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Virology Books

Our high level virology books bring together expert international authors under the skilled editorship of leading scientists to produce state-of-the-art compendiums of current research. Aimed at the research scientist, graduate student, medical reseacher and other professionals, these books are highly recommended for all virology laboratories. Every virology, microbiology and bioscience library should have a copy of each of the following books.
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Advanced Vaccine Research Methods for the Decade of Vaccines
Edited by: Fabio Bagnoli and Rino Rappuoli
Published: 2015
Hardback: ISBN 978-1-910190-03-6 £180, $360. Ebook: ISBN 978-1-910190-04-3 £180, $360
We have retained the same format of our 2011 book and divided the book into two main parts. The first explores in considerable depth the key innovations that we think are dramatically changing the field; both for preclinical as well as clinical vaccine research fields. Some of the topics covered include: the use of deep sequencing, cellular screens to interrogate the human T and B cell repertoires, comparative genomics to track bacterial pathogens, quantitative proteomics, structural biology, novel strategies for vaccine administration, T-cell inducing vaccines, etc. The second part focuses on diseases for which current medical treatment is not very effective and disease that could be either prevented or treated by vaccination. The examples that we have used comprise very different diseases; we include not only infectious diseases (e.g. caused by bacteria), but also cancer. We believe that these will be the vaccines of the future, the 'vaccines for 2020'. This books is essential reading for everyone working in vaccine R and D in academia, biotechnology companies, and the pharmaceutical industry and a recommended volume for all microbiology libraries. read more ...
Antibiotics: Current Innovations and Future Trends
Edited by: Sergio Sánchez and Arnold L. Demain
Published: 2015
Hardback: ISBN 978-1-908230-54-6 £180, $360. Ebook: ISBN 978-1-908230-55-3 £180, $360
In this timely book respected international experts summarize the most important research to provide a timely overview of the field. Opening chapters define 'antibiotic', explain why we need new compounds, outline the applications of antibiotics, both old and new, and describe the producing microbes. These are followed by chapters that cover antibiotic resistance, toxicity, overuse, new antimicrobial sources, new targets, novel technologies for antibiotic discovery (e.g. silent gene clusters), lantibiotics, natural antivirals, new macrolide derivatives, and antibiotics in the pipeline. This books is essential reading for everyone working in antimicrobial research in academia, biotechnology companies, and the pharmaceutical industry and a recommended volume for all microbiology libraries. read more ...
Applied RNAi: From Fundamental Research to Therapeutic Applications
Edited by: Patrick Arbuthnot and Marc S. Weinberg
Published: 2014
Hardback: ISBN 978-1-908230-43-0 £159, $319. Ebook: ISBN 978-1-908230-67-6 £159, $319
In this book an international panel of RNAi experts critically reviews the most interesting advances in basic applied RNAi research, highlighting the applications in RNAi-based therapies and discussing the technical hurdles that remain. Topics covering the fundamental biological aspects of applied RNAi research include: the role of miRNAs in trinucleotide repeat disorders; miRNAs and HIV pathogenesis; miRNAs for epigenetic gene silencing; the role of miRNAs in virus-related cancers; non-canonical miRNA biogenesis. In the area of RNAi-based therapy, topics include: harnessing RNAi for the treatment of viral infections; optimising the design of exogenous RNAi activators; blocking miRNA function with synthetic agents; somatic cell reprogramming; high-content miRNA-based screening tools and the use of miRNA target sites for control of transgene expression. Essential reading for everyone involved in RNAi research, drug discovery and delivery, biomedical engineering and biomaterials. read more ...
Halophiles: Genetics and Genomes
Edited by: R. Thane Papke and Aharon Oren
Published: 2014
Hardback: ISBN 978-1-908230-42-3 £159, $319. Ebook: ISBN 978-1-908230-65-2 £159, $319
This book highlights current genetics and genomics research to provide a timely overview. Chapters are written by expert authors from around the world and include topics such as: ecology and evolution of Haloquadratum walsbyi; microdiversity of Salinibacter ruber; horizontal gene transfer in halobacteria; comparative genomics of haloarchaeal viruses; genomics of the halophilic bacteria Natranaerobius thermophilus and Halobacillus halophilus; the haloarchaeal cell wall; cell cycle and polyploidy in haloarchaea; cell regulation by proteolytic systems and protein conjugation. This major new work represents a valuable source of information to all those scientists interested in halophilic microorganisms, extremophiles, microbial ecology and environmental microbiology. read more ...
Molecular Diagnostics: Current Research and Applications
Edited by: Jim Huggett and Justin O'Grady
Published: 2014
Hardback: ISBN 978-1-908230-41-6 £159, $319. Ebook: ISBN 978-1-908230-64-5 £159, $319
The editors of this book have commissioned an excellent series of chapters representing two key molecular diagnostic areas: cancer and infectious diseases. The cancer section deals with the challenges in identifying genetic, epigenetic and transcriptomic biomarkers. The infectious disease section describes the current clinical applications of molecular diagnostics for the detection of viral, bacterial and fungal pathogens as well as an example of the use of molecular diagnostics outside the clinic environment. A cautionary tale describing what can go wrong when molecular methods are applied incorrectly is also provided and makes fascinating reading. A substantial component of the book is dedicated to the process of translating a preclinical test to the bedside and describes the progress in the near patient point-of-care molecular diagnostics market. This is a fundamental consideration for successful translation of diagnostics tests from bench to bedside and is crucial for molecular diagnostics to have an impact on patient care. The final chapter offers a prediction of future trends in the molecular diagnostics of infectious diseases. This volume is essential reading for anyone involved in the development or application of molecular diagnostics and is recommended for all clinical diagnostics laboratories. read more ...
Phage Therapy: Current Research and Applications
Edited by: Jan Borysowski, Ryszard Międzybrodzki and Andrzej Górski
Published: 2014
Hardback: ISBN 978-1-908230-40-9 £180, $360. Ebook: ISBN 978-1-908230-74-4 £180, $360
This volume is an essential reference for anyone interested in phage therapy and a highly recommended book for everyone working in the areas of antibacterial resistance, antimicrobial development, bacteriophage research, biocontrol and biodetection. read more ...
Prions: Current Progress in Advanced Research
Edited by: Akikazu Sakudo and Takashi Onodera
Published: 2013
Hardback: ISBN 978-1-908230-24-9 £120, $240. Ebook: ISBN 978-1-908230-89-8 £120, $240
In this book, renowned prion experts review the most recent advances to provide a timely and up-to-date overview of the field. Topics covered include: prion proteins (PrP) and their family members; PrP function; molecular mechanisms of prions diseases; immunological strategies for the prevention and treatment of prion disease; microglial inflammation and prion diseases; methods for prion inactivation; clinical aspects of CJD; the BSE and scrapie prions; chronic wasting disease; future strategies for the prevention and treatment of prion diseases. The book closes with a look to the future of prion research. Essential reading for everyone with an interest in prions and prion diseases. A recommended book for all biology, veterinary and medical libraries. read more ...
Cytomegaloviruses: From Molecular Pathogenesis to Intervention
Edited by: Matthias J. Reddehase
Published: 2013
Hardback: ISBN 978-1-908230-18-8 £300, $600. Ebook: ISBN 978-1-908230-83-6 £300, $600
This two-volume work, is an updated and upgraded 2nd-edition of 'Cytomegaloviruses: Molecular Biology and Immunology' (2006). The title 'Cytomegaloviruses: From Molecular Pathogenesis to Intervention' reflects its expanded commitment not only to cover cutting-edge basic science but also to include the translation of this to clinical science. In an interdisciplinary approach to understanding CMV disease and outlining options for prevention and treatment, leading international experts provide comprehensive and authoritative reviews on literally every aspect of current research with an unprecedented completeness, integrating research on human CMV and insights gained from experimental animal models. With contributions from over 100 authors, the topics covered in the 46 chapters range from the most contemporary systems biology 'omics' views on virus-host interaction to considerations of the health and economic impact of CMV disease for evaluating the hoped-for benefit from a vaccine. Volume I focuses on basic science laying the foundations of clinical research, starting with the comparative genomics of primate CMVs and ending with the emerging field of humanized mouse models. Volume II is more clinically-oriented, covering the immune response to CMV, the most pressing medical problems in the newborn and in transplantation patients, as well as diagnostics, the management of antiviral drug resistance, the state and future of a CMV vaccine, and the potential of using CMV as a vaccine vector to fight unrelated diseases. The book closes with a critical survey of disputed associations between CMV and atherosclerotic cardiovascular disease, certain tumors such as Glioblastoma Multiforme, and the phenomenon of 'immune senescence' in the elderly. The book is liberally illustrated with more than 200 figures, most of which are in full colour. There are over 60 tables and several thousand references which enhance the book even further making it an invaluable source of information. Essential reading for all virologists with an interest in cytomegaloviruses, for all clinicians in pediatric intensive-care medicine and at transplantation centers, for scientists working on antiviral drug and vaccine development, as well as for public health service and science funding system authorities. read more ...
Rhabdoviruses: Molecular Taxonomy, Evolution, Genomics, Ecology, Host-Vector Interactions, Cytopathology and Control
Edited by: Ralf G. Dietzgen and Ivan V. Kuzmin
Published: 2012
Hardback: ISBN 978-1-908230-11-9 £159, $319
Written by a select group of world-renowned virologists, this book reviews all of the most recent advances in rhabdovirology providing a timely overview of the field. Most contributions are written from a molecular and genomic perspective and contain expert insights upon which to base future research efforts. Topics covered include: morphology, genome organization, transcription, virus replication, taxonomy, characterization, virus evolution, vesiculovirus, lyssavirus, ephemeroviruses, fish novirhabdoviruses, the sigma viruses of Drosophila, virus-host protein interaction of plant-adapted rhabdoviruses, cereal-infecting rhabdoviruses, and rabies prevention and control including lyssavirus vaccine development. The book is a 'must read' for all virologists working on these and related negative sense RNA viruses. A recommended book for all biology, veterinary and medical libraries. read more ...
Small DNA Tumour Viruses
Edited by: Kevin Gaston
Published: 2012
Hardback: ISBN 978-1-904455-99-8 £159, $319
In this timely book leading scientists from around the world review current hot-topics in this area providing a fascinating overview of the molecular biology of these viruses and their interactions with the host. Topics covered include: HPV infections and the production of HPV virion stocks; viral oncoproteins and their functions; the replication and maintenance of viral genomes; virus induced alterations in cellular miRNAs; viral deregulation of DNA damage responses; the initiation of viral DNA replication; induction of genomic instability by viral oncoproteins; targeting of PML proteins and PML nuclear bodies by these viruses; adenoviruses and gene therapy. Essential reading for scientists and researchers working on small DNA tumour viruses and their associated diseases and a recommended text for anyone involved with DNA replication, DNA damage responses and genome instability, virus-host interactions, viral tumourigenesis or antiviral drug development. read more ...
Molecular Virology and Control of Flaviviruses
Edited by: Pei-Yong Shi
Published: 2012
Hardback: ISBN 978-1-904455-92-9 £180, $360
The editor of Molecular Virology and Control of Flaviviruses has assembled an up-to-date and cutting-edge anthology from the leading experts in the flavivirus field. Chapters are balanced by contributions from established investigators, who have dedicated their careers to flavivirus research, with those from newcomers who have recently made significant contributions to the flavivirus field. The book opens with a brief introduction then divides into two sections: Molecular Virology (Chapters 2-9) and Virus Prevention (Chapters 10-15). The first section covers: virion structure; virus replication; the NS1 glycoprotein; the NS3 protein; the NS5 protein; innate immunity and flavivirus infection; host responses to flavivirus infection; and flavivirus fitness and transmission. The second section includes: vaccines; antibody therapy; small molecule antiviral development; flavivirus diagnostics; vector-virus interactions; and vector control. The book represents an important update of flavivirus research and will serve as a reference to flavivirus researchers at the graduate level and beyond. A recommended text for all virology libraries. read more ...
Bunyaviridae: Molecular and Cellular Biology
Edited by: Alexander Plyusnin and Richard M. Elliott
Published: 2011
Hardback: ISBN 978-1-904455-90-5 £159, $319
The book is essential reading for everyone working on bunyaviruses and related viruses. A recommended text for all virology libraries. read more ...
Metagenomics: Current Innovations and Future Trends
Edited by: Diana Marco
Published: 2011
Hardback: ISBN 978-1-904455-87-5 £159, $319
This book covers the most innovative and recent advances in theoretical, methodological and applied areas of metagenomics. Topics covered include metagenomics integration with complementary technologies, bacterial genealogy, viral metagenomics, the regulation of prokaryotic communities, functional metagenomics, systems biology, next-generation sequencing, stable isotope probing, DNA sequencing of uncultured microbes, cyberinfrastructure resource, identification of novel viruses, metagenomics of fungal communities, the human microbiome, microbial bioremediation, metagenomic enzyme discovery, quorum-sensing, plant-pathogen interactions, and metagenomics of belowground microbial communities. The book is aimed at researchers and environmental managers involved in metagenomics, students starting research in this field and teachers interested in the new developments. read more ...
The Biology of Paramyxoviruses
Edited by: Siba K. Samal
Published: 2011
Hardback: ISBN 978-1-904455-85-1 £180, $360
This book provides a timely and comprehensive review of current knowledge of all paramyxoviruses and is written by renowned scientists who have made seminal contributions in their respective paramyxovirus fields of expertise. Topics include: mumps virus, simian virus 5, parainfluenza viruses, Newcastle disease and related avian paramyxoviruses, Sendai virus, Hendra virus, Nipah virus, measles virus, canine distemper virus, rinderpest virus, peste des petits ruminants virus, human respiratory syncytial virus, metapneumoviruses, and new and emerging paramyxoviruses. Each chapter covers our current knowledge on history, genome organization, viral proteins, reverse genetics, epidemiology, pathogenesis, immunity, diagnosis, prevention and control and future challenges. This book is an invaluable reference source of timely information for virologists, microbiologists, immunologists, physicians, veterinarians and scientists working on paramyxoviruses. It is also strongly recommended for all medical and veterinary school libraries. read more ...
Viruses and Interferon: Current Research
Edited by: Karen Mossman
Published: 2011
Hardback: ISBN 978-1-904455-81-3 £159, $319
In this book, a panel of international experts reviews the current hot-topics, producing a timely overview of this exciting field. The book opens with a chapter that comprehensively reviews the antiviral effects of extracellular double-stranded RNA, the "viral toxin". This is followed by chapters that review the properties of type I and type III interferons, and the role of interferon-stimulated genes. The next five chapters are devoted to understanding the diverse strategies used by clinically relevant human viruses to subvert host interferon responses. The closing chapter provides an interesting overview of the clinical application of interferon as antiviral and anticancer agents. Essential reading for every scientist involved in interferon or antiviral research and a recommended text for all virology laboratories. read more ...
Hepatitis C: Antiviral Drug Discovery and Development
Edited by: Seng-Lai Tan and Yupeng He
Published: 2011
Hardback: ISBN 978-1-904455-78-3 £180, $360
The editors of this book have recruited experts from around the world to produce a timely and well-compiled review of current HCV research with an emphasis on antiviral drug development. The chapters provide in-depth reviews of the most critical areas of research. Topics covered include: the HCV life cycle, HCV assays, HCV resources, HCV databases, HCV infection systems, models of hepatitis C infections, overview of the drug pipeline, clinical trial design, clinical virology and drug development, NS3 protease inhibitors, NS3-NS4A complex inhibitors, NS3 helicase inhibitors, NS4B targets and inhibitors, NS5A inhibitors, nucleoside inhibitors, NS5B polymerase inhibitors, glycoprotein-dependent entry, host cell targets and inhibitors, and innate immunity for HCV antiviral therapy. An essential book for scientists involved with HCV and anyone interested in antiviral drug development. A recommended text for all virology libraries. read more ...
Alphaherpesviruses: Molecular Virology
Edited by: Sandra K. Weller
Published: 2011
Hardback: ISBN 978-1-904455-76-9 £180, $360
Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections. read more ...
Recent Advances in Plant Virology
Edited by: Carole Caranta, Miguel A. Aranda, Mark Tepfer and J.J. Lopez-Moya
Published: 2011
Hardback: ISBN 978-1-904455-75-2 £180, $360
Viruses that infect plants are responsible for reduction in both yield and quality of crops around the world, and are thus of great economic importance. This has provided the impetus for the extensive research into the molecular and cellular biology of these pathogens and into their interaction with their plant hosts and their vectors. However interest in plant viruses extends beyond their ability to damage crops. Many plant viruses, for example tobacco mosaic virus, have been used as model systems to provide basic understanding of how viruses express genes and replicate. Others permitted the elucidation of the processes underlying RNA silencing, now recognised as a core epigenetic mechanism underpinning numerous areas of biology. This book attests to the huge diversity of research in plant molecular virology. Written by world authorities in the field, the book opens with two chapters on the translation and replication of viral RNA. Following chapters cover topics such as viral movement within and between plants, plant responses to viral infection, antiviral control measures, virus evolution, and newly emerging plant viruses. To close there are two chapters on biotechnological applications of plant viruses. Throughout the book the focus is on the most recent, cutting-edge research, making this book essential reading for everyone, from researchers and scholars to students, working with plant viruses. read more ...
Vaccine Design: Innovative Approaches and Novel Strategies
Edited by: Rino Rappuoli and Fabio Bagnoli
Published: 2011
Hardback: ISBN 978-1-904455-74-5 £180, $360
In this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies. The book has been divided into two parts. The first part reviews the technologies and approaches used to identify, generate and test new vaccines. Topics include: new strategies to identify protective antigens, generation of improved adjuvants, use of alternative immunization routes, improving vaccine safety, and finding and establishing the correlates of protection. The second part of the book focuses on the development of new vaccines to replace or complement currently available products or for diseases against which prophylactic strategies are missing. Examples include vaccines against nosocomial infections, streptococci, emerging viral diseases, P. aeruginosa, and bovine mastitis. Essential reading for everyone with an interest in vaccine R & D. read more ...
Insect Virology
Edited by: Sassan Asgari and Karyn N. Johnson
Published: 2010
Hardback: ISBN 978-1-904455-71-4 £180, $360
Written by internationally renowned insect virologists, chapters review the current molecular biology of all the major groups of insect pathogenic viruses and suggest future directions for research. The book is divided into three parts: 1) DNA viruses 2) RNA viruses and 3) current hot-topics in insect virology. Virus groups covered include: Ascoviruses, Baculoviruses, Densoviruses, Entomopoxviruses, Hytrosaviruses, Iridoviruses, Nudiviruses, Polydnaviruses, Dicistroviruses, Iflaviruses, Nodaviruses, Tetraviruses and Cypoviruses. The special topics chapters review exciting recent developments in insect virology including RNAi, insect antiviral responses, structural comparison of insect RNA viruses, and viral ecology. The book is essential reading for every insect virologist in both the academic and private sectors. It is also strongly recommended for other virologists, particularly those interested in virus evolution, virus structure, viral vectors, biological control of insects and insect immunity. read more ...
Environmental Microbiology: Current Technology and Water Applications
Edited by: Keya Sen and Nicholas J. Ashbolt
Published: 2011
Hardback: ISBN 978-1-904455-70-7 £159, $319
Authors have included comparative tables and figures that address detection sensitivity, specificity, ease of use and other criteria. The value of the book emanates from its explanation of the principles of techniques and the comparison of related techniques. In addition the reader is introduced to key references and important web sites where further details of the technology can be found. An essential book for water microbiologists, environmental microbiologists and regulators and recommended reading for all microbiologists and environmental scientists. read more ...
Nanotechnology in Water Treatment Applications
Edited by: T. Eugene Cloete, Michele de Kwaadsteniet, Marelize Botes and J. Manuel López-Romero
Published: 2010
Hardback: ISBN 978-1-904455-66-0 £159, $319
This timely volume reviews the current state-of-the-art research and development of different nanomaterials (nanostructured catalytic membranes, nanosorbents, nanocatalysts and bioactive nanoparticles) and their application in water treatment, purification and disinfection. The expert authors have contributed chapters focusing on the cutting-edge research in this emerging technology and its applications in microbiology and water treatment. Topics covered include the detection of microbial pathogens, nanofibers and nanobiocides in water purification, nanozymes for biofilm removal, water and wastewater treatment and reverse osmosis. Also included is a chapter dedicated to the health and environmental concerns for the use of nanotechnology in water treatment. This book is aimed at everyone interested in nanobiotechnology, bioremediation, biodiagnostics, molecular diagnostics and environmental microbiology and is a recommended text for all microbiology laboratories. read more ...
Caliciviruses: Molecular and Cellular Virology
Edited by: Grant S. Hansman, Xi Jason Jiang and Kim Y. Green
Published: 2010
Hardback: ISBN 978-1-904455-63-9 £159, $319
In this book, a panel of experts distil the most important up-to-date research findings in their respective calicivirus field of study producing timely and comprehensive reviews. Each chapter gives the reader a brief introduction to the topic followed by a descriptive discussion of the past and present research areas. Topics include: norovirus epidemiology; calicivirus contamination of the environment; genome organization and recombination, proteolytic cleavage and viral proteins; viral protein structures; virus-host interactions; calicivirus reverse genetics and replicon systems; feline calicivirus; swine calicivirus; murine norovirus pathogenesis and immunity; murine norovirus translation, replication and reverse genetics; and lagoviruses. This book is essential reading for all virologists working on caliciviruses and related viruses and is recommended for all virology, immunology and molecular biology laboratories. read more ...
Epstein-Barr Virus: Latency and Transformation
Edited by: Erle S. Robertson
Published: 2010
Hardback: ISBN 978-1-904455-62-2 £159, $319Paperback: ISBN 978-1-904455-64-6 £60, $120 In this book, expert EBV virologists comprehensively review this important subject from a genetic, biochemical, immunological, and cell biological perspective. Topics include: latent infections, EBV leader protein, EBNA-1 in viral DNA replication and persistence, EBNA-2 in transcription activation of viral and cellular genes, the nuclear antigen family 3 in regulation of cellular processes, molecular profiles of EBV latently infected cells, latent membrane protein 1 oncoprotein, regulation of latency by LMP2A, role of noncoding RNAs in EBV-induced cell growth and transformation and the regulation of EBV latency by viral lytic proteins. This book is essential reading for all EBV virologists as well as clinical and basic scientists working on oncogenic viruses. read more ...
Lentiviruses and Macrophages: Molecular and Cellular Interactions
Edited by: Moira Desport
Published: 2010
Hardback: ISBN 978-1-904455-60-8 £159, $319
In this timely book, top lentivirus and macrophage specialists comprehensively review cutting-edge topics in the molecular and cellular biology of the lentivirus-macrophage interaction. Topics include: lentivirus tropism and disease, macrophage biology, macrophage in HIV-1 infection and disease progression, post-entry restrictions to lentiviral replication, HIV-2 tropism and disease, SHIV model of disease, the felid immunodeficiency viruses, EIAV, small ruminant lentiviruses, bovine lentiviruses, coinfections and superinfections. Essential reading for every lentivirologist and retrovirologist, this is also a recommended text for all virology, immunology and molecular biology laboratories. read more ...
Influenza: Molecular Virology
Edited by: Qinghua Wang and Yizhi Jane Tao
Published: 2010
Hardback: ISBN 978-1-904455-57-8 £159, $319
In this timely book, internationally renowned scientists critically review the current research and the most important discoveries in this highly topical field. Subjects covered include the NS1 protein of influenza A virus, the structure of influenza NS1, influenza B hemagglutinin, influenza A nucleoprotein, influenza A hemagglutinin glycoproteins, the M2 channel, virulence genes of the 1918 pandemic influenza, influenza virus polymerase, gene diagnostic microarrays, and computer-assisted vaccine design. Highly informative and well referenced, this book is essential reading for all influenza specialists and is recommended reading for all virologists, immunologists, molecular biologists, public health scientists and research scientists in pharmaceutical companies. read more ...
RNA Interference and Viruses: Current Innovations and Future Trends
Edited by: Miguel Angel Martínez
Published: 2010
Hardback: ISBN 978-1-904455-56-1 £159, $319
In this book, expert RNAi specialists from around the world have teamed up to produce a timely and thought-provoking review of the area. The two central themes are: 1) the latest findings on RNAi-virus interactions and 2) progress in the development of RNAi-based antiviral therapeutics. A number of chapters explain general concepts concerned with the role of RNAi in natural antiviral defense mechanisms, other chapters discuss how to improve the efficacy and safety of RNAi-based antiviral drugs, while others describe how this technology is being developed as a new therapeutic tool for fighting specific viruses, including HIV, HCV and respiratory viruses. Authors also outline potential new avenues for research thus providing a stimulus for further research. Essential reading for researchers involved in RNAi or antiviral research and a recommended text for all virology laboratories. read more ...
Retroviruses: Molecular Biology, Genomics and Pathogenesis
Edited by: Reinhard Kurth and Norbert Bannert
Published: 2010
Hardback: ISBN 978-1-904455-55-4 £159, $319
Written by the top retroviral specialists, this book reviews the genomics, molecular biology, and pathogenesis of these important viruses, comprehensively covering all the recent advances. Topics include: host and retroelement interactions, endogenous retroviruses, retroviral proteins and genomes, viral entry and uncoating, reverse transcription and integration, transcription, splicing and RNA transport, pathogenesis of oncoviral infections, pathogenesis of immunodeficiency virus infections, retroviral restriction factors molecular vaccines and correlates of protection, gammaretroviral and lentiviral vectors, non-primate mammalian and fish retroviruses, simian exogenous retroviruses, and HTLV and HIV. Essential reading for every retrovirologist and a recommended text for all virology and molecular biology laboratories. read more ...
Frontiers in Dengue Virus Research
Edited by: Kathryn A. Hanley and Scott C. Weaver
Published: 2010
Hardback: ISBN 978-1-904455-50-9 £159, $319
This book brings together a panel of expert dengue virologists to produce a timely review of the rapidly expanding dengue research literature. In addition authors identify the most pressing questions that remain to be answered, thus providing a stimulus for future research. Topics include: evolutionary history, epidemiology, translation and processing of the viral polyprotein, viral replication, the role of the viral untranslated regions, pathogenesis, host response to DENV, development of animal models, DENV-mosquito interactions, dynamics of dengue virus transmission, emergence of DENV from its ancestral, sylvatic cycle, vaccines, novel anti-dengue drugs, and passive immunotherapy. Essential reading for every dengue virologist and highly recommended for all flavivirus and arbovirus virologists. read more ...
Animal Viruses: Molecular Biology
Edited by: Thomas C. Mettenleiter and Francisco Sobrino
Published: 2008
Hardback: ISBN 978-1-904455-22-6 £159, $319
In this book an international panel of leading virologists provide a state-of-the-art overview of the field, comprehensively detailing the current understanding of viruses, their replication, evolution and interaction with the host. The authors emphasize strategic and methodological aspects of current research, and provide key related references. Topics include foot-and-mouth disease virus, Pestivirus, Arteriviridae, Coronaviruses (including SARS), Herpesviridae, Paramyxoviridae, influenza viruses, Reoviridae, porcine circoviruses, Asfarviridae and much more. An essential text for all virology laboratories. read more ...
Segmented Double-stranded RNA Viruses: Structure and Molecular Biology
Edited by: John T. Patton
Published: 2008
Hardback: ISBN 978-1-904455-21-9 £159, $319
This timely book brings together all of the key recent research on this disparate group of viruses, providing for the first time a single resource reviewing dsRNA viral structure and molecular biology. Written by well respected and experienced virologists, topics include: the structures of orthoreoviruses, rotavirus, phytoreoviruses, and bluetongue virus, entry into the bacterial cell, crystal structure of reovirus polymerase λ3, assembly of the reovirus genome, genomic RNA packaging and replication in the Cystoviridae, and much more. Essential reading for all dsRNA virologists and all other virologists with an interest in molecular and structural biology. read more ...
Coronaviruses: Molecular and Cellular Biology
Edited by: Volker Thiel
Published: 2007
Hardback: ISBN 978-1-904455-16-5 £159, $319
In this timely book, internationally renowned experts review literally every aspect of cutting edge coronavirus research providing the first coherent picture of the molecular and cellular biology since the outbreak of SARS in 2003. The book is divided into two sections: Part I focuses on the molecular biology of the virus itself and includes topics such as coronavirus binding and entry, replicase gene function, cis-acting RNA elements, coronavirus discontinuous transcription, reverse genetics, genome packaging and molecular evolution. In Part II of the book, the focus is on molecular and cellular pathogenesis and infection control. This section includes reviews of the three prototype viruses, namely avian infectious bronchitis virus, feline coronavirus and mouse hepatitis virus. Other topics include SARS-CoV virus pathogenesis, SARS-CoV interaction with the host INF and antiviral cytokines, the newly recognized bat coronaviruses and human coronavirus NL63, and strategies for coronavirus vaccine development and the development of novel antiviral coronavirus agents. Essential reading for all coronavirologists as well as scientists working on other viruses of the respiratory and/or gastrointestinal tract. read more ...
Bacteriophage: Genetics and Molecular Biology
Edited by: Stephen Mc Grath and Douwe van Sinderen
Published: 2007
Hardback: ISBN 978-1-904455-14-1 £159, $319
Written by eminent international researchers actively involved in the disparate areas of bacteriophage research this book focuses on the current rapid developments in this exciting field. The book opens with an excellent chapter that provides a broad overview of the topics and also highlights the multifaceted nature of bacteriophage research. This is followed by a series of reviews that focus on the current most cutting-edge topics including bioinformatics and genomics, phage in the environment, bacteriophage in medicine, transfer of phage DNA to the host, contribution to host phenotype and much more. Essential reading for all phage researchers and of interest to molecular biologists and microbiologists working on bacteria in academia, biotechnology and pharmaceutical companies, and in the food and other industries read more ...
AIDS Vaccine Development: Challenges and Opportunities
Edited by: Wayne Koff, Patricia Kahn and Ian D. Gust
Published:
Paperback: ISBN 978-1-904455-11-0 £49, $99
This book reviews the scientific challenges that have impeded the search for an effective AIDS vaccine and discusses current novel research that is accelerating progress. In a series of mini-reviews by the world's leading experts in AIDS vaccine research the book is essential reading for everyone interested in the current progress and future direction of AIDS vaccine development. read more ...
Alpha Herpesviruses: Molecular and Cellular Biology
Edited by: R. M. Sandri-Goldin
Published: 2006
Hardback: ISBN 978-1-904455-09-7 £180, $360
Written by internationally recognized experts, this book highlights the more provocative and exciting findings in herpesvirus research. Each chapter is a review of a specific area with an emphasis on recent advances and the latest developments. Topics include: multifunctional proteins, advances in DNA replication, new information on the regulation of gene expression, the emergence of new technologies, recent technological advances in fluorescent probes, the induction of apoptosis, the disruption of interferon, vaccine development and drug design. With a specific focus on new and topical herpesvirus research, this book is essential reading for everyone with an interest in herpesviruses and recommended reading for other scientists working in viral pathogenesis, viral genomics and antiviral research. read more ...
Influenza Virology: Current Topics
Edited by: Yoshihiro Kawaoka
Published: 2006
Hardback: ISBN 978-1-904455-06-6 £159, $319
Despite extensive, coordinated efforts by various agencies and disciplines, both national and international, we are ill-equipped for a new influenza pandemic. In fact it is highly unlikely that adequate supplies of vaccine for the H5N1 viruses will be prepared prior to the occurrence of the next pandemic. Many countries are stockpiling influenza drugs, with the hope that the inevitable emergence of drug-resistant viruses will not nullify those efforts immediately. To combat the outbreaks that will undoubtedly occur in the near future a better understanding of influenza virus itself, the virus-host interaction, and mechanisms of drug resistance is urgently needed.
In this timely book world renowned scientists (including the 1996 Nobel Prize Winner, Peter Doherty) critically review the most important issues in this rapidly expanding field. Topics covered include analysis of influenza RNP, viral entry and intracellular transport, epidemiology, host range and pathogenicity, antivirals, vaccines, H5 viruses, and much more. Essential reading for all influenza virologists, molecular biologists, public health scientists and research scientists in pharmaceutical companies.
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Microbial Subversion of Immunity: Current Topics
Edited by: Peter J. Lachmann and M.B.A. Oldstone
Published: 2006
Hardback: ISBN 978-1-904455-05-9 £159, $319
In this book internationally renowned scientists critically review the current cutting-edge research in this area. Topics covered include the subversion of complement, NK cell function, mucosal innate immune response, evasion/subversion mechanisms used by bacteria, helminths, viruses, and the measles model system. Containing over 1,700 references, this book is an essential resource book for researchers in the fields of microbiology, immunology, pharmacology and molecular medicine. read more ...
Papillomavirus Research: From Natural History To Vaccines and Beyond
Edited by: M. Saveria Campo
Published: 2006
Hardback: ISBN 978-1-904455-04-2 £159, $319
In this timely book leading scientists review current aspects of papillomavirus research providing a fascinating insight into papillomavirus molecular biology, interactions with the host, immunology and vaccine development. Topics covered include epidemiology and taxonomy, phylogenetic analyses, gene expression, regulation of DNA replication, transcription factor proteins, organotypic raft cultures, virus-like particles, and much more. Essential reading for scientists and researchers working on papillomavirus and a recommended text for anyone involved with antiviral drug and vaccine development. read more ...
Epstein-Barr Virus
Edited by: Erle S. Robertson
Published: 2005
Hardback: ISBN 978-1-904455-03-5 £159, $319
Epstein-Barr virus (EBV) is a human gamma herpes virus that remains one of the most successful viral parasites known to man. It is the etiological agent of infectious mononucleosis and is the major biological cofactor contributing to a number of human cancers including B-cell neoplasms (e.g. Burkitt's lymphoma, Hodgkin's disease and immunoblastic lymphomas), certain forms of T-cell lymphoma, and some epithelial tumours (e.g. nasopharyngeal carcinomas and gastric carcinomas). The virus has the unique ability to persist in the infected, apparently healthy host for life. Understanding the molecular interaction between EBV and its human host, the ability of the virus to modulate the host immune system, its ability to "hide" in B-memory cells and factors that trigger viral reactivation are fundamental to understanding the cellular and molecular pathogenesis of the virus. This is critical for the development of strategies for the prevention and control of infection and disease. In this book, world renowned EBV experts provide a critical and comprehensive review of every aspect of this important virus. By integrating genetic, immunologic, and cell biologic approaches to elucidate pathogenesis, penetrating new insights into the molecular and cellular interaction between EBV and its human host have emerged. Topics covered include: Discovery, history and seroepidemiology, EBV and the immune response, EBV genetics, EBV infection and persistence, latency, lytic proteins and reactivation control, vaccine approaches, animal models, and the future of EBV studies. This is essential reading for all EBV virologists as well as clinical and research scientists working on oncogenic viruses. read more ...
Cytomegaloviruses: Molecular Biology and Immunology
Edited by: Matthias J. Reddehase
Published: 2006
Hardback: ISBN 978-1-904455-02-8 £159, $319
In this book leading international experts provide comprehensive and authoritative reviews on every aspect of current research. By integrating viral genomics, proteomics, immunology and molecular biology with the emerging knowledge of the genomics of the host organism, penetrating new insights into the virus-host interaction are provided. The focus of the book is on the molecular and genomic aspects and the authors provide an insight into the current understanding of the subject and the future direction of research. Topics covered include disease mechanisms, genomics, proteomics, BAC mutagenesis, virus entry and activation of innate immunity, regulation of viral gene expression, regulation of viral mRNA export, animal models of infection, novel therapeutics, vaccine development, antivirals, and much more. The book is liberally illustrated with many figures in full colour and is set is a clear, easy-to-follow layout. Essential reading for all virologists with an interest in cytomegaloviruses and a recommended text for scientists working on antiviral drug and vaccine development. read more ...
Foodborne Pathogens: Microbiology and Molecular Biology
Edited by: Pina M. Fratamico, Arun K. Bhunia, and James L. Smith
Published: 2005
Hardback: ISBN 978-1-904455-00-4 £159, $319. Paperback: ISBN 978-1-898486-52-7 £99, $199
Foodborne pathogens continue to cause major public health problems worldwide. These organisms are the leading causes of illness and death in less developed countries, killing approximately 1.8 million people annually. In developed countries Foodborne pathogens are responsible for millions of cases of infectious gastrointestinal diseases each year, costing billions of dollars in medical care and lost productivity. In addition, new Foodborne diseases are likely to emerge driven by factors such as pathogen evolution, changes in agricultural and food manufacturing practices, and changes to the human host status. A third problem is that there are growing concerns that terrorists could use pathogens to contaminate food and water supplies in attempts to incapacitate thousands of people and disrupt economic growth. Fuelled by these concerns research into the genomics, molecular biology and microbiology of the most important Foodborne pathogens has escalated to unprecedented levels in recent years. Written by leaders in the field, this book represents a cutting edge summary of all the latest advances, providing the first coherent picture of the current status. Opening chapters tackle topics such as pathogen detection (molecular, biosensor), molecular typing, viable but non-culturable organisms, predictive modeling, and stress responses. The next section covers groups of organisms: enteric viruses, protozoan parasites, and mycotoxins. This is followed by chapters on specific bacteria: Yersinia enterocolitica, Vibrio spp., Staphylococcus aureus, Campylobacter Infections, Listeria monocytogenes, Salmonella spp., Shigella spp., Escherichia coli, Clostridium botulinum, Clostridium perfringens and Bacillus cereus. The final chapters provide a fascinating review of the ability of pathogens to contaminate a food supply and provide an overview of emerging Foodborne pathogens. The book is essential reading for all microbiologists and food scientists and of particular interest to anyone involved in food safety. read more ...
HIV Chemotherapy: A Critical Review
Edited by: Salvatore T. Butera
Published: 2005
Hardback: ISBN 978-0-9542464-9-5 £159, $319
Since the beginning of the AIDS pandemic in the early 1980's nearly 50 million people have been infected and over 16 million of those have died of AIDS. Combination anti-HIV therapy has dramatically reduced mortality rates and increased life expectancy in infected individuals. However it has not eradicated AIDS: the endemic is merely contained in industrialized nations and continues unabated in developing countries, e.g. Africa and parts of Asia. Since current anti-HIV drugs are virostatic rather than virotoxic, infected individuals must remain on drug therapy for life. This is a major problem since all of the existing anti-HIV drugs have side effects, some of which are serious and potentially fatal. In addition, the naturally occurring and extensive genetic variation found in HIV has led to the emergence of drug-resistant viruses. These challenges have prompted the urgent search for novel, molecular-based drugs and therapeutic strategies that target the different stages of viral infection of and interaction with the host. This is a book aimed at the scientist in the research laboratory. Written by expert international authors, the book is an essential reference for scientists working on AIDS, HIV and other retroviruses. Expert AIDS researchers critically review every aspect of this highly topical subject. The opening chapters deal with the management of HIV infections and include a fascinating review of current molecular strategies to protect and strengthen the host immune system at the cellular level. Chapters 6 and 7 summarises the strategies required for the implementation of effective anti-HIV therapies in developing countries (90% of worldwide AIDS cases). Two excellent chapters (4 and 5) comprehensively review the genetics of viral drug resistance, and current drug-resistance testing technologies. The remaining chapters provide cutting-edge reviews of the latest viral and cellular targets for anti-HIV chemotherapy, the development of iRNA based therapeutics and molecular based strategies that target latent virus reservoirs in infected individuals. Essential reading for scientists and clinicians working on AIDS, HIV, and other retroviruses as well as all health care professionals interested in expanding their current understanding of the subject. read more ...