should enable a greater understanding of the living parasite and it's interaction with the insect vector and human host. In this book internationally renown experts provide up to date reviews of the most important aspects of post-genomic malaria research. Topics covered include: the P. falciparum genome and model parasites, bioinformatics and genome databases, microsatellite analysis, analysis of chromosome structure, cell cycle to RNA polymerase I and II mediated gene expression, role of the nuclear genome, the parasite surface and cell biology, and much much more. read more ...

MRSA: Current Perspectives Buy now!

Edited by: Ad C. Fluit and Franz-Josef Schmitz
Published: 2003   ISBN: 978-0-9542464-5-7
Price: GB £159 or US $319
Methicillin-resistant S. aureus (MRSA) strains continue to present unique challenges to clinicians, microbiologists, and the molecular biologists around the world. These organisms are typically resistant to several other antimicrobial agents, including aminoglycosides, chloramphenicol, clindamycin, fluoroquinolones and macrolides and are susceptible only to vancomycin. Internationally renown authors comprehensively review all aspects of MRSA research. Topics covered include strategies for the detection and typing of MRSA strains, epidemiological characterisation, molecular evolution of MRSA, vancomycin resistant S. aureus, mechanisms of methicillin resistance, virulence mechanisms in MRSA pathogenesis, recommended treatment of MRSA infections and options for the prevention and control of MRSA infections. read more ...

Frontiers in Computational Genomics Buy now!

Edited by: Michael Y. Galperin and Eugene V. Koonin
Published: 2003   ISBN: 978-0-9542464-4-0
Price: GB £159 or US $319
Computational biology and bioinformatics form a major, integral part of genomics. From sequence fragment assembly, to gene prediction, to prediction of protein functions and structure, to identification of regulatory signals in DNA, to building phylogenetic trees, it would not be an exaggeration to state that genomics is primarily computational. Major new programs, software and internet facilities have evolved recently that facilitate computational analysis and more novel technologies are currently being developed. Written by experts in the field, this volume highlights research on the emerging, perhaps somewhat controversial, topics in genomics and shows the feedback between the new developments and the established methods of computational biology. An essential book for anyone involved in genomic science or bioinformatics. read more ...

Genomics of GC-Rich Gram-Positive Bacteria Buy now!

Edited by: Antoine Danchin
Published: 2002   ISBN: 978-0-9542464-3-3
Price: GB £159 or US $319
Eminent scientists have contributed comprehensive reviews on all aspects of the genomics of Rhodococcus, Mycobacteria, Streptomyces and other organisms. The authors provide an insight into the many facets of large-scale functional investigation in a variety of bacteria with the explicit goal to find common rules in the dynamic and structural organisation of these organisms. This volume is the definitive guide to current research in this increasingly important area. read more ...

Genomic Technologies: Present and Future Buy now!

Edited by: David J. Galas
Published: 2002   ISBN: 978-0-9542464-2-6
Price: GB £159 or US $319
The chapters in this book reflect the range of technical advances and their applications that are currently transforming biology. Topics covered include the application of computational methods, the robotics of modern automation methodologies, the new chemical and imaging methods that reveal chromosome structure and elucidate gene function, and the emergence of evolutionary and functional information by comparative genomics. Eminent international scientists describe in detail the new technology necessary to study the entire genome in a holistic manner and all the high throughput and large-scale experimental methodologies currently being used in genomic science. In addition the authors describe the progress of the newest technologies that are currently being developed. read more ...

Probiotics and Prebiotics: Where are We Going? Buy now!

Edited by: Gerald W. Tannock,
Published: 2002   ISBN: 978-0-9542464-1-9
Price: GB £159 or US $319
Contains state-of-the-art commentaries on all aspects of the intestinal microflora and probiotics and provides an authoritative review of important aspects of probiotic and prebiotic research. Written by leading experts in the field, each chapter affords a critical insight to a particular topic, reviews current research, discusses future direction and aims to stimulate discussion. Topics covered include the genomics of probiotic microorganisms, the developing technologies for analysis of gut microorganisms, evaluation and future potential of prebiotic substances, and the potential for disease prevention in the host by probiotic organisms. read more ...